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Incyte Corporation (INCY)INCY
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Upturn Advisory Summary
11/20/2024: INCY (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: WEAK BUY |
Historic Profit: -8.96% | Upturn Advisory Performance 3 | Avg. Invested days: 39 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 11/20/2024 |
Type: Stock | Today’s Advisory: WEAK BUY |
Historic Profit: -8.96% | Avg. Invested days: 39 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 11/20/2024 | Upturn Advisory Performance 3 |
Key Highlights
Company Size Large-Cap Stock | Market Capitalization 13.59B USD |
Price to earnings Ratio 784 | 1Y Target Price 78.05 |
Dividends yield (FY) - | Basic EPS (TTM) 0.09 |
Volume (30-day avg) 2200638 | Beta 0.71 |
52 Weeks Range 50.35 - 83.95 | Updated Date 11/20/2024 |
Company Size Large-Cap Stock | Market Capitalization 13.59B USD | Price to earnings Ratio 784 | 1Y Target Price 78.05 |
Dividends yield (FY) - | Basic EPS (TTM) 0.09 | Volume (30-day avg) 2200638 | Beta 0.71 |
52 Weeks Range 50.35 - 83.95 | Updated Date 11/20/2024 |
Earnings Date
Report Date 2024-10-29 | When BeforeMarket |
Estimate 1.07 | Actual 1.07 |
Report Date 2024-10-29 | When BeforeMarket | Estimate 1.07 | Actual 1.07 |
Profitability
Profit Margin 0.8% | Operating Margin (TTM) 14.96% |
Management Effectiveness
Return on Assets (TTM) -0.12% | Return on Equity (TTM) 0.8% |
Revenue by Products
Revenue by Products - Current and Previous Year
Revenue by Geography
Revenue by Geography - Current and Previous Year
Valuation
Trailing PE 784 | Forward PE 10.93 |
Enterprise Value 11855220569 | Price to Sales(TTM) 3.34 |
Enterprise Value to Revenue 2.91 | Enterprise Value to EBITDA 32.5 |
Shares Outstanding 192650000 | Shares Floating 160211800 |
Percent Insiders 2.04 | Percent Institutions 97.86 |
Trailing PE 784 | Forward PE 10.93 | Enterprise Value 11855220569 | Price to Sales(TTM) 3.34 |
Enterprise Value to Revenue 2.91 | Enterprise Value to EBITDA 32.5 | Shares Outstanding 192650000 | Shares Floating 160211800 |
Percent Insiders 2.04 | Percent Institutions 97.86 |
Analyst Ratings
Rating 3.81 | Target Price 82.13 | Buy 2 |
Strong Buy 10 | Hold 13 | Sell 1 |
Strong Sell - |
Rating 3.81 | Target Price 82.13 | Buy 2 | Strong Buy 10 |
Hold 13 | Sell 1 | Strong Sell - |
AI Summarization
Incyte Corporation: A Comprehensive Overview
Company Profile
History and Background:
Founded in 1991, Incyte Corporation (Nasdaq: INCY) is a global biopharmaceutical company dedicated to discovering, developing, and commercializing novel and effective therapies for patients with unmet medical needs. Headquartered in Wilmington, Delaware, Incyte initially focused on the discovery and development of selective inhibitors of protein kinases, which play a crucial role in cellular signaling pathways. In 2001, the company acquired rights to Jakafi, a JAK inhibitor, which marked a pivotal point in its growth trajectory.
Today, Incyte's portfolio consists of marketed products targeting various hematological malignancies, myelofibrosis, and inflammatory conditions. The company actively engages in clinical development programs across diverse therapeutic areas.
Core Business Areas:
- Hematology/Oncology: Incyte's core business revolves around developing and commercializing therapies for hematologic malignancies, primarily myelofibrosis, a rare bone marrow disorder. The company's flagship product, Jakafi, holds a dominant position in this market. Additionally, Incyte boasts a promising pipeline of novel therapies in this space.
