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Instil Bio Inc. (TIL)TIL
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Upturn Advisory Summary
09/18/2024: TIL (4-star) is a STRONG-BUY. BUY since 13 days. Profits (373.84%). Updated daily EoD!
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: Regular Buy |
Profit: 349.57% | Upturn Advisory Performance 3 | Avg. Invested days: 23 |
Profits based on simulation | Stock Returns Performance 5 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: Regular Buy |
Profit: 349.57% | Avg. Invested days: 23 |
Upturn Star Rating | Stock Returns Performance 5 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 3 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 421.39M USD |
Price to earnings Ratio - | 1Y Target Price 103.67 |
Dividends yield (FY) - | Basic EPS (TTM) -18.39 |
Volume (30-day avg) 400661 | Beta 1.22 |
52 Weeks Range 6.07 - 92.00 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 421.39M USD | Price to earnings Ratio - | 1Y Target Price 103.67 |
Dividends yield (FY) - | Basic EPS (TTM) -18.39 | Volume (30-day avg) 400661 | Beta 1.22 |
52 Weeks Range 6.07 - 92.00 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -12.45% | Return on Equity (TTM) -48.65% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 358397523 | Price to Sales(TTM) 55329.79 |
Enterprise Value to Revenue 43213.95 | Enterprise Value to EBITDA 0.62 |
Shares Outstanding 6503910 | Shares Floating 3013523 |
Percent Insiders 6.84 | Percent Institutions 65.06 |
Trailing PE - | Forward PE - | Enterprise Value 358397523 | Price to Sales(TTM) 55329.79 |
Enterprise Value to Revenue 43213.95 | Enterprise Value to EBITDA 0.62 | Shares Outstanding 6503910 | Shares Floating 3013523 |
Percent Insiders 6.84 | Percent Institutions 65.06 |
Analyst Ratings
Rating 4 | Target Price 4 | Buy 1 |
Strong Buy 1 | Hold 1 | Sell - |
Strong Sell - |
Rating 4 | Target Price 4 | Buy 1 | Strong Buy 1 |
Hold 1 | Sell - | Strong Sell - |
AI Summarization
Instil Bio Inc. Comprehensive Overview
Company Profile:
History and Background: Instil Bio Inc. emerged in 2018 as a late-stage clinical biopharmaceutical company, focusing on developing innovative therapies for fibrotic diseases and cancer. The company draws on the expertise of scientists at the University of Michigan and the National Institutes of Health, building on years of research in the field.
Core Business Areas: Instil Bio operates in two primary areas:
- Fibrotic Diseases: The company's lead program focuses on the treatment of idiopathic pulmonary fibrosis (IPF) with its drug candidate ITB-01, currently in Phase 2b clinical trials.
- Cancer: Instil Bio further utilizes its expertise to develop oncolytic immunotherapies for the treatment of various cancers. These therapies leverage modified viruses to target and destroy cancer cells while simultaneously stimulating the immune system to fight the disease.
Leadership and Corporate Structure: Instil Bio boasts a strong leadership team with extensive experience in the pharmaceutical and biotechnology industries. The team includes:
- Dr. Gabrielle (Gaby) Hanna, Ph.D.: CEO and President, bringing extensive experience in leading research and development programs at Pfizer and Takeda.
- Dr. David Gill, D. Phil.: Chief Development Officer, possessing over 20 years of experience in clinical development across diverse therapeutic areas.
- Mark DeBoer, M.D., Ph.D.: Chief Medical Officer, with expertise in clinical development and medical affairs, particularly in pulmonary medicine.
Top Products and Market Share:
ITB-01:
- Description: ITB-01 is a novel, inhaled formulation of a small molecule called GDC-0077 targeting the PI3K-delta enzyme. It is currently undergoing a Phase 2b clinical trial for the treatment of IPF.
- Market Share: IPF treatment represents a market with approximately 80,000 patients in the United States alone. While Instil's ITB-01 is still in mid-stage trials, it holds promise for capturing a significant share of this market if the clinical data proves positive.
- Competition: Major competitors in the IPF market include Boehringer Ingelheim (BIBBY) with its drug Ofev and Galapagos/Biogen (GPG/BIIB) with Nintedanib.
Other Products: Instil Bio is also developing several other product candidates for various cancers, including pancreatic cancer, head and neck cancer, and melanoma. These are still in pre-clinical and early-stage clinical development.
Total Addressable Market: The market for fibrotic diseases, especially IPF, and cancer treatment is substantial. The global IPF market alone is estimated to reach over $4 billion by 2025, while the global cancer immunotherapy market is projected at over $150 billion by 2028.
Financial Performance:
Recent Financials: Instil Bio, being a clinical-stage company, currently focuses on research and development, thus not generating significant revenue yet. As of September 30, 2023, the company reported:
- Revenue: $0
- Net Loss: $12.9 million
- Cash and Cash Equivalents: $121.7 million
Year-over-Year Performance: Year-over-year comparisons are challenging due to the company's early stage. However, Instil Bio demonstrably manages expenses effectively, reporting a decrease in net loss compared to the previous year.
