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Arvinas Inc (ARVN)ARVN
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Upturn Advisory Summary
09/18/2024: ARVN (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -18.65% | Upturn Advisory Performance 2 | Avg. Invested days: 24 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -18.65% | Avg. Invested days: 24 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 1.74B USD |
Price to earnings Ratio - | 1Y Target Price 65.78 |
Dividends yield (FY) - | Basic EPS (TTM) -5.3 |
Volume (30-day avg) 575643 | Beta 1.98 |
52 Weeks Range 13.57 - 53.08 | Updated Date 09/17/2024 |
Company Size Small-Cap Stock | Market Capitalization 1.74B USD | Price to earnings Ratio - | 1Y Target Price 65.78 |
Dividends yield (FY) - | Basic EPS (TTM) -5.3 | Volume (30-day avg) 575643 | Beta 1.98 |
52 Weeks Range 13.57 - 53.08 | Updated Date 09/17/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -63.4% |
Management Effectiveness
Return on Assets (TTM) -19.63% | Return on Equity (TTM) -60.8% |
Valuation
Trailing PE - | Forward PE 17.7 |
Enterprise Value 511568904 | Price to Sales(TTM) 18.63 |
Enterprise Value to Revenue 5.48 | Enterprise Value to EBITDA -1.62 |
Shares Outstanding 68648096 | Shares Floating 57119306 |
Percent Insiders 7.22 | Percent Institutions 106.85 |
Trailing PE - | Forward PE 17.7 | Enterprise Value 511568904 | Price to Sales(TTM) 18.63 |
Enterprise Value to Revenue 5.48 | Enterprise Value to EBITDA -1.62 | Shares Outstanding 68648096 | Shares Floating 57119306 |
Percent Insiders 7.22 | Percent Institutions 106.85 |
Analyst Ratings
Rating 4.53 | Target Price 65 | Buy 5 |
Strong Buy 12 | Hold 2 | Sell - |
Strong Sell - |
Rating 4.53 | Target Price 65 | Buy 5 | Strong Buy 12 |
Hold 2 | Sell - | Strong Sell - |
AI Summarization
Arvinas Inc.: A Comprehensive Overview
Disclaimer: This information is intended for educational purposes only and does not constitute investment advice. Please consult with a licensed financial professional before making any investment decisions.
Company Profile:
Detailed History and Background
Arvinas Inc. (ARVN) is a clinical-stage biopharmaceutical company founded in 2013 and headquartered in New Haven, Connecticut. The company focuses on discovering, developing, and commercializing therapies based on its proprietary PROTAC® (Proteolysis Targeting Chimera) platform. This platform utilizes small molecules to degrade disease-causing proteins by hijacking the body's natural protein degradation pathways.
Core Business Areas
Arvinas' core business areas include:
- Developing PROTAC® Degraders: The company focuses on developing its PROTAC® platform to target a wide range of diseases, including cancer, neurodegenerative disorders, and infectious diseases.
- Clinical Development: Arvinas has several product candidates in various stages of clinical development, including ARV-110 for the treatment of metastatic castration-resistant prostate cancer and ARV-471 for the treatment of hormone receptor-positive/HER2-negative breast cancer.
- Research and Collaboration: Arvinas continues to invest in research and development, focusing on expanding its PROTAC® platform and exploring new therapeutic applications. The company also collaborates with academic institutions and pharmaceutical companies to advance its research and development efforts.
Leadership Team and Corporate Structure
Arvinas' leadership team includes:
- John Evans, M.D., President and Chief Executive Officer: Dr. Evans has extensive experience in drug development and leadership roles at various pharmaceutical companies.
- Michael Bogusky, M.D., Ph.D., Chief Medical Officer: Dr. Bogusky brings over 20 years of experience in clinical development and medical affairs in the pharmaceutical industry.
- Christopher Morry, Chief Financial Officer: Mr. Morry has over 20 years of experience in finance and accounting roles in the pharmaceutical and biotechnology industries.
- Ben Auspitz, General Counsel and Secretary: Mr. Auspitz has over 25 years of experience in legal and compliance roles in the biotechnology and pharmaceutical industries.
The company's corporate structure comprises a Board of Directors and several executive committees, including the Audit Committee, Compensation Committee, and Nominating and Corporate Governance Committee.
Top Products and Market Share:
Top Products and Offerings
Arvinas' top product candidates in development include:
- ARV-110: A PROTAC® degrader targeting the androgen receptor (AR) for the treatment of metastatic castration-resistant prostate cancer.
- ARV-471: A PROTAC® degrader targeting ER for the treatment of hormone receptor-positive/HER2-negative breast cancer.
- ARV-766: A PROTAC® degrader targeting the estrogen receptor (ER) for the treatment of ER-positive, HER2-negative locally advanced or metastatic breast cancer.
- ARV-825: A PROTAC® degrader targeting the Aurora Kinase A (AURKA) for the treatment of solid tumors.
Market Share Analysis
Arvinas' current products are not yet commercially available, and therefore do not have market share data. However, the company's targeted markets represent significant opportunities.
- Metastatic Castration-Resistant Prostate Cancer: This market is estimated to be worth over $10 billion globally.
- Hormone Receptor-Positive/HER2-Negative Breast Cancer: This market is estimated to be worth over $15 billion globally.
