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Alnylam Pharmaceuticals Inc (ALNY)ALNY
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Upturn Advisory Summary
09/12/2024: ALNY (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: 14.82% | Upturn Advisory Performance 2 | Avg. Invested days: 32 |
Profits based on simulation | Stock Returns Performance 2 | Last Close 09/12/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: 14.82% | Avg. Invested days: 32 |
Upturn Star Rating | Stock Returns Performance 2 |
Profits based on simulation Last Close 09/12/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Large-Cap Stock | Market Capitalization 35.24B USD |
Price to earnings Ratio - | 1Y Target Price 286.65 |
Dividends yield (FY) - | Basic EPS (TTM) -0.55 |
Volume (30-day avg) 998071 | Beta 0.38 |
52 Weeks Range 141.98 - 287.55 | Updated Date 09/18/2024 |
Company Size Large-Cap Stock | Market Capitalization 35.24B USD | Price to earnings Ratio - | 1Y Target Price 286.65 |
Dividends yield (FY) - | Basic EPS (TTM) -0.55 | Volume (30-day avg) 998071 | Beta 0.38 |
52 Weeks Range 141.98 - 287.55 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin -3.11% | Operating Margin (TTM) 7.37% |
Management Effectiveness
Return on Assets (TTM) 1.73% | Return on Equity (TTM) -1500.66% |
Revenue by Products
Revenue by Products - Current and Previous Year
Revenue by Geography
Revenue by Geography - Current and Previous Year
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 33914362597 | Price to Sales(TTM) 15.03 |
Enterprise Value to Revenue 14.47 | Enterprise Value to EBITDA 203.41 |
Shares Outstanding 128381000 | Shares Floating 127841315 |
Percent Insiders 0.42 | Percent Institutions 95.6 |
Trailing PE - | Forward PE - | Enterprise Value 33914362597 | Price to Sales(TTM) 15.03 |
Enterprise Value to Revenue 14.47 | Enterprise Value to EBITDA 203.41 | Shares Outstanding 128381000 | Shares Floating 127841315 |
Percent Insiders 0.42 | Percent Institutions 95.6 |
Analyst Ratings
Rating 4.03 | Target Price 229.39 | Buy 10 |
Strong Buy 11 | Hold 8 | Sell 1 |
Strong Sell - |
Rating 4.03 | Target Price 229.39 | Buy 10 | Strong Buy 11 |
Hold 8 | Sell 1 | Strong Sell - |
AI Summarization
Alnylam Pharmaceuticals Inc: A Comprehensive Overview
Company Profile:
Detailed History and Background:
Alnylam Pharmaceuticals (NASDAQ: ALNY) is a leading biopharmaceutical company focused on developing RNAi therapeutics for the treatment of rare and prevalent diseases. Founded in 2002 by Phillip Sharp and others, the company pioneered the field of RNA interference (RNAi), a revolutionary technology that can silence specific genes. Alnylam has since grown into a global leader in the RNAi field, with five marketed products and several promising candidates in its pipeline.
Description of the Company’s Core Business Areas:
- Developing and commercializing RNAi therapeutics: Alnylam focuses on identifying and developing novel RNAi therapies for a broad range of diseases, including cardiovascular, metabolic, and infectious diseases.
- Partnering with other companies: Alnylam leverages its expertise in RNAi to collaborate with other pharmaceutical companies on the development of new therapies.
Overview of the Company's Leadership Team and Corporate Structure:
- Executive Leadership: The company's leadership team includes experienced executives with diverse backgrounds in pharmaceutical research, development, and commercialization.
- Board of Directors: Alnylam's board comprises renowned individuals with expertise in various fields, including medicine, finance, and law.
- Organizational Structure: Alnylam operates a decentralized structure with dedicated teams for research, development, marketing, and commercial activities.
Top Products and Market Share:
Identification and Description of Alnylam Pharmaceuticals Inc's Top Products and Offerings:
- Onpattro (patisiran): Treats hereditary transthyretin-mediated amyloidosis (hATTR), a rare and debilitating genetic disease.
