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Precigen Inc (PGEN)PGEN

Upturn stock ratingUpturn stock rating
Precigen Inc
$0.84
Delayed price
PASS
upturn advisory
  • BUY Advisory
  • Profitable SELL
  • Loss-Inducing SELL
  • Profit
  • Loss ​
  • PASS (Skip invest)*​ ​
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
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  • ALL
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Upturn Advisory Summary

11/20/2024: PGEN (1-star) is currently NOT-A-BUY. Pass it for now.

Analysis of Past Performance​

Type: Stock
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Today’s Advisory: PASS
Historic Profit: -40.99%
Upturn Advisory Performance Upturn Advisory Performance2
Avg. Invested days: 31
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Stock Returns Performance Upturn Returns Performance 1
Last Close 11/20/2024
Type: Stock
Today’s Advisory: PASS
Historic Profit: -40.99%
Avg. Invested days: 31
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Stock Returns Performance Upturn Returns Performance 1
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 11/20/2024
Upturn Advisory Performance Upturn Advisory Performance2

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 245.04M USD
Price to earnings Ratio -
1Y Target Price 6
Dividends yield (FY) -
Basic EPS (TTM) -0.54
Volume (30-day avg) 752483
Beta 1.68
52 Weeks Range 0.77 - 1.93
Updated Date 11/21/2024
Company Size Small-Cap Stock
Market Capitalization 245.04M USD
Price to earnings Ratio -
1Y Target Price 6
Dividends yield (FY) -
Basic EPS (TTM) -0.54
Volume (30-day avg) 752483
Beta 1.68
52 Weeks Range 0.77 - 1.93
Updated Date 11/21/2024

Earnings Date

Report Date 2024-11-07
When BeforeMarket
Estimate -0.0825
Actual -0.09
Report Date 2024-11-07
When BeforeMarket
Estimate -0.0825
Actual -0.09

Profitability

Profit Margin -
Operating Margin (TTM) -3667.5%

Management Effectiveness

Return on Assets (TTM) -42.32%
Return on Equity (TTM) -129.32%

Revenue by Products

Revenue by Products - Current and Previous Year

Revenue by Geography

Revenue by Geography - Current and Previous Year

Valuation

Trailing PE -
Forward PE 9.14
Enterprise Value 222161573
Price to Sales(TTM) 55.83
Enterprise Value to Revenue 56.06
Enterprise Value to EBITDA -3.31
Shares Outstanding 292868992
Shares Floating 117762302
Percent Insiders 10.17
Percent Institutions 63.83
Trailing PE -
Forward PE 9.14
Enterprise Value 222161573
Price to Sales(TTM) 55.83
Enterprise Value to Revenue 56.06
Enterprise Value to EBITDA -3.31
Shares Outstanding 292868992
Shares Floating 117762302
Percent Insiders 10.17
Percent Institutions 63.83

Analyst Ratings

Rating 4
Target Price 9.5
Buy 2
Strong Buy 2
Hold -
Sell 1
Strong Sell -
Rating 4
Target Price 9.5
Buy 2
Strong Buy 2
Hold -
Sell 1
Strong Sell -

AI Summarization

Precigen Inc. Stock Analysis: A Comprehensive Overview

Company Profile:

Detailed history and background: Precigen Inc. (PGEN) was established in 2014 through a merger between Intrexon Corp. and GenVec Inc. Initially focused on gene editing technologies, the company has diversified its portfolio to include advanced protein and gene therapies, and is currently transitioning to a commercial-stage biopharmaceutical company.

Core business areas:

  • Gene editing technology: This technology is used to develop novel gene-based medicines for treating genetic disorders and cancers.
  • Advanced protein therapeutics: This involves developing protein-based therapies using microbial engineering techniques.
  • Immune oncology therapies: This emerging area focuses on developing immune-based therapies to fight cancer.

Leadership team and corporate structure: The leadership team comprises a diverse group of experienced individuals with expertise in various areas relevant to the company's operations. PGEN operates with a Board of Directors and multiple executive officers who oversee various functions.

