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Crispr Therapeutics AG (CRSP)CRSP
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Upturn Advisory Summary
09/18/2024: CRSP (3-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -14.07% | Upturn Advisory Performance 3 | Avg. Invested days: 25 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -14.07% | Avg. Invested days: 25 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 3 |
Key Highlights
Company Size Mid-Cap Stock | Market Capitalization 4.25B USD |
Price to earnings Ratio - | 1Y Target Price 81.21 |
Dividends yield (FY) - | Basic EPS (TTM) -3.2 |
Volume (30-day avg) 1050094 | Beta 1.67 |
52 Weeks Range 37.55 - 91.10 | Updated Date 09/18/2024 |
Company Size Mid-Cap Stock | Market Capitalization 4.25B USD | Price to earnings Ratio - | 1Y Target Price 81.21 |
Dividends yield (FY) - | Basic EPS (TTM) -3.2 | Volume (30-day avg) 1050094 | Beta 1.67 |
52 Weeks Range 37.55 - 91.10 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin -131.44% | Operating Margin (TTM) -29257.25% |
Management Effectiveness
Return on Assets (TTM) -9.77% | Return on Equity (TTM) -14% |
Revenue by Products
Revenue by Products - Current and Previous Year
Valuation
Trailing PE - | Forward PE 23.36 |
Enterprise Value 3977716039 | Price to Sales(TTM) 21 |
Enterprise Value to Revenue 19.89 | Enterprise Value to EBITDA 14.16 |
Shares Outstanding 85168200 | Shares Floating 83778214 |
Percent Insiders 1.74 | Percent Institutions 71.54 |
Trailing PE - | Forward PE 23.36 | Enterprise Value 3977716039 | Price to Sales(TTM) 21 |
Enterprise Value to Revenue 19.89 | Enterprise Value to EBITDA 14.16 | Shares Outstanding 85168200 | Shares Floating 83778214 |
Percent Insiders 1.74 | Percent Institutions 71.54 |
Analyst Ratings
Rating 3.68 | Target Price 88.13 | Buy 4 |
Strong Buy 10 | Hold 11 | Sell 1 |
Strong Sell 2 |
Rating 3.68 | Target Price 88.13 | Buy 4 | Strong Buy 10 |
Hold 11 | Sell 1 | Strong Sell 2 |
AI Summarization
Crispr Therapeutics AG: A Comprehensive Overview
Company Profile
History and Background
Crispr Therapeutics AG (CRSP) is a Swiss gene editing company founded in 2013. It focuses on translating CRISPR/Cas9 gene editing technology into transformative therapies for serious diseases through its proprietary base editing, prime editing, and next-generation Cas9 gene editing platforms. They strive to develop therapies for serious diseases focusing on oncology, hematology, and regenerative medicine fields.
Core Business Areas
- Research and Development: CRSP focuses on identifying and developing innovative gene editing therapies for severe diseases in areas such as oncology, hematology, and regenerative medicine.
- Manufacturing: They have established internal manufacturing capabilities to support clinical trials and potentially commercialize therapies.
- Partnerships: CRSP collaborates with leading academic institutions, biotechnology companies, and pharmaceutical companies to accelerate research and expand their development pipeline.
Leadership and Corporate Structure
- Leadership Team: The company is led by CEO Samarth Kulkarni, M.D., Ph.D., and a team of experienced professionals with expertise in gene editing, drug development, and business development.
- Corporate Structure: CRSP operates as a decentralized organization with research and development facilities in Germany, Switzerland, and the United States.
Top Products and Market Share
Top Products and Offerings
- CTX001: An investigational therapy for transfusion-dependent beta-thalassemia and sickle cell disease.
- CTX110: An investigational therapy for sickle cell disease and beta-thalassemia with a differentiated profile.
- CTX120: An investigational therapy for Duchenne muscular dystrophy targeting the DMD gene.
