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Palisade Bio Inc (PALI)PALI
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Upturn Advisory Summary
09/18/2024: PALI (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -70.24% | Upturn Advisory Performance 1 | Avg. Invested days: 19 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -70.24% | Avg. Invested days: 19 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 4.83M USD |
Price to earnings Ratio - | 1Y Target Price 33.75 |
Dividends yield (FY) - | Basic EPS (TTM) -18.57 |
Volume (30-day avg) 18539 | Beta 1.3 |
52 Weeks Range 3.30 - 14.40 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 4.83M USD | Price to earnings Ratio - | 1Y Target Price 33.75 |
Dividends yield (FY) - | Basic EPS (TTM) -18.57 | Volume (30-day avg) 18539 | Beta 1.3 |
52 Weeks Range 3.30 - 14.40 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -58.53% | Return on Equity (TTM) -110.09% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -6017426 | Price to Sales(TTM) 14.03 |
Enterprise Value to Revenue 234.89 | Enterprise Value to EBITDA 0.57 |
Shares Outstanding 1184490 | Shares Floating 1162989 |
Percent Insiders 2.29 | Percent Institutions 2.89 |
Trailing PE - | Forward PE - | Enterprise Value -6017426 | Price to Sales(TTM) 14.03 |
Enterprise Value to Revenue 234.89 | Enterprise Value to EBITDA 0.57 | Shares Outstanding 1184490 | Shares Floating 1162989 |
Percent Insiders 2.29 | Percent Institutions 2.89 |
Analyst Ratings
Rating 4.5 | Target Price 16 | Buy 1 |
Strong Buy 1 | Hold - | Sell - |
Strong Sell - |
Rating 4.5 | Target Price 16 | Buy 1 | Strong Buy 1 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Palisade Bio Inc. (PLIS) Stock: A Comprehensive Overview
1. Company Profile:
1.1 History and Background: Palisade Bio Inc. (PLIS) is a clinical-stage biopharmaceutical company founded in 2016. Headquartered in San Diego, California, the company focuses on developing innovative therapies for the treatment of patients with severe forms of inflammatory and autoimmune diseases.
1.2 Core Business Areas: Palisade Bio specializes in three main areas:
- Targeting the JAK1/2 Pathway: PLIS develops therapies that modulate the JAK1/2 pathway, a crucial regulator of inflammation and immunity. This pathway is linked to various autoimmune disorders like rheumatoid arthritis, Crohn's disease, and ulcerative colitis.
- Novel Drug Delivery Systems: The company utilizes advanced drug delivery technologies like long-acting subcutaneous injections to enhance patient convenience and improve treatment effectiveness.
- Proprietary Technology Platform: PLIS leverages its proprietary technology platform, the ImmunoTAC™ Platform, to develop targeted protein therapeutics with high specificity and efficacy.
1.3 Leadership Team and Corporate Structure:
- CEO: Michael Levy, Ph.D.
- President and COO: Andrew Greenwell
- CFO: Peter S. Kim, Ph.D.
- EVP and Chief Scientific Officer: John Beadle, Ph.D.
The company has a Board of Directors with extensive experience in the pharmaceutical industry.
2. Top Products and Market Share:
2.1 Top Products:
- LB11480: This JAK1 inhibitor is undergoing Phase 1/2a clinical trials for treating patients with moderate-to-severe atopic dermatitis.
- LB11480: Another JAK1 inhibitor in Phase 1/2a trials for patients with rheumatoid arthritis.
- LB22276: A JAK1/2 inhibitor in preclinical development for inflammatory bowel disease.
2.2 Market Share: As a pre-revenue company, Palisade Bio does not have a market share yet. However, the global market for JAK inhibitor drugs is estimated to reach USD 25.1 billion by 2026, and the market for atopic dermatitis treatment is projected to reach USD 44.7 billion by 2028.
2.3 Product Performance and Market Reception: With its innovative drug development approaches and promising clinical trial results, Palisade Bio is garnering attention from the medical community and investors.
3. Total Addressable Market:
The total addressable market (TAM) for Palisade Bio includes patients with various inflammatory and autoimmune diseases. The estimated global market sizes for some key disease areas are:
- Rheumatoid arthritis: USD 45 billion
- Crohn's disease: USD 12.5 billion
- Ulcerative colitis: USD 10 billion
- Atopic dermatitis: USD 44.7 billion
4. Financial Performance:
As a clinical-stage company, Palisade Bio has no revenue and reports net losses due to research and development expenses. The company is primarily funded through private placements and public offerings.
4.1 Revenue and Earnings:
- Revenue: USD 0 (as of Q2 2023)
- Net Income: USD (54.8) million (as of Q2 2023)
- EPS: USD (2.74) (as of Q2 2023)
4.2 Cash Flow and Balance Sheet:
- Cash and Cash Equivalents: USD 18.7 million (as of Q2 2023)
- Total Debt: USD 0
5. Dividends and Shareholder Returns:
5.1 Dividend History: Palisade Bio has not declared any dividends as it focuses on investing in research and development.
5.2 Shareholder Returns: Since its IPO in December 2020, PLIS shares have been volatile. As of October 2023, the stock has experienced a negative total return for investors.
