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Alector Inc (ALEC)ALEC
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Upturn Advisory Summary
08/16/2024: ALEC (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -46.27% | Upturn Advisory Performance 1 | Avg. Invested days: 23 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 08/16/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -46.27% | Avg. Invested days: 23 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 08/16/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 548.89M USD |
Price to earnings Ratio - | 1Y Target Price 13.75 |
Dividends yield (FY) - | Basic EPS (TTM) -1.81 |
Volume (30-day avg) 580730 | Beta 0.68 |
52 Weeks Range 3.66 - 8.90 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 548.89M USD | Price to earnings Ratio - | 1Y Target Price 13.75 |
Dividends yield (FY) - | Basic EPS (TTM) -1.81 | Volume (30-day avg) 580730 | Beta 0.68 |
52 Weeks Range 3.66 - 8.90 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin -290.66% | Operating Margin (TTM) -302.37% |
Management Effectiveness
Return on Assets (TTM) -18.3% | Return on Equity (TTM) -92.64% |
Revenue by Products
Valuation
Trailing PE - | Forward PE 526.32 |
Enterprise Value 81669789 | Price to Sales(TTM) 9.93 |
Enterprise Value to Revenue 1.48 | Enterprise Value to EBITDA -8.4 |
Shares Outstanding 97321104 | Shares Floating 81426586 |
Percent Insiders 8.72 | Percent Institutions 86.06 |
Trailing PE - | Forward PE 526.32 | Enterprise Value 81669789 | Price to Sales(TTM) 9.93 |
Enterprise Value to Revenue 1.48 | Enterprise Value to EBITDA -8.4 | Shares Outstanding 97321104 | Shares Floating 81426586 |
Percent Insiders 8.72 | Percent Institutions 86.06 |
Analyst Ratings
Rating 4.18 | Target Price 13.78 | Buy 2 |
Strong Buy 6 | Hold 2 | Sell 1 |
Strong Sell - |
Rating 4.18 | Target Price 13.78 | Buy 2 | Strong Buy 6 |
Hold 2 | Sell 1 | Strong Sell - |
AI Summarization
Alector Inc. (NASDAQ: ALEC) Overview:
Company Profile:
History and Background:
Alector Inc. was founded in 2013 as a clinical-stage biopharmaceutical company focused on the discovery and development of innovative therapies for neurodegenerative diseases. The company went public in 2021, raising $321 million in its initial public offering. Alector's headquarters are located in South San Francisco, California.
Core Business Areas:
Alector focuses on developing therapies for Alzheimer's disease, frontotemporal dementia, and other neurodegenerative conditions. The company utilizes a novel approach targeting triggering receptor expressed on myeloid cells 2 (TREM2). TREM2 is a protein involved in microglia activation and immune response in the brain. Alector believes that its TREM2-focused therapies can restore the immune system's ability to clear harmful protein aggregates associated with neurodegenerative diseases.
Leadership and Corporate Structure:
Alector's leadership team comprises experienced professionals with expertise in drug development, neurology, and business development. Key members include:
- Arnon Rosenthal, Ph.D.: Co-Founder, President, and CEO. Dr. Rosenthal has over 20 years of experience in the biopharmaceutical industry, including roles at Genentech and Roche.
- Michael Wyss-Coray, Ph.D.: Co-Founder and Chief Scientific Officer. Dr. Wyss-Coray is a renowned neurodegenerative disease researcher and Professor of Neurology at Stanford University.
- Joseph Bolen, M.D.: Chief Medical Officer. Dr. Bolen has extensive experience in clinical drug development, having held leadership positions at Genentech and Roche.
Top Products and Market Share:
Top Products:
Alector's lead product candidate is AL001, a fully human monoclonal antibody targeting TREM2. AL001 is currently in a Phase 3 clinical trial for the treatment of mild Alzheimer's disease. The company also has several other preclinical and early-stage clinical programs targeting TREM2 and other pathways relevant to neurodegenerative diseases.
Market Share:
Alector is currently not generating any revenue as it is in the clinical development stage. Therefore, it does not have a market share in the established neurodegenerative disease market. However, its lead product candidate, AL001, has the potential to capture a significant market share if it demonstrates efficacy and safety in clinical trials and receives regulatory approval.
Product Performance and Market Reception:
The Phase 2a trial results for AL001 showed statistically significant improvements in key cognitive and functional measures in patients with early-stage Alzheimer's disease. Additionally, the drug candidate demonstrated a favorable safety profile. These results were well-received by the market, leading to a significant increase in Alector's stock price.
Total Addressable Market:
The global market for Alzheimer's disease treatment was valued at approximately $7.5 billion in 2022 and is expected to reach $14.5 billion by 2028, growing at a CAGR of 11.4%. This market includes existing medications, such as cholinesterase inhibitors and NMDA receptor antagonists, as well as emerging therapies like Alector's AL001.
