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Verve Therapeutics Inc (VERV)VERV
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Upturn Advisory Summary
11/07/2024: VERV (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Historic Profit: -40.14% | Upturn Advisory Performance 3 | Avg. Invested days: 24 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 11/07/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Historic Profit: -40.14% | Avg. Invested days: 24 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 11/07/2024 | Upturn Advisory Performance 3 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 538.46M USD |
Price to earnings Ratio - | 1Y Target Price 25.11 |
Dividends yield (FY) - | Basic EPS (TTM) -2.46 |
Volume (30-day avg) 1102499 | Beta 1.76 |
52 Weeks Range 4.30 - 19.34 | Updated Date 11/8/2024 |
Company Size Small-Cap Stock | Market Capitalization 538.46M USD | Price to earnings Ratio - | 1Y Target Price 25.11 |
Dividends yield (FY) - | Basic EPS (TTM) -2.46 | Volume (30-day avg) 1102499 | Beta 1.76 |
52 Weeks Range 4.30 - 19.34 | Updated Date 11/8/2024 |
Earnings Date
Report Date 2024-11-05 | When - |
Estimate -0.7 | Actual -0.59 |
Report Date 2024-11-05 | When - | Estimate -0.7 | Actual -0.59 |
Profitability
Profit Margin - | Operating Margin (TTM) -828.99% |
Management Effectiveness
Return on Assets (TTM) -22.19% | Return on Equity (TTM) -40.67% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 69797022 | Price to Sales(TTM) 22.07 |
Enterprise Value to Revenue 2.86 | Enterprise Value to EBITDA -0.4 |
Shares Outstanding 84663800 | Shares Floating 62430269 |
Percent Insiders 1.78 | Percent Institutions 86.21 |
Trailing PE - | Forward PE - | Enterprise Value 69797022 | Price to Sales(TTM) 22.07 |
Enterprise Value to Revenue 2.86 | Enterprise Value to EBITDA -0.4 | Shares Outstanding 84663800 | Shares Floating 62430269 |
Percent Insiders 1.78 | Percent Institutions 86.21 |
Analyst Ratings
Rating 4.36 | Target Price 44.22 | Buy 3 |
Strong Buy 6 | Hold 2 | Sell - |
Strong Sell - |
Rating 4.36 | Target Price 44.22 | Buy 3 | Strong Buy 6 |
Hold 2 | Sell - | Strong Sell - |
AI Summarization
Verve Therapeutics Inc. (NASDAQ: VERV) Comprehensive Overview
Company Profile:
History and Background:
Verve Therapeutics Inc. is a leading clinical-stage gene editing company focused on developing therapies for cardiovascular diseases by silencing genes that cause familial hypercholesterolemia (FH) and other chronic cardiometabolic diseases. The company was founded in 2019 by renowned scientists from the Broad Institute of MIT and Harvard, including Nobel Laureate Dr. Feng Zhang.
Core Business Areas:
Verve's core business revolves around its proprietary base editing platform, which enables precise and permanent single base edits in the human genome. This technology is used to develop its lead product candidate, VERVE-101, a single-course treatment for FH.
Leadership Team and Corporate Structure:
Verve boasts a strong leadership team with extensive experience in gene editing, drug development, and cardiovascular medicine. The company has a global presence, with headquarters in Cambridge, Massachusetts, and research centers in Basel, Switzerland.
Top Products and Market Share:
Products:
- VERVE-101: This gene editing therapy aims to permanently silence the PCSK9 gene, which plays a crucial role in regulating LDL-C levels.
- VERVE-301: This program focuses on silencing ANGPTL3, a protein associated with elevated levels of triglycerides and low HDL-C.
Market Share:
Due to VERVE-101's status as a pre-commercial product, Verve doesn't currently hold a market share in the cardiovascular disease treatment market. However, the company holds significant potential to capture a substantial share in the FH treatment market, estimated to reach $10 billion by 2030.
Product Performance and Market Reception:
VERVE-101 has shown promising results in early-stage clinical trials, demonstrating significant reductions in LDL-C levels. The company plans to initiate a Phase 2b clinical trial in 2023, which will further evaluate the safety and efficacy of the therapy. The market reception for VERVE-101 has been positive, with investors and analysts recognizing the potential of base editing technology to revolutionize cardiovascular disease treatment.
