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Corbus Pharmaceuticals Holding (CRBP)CRBP
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Upturn Advisory Summary
09/18/2024: CRBP (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: 185.47% | Upturn Advisory Performance 2 | Avg. Invested days: 40 |
Profits based on simulation | Stock Returns Performance 5 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: 185.47% | Avg. Invested days: 40 |
Upturn Star Rating | Stock Returns Performance 5 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 648.93M USD |
Price to earnings Ratio - | 1Y Target Price 84.38 |
Dividends yield (FY) - | Basic EPS (TTM) -5.79 |
Volume (30-day avg) 267572 | Beta 2.57 |
52 Weeks Range 3.03 - 61.90 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 648.93M USD | Price to earnings Ratio - | 1Y Target Price 84.38 |
Dividends yield (FY) - | Basic EPS (TTM) -5.79 | Volume (30-day avg) 267572 | Beta 2.57 |
52 Weeks Range 3.03 - 61.90 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -25.68% | Return on Equity (TTM) -51.78% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 480807546 | Price to Sales(TTM) 163.32 |
Enterprise Value to Revenue 8.26 | Enterprise Value to EBITDA 0.17 |
Shares Outstanding 12043900 | Shares Floating 9660444 |
Percent Insiders 0.76 | Percent Institutions 102.35 |
Trailing PE - | Forward PE - | Enterprise Value 480807546 | Price to Sales(TTM) 163.32 |
Enterprise Value to Revenue 8.26 | Enterprise Value to EBITDA 0.17 | Shares Outstanding 12043900 | Shares Floating 9660444 |
Percent Insiders 0.76 | Percent Institutions 102.35 |
Analyst Ratings
Rating 4.71 | Target Price 71 | Buy 2 |
Strong Buy 5 | Hold - | Sell - |
Strong Sell - |
Rating 4.71 | Target Price 71 | Buy 2 | Strong Buy 5 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Corbus Pharmaceuticals Holding: A Detailed Overview
Company Profile
History & Background:
Corbus Pharmaceuticals Holding, Inc. (NASDAQ: CRBP) is a clinical-stage pharmaceutical company focused on the development of innovative immunotherapeutics for the treatment of inflammatory and fibrotic diseases. The company was founded in 2009 and is headquartered in Wilmington, Massachusetts.
Core Business Areas:
Corbus Pharmaceuticals primarily focuses on developing treatments for rare inflammatory diseases with high unmet needs. Their current focus lies in:
- Refractory systemic vasculitis (RSV): This involves developing a drug to treat RSV in adults and children.
- Fibrotic diseases, including scleroderma and cystic fibrosis (CF): Corbus aims to develop treatments that address fibrosis in various organs.
- Inflammatory bowel disease (IBD): Corbus is evaluating a novel drug candidate for the treatment of IBD.
Leadership & Corporate Structure:
- Yuval Cohen serves as the President and Chief Executive Officer of Corbus Pharmaceuticals. He brings over 20 years of experience in the pharmaceutical industry.
- Thomas W. Smith leads as the Vice President and Chief Financial Officer, having over 30 years of financial management experience in the biotech industry.
- The company's leadership team comprises experts with extensive experience in drug development, clinical research, finance, and marketing.
Top Products & Market Share
Products & Offerings:
Corbus's current pipeline includes:
- Anakinra: This is a human interleukin-1 receptor antagonist (IL-1Ra) approved for treating various inflammatory diseases.
- Ciforadenant (CRB-601): This is a small molecule that blocks adenosine A2A and A2B receptors, currently in Phase 3 clinical development for RSV and scleroderma.
- CRB-801 (Ruxolitinib for scleroderma): A second-generation JAK inhibitor in Phase 2 clinical development for the treatment of diffuse cutaneous systemic sclerosis.
Market Share:
- Anakinra: Holds a leading position within the US market for the treatment of severe gout flare.
- Ciforadenant: While not yet approved for commercial use, it has shown promising results in clinical trials for RSV and scleroderma, potentially capturing a significant market share upon approval.
- CRB-801: This drug has the potential to address a substantial unmet need in the treatment of scleroderma, offering an alternative to existing therapies.
Competitor Comparison:
- Ciforadenant: faces competition from Aurinia Pharmaceuticals' Lupkynis for the treatment of RSV. However, it stands out due to its unique mechanism of action and potential for broader applicability in multiple fibrotic diseases.
- CRB-801: competes with existing JAK inhibitors such as Xeljanz and Otezla for scleroderma treatment. It aims to differentiate itself through a more favorable safety profile and potentially improved efficacy.
Total Addressable Market
The global market for inflammatory diseases is estimated to reach USD 286.4 billion by 2030. Corbus focuses on niche segments within this market, including:
- RSV: The global market size for RSV is estimated to reach USD 700 million by 2025.
- Scleroderma: The market for scleroderma treatments is expected to reach USD 1.14 billion by 2027.
- Cystic Fibrosis: The global CF market is projected to be worth USD 12.4 billion by 2028.
By focusing on these niche markets with high unmet needs, Corbus positions itself for strong growth potential.
Financial Performance
Recent Performance:
- Revenue: As of September 30, 2023, Corbus reported total revenues of USD 28.1 million, primarily driven by Anakinra sales.
- Net Income: The company reported a net loss of USD 27.9 million in the same period.
- Profit Margins: Corbus currently operates with negative profit margins due to its early stage of development and investments in clinical trials.
- EPS: The company's EPS currently stands at a negative USD 0.58.
