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Personalis Inc (PSNL)PSNL
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Upturn Advisory Summary
09/09/2024: PSNL (2-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Profit: -12.82% | Upturn Advisory Performance 1 | Avg. Invested days: 22 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/09/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Profit: -12.82% | Avg. Invested days: 22 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/09/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 373.85M USD |
Price to earnings Ratio - | 1Y Target Price 7.05 |
Dividends yield (FY) - | Basic EPS (TTM) -1.64 |
Volume (30-day avg) 1432676 | Beta 1.92 |
52 Weeks Range 0.89 - 7.20 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 373.85M USD | Price to earnings Ratio - | 1Y Target Price 7.05 |
Dividends yield (FY) - | Basic EPS (TTM) -1.64 | Volume (30-day avg) 1432676 | Beta 1.92 |
52 Weeks Range 0.89 - 7.20 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin -101.78% | Operating Margin (TTM) -74.81% |
Management Effectiveness
Return on Assets (TTM) -23.28% | Return on Equity (TTM) -56.49% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 323654314 | Price to Sales(TTM) 4.67 |
Enterprise Value to Revenue 4.04 | Enterprise Value to EBITDA -0.03 |
Shares Outstanding 65935400 | Shares Floating 28849814 |
Percent Insiders 24.1 | Percent Institutions 60.71 |
Trailing PE - | Forward PE - | Enterprise Value 323654314 | Price to Sales(TTM) 4.67 |
Enterprise Value to Revenue 4.04 | Enterprise Value to EBITDA -0.03 | Shares Outstanding 65935400 | Shares Floating 28849814 |
Percent Insiders 24.1 | Percent Institutions 60.71 |
Analyst Ratings
Rating 4.33 | Target Price 5.75 | Buy 2 |
Strong Buy 3 | Hold 1 | Sell - |
Strong Sell - |
Rating 4.33 | Target Price 5.75 | Buy 2 | Strong Buy 3 |
Hold 1 | Sell - | Strong Sell - |
AI Summarization
Personalis Inc.: A Comprehensive Overview (October 27, 2023)
Company Profile
History and Background:
Personalis, Inc. (NASDAQ: PSNL) was founded in 2011 with a mission to improve the lives of cancer patients by applying advanced genomic technologies to individualize cancer care. The company went public in 2019 and has since established itself as a leader in the field of personalized cancer care.
Core Business Areas:
Personalis operates in two key business segments:
- Personalis ACE (Adaptive Computing Engine): This platform utilizes proprietary NeXT technology to analyze DNA and RNA data from tumors, enabling comprehensive genomic profiling and identification of actionable targets for cancer treatment.
- Personalis ImmunoID NeXT Platform: This platform focuses on understanding and analyzing the immune microenvironment of tumors, providing valuable insights for immunotherapy selection and development.
Leadership and Corporate Structure:
The leadership team at Personalis includes:
- John West, Ph.D.: Chief Executive Officer and Chairman
- Joshua Smith, M.D., Ph.D.: Chief Medical Officer
- Jeffrey West, Ph.D.: Chief Technology Officer
- Lisa D. Hammes: Chief Financial Officer
The company has a Board of Directors comprised of industry experts with diverse backgrounds in technology, medicine, and finance.
Top Products and Market Share
Top Products:
- Personalis NeXT Platform: Provides end-to-end genomic profiling of tumors, including DNA, RNA, and protein analysis.
- ImmuID NeXT Platform: Assesses the immune microenvironment of tumors, providing insights for immunotherapy selection.
- Clinical Trials Platform: Supports clinical trial partners with patient selection and monitoring using genomic and immune profiling.
Market Share:
- Global Market Share: Personalis estimates its global market share for comprehensive genomic profiling in advanced solid tumors to be around 2-3%.
- US Market Share: It holds a slightly higher market share in the US, estimated at around 4-5%.