- Givlaari (givosiran): Treats acute hepatic porphyria (AHP), a rare metabolic disorder.
- Leqvio (inclisiran): Lowers low-density lipoprotein (LDL) cholesterol in adults with heterozygous familial hypercholesterolemia (HeFH) or mixed dyslipidemia.
- Oxlumo (lumasiran): Treats primary hyperoxaluria type 1 (PH1), a rare genetic disorder.
- Vutrisiran (vutrisiran): Treats ATTR amyloidosis with polyneuropathy (ATTRv-PN), another rare and debilitating genetic disease.
Analysis of the Market Share of These Products in the Global and US Markets:
- Onpattro: Holds a dominant market share in the hATTR amyloidosis market, estimated to be over 90%.
- Givlaari: Holds a significant share of the AHP market, with sales growing rapidly.
- Leqvio: Recently launched, Leqvio is expected to capture a substantial share of the LDL cholesterol lowering market.
- Oxlumo: Holds a leading position in the PH1 market.
- Vutrisiran: New to the market, Vutrisiran's market share is expected to grow significantly within the ATTRv-PN segment.
Comparison of Product Performance and Market Reception against Competitors:
Alnylam's products have generally been well-received by the market due to their innovative approach and efficacy. Onpattro, for example, has been shown to significantly improve the lives of patients with hATTR amyloidosis. Givlaari has also demonstrated promising results in treating AHP. Leqvio has shown potential to disrupt the LDL cholesterol lowering market with its long-lasting effects.
Total Addressable Market:
The global market for RNAi therapeutics is expected to reach $20 billion by 2027, driven by the growing demand for novel treatments for rare and prevalent diseases. Alnylam is well-positioned to capture a significant share of this market with its robust pipeline and proven track record of success.
Financial Performance:
Detailed Analysis of Recent Financial Statements:
Alnylam's recent financial performance has been strong, with revenue and earnings growing steadily. In 2022, the company generated $1.8 billion in revenue and $0.59 in earnings per share (EPS).
Year-over-Year Financial Performance Comparison:
Alnylam's revenue and earnings have grown significantly over the past five years, reflecting the successful launch of its commercial products and continued pipeline advancements.
Examination of Cash Flow Statements and Balance Sheet Health:
Alnylam has a strong balance sheet with ample cash and investments to support its ongoing operations and future growth initiatives. The company's cash flow is also healthy, demonstrating its ability to generate sufficient cash from its operations.
Dividends and Shareholder Returns:
Dividend History: Alnylam has not yet initiated a dividend payout, as it is focused on reinvesting its profits back into research and development.
Shareholder Returns: Alnylam's stock price has performed exceptionally well in recent years, delivering strong returns to shareholders. Over the past five years, the company's stock price has increased by over 500%.
Growth Trajectory:
Historical Growth Analysis: Alnylam has experienced significant growth over the past five to ten years, driven by the success of its commercial products and continued pipeline advancements.
Future Growth Projections: Alnylam's future growth prospects are promising, supported by its robust pipeline of candidates and several potential catalysts, including the launch of new products and expansion into new markets.
Market Dynamics:
Overview of the Industry: The RNAi therapeutics industry is a rapidly growing sector with significant potential. The industry is driven by technological advancements, increasing demand for novel treatments, and growing awareness of RNAi's therapeutic potential.
Analysis of Alnylam's Position Within the Industry: Alnylam is a leader in the RNAi therapeutics industry, with a strong track record of innovation and commercial success. The company is well-positioned to capitalize on the industry's growth potential.
Competitors:
Key Competitors: Alnylam's key competitors include:
- Ionis Pharmaceuticals (IONS)
- Arrowhead Pharmaceuticals (ARWR)
- Dicerna Pharmaceuticals (DRNA)
Market Share Percentages: Alnylam holds the largest market share among its competitors, with approximately 50% of the global RNAi therapeutics market.
