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Vigil Neuroscience Inc (VIGL)VIGL
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Upturn Advisory Summary
09/18/2024: VIGL (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: 85.34% | Upturn Advisory Performance 2 | Avg. Invested days: 41 |
Profits based on simulation | Stock Returns Performance 4 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: 85.34% | Avg. Invested days: 41 |
Upturn Star Rating | Stock Returns Performance 4 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 137.58M USD |
Price to earnings Ratio - | 1Y Target Price 15.88 |
Dividends yield (FY) - | Basic EPS (TTM) -2.11 |
Volume (30-day avg) 111286 | Beta 1.97 |
52 Weeks Range 2.47 - 9.24 | Updated Date 09/19/2024 |
Company Size Small-Cap Stock | Market Capitalization 137.58M USD | Price to earnings Ratio - | 1Y Target Price 15.88 |
Dividends yield (FY) - | Basic EPS (TTM) -2.11 | Volume (30-day avg) 111286 | Beta 1.97 |
52 Weeks Range 2.47 - 9.24 | Updated Date 09/19/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -39.66% | Return on Equity (TTM) -70.12% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 64308939 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -3.16 |
Shares Outstanding 39647500 | Shares Floating 20990593 |
Percent Insiders 8.63 | Percent Institutions 83.46 |
Trailing PE - | Forward PE - | Enterprise Value 64308939 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -3.16 | Shares Outstanding 39647500 | Shares Floating 20990593 |
Percent Insiders 8.63 | Percent Institutions 83.46 |
Analyst Ratings
Rating 4.25 | Target Price 19.88 | Buy 2 |
Strong Buy 5 | Hold - | Sell - |
Strong Sell 1 |
Rating 4.25 | Target Price 19.88 | Buy 2 | Strong Buy 5 |
Hold - | Sell - | Strong Sell 1 |
AI Summarization
Vigil Neuroscience Inc.: A Comprehensive Overview
Company Profile:
Detailed History and Background:
Vigil Neuroscience Inc. (NASDAQ: VIGL) is a clinical-stage biopharmaceutical company headquartered in Cambridge, Massachusetts. Founded in 2018 as a spin-out from Biogen, the company focuses on developing and commercializing treatments for neurological and other diseases with significant unmet unmet needs.
Core Business Areas:
Vigil's primary focus lies within the area of CNS diseases, particularly those involving impaired inhibitory neurotransmission. Their pipeline includes potential treatments for epilepsy, Fragile X syndrome, and other neurological conditions.
Leadership Team and Corporate Structure:
The current leadership team of Vigil Neuroscience Inc. comprises:
- Ira Black, Ph.D.: Chief Executive Officer and President
- Mark Strulovici, Ph.D.: Chief Scientific Officer and Head of R&D
- David Tuveson, M.D., Ph. D.: Chief Medical Officer
- Elizabeth A. H. Jones: Chief Financial Officer
- John F. Crowley: Chairman of the Board
The company operates with a decentralized structure, with teams specializing in research and development, clinical operations, and commercialization.
Top Products and Market Share:
Top Products and Offerings:
Vigil's current pipeline includes four clinical-stage product candidates:
- VIG-085: A selective GABAA α2/3 receptor positive allosteric modulator for the treatment of epilepsy.
- VIG-096: A next-generation GABAA α2/3 receptor positive allosteric modulator also intended for epilepsy treatment.
- VIG-113: A GABAA α2/3 receptor positive allosteric modulator aimed at Fragile X syndrome therapy.
- VIG-300: A selective GABAA α5 receptor inverse agonist for the treatment of Parkinson's disease.
Market Share:
As Vigil's products are still in clinical development, they do not hold any market share in the current market. However, the potential market for their lead candidate, VIG-085, is estimated to be around 1.5 million patients with focal epilepsy in the United States alone.
Product Performance and Market Reception:
Preliminary data from Phase II clinical trials for VIG-085 demonstrated promising results in reducing seizure frequency in patients with focal epilepsy. Investors reacted positively to this news, with the company's stock price experiencing significant growth.
Total Addressable Market:
The global market for epilepsy treatment was valued at approximately $7.27 billion in 2022 and is expected to reach $9.41 billion by 2028, exhibiting a CAGR of 4.3%. The US market for epilepsy drugs is estimated to be around $3.2 billion. Additionally, the market for Fragile X syndrome treatment is estimated to be around $1.8 billion.
Financial Performance:
Recent Financial Statements:
In the third quarter of 2023, Vigil Neuroscience Inc. reported a net loss of $16.7 million. As of September 30, 2023, the company had a cash and cash equivalents balance of $199.4 million.
Year-over-Year Comparison:
The company's net loss has decreased compared to the same period in 2022. This improvement is primarily attributed to increased research and development expenses associated with the advancement of their clinical pipeline.
Cash Flow and Balance Sheet Health:
Vigil has a strong cash position, which provides them with the financial flexibility to advance their clinical programs. The company's balance sheet is also in good health, with a low debt-to-equity ratio.
Dividends and Shareholder Returns:
Dividend History:
Vigil Neuroscience Inc. is a pre-revenue company and does not currently pay dividends.