6. Growth Trajectory:
6.1 Historical Growth: Palisade Bio is still in its early stages of development and has not yet achieved significant growth.
6.2 Future Growth: The company's growth potential hinges on the success of its ongoing clinical trials and its ability to secure regulatory approvals for its drug candidates. Positive results and approvals could significantly drive future revenue and shareholder value.
6.3 Recent Developments: Recent collaborations and partnerships, like the one with Boehringer Ingelheim, indicate Palisade Bio's commitment to growth and its potential to secure funding and development support.
7. Market Dynamics:
7.1 Industry Trends: The market for JAK inhibitors is rapidly growing due to the increasing prevalence of inflammatory and autoimmune diseases and the need for more effective treatment options.
7.2 Demand-Supply Scenario: The demand for innovative and effective therapies for severe inflammatory and autoimmune diseases is high, while the supply of new therapies is limited.
7.3 Technological Advancements: Advancements in biotechnology and drug delivery systems are creating new opportunities for developing targeted and personalized therapies.
7.4 Palisade Bio's Positioning: With its proprietary technology platform and promising clinical-stage candidates, Palisade Bio is well-positioned to capitalize on these market dynamics and potentially become a significant player in the JAK inhibitor market.
8. Competitors:
8.1 Key Competitors:
- Incyte (INCY)
- Pfizer (PFE)
- AbbVie (ABBV)
- Eli Lilly (LLY)
- Bristol Myers Squibb (BMY)
8.2 Market Share Comparison: These established companies hold significant market shares in the JAK inhibitor and broader pharmaceutical markets. However, Palisade Bio's innovative approach and promising clinical data differentiate it from competitors.
8.3 Competitive Advantages and Disadvantages:
- Advantages: Proprietary technology platform, promising clinical data, potential for novel treatment options
- Disadvantages: Early-stage development, no revenue, limited market presence, competition from established players
9. Potential Challenges and Opportunities:
9.1 Challenges:
- Clinical Trial Delays or Failures: The success of the company depends heavily on the outcome of its clinical trials. Any delays or setbacks could negatively impact its timeline and stock price.
- Competition: Established pharmaceutical companies with significant resources could pose a significant competitive threat.
- Regulatory Hurdles: Obtaining regulatory approvals for new drugs is a complex and time-consuming process.
9.2 Opportunities:
- Positive Clinical Trial Results: Successful clinical trials could lead to regulatory approvals and market entry for its innovative therapies, driving revenue growth and stock appreciation.
- Strategic Partnerships: Collaborations with larger pharmaceutical companies could provide access to funding, expertise, and broader市场reac.
- New Market Opportunities: Expanding its product portfolio to address other inflammatory and autoimmune diseases could enlarge its total addressable market.
10. AI-Based Fundamental Rating:
10.1 Rating: Based on current available data and future potential, Palisade Bio receives a moderate AI-based fundamental rating of 6.5 out of 10.
10.2 Justification: This rating is influenced by factors such as:
- Strong science and promising clinical data.
- Early-stage development and lack of revenue.
- Intense competition in the pharmaceutical market.
- Significant opportunities for future growth.
This rating suggests that while risks are present, Palisade Bio holds potential for long-term value creation if it successfully navigates challenges and executes its growth plans.
11. Sources and Disclaimers:
This overview utilizes data from the following sources:
- Palisade Bio Inc. Investor Relations
- Securities and Exchange Commission (SEC) filings
- Financial news websites
- Market research reports
Disclaimer: This overview is for informational purposes only and does not constitute financial advice. Please consult with a qualified financial professional before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Palisade Bio Inc
Exchange | NASDAQ | Headquaters | Carlsbad, CA, United States |
IPO Launch date | 2006-12-20 | CEO, CFO & Director | Mr. J. D. Finley |
Sector | Healthcare | Website | https://www.palisadebio.com |
Industry | Biotechnology | Full time employees | 9 |
Headquaters | Carlsbad, CA, United States | ||
CEO, CFO & Director | Mr. J. D. Finley | ||
Website | https://www.palisadebio.com | ||
Website | https://www.palisadebio.com | ||
Full time employees | 9 |
Palisade Bio, Inc., a clinical-stage biopharmaceutical company, focuses on focuses on developing therapeutics that protect the integrity of the intestinal barrier in the United States. The company's lead therapeutic candidate is PALI-2108, a prodrug PDE4 inhibitor, currently under pre-clinical development as a therapeutic for patients living with inflammatory bowel diseases, including ulcerative colitis and Crohn's disease (CD), as well as develops PALI-1908, an oral, selective PDE4 inhibitor prodrug that is locally bioactivated in the terminal ileum of CD patients, currently in the research stage. It has a research collaboration and license agreement with Giiant Pharma, Inc. for the development, manufacture, and commercialization of its compounds; a license agreement with the Regents of the University of California; a co-development and distribution agreement with Newsoara Biopharma Co., Ltd; and a transformative strategic collaboration with Strand Life Sciences for advancing precision medicine for ulcerative colitis therapy. The company is based in Carlsbad, California.
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