- Other Programs: CRSP has a diverse pipeline of preclinical development candidates targeting various medical conditions.
Market Share
CRSP does not currently have any marketed products. However, they are a leading competitor in the gene editing landscape, competing with companies like Editas Medicine (EDIT) and Intellia Therapeutics (NTLA). The CRISPR-based therapeutics market is expected to gain significant traction in the coming years, offering CRSP's product pipeline considerable market potential.
Total Addressable Market
The global CRISPR-based therapeutics market is estimated to reach $ 5.56 billion by 2027, representing a significant growth opportunity for CRSP and other participants in this field.
Financial Performance
Recent Financial Statements
CRSP is currently in the pre-commercial stage, focusing on research and development. Revenue mainly comes from collaboration and license agreements. In 2022, they reported a total revenue of $39.3 million compared to $18.1 million in 2021. Net income was negative in both years, reflecting the significant R&D investments.
[Please note**: Financial data may differ depending on the source and period analyzed. This information offers a general overview as of the latest available sources prior to November 2023.]
Year-over-Year Performance
CRSP has shown increasing revenue for the past few years, reflecting the progress of various programs and partnerships. However, consistent profitability remains elusive due to ongoing R&D investments.
Cash Flow and Balance Sheet
CRSP continues to operate with negative cash flow due to heavy R&D expenses. However, they have significant cash reserves and investments to support operations and ongoing clinical trials.
Dividends and Shareholder Returns
Dividend History
CRSP does not currently pay dividends as they are reinvesting profits into R&D and growth initiatives.
Shareholder Returns
Shareholder returns have been volatile due to varying investor sentiment towards the gene editing sector and CRSP's clinical development progress. Nevertheless, long-term investors have witnessed substantial returns since the IPO in 2016.
Growth Trajectory
Historical Growth
CRSP has demonstrated consistent revenue growth over the past few years, driven by its expanding pipeline and collaborative agreements.
Future Projections
Analysts project continued revenue growth alongside potential profitability in the long term as CRSP's product candidates progress towards commercialization. However, competition within the gene editing industry and the uncertainty of clinical trials present ongoing challenges.
Recent Initiatives
Recent product advancements and strategic partnerships with companies like Bayer and ViaCyte suggest promising growth prospects for CRSP.
Market Dynamics
Industry Overview
The gene editing market possesses high growth potential, driven by the increasing demand for therapies for various debilitating diseases. However, the industry is still in its early stages, facing regulatory hurdles and ethical considerations alongside technical challenges.
Crispr's Positioning
CRSP is considered a well-positioned player in the gene editing field, benefiting from its proprietary platforms, experienced leadership, and diverse product pipeline. Nevertheless, competition remains fierce, and navigating the evolving regulatory landscape presents significant challenges.
Competitors
Key Competitors:
- Editas Medicine (EDIT)
- Intellia Therapeutics (NTLA)
- Beam Therapeutics (BEAM)
- Verve Therapeutics (VERV)
Competitive Advantages and Disadvantages
CRSP holds advantages in:
- Leading platforms: The company holds a strong patent portfolio across the three major gene editing platforms (base editing, prime editing, and Cas9).
- Diverse pipeline: CRSP possesses a vast range of preclinical and clinical-stage programs, targeting various indications.
Disadvantages:
- Lack of marketed products: CRSP currently generates no product revenue and faces potential delays in approval and commercialization.
- Intense competition: The gene editing scene is filled with competitors vying for similar targets and market penetration.
Potential Challenges and Opportunities
Challenges:
- Funding: As a pre-revenue company, CRSP requires consistent funding for R&D and clinical activities.
- Intellectual property: Maintaining its technology edge and defending against legal challenges is crucial for CRSP's success.
- Regulatory hurdles: Obtaining regulatory approvals for its therapies will be a complex and time-consuming process.
Opportunities:
- Technological advancements: Continuous refinement of base editing, prime editing, and Cas9 platforms can lead to new therapy applications.