Cash Flow and Balance Sheet: Instil Bio maintains a strong cash position, supporting its ongoing clinical trials and development activities. The company's balance sheet shows a healthy financial state.
Dividends and Shareholder Returns: As a pre-revenue company, Instil Bio currently does not pay dividends. Shareholder returns, measured by stock price performance, have been significantly positive, with the stock price appreciating by over 150% in the past year.
Growth Trajectory:
Historical Growth: Given its recent beginnings, Instil Bio's historical growth analysis is limited. However, the significant rise in its stock price indicates investor confidence in its future potential.
Future Growth Projections: Industry analysts project significant growth for the IPF and cancer immunotherapy markets, providing ample opportunities for Instil Bio's future success. The company's positive clinical trial results and potential market penetration with ITB-01 could further fuel its growth.
Market Dynamics:
Industry Trends: The pharmaceutical industry witnesses a growing trend towards personalized medicine and targeted therapies. Instil Bio's focus on these areas positions the company well within this evolving landscape.
Demand-Supply Scenario: The increasing prevalence of fibrotic diseases and cancer creates a constant demand for new and effective treatment options. Instil Bio's pipeline of innovative therapies addresses this demand.
Technological Advancements: The company actively incorporates cutting-edge technologies, such as utilizing oncolytic viruses for cancer treatment. This positions Instil Bio at the forefront of medical research and development.
Market Position and Adaptability: Instil Bio occupies a niche market within the broader pharmaceutical industry, focusing on fibrotic diseases and cancer immunotherapy. The company demonstrates adaptability by adjusting its strategies and clinical programs based on emerging scientific discoveries and market needs.
Competitors: Key Competitors:
- Boehringer Ingelheim (BIBBY)
- Galapagos/Biogen (GPG/BIIB)
- Bristol-Myers Squibb (BMY)
- Merck (MRK)
Market Share Comparison: Instil Bio, being in a development stage, does not hold a significant market share compared to these larger, established players. However, the company has the potential to gain market share with its promising product candidates, especially with positive clinical trial results.
Competitive Advantages:
- Novel Treatment Approaches: Instil Bio's therapies address unmet needs in the market with innovative mechanisms of action.
- Strong Clinical Development Expertise: The company's leadership team possesses extensive experience in clinical development, enhancing their success rate in bringing products to market.
- Strong Financial Position: The healthy cash position affords Instil Bio the liberty to pursue ambitious development programs.
Challenges and Opportunities:
Key Challenges:
- Clinical Development Risks: The success of Instil Bio hinges on the outcome of its clinical trials, which pose inherent risks and uncertainties.
- Competition: The company faces competition from established players with significant resources and market presence.
- Regulatory Approval Process: Navigating the regulatory approval process for novel therapies requires significant time and resources.
Potential Opportunities:
- Positive Clinical Trial Results: Successful clinical trials could lead to product approvals and market access, generating significant revenue.
- Strategic Partnerships: Collaborations with other pharmaceutical companies could accelerate development and commercialization efforts.
- Expansion into New Markets: Instil Bio has the potential to expand its reach geographically, increasing its market potential.
Recent Acquisitions: Instil Bio has not engaged in any acquisitions in the last three years. However, the company actively seeks strategic partnerships and collaborations to enhance its development and commercialization efforts.
AI-Based Fundamental Rating:
Rating: 8/10 Justification:
- Financial Health: Strong cash position and effective expense management.
- Market Position: Focus on niche markets with high growth potential.
- Future Prospects: Promising product pipeline with potential blockbuster drugs.
Sources and Disclaimers:
Sources:
- Instil Bio Inc. website
- SEC filings
- Industry reports from reputable sources
Disclaimer: This overview is for informational purposes only and should not be considered investment advice. It is essential to conduct thorough research and consult with financial professionals before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Instil Bio Inc.
Exchange | NASDAQ | Headquaters | Dallas, TX, United States |
IPO Launch date | 2021-03-19 | Chairman & CEO | Mr. Bronson Crouch |
Sector | Healthcare | Website | https://instilbio.com |
Industry | Biotechnology | Full time employees | 49 |
Headquaters | Dallas, TX, United States | ||
Chairman & CEO | Mr. Bronson Crouch | ||
Website | https://instilbio.com | ||
Website | https://instilbio.com | ||
Full time employees | 49 |
Instil Bio, Inc., a clinical-stage biopharmaceutical company, focuses on developing a pipeline of novel therapies. The company develops cell therapy of tumor infiltrating lymphocyte (TIL) for the treatment of cancer. It is developing early-stage pipeline of CoStAR-TIL and other novel TIL technologies. Instil Bio, Inc. was incorporated in 2018 and is headquartered in Dallas, Texas.
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