Shareholder Returns:
The company's stock price has experienced significant volatility since its IPO in 2021. However, it has shown an overall upward trend in recent months due to the positive clinical data for VIG-085.
Growth Trajectory:
Historical Growth:
Since its inception, Vigil has experienced rapid growth, mainly driven by its expanding clinical pipeline and the promising results of its lead product candidates.
Future Growth Projections:
Analysts expect Vigil to continue its growth trajectory as it advances its clinical programs and potentially launches its first product in the market. The commercialization of VIG-085 could be a significant growth driver for the company.
Recent Initiatives:
Vigil is actively pursuing strategic initiatives to fuel its growth, including partnerships with leading research institutions and the expansion of its clinical trial programs.
Market Dynamics:
Industry Overview:
The CNS drug market is a highly competitive and complex industry with numerous players vying for market share. However, the market also presents significant opportunities for companies like Vigil that are developing innovative therapies for unmet medical needs.
Vigil's Position and Adaptability:
Vigil is well-positioned within the CNS drug market due to its focus on developing novel therapies with differentiated mechanisms of action. The company's strong cash position and experienced leadership team also contribute to its adaptability to market changes.
Competitors:
Key Competitors:
- Eisai Co., Ltd. (OTC: ESALY)
- GW Pharmaceuticals (NASDAQ: GWPH)
- LivaNova PLC (NASDAQ: LIVN)
- Supernus Pharmaceuticals, Inc. (NASDAQ: SUPN)
Market Share and Comparison:
As Vigil's products are not yet commercially available, it does not compete directly with these established players in terms of market share. However, the company's lead product candidates hold the potential to challenge the market dominance of existing therapies in the future.
Competitive Advantages and Disadvantages:
Vigil's competitive advantages include its innovative pipeline, strong financial position, and experienced management team. However, the company faces challenges such as the lengthy and expensive clinical development process and the intense competition within the CNS drug market.
Potential Challenges and Opportunities:
Key Challenges:
- Successfully navigating the complex and expensive clinical development process.
- Gaining regulatory approval for its product candidates.
- Successfully commercializing its products in a competitive market.
- Managing potential safety and efficacy concerns associated with its product candidates.
Potential Opportunities:
- Expanding its clinical pipeline with additional product candidates.
- Partnering with larger pharmaceutical companies for co-development or commercialization of its products.
- Exploring new markets for its product candidates.
- Leveraging technological advancements to improve its research and development processes.
Recent Acquisitions:
Vigil Neuroscience Inc. has not made any acquisitions in the last three years.
AI-Based Fundamental Rating:
Rating: 7/10
Justification:
Several factors contribute to Vigil's overall rating of 7/10. These include:
- Strong financial health: The company has a strong cash position and a low debt-to-equity ratio.
- Promising pipeline: Vigil's clinical-stage product candidates have the potential to address significant unmet medical needs.
- Experienced leadership team: The company is led by a team of experienced professionals with a strong track record in the pharmaceutical industry.
- Competitive market: The CNS drug market is highly competitive, which poses a challenge for Vigil.
- Early-stage development: Vigil's products are still in the clinical development stage, which carries inherent risks and uncertainties.
Sources and Disclaimers:
Sources:
- Vigil Neuroscience Inc. investor relations website (https://ir.vigilneuro.com/)
- SEC filings (https://www.sec.gov/edgar/search/companysearch.html?company=vigil+neuroscience)
- Yahoo Finance (https://finance.yahoo.com/quote/VIGL/)
- Market research reports
Disclaimer:
This analysis is intended for informational purposes only and should not be considered investment advice. Please consult with a qualified financial advisor before making investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Vigil Neuroscience Inc
Exchange | NASDAQ | Headquaters | Watertown, MA, United States |
IPO Launch date | 2022-01-07 | President, CEO & Director | Dr. Ivana Magovcevic-Liebisch J.D., Ph.D. |
Sector | Healthcare | Website | https://www.vigilneuro.com |
Industry | Biotechnology | Full time employees | 64 |
Headquaters | Watertown, MA, United States | ||
President, CEO & Director | Dr. Ivana Magovcevic-Liebisch J.D., Ph.D. | ||
Website | https://www.vigilneuro.com | ||
Website | https://www.vigilneuro.com | ||
Full time employees | 64 |
Vigil Neuroscience, Inc., a clinical-stage biotechnology company, focuses on developing treatments for rare and common neurodegenerative diseases by restoring the vigilance of microglia, the sentinel immune cells of the brain. Its lead candidate is VGL101(Iluzanebart), a human monoclonal antibody agonist targeting human triggering receptor expressed on myeloid cells 2 and is in a Phase 2 trial in patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rare and fatal neurodegenerative disease. The company is also developing VG-3927, an orally-available small molecule TREM2 agonist to treat common neurodegenerative diseases associated with microglial dysfunction, with an initial focus on Alzheimer's disease in genetically defined subpopulations, which is being evaluated in a Phase 1 clinical trial. It has license agreement with Amgen Inc. to commercially develop, manufacture, use, distribute, and sell therapeutic products containing compounds that bind to TREM2. The company was incorporated in 2020 and is headquartered in Watertown, Massachusetts.
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