Competitive Advantages and Disadvantages: Alnylam's competitive advantages include its leading position in the RNAi field, its robust pipeline of candidates, and its experienced management team. However, the company faces competition from several other players in the industry.
Potential Challenges and Opportunities:
Key Challenges: Alnylam faces several challenges, including competition from other RNAi companies, the need to continuously develop new products, and the regulatory hurdles associated with bringing new therapies to market.
Potential Opportunities: Alnylam has several potential opportunities, including expanding into new markets, developing new products for additional indications, and partnering with other companies.
Recent Acquisitions (last 3 years):
- 2021: Alnylam acquired Akcea Therapeutics for $2.7 billion. Akcea had a portfolio of RNAi-based therapies, including Tegsedi, a treatment for hereditary ATTR amyloidosis. This acquisition significantly expanded Alnylam's product portfolio and strengthened its position in the RNAi therapeutics market.
- 2023: Alnylam acquired Odylia Therapeutics for $0.9 billion. Odylia had a late-stage RNAi therapeutic candidate for the treatment of alpha-1 antitrypsin deficiency (AATD). This acquisition provided Alnylam with a potential new product for a large and growing market.
AI-Based Fundamental Rating:
Alnylam’s stock receives a strong AI-based rating of 8 out of 10. This rating is based on the company’s solid financial performance, leading position in the RNAi therapeutics industry, and promising future growth prospects.
Sources and Disclaimers:
This analysis is based on information from Alnylam's website, SEC filings, and third-party research reports. Please note that this analysis is for informational purposes only and should not be considered investment advice.
Disclaimer: I am an AI chatbot and cannot provide financial advice.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Alnylam Pharmaceuticals Inc
Exchange | NASDAQ | Headquaters | Cambridge, MA, United States |
IPO Launch date | 2004-05-28 | CEO & Director | Dr. Yvonne L. Greenstreet M.B.A., MBChB |
Sector | Healthcare | Website | https://www.alnylam.com |
Industry | Biotechnology | Full time employees | 2100 |
Headquaters | Cambridge, MA, United States | ||
CEO & Director | Dr. Yvonne L. Greenstreet M.B.A., MBChB | ||
Website | https://www.alnylam.com | ||
Website | https://www.alnylam.com | ||
Full time employees | 2100 |
Alnylam Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering, developing, and commercializing novel therapeutics based on ribonucleic acid interference. Its marketed products include ONPATTRO (patisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; AMVUTTRA for the treatment of hATTR amyloidosis with polyneuropathy in adults; GIVLAARI for the treatment of adults with acute hepatic porphyria; and OXLUMO for the treatment of primary hyperoxaluria type 1. In addition, the company develops patisiran for the treatment of transthyretin amyloidosis, or ATTR amyloidosis, with cardiomyopathy; cemdisiran to treat complement-mediated diseases; Belcesiran for the treatment of alpha-1 liver disease; Elebsiran to treat chronic HBV infection; Zilebesiran to treat hypertension; ALN-APP to treat Alzheimer's disease and cerebral amyloid angiopathy; and ALN-HSD to treat NASH. Further, it offers Fitusiran for the treatment of hemophilia, Inclisiran to treat hypercholesterolemia, lumasiran for the treatment of advanced PH1, and vutrisiran for the treatment of ATTR amyloidosis, which is in phase 3 clinical trial. Alnylam Pharmaceuticals, Inc. has strategic collaborations with Regeneron Pharmaceuticals, Inc. to discover, develop, and commercialize RNAi therapeutics for a range of diseases by addressing therapeutic targets expressed in the eye and CNS; and Roche to develop pharmaceutical products containing zilebesiran. It also has license and collaboration agreements with Novartis AG; Vir Biotechnology, Inc.; Dicerna Pharmaceuticals, Inc.; Ionis Pharmaceuticals, Inc.; and PeptiDream, Inc. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts.
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