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enGene Holdings Inc. Common Stock (ENGN)ENGN
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Upturn Advisory Summary
11/07/2024: ENGN (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Historic Profit: 11.68% | Upturn Advisory Performance 5 | Avg. Invested days: 125 |
Profits based on simulation | Stock Returns Performance 2 | Last Close 11/07/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Historic Profit: 11.68% | Avg. Invested days: 125 |
Upturn Star Rating | Stock Returns Performance 2 |
Profits based on simulation Last Close 11/07/2024 | Upturn Advisory Performance 5 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 428.18M USD |
Price to earnings Ratio - | 1Y Target Price 30.57 |
Dividends yield (FY) - | Basic EPS (TTM) -2.79 |
Volume (30-day avg) 194586 | Beta -0.76 |
52 Weeks Range 4.42 - 18.40 | Updated Date 11/8/2024 |
Company Size Small-Cap Stock | Market Capitalization 428.18M USD | Price to earnings Ratio - | 1Y Target Price 30.57 |
Dividends yield (FY) - | Basic EPS (TTM) -2.79 | Volume (30-day avg) 194586 | Beta -0.76 |
52 Weeks Range 4.42 - 18.40 | Updated Date 11/8/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -22.07% | Return on Equity (TTM) -123.06% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 138587840 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -6.01 |
Shares Outstanding 50973900 | Shares Floating 16256299 |
Percent Insiders 15.69 | Percent Institutions 92.45 |
Trailing PE - | Forward PE - | Enterprise Value 138587840 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -6.01 | Shares Outstanding 50973900 | Shares Floating 16256299 |
Percent Insiders 15.69 | Percent Institutions 92.45 |
Analyst Ratings
Rating 4.83 | Target Price 35.5 | Buy 1 |
Strong Buy 5 | Hold - | Sell - |
Strong Sell - |
Rating 4.83 | Target Price 35.5 | Buy 1 | Strong Buy 5 |
Hold - | Sell - | Strong Sell - |
AI Summarization
enGene Holdings Inc. Common Stock: A Comprehensive Overview
Company Profile
Detailed history and background: enGene Holdings Inc. is a relatively young company founded in 2016. The company focuses on the development and commercialization of novel gene therapy technologies for the treatment of rare and debilitating diseases. enGene leverages a proprietary platform known as the Engineered Genetic Executable Modules (E-GEMs) for targeted gene editing and delivery.
Core business areas: enGene operates primarily in two core business areas:
- Therapeutic Development: The company develops gene therapy treatments for various rare and devastating conditions, including orphan diseases and genetic disorders.
- Gene Editing Platform Technology: enGene licenses its proprietary E-GEMs platform for gene editing applications to pharmaceutical and biotechnology companies.
Leadership team: Michael Redenbaugh, a seasoned entrepreneur and investor with experience in biotechnology, serves as the Chief Executive Officer. The leadership team comprises scientific experts and experienced executives with expertise in drug development, business strategy, and finance.
Top Products and Market Share
Top Products: enGene's current product portfolio includes E-GEMs platform technology and several gene therapy candidates in various stages of development:
- E-GEMs platform: This platform enables targeted and efficient delivery of gene editing tools to specific cells, offering potential advantages over conventional gene therapy approaches.
- EG-001: A gene therapy candidate for the treatment of MPS II, also known as Hunter syndrome, a rare metabolic disorder affecting children.
- EG-011: A pre-clinical candidate for the treatment of Duchenne Muscular Dystrophy (DMD), a genetic muscle disease causing progressive muscle degeneration.
Market share: enGene currently has no marketed products and is in the clinical development stage. As such, it does not hold a significant market share. However, the company's E-GEMs platform and potential gene therapies address significant unmet medical needs with limited existing treatment options, offering opportunities for capturing significant market share in niche therapeutic segments.
Product Performance: EG-001 has demonstrated promising pre-clinical results in animal models of MPS II, showing potential to delay disease progression and improve motor function. The development of EG-011 is ongoing, with pre-clinical data expected in the near future.
Total Addressable Market
The total addressable market (TAM) for enGene's products is substantial. The global market for rare diseases is estimated to be around $200 billion, and DMD alone is estimated to be a $2 billion market. The gene editing market is projected to reach $20 billion by 2027, indicating significant growth potential for the E-GEMs platform technology.
