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Tyra Biosciences Inc (TYRA)TYRA
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Upturn Advisory Summary
09/18/2024: TYRA (1-star) is a SELL. SELL since 3 days. Profits (0.25%). Updated daily EoD!
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: SELL |
Profit: -53.45% | Upturn Advisory Performance 2 | Avg. Invested days: 27 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: SELL |
Profit: -53.45% | Avg. Invested days: 27 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 1.23B USD |
Price to earnings Ratio - | 1Y Target Price 26.33 |
Dividends yield (FY) - | Basic EPS (TTM) -1.7 |
Volume (30-day avg) 160804 | Beta 1.01 |
52 Weeks Range 10.38 - 24.25 | Updated Date 09/19/2024 |
Company Size Small-Cap Stock | Market Capitalization 1.23B USD | Price to earnings Ratio - | 1Y Target Price 26.33 |
Dividends yield (FY) - | Basic EPS (TTM) -1.7 | Volume (30-day avg) 160804 | Beta 1.01 |
52 Weeks Range 10.38 - 24.25 | Updated Date 09/19/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -18.57% | Return on Equity (TTM) -26.5% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 857705378 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -6.95 |
Shares Outstanding 52806100 | Shares Floating 16199058 |
Percent Insiders 4.67 | Percent Institutions 98.51 |
Trailing PE - | Forward PE - | Enterprise Value 857705378 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -6.95 | Shares Outstanding 52806100 | Shares Floating 16199058 |
Percent Insiders 4.67 | Percent Institutions 98.51 |
Analyst Ratings
Rating 4.43 | Target Price 24.4 | Buy 2 |
Strong Buy 4 | Hold 1 | Sell - |
Strong Sell - |
Rating 4.43 | Target Price 24.4 | Buy 2 | Strong Buy 4 |
Hold 1 | Sell - | Strong Sell - |
AI Summarization
Tyra Biosciences Inc.: A Comprehensive Overview
Company Profile
History and Background
Tyra Biosciences Inc. is a public biotechnology company headquartered in Waltham, Massachusetts, dedicated to the discovery and development of novel protein-based immunotherapies for the treatment of cancer. Founded in 2013, the company utilizes its proprietary technology platform, TyraBody®, to engineer highly differentiated antibody-drug conjugates (ADCs) designed to improve clinical outcomes for patients with solid tumors.
Core Business Areas
Tyra Biosciences currently focuses on two key business areas:
- Development of TYRA-353: A first-in-class ADC targeting the GPC2 protein, which is overexpressed in various cancers, including triple-negative breast cancer (TNBC). Tyra-353 is currently in Phase 1b clinical trials.
- TyraBody® platform development: This platform enables the design and engineering of next-generation ADCs and other protein therapeutics with tailored functionalities.
Leadership Team and Corporate Structure
Executive Leadership:
- Jason Brayton, Ph.D.: President and Chief Executive Officer
- Barbara Smith, M.D.: Chief Medical Officer
- Joseph Miceli, Ph.D.: Chief Scientific Officer
- Scott Miller, CPA: Chief Financial Officer
- Brian M. Davis: General Counsel
Board of Directors:
- William Burckart: Chairman & Lead Independent Director
- Jason Brayton, Ph.D.: President & CEO
- Catherine Auger, Ph.D.: Chief Technology Officer at Alexion Pharmaceuticals
- William D. Nelson, Ph.D.: CEO of Gilead Sciences
- Richard Hynes, Ph.D.: Daniel K. Ludwig Professor for Cancer Research at MIT
- Paul Wotton, Ph.D.: Former Senior Vice President at Shire
Top Products and Market Share
Top Products
- TYRA-353: This ADC is designed to selectively target and deliver cytotoxic therapy to GPC2-positive tumor cells while minimizing systemic exposure.
- TYRA-544: A next-generation ADC that uses the TyraBody® platform to combine a novel targeting antibody with a potent cytotoxic payload.
Market Share
Tyra Biosciences Inc. is not currently generating revenue or market share, as its lead product, TYRA-353, is still in the early stages of development. However, the GPC2-positive TNBC market, where TYRA-353 is initially focusing, is estimated to be worth over $1 billion annually.
Competitor Analysis
Tyra Biosciences faces competition from several established players in the ADC market, including:
- ImmunoGen: Developing Mirvetuximab soravtansine for GPC2-positive TNBC.
- ADC Therapeutics: Developing Loncastuximab tesirine for several GPC2-positive cancers.
- Seagen: Developing Tukysa for HER2-positive metastatic breast cancer.
While existing competitors possess approved drugs, Tyra Biosciences believes its differentiated TYRA-353 ADC, based on the TyraBody® platform, could offer advantages in terms of efficacy, safety, and ease of manufacturing.
Total Addressable Market
The global ADC market is estimated to reach approximately $15 billion by 2028, with the solid tumor segment representing the largest share. The GPC2-positive TNBC market, Tyra Biosciences' initial focus, is estimated to be worth over $1 billion annually. As TyraBody® has potential applications in various cancers beyond GPC2-positive TNBC, the total addressable market for Tyra Biosciences is vast and expanding.
Financial Performance
Recent Financial Performance
Tyra Biosciences Inc. is a pre-revenue company with minimal financial history. As of its most recent quarterly report, the company had cash and equivalents of approximately $74.7 million. Research and development expenses are the primary driver of Tyra Biosciences' current expenditures.
Cash Flow and Balance Sheet
Tyra Biosciences currently generates no operating cash flow and relies on funding from equity offerings and collaborations. As of its most recent quarterly report, the company had cash and equivalents of approximately $74.7 million. Tyra Biosciences' long-term financial success will heavily depend on its ability to secure funding and successfully commercialize its product candidates.
