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Verve Therapeutics Inc (VERV)VERV

Upturn stock ratingUpturn stock rating
Verve Therapeutics Inc
$6.36
Delayed price
Profit since last BUY7.07%
Consider higher Upturn Star rating
upturn advisory
BUY since 9 days
  • BUY Advisory
  • Profitable SELL
  • Loss-Inducing SELL
  • Profit
  • Loss ​
  • PASS (Skip invest)*​ ​
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
  • ALL
  • YEAR
  • MONTH
  • WEEK
Time period over

Upturn Advisory Summary

11/07/2024: VERV (1-star) has a low Upturn Star Rating. Not recommended to BUY.

Analysis of Past Performance​

Type: Stock
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Today’s Advisory: Consider higher Upturn Star rating
Historic Profit: -40.14%
Upturn Advisory Performance Upturn Advisory Performance3
Avg. Invested days: 24
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Stock Returns Performance Upturn Returns Performance 1
Last Close 11/07/2024
Type: Stock
Today’s Advisory: Consider higher Upturn Star rating
Historic Profit: -40.14%
Avg. Invested days: 24
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Stock Returns Performance Upturn Returns Performance 1
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 11/07/2024
Upturn Advisory Performance Upturn Advisory Performance3

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 538.46M USD
Price to earnings Ratio -
1Y Target Price 25.11
Dividends yield (FY) -
Basic EPS (TTM) -2.46
Volume (30-day avg) 1102499
Beta 1.76
52 Weeks Range 4.30 - 19.34
Updated Date 11/8/2024
Company Size Small-Cap Stock
Market Capitalization 538.46M USD
Price to earnings Ratio -
1Y Target Price 25.11
Dividends yield (FY) -
Basic EPS (TTM) -2.46
Volume (30-day avg) 1102499
Beta 1.76
52 Weeks Range 4.30 - 19.34
Updated Date 11/8/2024

Earnings Date

Report Date 2024-11-05
When -
Estimate -0.7
Actual -0.59
Report Date 2024-11-05
When -
Estimate -0.7
Actual -0.59

Profitability

Profit Margin -
Operating Margin (TTM) -828.99%

Management Effectiveness

Return on Assets (TTM) -22.19%
Return on Equity (TTM) -40.67%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 69797022
Price to Sales(TTM) 22.07
Enterprise Value to Revenue 2.86
Enterprise Value to EBITDA -0.4
Shares Outstanding 84663800
Shares Floating 62430269
Percent Insiders 1.78
Percent Institutions 86.21
Trailing PE -
Forward PE -
Enterprise Value 69797022
Price to Sales(TTM) 22.07
Enterprise Value to Revenue 2.86
Enterprise Value to EBITDA -0.4
Shares Outstanding 84663800
Shares Floating 62430269
Percent Insiders 1.78
Percent Institutions 86.21

Analyst Ratings

Rating 4.36
Target Price 44.22
Buy 3
Strong Buy 6
Hold 2
Sell -
Strong Sell -
Rating 4.36
Target Price 44.22
Buy 3
Strong Buy 6
Hold 2
Sell -
Strong Sell -

AI Summarization

Verve Therapeutics Inc. (NASDAQ: VERV) Comprehensive Overview

Company Profile:

History and Background:

Verve Therapeutics Inc. is a leading clinical-stage gene editing company focused on developing therapies for cardiovascular diseases by silencing genes that cause familial hypercholesterolemia (FH) and other chronic cardiometabolic diseases. The company was founded in 2019 by renowned scientists from the Broad Institute of MIT and Harvard, including Nobel Laureate Dr. Feng Zhang.

Core Business Areas:

Verve's core business revolves around its proprietary base editing platform, which enables precise and permanent single base edits in the human genome. This technology is used to develop its lead product candidate, VERVE-101, a single-course treatment for FH.

Leadership Team and Corporate Structure:

Verve boasts a strong leadership team with extensive experience in gene editing, drug development, and cardiovascular medicine. The company has a global presence, with headquarters in Cambridge, Massachusetts, and research centers in Basel, Switzerland.

Top Products and Market Share:

Products:

  • VERVE-101: This gene editing therapy aims to permanently silence the PCSK9 gene, which plays a crucial role in regulating LDL-C levels.
  • VERVE-301: This program focuses on silencing ANGPTL3, a protein associated with elevated levels of triglycerides and low HDL-C.

Market Share:

Due to VERVE-101's status as a pre-commercial product, Verve doesn't currently hold a market share in the cardiovascular disease treatment market. However, the company holds significant potential to capture a substantial share in the FH treatment market, estimated to reach $10 billion by 2030.