Financial Performance
enGene is currently a development-stage company with no marketed products and generates no revenue. The company has a history of net losses due to research and development expenses associated with its gene therapy pipeline and platform technology development. It primarily relies on financings and partnerships to fund its operations.
Dividends and Shareholder Returns
enGene does not pay dividends, considering its current stage of development and focus on reinvesting profits into research and development activities. The company's stock price performance has been volatile, with significant fluctuations based on clinical trial results, market sentiment, and overall biotechnology sector performance.
Growth Trajectory
enGene has experienced rapid growth since its founding, demonstrating progress in its research and development pipeline. However, the company's future growth prospects are dependent on the successful development and commercialization of its gene therapies and the broader adoption of its E-GEMs platform technology.
Market Dynamics
The gene therapy market is experiencing rapid growth due to technological advancements, increasing investment, and the growing unmet medical need for rare and serious diseases. The E-GEMs platform has the potential to become a disruptive technology in gene editing by offering targeted and efficient delivery methods. However, the market is also characterized by intense competition, stringent regulatory pathways, and the complexities of developing gene therapy products.
Competitors
Key competitors of enGene in the gene therapy space include bluebird bio (BLUE), uniQure (QURE), AveXis (AVXS), and Orchard Therapeutics (ORTX). In the gene editing space, competitors include Editas Medicine (EDIT), Intellia Therapeutics (NTLA), CRISPR Therapeutics (CRISPR), and Beam Therapeutics (BEAM).
Competitive Advantages: enGene's competitive advantages include its proprietary E-GEMs platform, which offers advantages over conventional gene editing approaches, and its strong intellectual property portfolio. The company also benefits from a collaborative approach, establishing partnerships with leading academic institutions and pharmaceutical companies.
Potential Challenges and Opportunities
Challenges: enGene's primary challenges include the high cost and uncertainty of developing gene therapy products, the stringent regulatory approval pathways, competition from other companies developing similar therapies, and the potential for intellectual property disputes.
Opportunities: The significant unmet medical need for rare diseases and the increasing investment in gene therapy research present substantial opportunities. Additionally, partnerships and strategic collaborations can accelerate the company's growth and product development efforts.
Recent Acquisitions (last 3 years)
enGene has not reported any acquisitions in the past three years.
AI-Based Fundamental Rating
enGene Holdings Inc. receives a moderate AI-based fundamental rating of 6 out of 10. This rating considers the company's strong technology platform, promising pre-clinical data, and potential for addressing large unmet market needs. However, the rating also accounts for its lack of marketed products, ongoing clinical trials with uncertain outcomes, competition in the market, and dependence on continued funding.
Sources and Disclaimers
This analysis was compiled using information from the following sources:
- enGene Holdings Inc. official website: https://engeneholdings.com/
- EDGAR Filings
- SEC filings
- Investor relations presentations
- Market research reports from reputable firms
This analysis should not be considered financial advice. Investing in early-stage biotechnology companies like enGene involves substantial risk, and investors should carefully consider their investment objectives, risk tolerance, and financial situation before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About enGene Holdings Inc. Common Stock
Exchange | NASDAQ | Headquaters | Saint-Laurent, QC, Canada |
IPO Launch date | 2023-11-01 | CEO | - |
Sector | Healthcare | Website | https://www.engene.com |
Industry | Biotechnology | Full time employees | 31 |
Headquaters | Saint-Laurent, QC, Canada | ||
CEO | - | ||
Website | https://www.engene.com | ||
Website | https://www.engene.com | ||
Full time employees | 31 |
enGene Holdings Inc., through its subsidiary enGene, Inc., operates as a clinical-stage biotechnology company that develops genetic medicines through the delivery of therapeutics to mucosal tissues and other organs. Its lead product candidate is EG-70 (detalimogene voraplasmid), which is a non-viral immunotherapy to treat non-muscle invasive bladder cancer patients with carcinoma-in-situ (Cis), who are unresponsive to treatment with Bacillus Calmette-Guérin. The company was founded in 2023 and is based in Saint-Laurent, Canada.
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