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Tonix Pharmaceuticals Holding Corp (TNXP)



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Upturn Advisory Summary
03/20/2025: TNXP (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type Stock | Historic Profit -45.56% | Avg. Invested days 33 | Today’s Advisory PASS |
Upturn Star Rating ![]() ![]() | Upturn Advisory Performance ![]() | Stock Returns Performance ![]() |
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Key Highlights
Company Size Small-Cap Stock | Market Capitalization 91.01M USD | Price to earnings Ratio - | 1Y Target Price 516.67 |
Price to earnings Ratio - | 1Y Target Price 516.67 | ||
Volume (30-day avg) 1813632 | Beta 2.24 | 52 Weeks Range 6.76 - 672.00 | Updated Date 03/30/2025 |
52 Weeks Range 6.76 - 672.00 | Updated Date 03/30/2025 | ||
Dividends yield (FY) - | Basic EPS (TTM) -8039 |
Earnings Date
Report Date 2025-03-31 | When Before Market | Estimate - | Actual -9.767 |
Profitability
Profit Margin - | Operating Margin (TTM) -551.17% |
Management Effectiveness
Return on Assets (TTM) -44.07% | Return on Equity (TTM) -138.69% |
Valuation
Trailing PE - | Forward PE - | Enterprise Value 24334323 | Price to Sales(TTM) 12.86 |
Enterprise Value 24334323 | Price to Sales(TTM) 12.86 | ||
Enterprise Value to Revenue 2.41 | Enterprise Value to EBITDA 0.94 | Shares Outstanding 5590440 | Shares Floating 1868942 |
Shares Outstanding 5590440 | Shares Floating 1868942 | ||
Percent Insiders - | Percent Institutions 3.32 |
Analyst Ratings
Rating 5 | Target Price 5.83 | Buy - | Strong Buy 2 |
Buy - | Strong Buy 2 | ||
Hold - | Sell - | Strong Sell - | |
Strong Sell - |
Upturn AI SWOT
Tonix Pharmaceuticals Holding Corp

Company Overview
History and Background
Tonix Pharmaceuticals Holding Corp. was founded in 2007. Initially focused on repurposing existing drugs, the company has evolved to develop novel therapeutics for central nervous system (CNS) and immunological conditions. Significant milestones include advancing drug candidates through clinical trials and strategic acquisitions.
Core Business Areas
- Central Nervous System (CNS): Developing treatments for conditions like fibromyalgia, PTSD, and depression. Focus is on novel formulations and new chemical entities.
- Immunology: Developing treatments for conditions that include organ transplant rejection.
Leadership and Structure
Dr. Seth Lederman is the CEO and Chairman. The company has a typical corporate structure with a board of directors and various departments for research, development, and commercialization.
Top Products and Market Share
Key Offerings
- TNX-102 SL (Cyclobenzaprine HCl sublingual tablet): This is Tonix's most advanced product candidate for managing fibromyalgia. Currently in Phase 3 clinical development. Market share is currently 0% as the product is not yet approved. Competitors include Lyrica (Pfizer), Cymbalta (Eli Lilly), and Savella (Allergan), as well as generic pain medications.
- TNX-1900 (intranasal potentiated oxytocin): In development to prevent and treat Migraine. Currently in Phase 2 clinical trials. No current market share. Amgen and Eli Lilly are competitors in this space.
- TNX-1500 (CD40-lg): A clinical stage anti-CD40L monoclonal antibody being developed for organ transplant rejection and autoimmune diseases. Has Orphan Drug designation. Competitors include Bristol Myers Squibb and others developing monoclonal antibodies for similar conditions.
Market Dynamics
Industry Overview
The pharmaceutical industry is highly competitive and regulated. It involves significant R&D investment, clinical trials, and regulatory approvals. The market for CNS and immunology drugs is large and growing due to aging populations and increased disease prevalence.
Positioning
Tonix is a clinical-stage biopharmaceutical company focusing on developing novel therapies for unmet medical needs. Their competitive advantage lies in their unique formulations and targeted approaches to specific diseases.
Total Addressable Market (TAM)
The TAM for fibromyalgia and other CNS disorders is estimated to be in the billions of dollars. Tonix aims to capture a significant portion of this market with its lead product candidate. The organ transplant market is expected to be in the range of $13 billion by 2030. Tonix's portion of the market share will depend on regulatory approval and market penetration.