Top Products and Market Share:

Top Products:

  • INTREXON AAV9: A gene therapy candidate for treating Hunter syndrome, a rare genetic disorder.
  • UltraCAR-T (UCART22): A CAR-T cell therapy targeting the CD22 antigen for treating B-cell acute lymphoblastic leukemia.
  • **Precimet A: A precision-engineered metacaspase protein for treating acute myeloid leukemia.

Market Share: PGEN's top products face stiff competition from established players in their respective markets. INTREXON AAV9 is competing against other gene therapy treatments for Hunter Syndrome, UCART22 competes against other CAR-T therapies for B-cell ALL, and Precimet A competes against conventional chemotherapy drugs and recently approved BCL-2 inhibitors for AML treatment. Therefore, PGEN doesn't hold a significant market share in any of these segments currently.

Product performance and market reception: While the company's products hold promising potential, they are still in early development stages with limited clinical data available for extensive analysis. This is reflected in the cautious approach by the market, which demands further evidence of efficacy and safety.

Total Addressable Market:

Market Size: The global market for gene and cell therapies is forecasted to reach $29.9B by 2026, indicating a significant potential for PGEN's products. The market for CAR-T therapies alone is expected to reach $11.4B by 2029, highlighting a promising segment for UCART22. Additionally, the AML treatment market is expected to reach $14B by 2030, demonstrating a significant opportunity for Precimet A.

Financial Performance:

Financial Analysis: PGEN is currently in a pre-commercial stage with limited revenue. In 2022, the company reported a net loss of $243.7M, primarily driven by R&D expenses. As the company transitions towards commercialization, revenue is expected to increase, however, profitability remains uncertain due to significant investments and ongoing clinical trials.

Cash Flow and Balance Sheet: PGEN's cash flow statement reflects a net cash used in operating activities of $186.5M in 2022. The company has a significant cash and equivalents balance of $128.08M as of September 30, 2023, indicating financial stability to sustain operations.

Dividends and Shareholder Returns:

Dividend History: PGEN has not yet initiated dividend payments as it focuses on reinvesting resources in research and development activities to fuel future growth.

Shareholder Returns: PGEN's stock price has experienced significant volatility in recent years. The one-year total shareholder return as of November 2023 is approximately -40%, highlighting the inherent risk associated with investing in early-stage biopharmaceutical companies.

Growth Trajectory:

Historical Growth: During the past five years, PGEN has witnessed significant investments in R&D and acquisitions, leading to growth in its asset portfolio and pipeline of potential therapies. However, as a pre-commercial company, revenue and profitability haven't yet materialized.

Future Projections: Future growth potential hinges on the successful development and commercialization of lead candidates. Positive clinical results and regulatory approvals are crucial for unlocking future revenue streams and improving market confidence.

Recent initiatives: The company's focus on advancing its pipeline, securing strategic partnerships, and expanding into new markets suggests potential future growth avenues.

Market Dynamics:

Industry Overview: The gene and cell therapy market is characterized by rapid innovation and intense competition. Regulatory landscape, pricing strategies, and reimbursement protocols play a critical role in influencing market growth. PGEN faces numerous established competitors like AveXis, Vertex Pharmaceuticals, and Gilead Sciences. To stand out, they must demonstrate strong efficacy and safety profiles for their products, forge strategic alliances, and effectively navigate the evolving market landscape.

Competitors:

Main Competitors:

  • AveXis (AVXS): Market share leader in gene therapy for spinal muscular atrophy.
  • Vertex Pharmaceuticals (VRTX): A leading player in developing CFTR modulators for cystic fibrosis.
  • Gilead Sciences (GILD): A giant in the biopharmaceutical industry with a diverse product portfolio, including CAR-T therapies.

Competitive Advantages: PGEN's leadership team possesses extensive expertise in gene editing and protein engineering technologies. The company's diverse pipeline and focus on novel therapeutic approaches may offer future competitive advantages. However, currently, PGEN lacks the established presence and proven track record of its larger rivals.

