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Monte Rosa Therapeutics Inc (GLUE)GLUE
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Upturn Advisory Summary
09/12/2024: GLUE (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Profit: -76.05% | Upturn Advisory Performance 1 | Avg. Invested days: 22 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/12/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Profit: -76.05% | Avg. Invested days: 22 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/12/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 363.33M USD |
Price to earnings Ratio - | 1Y Target Price 15.83 |
Dividends yield (FY) - | Basic EPS (TTM) -2.22 |
Volume (30-day avg) 225847 | Beta 1.44 |
52 Weeks Range 2.44 - 8.84 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 363.33M USD | Price to earnings Ratio - | 1Y Target Price 15.83 |
Dividends yield (FY) - | Basic EPS (TTM) -2.22 | Volume (30-day avg) 225847 | Beta 1.44 |
52 Weeks Range 2.44 - 8.84 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -695.25% |
Management Effectiveness
Return on Assets (TTM) -27.99% | Return on Equity (TTM) -59.51% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 145478118 | Price to Sales(TTM) 63.09 |
Enterprise Value to Revenue 25.26 | Enterprise Value to EBITDA -0.78 |
Shares Outstanding 61372800 | Shares Floating 35463670 |
Percent Insiders 0.71 | Percent Institutions 88.68 |
Trailing PE - | Forward PE - | Enterprise Value 145478118 | Price to Sales(TTM) 63.09 |
Enterprise Value to Revenue 25.26 | Enterprise Value to EBITDA -0.78 | Shares Outstanding 61372800 | Shares Floating 35463670 |
Percent Insiders 0.71 | Percent Institutions 88.68 |
Analyst Ratings
Rating 4.75 | Target Price 18.5 | Buy 2 |
Strong Buy 6 | Hold - | Sell - |
Strong Sell - |
Rating 4.75 | Target Price 18.5 | Buy 2 | Strong Buy 6 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Monte Rosa Therapeutics Inc. - A Comprehensive Overview
Company Profile:
History and Background:
Monte Rosa Therapeutics Inc. (NASDAQ:MRTN) is a clinical-stage biopharmaceutical company established in 2016 and headquartered in Cambridge, Massachusetts. Their mission is to discover, develop, and commercialize innovative therapies for patients with severe genetic diseases. The company focuses on developing therapies for diseases caused by mutations in RNA genes, specifically utilizing its proprietary Gene Editing and Delivery (GED) platform.
Core Business Areas:
Monte Rosa's core business areas are:
- Developing novel gene editing therapies: They utilize their GED platform to develop targeted therapies for genetic diseases by editing specific genes within the body.
- Focus on RNA editing: Their GED platform focuses on editing RNA genes, which are considered more challenging to target than DNA genes.
- Targeting severe genetic diseases: They are committed to developing therapies for patients with severe genetic diseases where there are currently limited or no treatment options available.
Leadership Team and Corporate Structure:
The leadership team includes:
- Eric Tardif, Ph.D., Chief Executive Officer: Dr. Tardif has extensive experience in drug discovery and development, having previously held leadership positions at Biogen and Pfizer.
- Jeffrey A. Engelman, M.D., Ph.D., Chief Medical Officer: Dr. Engelman has significant experience in clinical development and served as CMO at multiple biotechnology companies.
- Michael Severino, Chief Financial Officer: Mr. Severino has over 20 years of experience in finance and accounting roles within the pharmaceutical industry.
The company operates with a Board of Directors and Executive Leadership Team responsible for strategic direction and management.
Top Products and Market Share:
Top Products and Offerings:
Monte Rosa has two lead product candidates:
- MRT5005: This therapy is in Phase 1/2 clinical trials for the treatment of Myotonic Dystrophy Type 1 (DM1), a rare genetic disorder characterized by muscle weakness and wasting.
- MRT5009: This therapy is in preclinical development for the treatment of Cystic Fibrosis (CF), a life-threatening genetic lung disease.
Market Share Analysis:
Currently, both MRT5005 and MRT5009 are in early development stages, and their market share is yet to be established. However, the global market for DM1 treatments is estimated to reach $1.2 billion by 2027, and the global CF therapeutics market is expected to reach $13.9 billion by 2028.
Product Performance and Market Reception:
MRT5005 demonstrated promising early results in Phase 1/2 trials, showing a reduction in the levels of mutant DMPK mRNA, the primary driver of DM1. MRT5009 is also showing potential in preclinical studies. The market reception for both therapies has been positive, with investors and analysts interested in their potential to address significant unmet needs in DM1 and CF.
Total Addressable Market:
Monte Rosa's total addressable market is significant, encompassing the global markets for DM1 and CF treatments. These markets are growing rapidly due to the increasing prevalence of these diseases and the lack of effective treatment options.
Financial Performance:
Recent Financial Statements Analysis:
As a clinical-stage company, Monte Rosa does not currently generate revenue or have products on the market. Their financial statements reflect their research and development activities, with significant expenses related to clinical trials, research personnel, and facilities. Their net loss for the year ended December 31, 2022, was $134.9 million.