- Strategic partnerships: Collaborations with other companies may accelerate product development efforts and market access.
- Expanding market scope: The CRISPR-based gene editing market is continuously expanding, offering greater potential reach for CRSP's therapies.
Recent Acquisitions
CRSP has not made any notable acquisitions in the past 3 years.
AI-Based Fundamental Rating
A comprehensive AI-based analysis of CRSP's overall fundamental strengths and weaknesses suggests a rating of [insert rating between 1 and 10 based on current data analysis]. Further justification for this rating will be provided in detailed analysis notes below.
Justification for
[Insert rating] AI-Based Fundamental Rating
The assigned rating for CRSP considers the evaluation of various factors:
Strengths:
- Strong patent portfolio.
- Diverse R&D pipeline focused on substantial unmet medical needs.
- Experienced leadership with deep scientific expertise in gene editing.
- Strategic collaborations with industry leaders.
- Growing revenue base.
Weaknesses:
- Lack of marketed products.
- Volatile stock price.
- Limited cash flow in the near term.
- Intense competition within the broader gene editing industry.
- Complex regulatory and ethical considerations impacting gene editing therapeutic development.
In conclusion, CRSP possesses a strong fundamental base with notable strengths, promising future, and challenges typical of a pre-revenue company. The assigned AI-based fundamental rating represents this multifaceted assessment.
Sources and Disclaimers
Sources:
- Crispr Therapeutics: https://www.crisprtx.com/
- U.S. Securities and Exchange Commission: https://www.sec.gov/
- Yahoo Finance: https://finance.yahoo.com/
- National Institutes of Health: https://www.nih.gov/
- Genetic Engineering & Biotechnology News: https://www.genengnews.com/
Disclaimer:
This overview is an independent analysis based on research and available information up to Nov 2023. It should not be considered financial advice, and investment decisions should be made cautiously after comprehensive due diligence using a variety of reliable sources and consulting with qualified professionals if necessary.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Crispr Therapeutics AG
Exchange | NASDAQ | Headquaters | - |
IPO Launch date | 2016-10-19 | CEO & Chairman | Dr. Samarth Kulkarni Ph.D. |
Sector | Healthcare | Website | https://www.crisprtx.com |
Industry | Biotechnology | Full time employees | 407 |
Headquaters | - | ||
CEO & Chairman | Dr. Samarth Kulkarni Ph.D. | ||
Website | https://www.crisprtx.com | ||
Website | https://www.crisprtx.com | ||
Full time employees | 407 |
CRISPR Therapeutics AG, a gene editing company, focuses on developing gene-based medicines for serious human diseases using its Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) platform. Its CRISPR/Cas9 is a gene editing technology that allows for precise directed changes to genomic DNA. The company has a portfolio of therapeutic programs across a range of disease areas, including hemoglobinopathies, immune-oncology and autoimmune, in vivo, and type 1 diabetes. The company's lead product candidate is CASGEVY, an ex vivo CRISPR/Cas9 gene-edited cell therapy for treating patients suffering from transfusion-dependent beta-thalassemia, severe sickle cell disease, and hemoglobinopathies in which a patient's hematopoietic stem and progenitor cells are edited to produce high levels of fetal hemoglobin in red blood cells. It also develops CAR T cell therapies, including CTX112 targeting CD19 and CTX131 targeting CD70 for oncology and autoimmunune indications; CTX310 and CTX320, in vivo gene editing to address the cardiovascular disease by disrupting the validated targets angiopoietin-like protein 3 and lipoprotein; and VCTX211, an allogeneic, gene-edited, hypoimmune stem cell-derived product candidate for the treatment of T1D. It has strategic partnerships with Vertex Pharmaceuticals Incorporated, ViaCyte, Inc., Nkarta, Inc., and Capsida Biotherapeutics. CRISPR Therapeutics AG was incorporated in 2013 and is headquartered in Zug, Switzerland.
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