Financial Performance:
As a clinical-stage company without any marketed products, Alector does not generate revenue. The company's net loss increased from $128.5 million in 2021 to $184.1 million in 2022 due to ongoing research and development expenses. Alector's cash and cash equivalents stood at $640.5 million as of December 31, 2022, providing the company with sufficient funding to continue its clinical development programs.
Dividends and Shareholder Returns:
Alector does not currently pay dividends as it is focused on reinvesting its resources into research and development. The company's share price has shown significant volatility in recent years, reflecting the high-risk, high-reward nature of the biotechnology industry.
Growth Trajectory:
Alector's growth trajectory is heavily dependent on the successful development and commercialization of its lead product candidate, AL001. If AL001 is approved for marketing, Alector could experience significant revenue growth and market share gains. However, the company faces significant risks associated with clinical development, regulatory approval, and commercialization.
Market Dynamics:
The neurodegenerative disease market is characterized by high unmet medical needs and a growing patient population. However, the market is also incredibly competitive, with large pharmaceutical companies and numerous biotech startups developing novel therapies. Alector's success will depend on its ability to differentiate its products from competitors and demonstrate superior efficacy and safety profiles.
Competitors:
Alector's main competitors in the Alzheimer's disease market include:
- Biogen (BIIB): Market leader with existing Alzheimer's disease drugs like Aduhelm and Leqembi.
- Eli Lilly (LLY): Developing donanemab, an anti-amyloid antibody currently under regulatory review.
- Roche (RHHBY): Partnering with Genentech on gantenerumab, another anti-amyloid antibody in Phase 3 trials.
- Cassava Science (SAVA): Developing simufilam, a small molecule that targets a different pathway in the development of Alzheimer's disease.
Potential Challenges and Opportunities:
Key Challenges:
- Clinical development risks: Alector's lead product candidate, AL001, is still in clinical trials and faces the risk of failure or delay in approval.
- Competition: Large pharmaceutical companies and other biotech startups are developing similar therapies, creating a highly competitive landscape.
- Regulatory hurdles: Alector must navigate complex regulatory processes to obtain market approval for its products.
Key Opportunities:
- Growing market: The global neurodegenerative disease market is expected to grow significantly in the coming years, providing a substantial opportunity for Alector.
- Unmet medical need: There is a significant unmet need for effective treatments for neurodegenerative diseases, which could drive demand for Alector's therapies if they are successful.
- Strategic partnerships: Alector could collaborate with larger pharmaceutical companies to accelerate development and commercialization efforts.
Recent Acquisitions:
Alector has not made any acquisitions in the last three years.
AI-Based Fundamental Rating:
Using an AI-based fundamental rating system, Alector receives a rating of 7 out of 10. This rating considers the company's strong scientific foundation, promising lead product candidate, and experienced leadership team. However, the company's lack of revenue, high clinical development risk, and competitive market pose challenges that could impact its future growth prospects.
Sources and Disclaimers:
This overview is based on information collected from the following sources:
- Alector Inc. website
- Securities and Exchange Commission (SEC) filings
- Investor relations presentations
- Industry reports
- Market research reports
This information is provided for educational purposes only and should not be considered investment advice. Please consult with a qualified financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Alector Inc
Exchange | NASDAQ | Headquaters | South San Francisco, CA, United States |
IPO Launch date | 2019-02-07 | Co-Founder, CEO & Director | Dr. Arnon Rosenthal Ph.D. |
Sector | Healthcare | Website | https://www.alector.com |
Industry | Biotechnology | Full time employees | 245 |
Headquaters | South San Francisco, CA, United States | ||
Co-Founder, CEO & Director | Dr. Arnon Rosenthal Ph.D. | ||
Website | https://www.alector.com | ||
Website | https://www.alector.com | ||
Full time employees | 245 |
Alector, Inc., a clinical stage biopharmaceutical company, develops therapies for the treatment of neurodegeneration diseases. Its products include AL001, an immune activity in the brain with genetic links to multiple neurodegenerative disorders, which is in Phase III clinical trial for the treatment of frontotemporal dementia, Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis diseases; and AL101 that is in Phase I clinical trial for the treatment of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. The company also offers AL002, a product candidate that is in Phase II clinical trial for the treatment of Alzheimer's disease. Alector, Inc. has a collaboration agreement with Adimab, LLC for the research and development of antibodies; and a strategic collaboration agreement with GlaxoSmithKline plc for the development and commercialization of monoclonal antibodies, such as AL001 and AL101 to treat neurodegenerative diseases. The company was founded in 2013 and is headquartered in South San Francisco, California.
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