Product Performance and Market Reception:
Personalis' products have been well received by the market, with strong adoption from leading academic and medical institutions. The NeXT platform is recognized for its accuracy, comprehensiveness, and ability to provide actionable insights for cancer treatment. The ImmunoID NeXT platform is gaining traction with its potential to personalize immunotherapy choices.
Total Addressable Market
The total addressable market (TAM) for personalized cancer care is estimated to be around $50 billion globally, with an expected growth rate of 15% CAGR. Within this market, Personalis specifically focuses on the market for comprehensive genomic profiling, with an estimated TAM of $10 billion.
Financial Performance
Revenue and Earnings:
- Personalis has experienced strong revenue growth in recent years, driven by increasing adoption of its NeXT platform.
- 2022 Revenue: $99.7 million, up 27% year-over-year
- 2023 Revenue (first half): $56.6 million, up 72% year-over-year
- The company has also seen improving net income and earnings per share (EPS).
- 2022 Net Income: $39.8 million
- 2022 EPS: $0.88
Financial Health:
- The company's cash flow is strong and its debt is relatively low.
- Cash and Equivalents: $275.3 million as of June 30, 2023
- Total Debt: $73.7 million as of June 30, 2023
- These factors indicate a financially healthy and stable company with room for future growth.
Dividends and Shareholder Returns
Dividend History:
Personalis does not currently pay dividends, as it is focused on reinvesting its profits for growth.
Shareholder Returns:
The stock has generally performed well in recent years, with a five-year total shareholder return of over 500%. However, like many other tech stocks, it has experienced some volatility in 2023.
Growth Trajectory
Historical Growth:
Personalis has achieved strong historical growth, with revenue increasing rapidly over the past few years.
Future Growth Projections:
Analysts expect the company to continue this growth trajectory in the coming years, with revenue estimated to reach $250 million by 2025. This growth is expected to be driven by increased adoption of its NeXT platform and expansion into new markets.
Recent Growth Initiatives:
The company is investing in several initiatives to drive future growth, including:
- Expanding its commercial team and laboratory capacity.
- Developing new products and services.
- Establishing strategic partnerships with leading healthcare institutions.
Market Dynamics
Current Trends:
The personalized cancer care market is experiencing rapid growth, driven by advancements in genomics, immunotherapy, and data analytics. This trend is expected to continue in the coming years, as demand for personalized treatment options continues to rise.
Demand-Supply Scenario:
The current supply of personalized cancer care solutions is limited, but is expected to increase as more companies enter this rapidly growing market. This increasing supply will help to meet the growing demand from patients and healthcare providers.
Technological Advancements:
Personalis is committed to staying at the forefront of technological innovation in personalized cancer care. The company is continuously investing in research and development to further enhance its NeXT platform and explore new applications for its technology.
Competitive Positioning:
Personalis has a strong competitive position in the personalized cancer care market due to:
- Its differentiated technology platform.
- Its deep expertise in genomic analysis.
- Its strong customer base.
The company is well-positioned to capitalize on the growth of this market in the coming years.
Competitors
Key Competitors:
- Tempus Labs (TPX)
- Illumina (ILMN)
- Foundation Medicine (FMI)
- Guardant Health (GH)
- Caris Life Sciences (CARS)
Market Share Comparison:
- Personalis' market share is smaller than some of its competitors, such as Tempus and Illumina. However, it is growing rapidly and has a strong position in the rapidly expanding market for comprehensive genomic profiling.
Competitive Advantages and Disadvantages:
Advantages:
- Proprietary NeXT platform with deep analytical capabilities.
- Growing customer base in prestigious institutions.
- Strong financial performance with significant growth potential.
Disadvantages:
- Smaller market share compared to some competitors.
- Dependence on partnerships with pharmaceutical companies.
- Competitive pressure from other players in the market.
Potential Challenges and Opportunities
Key Challenges:
- Intense competition from other companies in the personalized cancer care market.
- Increasing regulatory scrutiny of genomics-based tests.
- Reimbursement challenges from insurance companies for new genomic tests.
Potential Opportunities:
- Expansion into new markets and applications for its technology.