- Inflammation & Autoimmunity: Building on its expertise in drug discovery, Incyte ventures into the field of inflammation and autoimmunity. The company's recent FDA approval of Opzelura, a topical cream for the treatment of mild to moderate atopic dermatitis in adults and adolescents, marks a significant milestone in this area.
Leadership and Corporate Structure:
Incyte's leadership team comprises highly experienced individuals with diverse backgrounds and expertise. Dr. Herve Hoppenot serves as the President and Chief Executive Officer, spearheading the company's strategic direction and growth. The leadership team further includes individuals with extensive experience in research and development, finance, commercialization, and legal affairs, ensuring effective and comprehensive management of the organization.
Top Products and Market Share:
Top Products:
- Jakafi (Ruxolitinib): A JAK1/JAK2 inhibitor approved for the treatment of myelofibrosis, polycythemia vera, and steroid-refractory acute graft-versus-host disease. Jakafi is Incyte's flagship product, generating significant revenue and driving growth.
- Opzelura (Ruxolitinib cream): A topical JAK inhibitor recently approved for the treatment of mild to moderate atopic dermatitis in adults and adolescents, expanding Incyte's portfolio beyond hematology/oncology.
Market Share:
- Jakafi: In the United States, Jakafi holds an estimated market share of over 70% in the treatment of myelofibrosis, signifying its dominant position within this niche market.
- Opzelura: While still relatively new, Opzelura faces competition from existing topical treatments for atopic dermatitis. However, its unique mechanism of action positions it for potential market share gain in this highly competitive landscape.
Product Performance & Market Reception:
- Jakafi: Jakafi has demonstrated consistent efficacy and safety profile, solidifying its place as the first-line therapy for myelofibrosis. The drug continues to generate strong sales and positive feedback from both patients and physicians.
- Opzelura: Despite its recent launch, Opzelura has received positive feedback for its efficacy and convenient topical formulation. However, its long-term performance and market reception require further observation.
Total Addressable Market:
Incyte operates in two major markets:
- Hematologic Malignancies: This market encompasses various blood cancers, including myelofibrosis, lymphoma, and leukemia. The global market for hematologic malignancies is estimated to reach $45.2 billion by 2026, highlighting the significant growth potential for Incyte in this area.
- Atopic Dermatitis: The global market for atopic dermatitis, a chronic inflammatory skin condition, is expected to reach $18.7 billion by 2027. With Opzelura, Incyte has entered this sizeable market, offering a novel treatment option for patients.
Financial Performance:
Recent Financial Statements:
- In 2022, Incyte generated total revenue of $2.76 billion, representing a 23% increase compared to the previous year.
- Net income stood at $633.8 million, with a net profit margin of 23.4%.
- Earnings per share (EPS) for 2022 reached $3.16, demonstrating strong profitability.
Year-over-Year Comparison:
Incyte has exhibited consistent year-over-year revenue growth, indicating a positive financial trajectory. The company's profitability remains healthy, with net income and EPS experiencing positive trends.
Cash Flow & Balance Sheet:
Incyte boasts a strong cash flow position with healthy operating cash flow in 2022. The company's balance sheet reflects a robust financial status, with manageable debt levels.
Dividends and Shareholder Returns:
Dividend History:
Incyte currently does not pay a dividend. However, the company has historically repurchased shares, returning value to shareholders.
Shareholder Returns:
- In the past year, Incyte's stock has generated a positive return of over 20%.
- Over a 5-year period, shareholders have experienced a remarkable return of approximately 150%.
- Long-term investors, who held Incyte's stock for 10 years, have enjoyed exceptional returns exceeding 1,100%.
Growth Trajectory:
Historical Growth Analysis:
Incyte has demonstrated consistent revenue and earnings growth over the past five to ten years, solidifying its leadership position in hematology/oncology and expanding its reach into new therapeutic areas.
Future Growth Projections:
Analysts project continued growth for Incyte, fueled by the ongoing success of Jakafi, the potential launch of novel therapies, and expansion into new markets like dermatology.