Upturn SWOT Analysis
Strengths
- Novel drug candidates
- Targeted therapeutic approach
- Experienced management team
- Orphan Drug designation for certain indications
Weaknesses
- Limited financial resources
- High R&D risk
- Dependence on clinical trial outcomes
- No currently approved products
Opportunities
- Partnerships and collaborations
- Successful clinical trial results
- Expansion into new indications
- FDA approval and commercialization
Threats
- Clinical trial failures
- Regulatory hurdles
- Competition from established players
- Patent expirations
Competitors and Market Share
Key Competitors
- LLY
- PFE
- ABBV
- BMY
Competitive Landscape
Tonix faces significant competition from established pharmaceutical companies with greater financial resources and broader product portfolios. Tonix's advantage lies in its novel drug candidates and targeted approach.
Major Acquisitions
FB Science Inc.
- Year: 2023
- Acquisition Price (USD millions): 36
- Strategic Rationale: Acquisition of assets related to vaccines for protecting against infectious diseases.
Growth Trajectory and Initiatives
Historical Growth: Historically, growth has been dependent on the successful advancement of drug candidates through the clinic. Their future growth relies heavily on regulatory success.
Future Projections: Future projections are highly uncertain and dependent on clinical trial outcomes and regulatory approvals. Analyst estimates vary widely.
Recent Initiatives: Recent initiatives include advancing TNX-102 SL through Phase 3 clinical trials, developing TNX-1900 for migraine, and advancing other pipeline assets.
Summary
Tonix Pharmaceuticals is a high-risk, high-reward clinical-stage company. Its future heavily depends on clinical trial successes and regulatory approvals of its drug candidates. While the company has novel therapeutic approaches, it faces significant competition and financial constraints. Currently, their growth depends on the success of their pipeline, particularly TNX-102 SL, and successful partnerships to offset high R&D costs.
Similar Companies
- LLY
- PFE
- ABBV
- BMY
Sources and Disclaimers
Data Sources:
- Company Website
- SEC Filings (10-K, 10-Q)
- Analyst Reports
- ClinicalTrials.gov
Disclaimers:
This analysis is for informational purposes only and should not be considered investment advice. The information is based on publicly available data and is subject to change. Investing in pharmaceutical companies carries significant risks, including clinical trial failures and regulatory setbacks.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Tonix Pharmaceuticals Holding Corp
Exchange NASDAQ | Headquaters Chatham, NJ, United States | ||
IPO Launch date 2012-05-10 | Co-Founder, President, CEO & Chairman Dr. Seth Lederman M.D. | ||
Sector Healthcare | Industry Biotechnology | Full time employees 81 | Website https://www.tonixpharma.com |
Full time employees 81 | Website https://www.tonixpharma.com |
Tonix Pharmaceuticals Holding Corp., a biopharmaceutical company, focuses on developing, discovering, commercializing, and licensing therapeutics to treat and prevent human disease and alleviate suffering. It markets Zembrace SymTouch and Tosymra for the treatment of acute migraine with or without aura in adults. Its portfolio focuses on central nervous system disorders, as well as rare disease, immunology, and infectious disease product candidates. The company's priority is to submit a New Drug Application (NDA) to the FDA for TNX-102 SL (cyclobenzaprine HCl sublingual tablet), which has completed two positive Phase 3 studies for the management of fibromyalgia. TNX-102 SL is also being developed to treat fibromyalgia-type Long COVID, a chronic post-acute COVID-19 condition. Its TNX-1300 (cocaine esterase) is a biologic designed to treat cocaine intoxication and has been granted breakthrough therapy designation by the FDA. The company's rare disease development portfolio comprises TNX-2900, an intranasal potentiated oxytocin for the treatment of Prader-Willi syndrome (PWS). Its immunology portfolio includes TNX-1500, which is a biologic to address organ transplant rejection and autoimmune diseases. The company's infectious disease pipeline includes TNX-801, a vaccine in development to prevent smallpox and mpox. TNX-801 also serves as the live virus vaccine platform or recombinant pox vaccine platform for other infectious diseases, including TNX-1800 and TNX-1850, in development as a vaccine to protect against COVID-19. Its infectious disease development portfolio also comprises TNX-3900, and TNX-4200 are orally available CD45 antagonists in preclinical development. Tonix Pharmaceuticals Holding Corp. has collaboration agreement with Bilthoven Biologicals to advance TNX-801 mpox vaccine candidate; and with X-Chem, Inc. to develop broad-spectrum antivirals. The company was founded in 2007 and is headquartered in Chatham, New Jersey.
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