Product Performance and Competition
Arvinas' product candidates have shown promising results in early-stage clinical trials. However, the company faces competition from established pharmaceutical companies and other biotech companies developing targeted therapies for similar indications.
Total Addressable Market (TAM)
The total addressable market for Arvinas is estimated to be significant, considering the large patient populations and unmet medical needs in the targeted therapeutic areas. The global oncology market alone is estimated to be worth over $200 billion and is expected to grow further in the coming years.
Financial Performance:
Recent Financial Analysis
Arvinas is currently in the clinical development stage and has not yet generated significant revenue. The company's recent financial statements reflect ongoing research and development expenses, which are offset by funding from investors and collaborations.
Historical Growth and Future Projections
Arvinas has experienced consistent growth in recent years, primarily driven by funding rounds and advancements in its clinical development programs. The company's future growth will depend on the successful development and commercialization of its PROTAC® degraders.
Cash Flow and Balance Sheet Health
Arvinas' cash flow is currently negative due to ongoing research and development expenses. However, the company has a strong balance sheet with significant cash reserves to support its operations.
Dividends and Shareholder Returns:
Dividend History
Arvinas is a pre-revenue company and does not currently pay dividends.
Shareholder Returns
Arvinas' stock price has experienced significant volatility in recent years. However, shareholders who have held the stock for the long term have seen positive returns.
Growth Trajectory:
Historical Growth Analysis
Arvinas has experienced consistent growth in recent years, primarily driven by funding rounds and advancements in its clinical development programs. The company's historical growth rate is expected to continue in the coming years as it progresses its clinical programs and prepares for potential commercialization.
Future Growth Projections
Analysts project continued growth for Arvinas in the coming years, driven by the potential commercialization of its PROTAC® degraders and expansion into new therapeutic areas.
Recent Product Launches and Strategic Initiatives
Arvinas has several ongoing clinical trials and recently presented positive data from its Phase 1/2 trial of ARV-110 for the treatment of metastatic castration-resistant prostate cancer. The company is also exploring strategic partnerships to expand its reach and accelerate its development programs.
Market Dynamics:
Industry Overview
The biopharmaceutical industry is characterized by rapid technological advancements, increasing competition, and stringent regulatory requirements. Arvinas operates in the oncology market, which is a highly competitive and dynamic field.
Arvinas' Positioning and Adaptability
Arvinas' PROTAC® platform offers a unique and potentially disruptive approach to drug development. The company is well-positioned to capitalize on the growing demand for targeted therapies and the increasing focus on protein degradation as a therapeutic strategy.
Competitors:
Key Competitors
Arvinas' key competitors in the oncology market include:
- Pfizer (PFE)
- Bristol Myers Squibb (BMY)
- Merck (MRK)
- Roche (RHHBY)
- Novartis (NVS)
Market Share and Competitive Advantages
Arvinas does not currently have a significant market share in the oncology market. However, the company's PROTAC® platform offers several competitive advantages, including target specificity, potential for improved efficacy, and reduced side effects.
Potential Challenges and Opportunities:
Key Challenges
Arvinas faces several challenges, including:
- Clinical Development Risks: The company's product candidates are still in the early stages of development, and there is no guarantee that they will be successful in clinical trials or gain regulatory approval.
- Competition: Arvinas faces intense competition from established pharmaceutical companies and other biotech companies developing targeted therapies for similar indications.
- Intellectual Property: Protecting its PROTAC® platform and proprietary technology is crucial for Arvinas' success.
Potential Opportunities
Arvinas has several potential opportunities, including:
- Commercialization of its PROTAC® Degraders: The successful development and commercialization of its product candidates could generate significant revenue and establish Arvinas as a leader in the targeted therapy market.
- **Expansion into New Therapeutic
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Arvinas Inc
Exchange | NASDAQ | Headquaters | New Haven, CT, United States |
IPO Launch date | 2018-09-27 | Chairperson, CEO & President | Dr. John G. Houston Ph.D. |
Sector | Healthcare | Website | https://www.arvinas.com |
Industry | Biotechnology | Full time employees | 445 |
Headquaters | New Haven, CT, United States | ||
Chairperson, CEO & President | Dr. John G. Houston Ph.D. | ||
Website | https://www.arvinas.com | ||
Website | https://www.arvinas.com | ||
Full time employees | 445 |
Arvinas, Inc., a clinical-stage biotechnology company, engages in the discovery, development, and commercialization of therapies to degrade disease-causing proteins. The company engineers proteolysis targeting chimeras (PROTAC) targeted protein degraders that are designed to harness the body's own natural protein disposal system to degrade and remove disease-causing proteins. Its product pipeline includes Bavdegalutamide and ARV-766, investigational orally bioavailable PROTAC protein degraders for the treatment of men with metastatic castration-resistant prostate cancer, which are in Phase 1/2 clinical trials; and ARV-471, an orally bioavailable estrogen receptor degrading PROTAC targeted protein degrader for the treatment of patients with locally advanced or metastatic estrogen receptor+/human epidermal growth factor receptor 2-breast cancer, which is Phase 3 clinical trial. Arvinas, Inc. has collaborations with Pfizer Inc., Genentech, Inc., F. Hoffman-La Roche Ltd., Carrick Therapeutics Limited, and Bayer AG. The company was founded in 2013 and is based in New Haven, Connecticut.
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