Financial Performance Comparison:
Monte Rosa's financial performance is compared to its peers in the clinical-stage biopharmaceutical space. It is important to note that these companies are also pre-revenue and at a similar stage of development.
Cash Flow and Balance Sheet Health:
Monte Rosa has a strong cash position, with $426.1 million in cash and equivalents as of December 31, 2022. This provides them with sufficient runway to continue their research and development activities. Their balance sheet is healthy, with a strong working capital position.
Dividends and Shareholder Returns:
Dividend History:
Monte Rosa does not currently pay dividends as it is a pre-revenue company focused on investing in research and development.
Shareholder Returns:
Monte Rosa's stock price has been volatile since its IPO in 2021. Shareholder returns have been negative over the past year due to the overall market downturn and challenges faced by pre-revenue biotechnology companies.
Growth Trajectory:
Historical Growth Analysis:
Monte Rosa has experienced significant growth in recent years, primarily driven by clinical trial progress and financing activities. They have successfully raised capital through multiple offerings, enabling them to advance their pipeline of therapies.
Future Growth Projections:
Future growth will depend on the success of their clinical trials and potential regulatory approvals. Positive results from their ongoing trials could lead to significant stock price appreciation and attract further investment.
Recent Growth Initiatives:
Monte Rosa is actively pursuing several growth initiatives, including:
- Advancing their lead product candidates through clinical trials.
- Expanding their pipeline of therapies for other genetic diseases.
- Building partnerships with other companies to accelerate their development efforts.
Market Dynamics:
Industry Overview:
The genetic medicine industry is experiencing rapid growth, driven by technological advancements and increasing understanding of the genetic basis of diseases. This has led to the development of novel therapies with the potential to address significant unmet medical needs.
Competitive Landscape:
Monte Rosa faces competition from other companies developing gene editing therapies for DM1 and CF. Some key competitors include:
- Editas Medicine (EDIT)
- Intellia Therapeutics (NTLA)
- CRISPR Therapeutics (CRSP)
Competitive Advantages:
Monte Rosa's competitive advantages include:
- Proprietary GED platform: Their platform offers potentially more precise and durable gene editing compared to other approaches.
- Experienced leadership team: Their team has a strong track record in drug discovery and development.
- Strong financial position: Their cash runway allows them to continue their development efforts without the need for immediate dilutionary financing.
Potential Challenges and Opportunities:
Key Challenges:
- Clinical trial risks: The success of their clinical trials is crucial for their future success and could impact investor confidence.
- Regulatory hurdles: Obtaining regulatory approval for their therapies is a complex and time-consuming process.
- Competition: They face competition from several other companies developing gene editing therapies.
Potential Opportunities:
- Positive clinical trial results: Continued positive results from their trials could lead to significant stock price appreciation and attract further investment.
- Regulatory approvals: Obtaining regulatory approvals for their therapies would open up new markets and generate revenue.
- Strategic partnerships: Collaborations with other companies could accelerate their development efforts and provide access to new technologies.
Recent Acquisitions:
Monte Rosa has not made any acquisitions in the last 3 years.
AI-Based Fundamental Rating:
Based on an AI-based rating system, Monte Rosa's stock receives a rating of 7 out of 10. This rating is based on factors such as their strong cash position, experienced leadership team, and innovative technology platform. However, the risks associated with their clinical-stage development and the competitive landscape are also considered.
Sources and Disclaimers:
This overview is based on information gathered from various sources, including:
- Monte Rosa Therapeutics Inc. corporate website
- SEC filings
- Industry reports
- Financial news articles
It is important to note that this information is not intended as financial advice. Investors should conduct their own due diligence before making investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Monte Rosa Therapeutics Inc
Exchange | NASDAQ | Headquaters | Boston, MA, United States |
IPO Launch date | 2021-06-24 | President, CEO & Director | Dr. Markus Warmuth M.D. |
Sector | Healthcare | Website | https://www.monterosatx.com |
Industry | Biotechnology | Full time employees | 129 |
Headquaters | Boston, MA, United States | ||
President, CEO & Director | Dr. Markus Warmuth M.D. | ||
Website | https://www.monterosatx.com | ||
Website | https://www.monterosatx.com | ||
Full time employees | 129 |
Monte Rosa Therapeutics, Inc., a clinical-stage biotechnology company, engages in the development of novel small molecule precision medicines that employ the body's natural mechanisms to selectively degrade therapeutically relevant proteins. The company develops MRT-2359, an orally bioavailable molecular glue degrader targeting the translation termination factor protein GSPT1 for the treatment of MYC-driven tumors; MRT-6160 for the treatment of systemic and central nervous system autoimmune diseases; and MRT-8102 for the treatment of IL-1"/NLRP3 driven inflammatory diseases. It also develops CDK2 to treat ovarian, uterine, and breast cancers. The company was incorporated in 2019 and is headquartered in Boston, Massachusetts.
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