Product Performance and Market Reception:

VERVE-101 has shown promising results in early-stage clinical trials, demonstrating significant reductions in LDL-C levels. The company plans to initiate a Phase 2b clinical trial in 2023, which will further evaluate the safety and efficacy of the therapy. The market reception for VERVE-101 has been positive, with investors and analysts recognizing the potential of base editing technology to revolutionize cardiovascular disease treatment.

Total Addressable Market:

The global cardiovascular disease market is massive, valued at approximately $166 billion in 2022. FH alone affects an estimated 1 in 250 individuals worldwide, representing a significant market opportunity for Verve.

Financial Performance:

Recent Financial Statements:

Verve is currently in the clinical development stage and does not generate revenue. However, the company has secured substantial funding through venture capital investments and partnerships. In 2022, Verve reported a net loss of $149.5 million, primarily due to research and development expenses.

Year-over-year Performance:

Verve's year-over-year financial performance reflects increasing R&D investments as the company progresses through clinical trials. The company's cash balance remains strong, supporting its ongoing development efforts.

Cash Flow and Balance Sheet Health:

Verve's cash flow primarily consists of operating expenses and funding activities. The company's balance sheet shows a strong cash position, which is essential for its clinical development activities.

Dividends and Shareholder Returns:

Verve, as a pre-revenue company, does not currently pay dividends. However, the company's long-term growth potential and positive market reception have translated into significant shareholder returns.

Growth Trajectory:

Since its inception, Verve has experienced rapid growth, fueled by promising clinical data and substantial funding. The company's future growth trajectory depends on the success of its ongoing clinical trials and market penetration with VERVE-101.

Market Dynamics:

The cardiovascular disease market is evolving rapidly, with a growing focus on innovative therapies and personalized approaches. Verve's gene editing technology positions the company at the forefront of this evolution, offering the potential for transformative treatments.

Competitors:

Verve's key competitors in the gene editing space include:

  • Intellia Therapeutics (NTLA)
  • Editas Medicine (EDIT)
  • CRISPR Therapeutics (CRSP)

These companies are also developing gene editing therapies for cardiovascular diseases, but Verve's base editing technology offers distinct advantages.

Potential Challenges and Opportunities:

Challenges:

Verve faces challenges such as navigating the complex regulatory landscape of gene editing therapies and demonstrating the long-term safety and efficacy of its products.

Opportunities:

The company has numerous opportunities, including expanding its product pipeline, entering new markets, and forging strategic partnerships.

Recent Acquisitions:

Verve has not made any acquisitions in the last three years.

AI-Based Fundamental Rating:

Verve's AI-based fundamental rating is 7.5 out of 10. This rating considers the company's strong technology, promising clinical data, and significant market potential. However, the pre-revenue status and dependence on clinical trial success introduce some uncertainty.

Sources and Disclaimers:

This analysis used data from Verve Therapeutics Inc.'s website, financial reports, and industry sources. Please note that this information is not financial advice and should not be considered investment recommendations.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.​

About Verve Therapeutics Inc

Exchange NASDAQ Headquaters Cambridge, MA, United States
IPO Launch date 2021-06-17 Co-Founder, CEO & Director Dr. Sekar Kathiresan M.D.
Sector Healthcare Website https://www.vervetx.com
Industry Biotechnology Full time employees 255
Headquaters Cambridge, MA, United States
Co-Founder, CEO & Director Dr. Sekar Kathiresan M.D.
Website https://www.vervetx.com
Website https://www.vervetx.com
Full time employees 255

Verve Therapeutics, Inc., a clinical stage genetic medicines company, engages in developing gene editing medicines for patients to treat cardiovascular diseases in the United States. The company's lead product candidate is VERVE-101, a single-course gene editing treatment that permanently turns off the PCSK9 gene in the liver; and VERVE-102, a product candidate that targets the PCSK9 gene for the treatment of HeFH. It engages in the development of ANGPTL3 program to permanently turn off the ANGPTL3 gene in the liver. It has a collaboration and license agreement with Beam Therapeutics Inc.; a development and option agreement with Acuitas Therapeutics, Inc.; and a Cas9 license agreement with The Broad Institute and the President and Fellows of Harvard College. The company was formerly known as Endcadia, Inc. and changed its name to Verve Therapeutics, Inc. in January 2019. Verve Therapeutics, Inc. was incorporated in 2018 and is headquartered in Cambridge, Massachusetts.

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