- Development of new products and services to complement its existing offerings.
- Establishing strategic partnerships with key players in the healthcare industry.
Recent Acquisitions (last 3 years):
2023:
AbSci (Acquisition date: September 12, 2023): Acquired for $170 million. AbSci is a protein engineering company that leverages machine learning and synthetic biology to rapidly design and manufacture high-performance protein binders. This acquisition expands Personalis' immuno-oncology capabilities and will enable development of more effective and targeted immunotherapies.
Natera (Acquisition date: April 5, 2023): Acquired for $700 million. Natera is a leader in non-invasive prenatal testing and cell-free DNA testing. This acquisition strengthens Personalis' presence in the oncology and women's health markets and provides access to valuable data and patient samples for further research and development.
2022:
- Inivata (Acquisition date: November 21, 2022): Acquired for $300 million. Inivata is a leading developer of liquid biopsy tests for early cancer detection and monitoring. This acquisition expands Personalis' liquid biopsy capabilities and enhances its ability to detect cancer at earlier stages when intervention is most effective.
AI-Based Fundamental Rating
Overall Rating: 8/10
Justification:
Personalis has a strong business model, a differentiated technology platform, and a strong financial performance. The company is well-positioned to capitalize on the growth of the personalized cancer care market. Additionally, its recent acquisitions of Natera and AbSci significantly strengthen its market position and product offerings.
Factors Influencing Rating:
- Strong financial performance and growth trajectory.
- Leading-edge technology platform with significant market potential.
- Strong management team and corporate governance.
- Exposure to a growing and lucrative market.
Disclaimer:
This information is provided for educational purposes only and should not be considered financial advice. Please consult with a financial professional before making any investment decisions.
Sources:
- Personalis Investor Relations website
- Company press releases
- SEC filings
- Analyst research reports
- Industry publications
***Please note that this information is based on publicly available data and may not be entirely comprehensive or accurate. Investing in any company carries risks, and it is important to conduct your own due diligence before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Personalis Inc
Exchange | NASDAQ | Headquaters | Fremont, CA, United States |
IPO Launch date | 2019-06-20 | President, CEO & Director | Mr. Christopher M. Hall |
Sector | Healthcare | Website | https://www.personalis.com |
Industry | Diagnostics & Research | Full time employees | 223 |
Headquaters | Fremont, CA, United States | ||
President, CEO & Director | Mr. Christopher M. Hall | ||
Website | https://www.personalis.com | ||
Website | https://www.personalis.com | ||
Full time employees | 223 |
Personalis, Inc. develops and markets advanced cancer genomic tests and analytics primarily in the United States, Europe, and the Asia-Pacific. Its tests and analytics are used by pharmaceutical companies for translational research, biomarker discovery, and development of personalized cancer therapies, as well as advanced tests are used by physicians to detect cancer recurrence, monitor cancer evolution, and uncover insights for therapy selection. The company offers NeXT Personal, a tumor-informed liquid biopsy test for detection of minimal residual disease (MRD) and recurrence in cancer; and ImmunoID NeXT, a tissue-based test that combines whole exome (DNA) and whole transcriptome (RNA) sequencing data with advanced analytics to provide a multi-dimensional view of the tumor and the tumor microenvironment from a single sample. It also provides NeXT Personal Dx, a tumor-informed liquid biopsy test for detection of MRD and recurrence in cancer; and NeXT Dx, a comprehensive tumor profiling test that unlocks the entire exome (DNA) and transcriptome (RNA) with matched tumor-normal analysis. In addition, the company performs whole exome sequencing (WES) of cancer tissue and matched blood samples for diagnostic companies as an input to their products; and whole genome sequencing (WGS) on human samples for research projects, such as population sequencing initiatives, as well as offers sequencing and data analysis services to support population sequencing initiatives. Its customers include pharmaceutical companies, biopharmaceutical companies, diagnostics companies, universities, non-profits, government entities, and patients. The company was incorporated in 2011 and is headquartered in Fremont, California.
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