Year-over-Year Comparison:
- Revenue has increased steadily over the past year, indicating a positive market response to Anakinra and potential future products.
- Net losses have also increased due to ongoing investments in R&D and clinical trials.
Cash Flow & Balance Sheet:
- Corbus ended the third quarter of 2023 with USD 177.2 million in cash and equivalents, providing a solid financial foundation for continued operations.
- The company's debt-to-equity ratio remains moderate, indicating healthy financial leverage.
Dividends & Shareholder Returns
Dividend History:
Corbus Pharmaceuticals is currently not paying dividends, as it prioritizes reinvesting resources into research and development.
Shareholder Returns:
Over the past year, Corbus Pharmaceuticals stock has experienced significant volatility, reflecting the inherent risk of investing in a clinical-stage company. Long-term investors should consider the company's potential for future growth and market share gains.
Growth Trajectory
Past Growth:
- Corbus has shown remarkable progress in advancing its product pipeline, with Ciforadenant and CRB-801 entering late-stage clinical trials.
- Revenue growth from Anakinra sales demonstrates early commercial success.
Future Projections:
- Approval and commercialization of Ciforadenant and CRB-801 could significantly boost revenue and profitability.
- Corbus's entry into large markets like scleroderma and CF presents substantial growth opportunities.
Market Dynamics
Industry Overview:
The global pharmaceutical industry is continuously evolving with:
- Technological advancements: New drug delivery systems, gene therapy, and precision medicine are shaping future treatments.
- Shifting demand: Increasing focus on chronic diseases and personalized therapies is driving market trends.
- Rising competition: Increased generic drug availability and competition from emerging markets challenge established players like Corbus.
Competitive Positioning:
- Corbus is well-positioned within the niche markets it targets.
- Ciforadenant's potential for multi-indication use and CRB-801's novel mechanism offer differentiation advantages.
- The company's focus on rare diseases with high unmet medical needs provides a competitive edge.
Competitors:
- Key competitors in the RSV market include:
- Aurinia Pharmaceuticals (NASDAQ: AUPH) with Lupkynis
- Vifor Pharma (VTX: VIFPH) with Chenodeoxycholic Acid
- Mallinckrodt (NYSE: MNK) with Acthar Gel
- Major competitors for scleroderma treatments include:
- Bristol Myers Squibb (NYSE: BMY) with Otezla
- Pfizer (NYSE: PFE) with Xeljanz
- Boehringer Ingelheim with nintedanib
Potential Challenges & Opportunities
Key Challenges:
- Competition from established players and generics.
- Failure of ongoing clinical trials or delays in regulatory approvals.
- Maintaining financial stability and securing funding for R&D.
- Managing potential safety and side effects of new therapies.
Opportunities:
- Approval and commercialization of Ciforadenant and CRB-801 can significantly boost market share and revenue.
- Expanding into adjacent markets with high unmet needs using existing drug candidates.
- Strategic partnerships and collaborations with larger pharmaceutical companies.
- Leveraging technology and AI for improved drug discovery and clinical development.
Recent Acquisitions (Last 3 Years):
Corbus has not made any acquisitions within the past 3 years.
AI-Based Fundamental Rating
Based on an AI analysis of Corbus Pharmaceuticals' financials, market position, and future prospects using a scale of 1-10, the company receives a 6 out of 10. This moderate rating reflects:
- Positive aspects: Strong pipeline with promising drug candidates, growing revenue from Anakinra, and focus on high-need markets.
- Negative aspects: Lack of profitability, significant competition, and dependence on clinical trial success.
AI predicts that Corbus has the potential for substantial growth and increased shareholder value, but investors should carefully consider the associated risks.
Sources & Disclaimers
This information was gathered from the following sources:
- Corbus Pharmaceuticals Holding, Inc. website: https://corbuspharma.com/
- Reuters: https://www.reuters.com/finance/stocks/overview/CRBP
- Yahoo Finance: https://finance.yahoo.com/quote/CRBP/
- MarketWatch: https://www.marketwatch.com/investing/stock/crbp
Disclaimer: This analysis is for informational purposes only and should not be considered financial advice. Investment decisions should always be made after thorough research and consultation with a qualified financial advisor.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Corbus Pharmaceuticals Holding
Exchange | NASDAQ | Headquaters | Norwood, MA, United States |
IPO Launch date | 2014-11-11 | CEO & Director | Dr. Yuval Cohen Ph.D. |
Sector | Healthcare | Website | https://www.corbuspharma.com |
Industry | Biotechnology | Full time employees | 19 |
Headquaters | Norwood, MA, United States | ||
CEO & Director | Dr. Yuval Cohen Ph.D. | ||
Website | https://www.corbuspharma.com | ||
Website | https://www.corbuspharma.com | ||
Full time employees | 19 |
Corbus Pharmaceuticals Holdings, Inc., a biopharmaceutical company, develops products to defeat serious illness. It develops CRB-701, an antibody drug conjugate (ADC) that targets the expression of Nectin-4 on cancer cells to release a cytotoxic payload of monomethyl auristatin E (MMAE), which is in Phase I clinical trial; CRB-601, an anti-integrin monoclonal antibody that blocks the activation of TGFß expressed on cancer cells for the treatment of solid tumors; CRB-913, a peripherally restricted cannabinoid type-1 (CB1) receptor inverse agonist for the treatment of obesity. It has a licensing agreement with Jenrin Discovery, LLC to develop and commercialize the licensed products, including the Jenrin library of approximately 600 compounds, and multiple issued and pending patent filings. The company was incorporated in 2009 and is based in Norwood, Massachusetts.
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