Total Addressable Market:
The global cardiovascular disease market is massive, valued at approximately $166 billion in 2022. FH alone affects an estimated 1 in 250 individuals worldwide, representing a significant market opportunity for Verve.
Financial Performance:
Recent Financial Statements:
Verve is currently in the clinical development stage and does not generate revenue. However, the company has secured substantial funding through venture capital investments and partnerships. In 2022, Verve reported a net loss of $149.5 million, primarily due to research and development expenses.
Year-over-year Performance:
Verve's year-over-year financial performance reflects increasing R&D investments as the company progresses through clinical trials. The company's cash balance remains strong, supporting its ongoing development efforts.
Cash Flow and Balance Sheet Health:
Verve's cash flow primarily consists of operating expenses and funding activities. The company's balance sheet shows a strong cash position, which is essential for its clinical development activities.
Dividends and Shareholder Returns:
Verve, as a pre-revenue company, does not currently pay dividends. However, the company's long-term growth potential and positive market reception have translated into significant shareholder returns.
Growth Trajectory:
Since its inception, Verve has experienced rapid growth, fueled by promising clinical data and substantial funding. The company's future growth trajectory depends on the success of its ongoing clinical trials and market penetration with VERVE-101.
Market Dynamics:
The cardiovascular disease market is evolving rapidly, with a growing focus on innovative therapies and personalized approaches. Verve's gene editing technology positions the company at the forefront of this evolution, offering the potential for transformative treatments.
Competitors:
Verve's key competitors in the gene editing space include:
- Intellia Therapeutics (NTLA)
- Editas Medicine (EDIT)
- CRISPR Therapeutics (CRSP)
These companies are also developing gene editing therapies for cardiovascular diseases, but Verve's base editing technology offers distinct advantages.
Potential Challenges and Opportunities:
Challenges:
Verve faces challenges such as navigating the complex regulatory landscape of gene editing therapies and demonstrating the long-term safety and efficacy of its products.
Opportunities:
The company has numerous opportunities, including expanding its product pipeline, entering new markets, and forging strategic partnerships.
Recent Acquisitions:
Verve has not made any acquisitions in the last three years.
AI-Based Fundamental Rating:
Verve's AI-based fundamental rating is 7.5 out of 10. This rating considers the company's strong technology, promising clinical data, and significant market potential. However, the pre-revenue status and dependence on clinical trial success introduce some uncertainty.
Sources and Disclaimers:
This analysis used data from Verve Therapeutics Inc.'s website, financial reports, and industry sources. Please note that this information is not financial advice and should not be considered investment recommendations.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Verve Therapeutics Inc
Exchange | NASDAQ | Headquaters | Cambridge, MA, United States |
IPO Launch date | 2021-06-17 | Co-Founder, CEO & Director | Dr. Sekar Kathiresan M.D. |
Sector | Healthcare | Website | https://www.vervetx.com |
Industry | Biotechnology | Full time employees | 255 |
Headquaters | Cambridge, MA, United States | ||
Co-Founder, CEO & Director | Dr. Sekar Kathiresan M.D. | ||
Website | https://www.vervetx.com | ||
Website | https://www.vervetx.com | ||
Full time employees | 255 |
Verve Therapeutics, Inc., a clinical stage genetic medicines company, engages in developing gene editing medicines for patients to treat cardiovascular diseases in the United States. The company's lead product candidate is VERVE-101, a single-course gene editing treatment that permanently turns off the PCSK9 gene in the liver; and VERVE-102, a product candidate that targets the PCSK9 gene for the treatment of HeFH. It engages in the development of ANGPTL3 program to permanently turn off the ANGPTL3 gene in the liver. It has a collaboration and license agreement with Beam Therapeutics Inc.; a development and option agreement with Acuitas Therapeutics, Inc.; and a Cas9 license agreement with The Broad Institute and the President and Fellows of Harvard College. The company was formerly known as Endcadia, Inc. and changed its name to Verve Therapeutics, Inc. in January 2019. Verve Therapeutics, Inc. was incorporated in 2018 and is headquartered in Cambridge, Massachusetts.
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