Recent Initiatives:
Incyte actively engages in several growth initiatives, including expanding the label indications for Jakafi, advancing its clinical development pipeline, and pursuing strategic partnerships to further diversify its product portfolio.
Market Dynamics:
Industry Overview:
Incyte operates in the highly dynamic and competitive biopharmaceutical industry. The industry is characterized by constant innovation, technological advancements, and evolving regulatory landscapes.
- Trends: Increasing prevalence of chronic diseases, personalized medicine approaches, and digitalization are shaping the future of the biopharmaceutical industry.
- Supply-Demand: While some therapeutic areas face challenges like drug shortages and pricing pressures, others present significant potential due to unmet medical needs and increasing demand for innovative treatments.
Competitive Landscape:
- Competitors: Major competitors in Incyte's core areas include Bristol Myers Squibb (BMY), AbbVie (ABBV), Pfizer (PFE), and Gilead Sciences (GILD). Each competitor possesses its own strengths and weaknesses, influencing market dynamics and creating competitive pressures.
- Market Share: Incyte holds a dominant market share in the treatment of myelofibrosis. However, the company faces intense competition in other segments, such as atopic dermatitis.
- Advantages: Incyte possesses advantages in its expertise in JAK inhibition, a promising pipeline of novel therapies, and a strong focus on research and development.
- Disadvantages: The company's reliance
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Incyte Corporation
Exchange | NASDAQ | Headquaters | Wilmington, DE, United States |
IPO Launch date | 1993-11-04 | CEO & Chairman | Mr. Herve Hoppenot |
Sector | Healthcare | Website | https://www.incyte.com |
Industry | Biotechnology | Full time employees | 2524 |
Headquaters | Wilmington, DE, United States | ||
CEO & Chairman | Mr. Herve Hoppenot | ||
Website | https://www.incyte.com | ||
Website | https://www.incyte.com | ||
Full time employees | 2524 |
Incyte Corporation, a biopharmaceutical company, engages in the discovery, development, and commercialization of therapeutics for hematology/oncology, and inflammation and autoimmunity areas in the United States and internationally. The company offers JAKAFI (ruxolitinib) for treatment of intermediate or high-risk myelofibrosis, polycythemia vera, and steroid-refractory acute graft-versus-host disease; MONJUVI (tafasitamab-cxix)/MINJUVI (tafasitamab) for relapsed or refractory diffuse large B-cell lymphoma; PEMAZYRE (pemigatinib), a fibroblast growth factor receptor kinase inhibitor that act as oncogenic drivers in liquid and solid tumor types; ICLUSIG (ponatinib) to treat chronic myeloid leukemia and Philadelphia-chromosome positive acute lymphoblastic leukemia; and ZYNYZ (retifanlimab-dlwr) to treat adults with metastatic or recurrent locally advanced Merkel cell carcinoma, as well as OPZELURA cream for treatment of atopic dermatitis. Its clinical stage products include retifanlimab under Phase 3 clinical trials for squamous cell carcinoma of the anal canal and non-small cell lung cancer; axatilimab, an anti-CSF-1R monoclonal antibody under Phase 2 that is being developed as a therapy for patients with chronic GVHD; INCA033989 to inhibit oncogenesis; INCB160058, which is being developed as a disease-modifying therapeutic; and INCB99280 and INCB99318 for the treatment solid tumors. The company also develops INCB123667, INCA32459, and INCA33890, as well as Ruxolitinib cream, Povorcitinib, and INCA034460. It has collaboration out-license agreements with Novartis and Lilly; in-license agreements with Agenus, Merus, MacroGenics, and Syndax; and collaboration and license agreement with China Medical System Holdings Limited for the development and commercialization of povorcitinib. The company sells its products to specialty, retail, and hospital pharmacies, distributors, and wholesalers. The company was formerly known as Incyte Genomics Inc and changed its name to Incyte Corporation in March 2003. Incyte Corporation
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