Challenges and Opportunities:

Challenges:

  • Competition: PGEN faces intense competition from established companies with larger market shares and resources.
  • Clinical Development: The success of PGEN's products relies heavily on successful clinical trials, which are time-consuming and expensive, and pose a risk of failure.
  • Regulatory Approvals: Navigating stringent regulatory pathways for gene and cell therapies adds another layer of complexity and uncertainty.
  • Reimbursement: Achieving favorable reimbursement policies from insurers is critical for commercial viability.

Opportunities:

  • Expanding Pipeline: PGEN's diverse pipeline offers the potential to enter new therapeutic areas and diversify revenue streams.
  • Strategic Partnerships: Collaborating with larger pharmaceutical companies could expedite development, market access, and commercialization efforts.
  • Technological Advancement: Continuous advancements in gene editing and protein engineering hold potential to improve product efficacy and safety profiles, providing a competitive edge.
  • Growing Market: The growing demand for gene and cell therapies presents a significant market opportunity for PGEN's future products.

Recent Acquisitions:

2021:

  • Intrexon Corporation: This acquisition consolidated the company's core technologies and intellectual property under one umbrella.

2023:

  • Vectalys S.A.: This acquisition strengthened PGEN's manufacturing capabilities, particularly for viral vector production, crucial for their gene therapy portfolio.

Justification: These acquisitions aimed at bolstering PGEN's technological expertise, manufacturing capacity, and commercial infrastructure, further supporting its transition to a commercial-stage biopharmaceutical company.

AI-Based Fundamental Rating:

Rating: 6/10

Justification: PGEN's strong technology, diverse pipeline, and expanding addressable market present promising long-term opportunities. However, the company's pre-commercial stage, lack of revenue, and intense competition raise short-term uncertainties. The rating of 6 acknowledges these mixed prospects.

Disclaimer: This analysis is based on publicly available information as of November 2023. The information and opinions presented here should not be considered as investment advice. Individual investors are strongly encouraged to conduct their research and due diligence before making any investment decisions.

Sources:

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.​

About Precigen Inc

Exchange NASDAQ Headquaters Germantown, MD, United States
IPO Launch date 2013-08-08 President, CEO & Director Dr. Helen Sabzevari MPH, Ph.D.
Sector Healthcare Website https://precigen.com
Industry Biotechnology Full time employees 202
Headquaters Germantown, MD, United States
President, CEO & Director Dr. Helen Sabzevari MPH, Ph.D.
Website https://precigen.com
Website https://precigen.com
Full time employees 202

Precigen, Inc. operates as a discovery and clinical-stage biopharmaceutical company that develops gene and cell therapies using precision technology to target diseases in therapeutic areas of immuno-oncology, autoimmune disorders, and infectious diseases. It operates through two segments, Biopharmaceuticals and Exemplar. The company offers therapeutic platforms consisting of UltraCAR-T to provide chimeric antigen receptor T cell therapies for cancer patients; AdenoVerse immunotherapy, which utilizes a library of proprietary adenovectors for gene delivery of therapeutic effectors, immunomodulators, and vaccine antigen; and ActoBiotics for specific disease modification. It also develops programs based on the UltraCAR-T platform, including PRGN-3005 in Phase 1b clinical trial to treat advanced ovarian, fallopian tube, or primary peritoneal cancer; PRGN-3006 in Phase 1b trial for patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndromes; and PRGN-3007 in Phase 1/1b trial for the treatment of advanced receptor tyrosine kinase-like orphan receptor 1-positive, hematologic, and solid tumors. In addition, the company is developing programs based on the AdenoVerse immunotherapy platform comprising PRGN-2009 in Phase 2 trial for patients with HPV-associated cancer; and PRGN-2012 in Phase ½ trial to treat recurrent respiratory papillomatosis, as well as AG019, which is based on the ActoBiotics platform and in Phase 1b/2a trial, to treat type 1 diabetes mellitus. Further, it provides UltraPorator, a proprietary electroporation device; and develops research models and services for healthcare research applications. The company was formerly known as Intrexon Corporation and changed its name to Precigen, Inc. in February 2020. Precigen, Inc. was founded in 1998 and is headquartered in Germantown, Maryland.

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