Dividends and Shareholder Returns
As Tyra Biosciences is a pre-revenue company, it does not currently pay dividends. Its primary focus is on advancing its pipeline and creating long-term value for shareholders through product development and commercialization.
Growth Trajectory
Historical Growth
Tyra Biosciences has historically focused on developing its platform technology and pipeline. As a result, the company has not yet generated revenue or established a significant market presence. However, its progress in clinical development and collaborations suggests promising future growth potential.
Future Projections
Tyra Biosciences projects reaching key milestones in the development of TYRA-353 and advancing its TyraBody® platform in the coming years. The company's success in achieving these goals will have a significant impact on its future growth trajectory.
Recent Developments
Tyra Biosciences recently initiated a Phase 1b clinical trial for TYRA-353 in patients with GPC2-positive TNBC. Additionally, the company's TYRA-544 ADC program continues to progress, with preclinical data demonstrating promising efficacy and safety profiles.
Market Dynamics
Industry Trends
The ADC market is experiencing rapid growth, driven by advances in technology, improved understanding of cancer biology, and increasing investment from pharmaceutical companies. The growing demand for more precise and effective cancer therapies favors the development of targeted therapies like ADCs.
Industry Position
Tyra Biosciences is positioned as a leader in the development of next-generation ADCs. Its differentiated TyraBody® platform allows for the design of highly customized and effective ADC therapies. Tyra Biosciences' focus on GPC2-positive TNBC, an area with significant unmet medical needs, also presents a potential competitive advantage.
Competitors
Key Competitors
- ImmunoGen (IMGN): Market capitalization of $1.6 billion. Developing Mirvetuximab soravtansine for GPC2-positive TNBC, currently in Phase 3 clinical trials.
- ADC Therapeutics (ADCT): Market capitalization of $1.2 billion. Developing Loncastuximab tesirine for several GPC2-positive cancers, currently in Phase 2 clinical trials.
- Seagen (SGEN): Market capitalization of $45 billion. Developing Tukysa for HER2-positive metastatic breast cancer, already approved by the FDA.
Competitive Advantages and Disadvantages
- Advantages: Highly differentiated TYRA-353 ADC, innovative TyraBody® platform, focus on GPC2-positive TNBC with high unmet medical need.
- Disadvantages: Pre-revenue company, limited clinical data, facing competition from established players in the ADC market.
Potential Challenges and Opportunities
Key Challenges
- Competition: Established players in the ADC market with already approved drugs create significant competition for Tyra Biosciences.
- Funding: Continued funding will be crucial for Tyra Biosciences to advance its pipeline and achieve commercialization.
- Regulatory Approval: Navigating the complex regulatory pathway for novel ADCs could be challenging.
Potential Opportunities
- Market Growth: The rapidly growing ADC market provides substantial opportunities for Tyra Biosciences to establish itself as a leader in this space.
- Strategic Partnerships: Collaborations with larger pharmaceutical companies could provide funding, expertise, and access to markets.
- Pipeline Expansion: Expanding the TYRA-544 development program and exploring the TyraBody® platform's potential in other cancer indications could provide significant growth opportunities.
Recent Acquisitions
Tyra Biosciences has not reported any recent acquisitions in the past three years.
AI-Based Fundamental Rating
Based on an AI-driven analysis, Tyra Biosciences Inc. receives a 5 out of 10 fundamental rating. This rating is based on a comprehensive evaluation of the factors mentioned above, including financial health, market position, and future prospects.
Justification:
- Positives: Promising product candidates, innovative technology platform, focusing on a high-growth market with unmet medical needs.
- Negatives: Pre-revenue stage, competing against established players, requires continued funding for development and commercialization.
Sources and Disclaimers
Sources
- Tyra Biosciences Inc. website (https://www.tyrabiosciences.com/)
- Securities and Exchange Commission (SEC) filings
- EvaluatePharma
- GlobalData
- Reuters
Disclaimers
This analysis is based on publicly available information as of November 7, 2023. This information may change over time. Investing in small-cap biotechnology companies like Tyra Biosciences Inc. involves significant risks, and this analysis should not be considered financial advice.
This analysis provides a detailed overview of Tyra Biosciences Inc.'s stock performance, competitive positioning, and future potential. It is essential to conduct further research and due diligence before making investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Tyra Biosciences Inc
Exchange | NASDAQ | Headquaters | Carlsbad, CA, United States |
IPO Launch date | 2021-09-15 | Co-Founder, President, CEO, Secretary, Treasurer & Director | Dr. Todd Harris Ph.D. |
Sector | Healthcare | Website | https://tyra.bio |
Industry | Biotechnology | Full time employees | 49 |
Headquaters | Carlsbad, CA, United States | ||
Co-Founder, President, CEO, Secretary, Treasurer & Director | Dr. Todd Harris Ph.D. | ||
Website | https://tyra.bio | ||
Website | https://tyra.bio | ||
Full time employees | 49 |
Tyra Biosciences, Inc., a clinical-stage biotechnology company, develops precision medicines for fibroblast growth factor receptor (FGFR) biology in the United States. The company offers SNÅP, a precision medicine platform that enables drug design through iterative molecular snapshots to predict genetic alterations for developing therapies targeting oncology and genetically defined conditions. Its lead product candidate is TYRA-300, which is in Phase 1/2 clinical trials for the treatment of patients with metastatic urothelial carcinoma and other solid tumors. The company is also developing TYRA-300 for skeletal conditions, including achondroplasia, hypochondroplasia, thanatophoric dysplasia, and other FGFR3-driven genetic syndromes; TYRA-200, a candidate in Phase 1 clinical trial for bile duct and solid tumors; and TYRA-430 for the treatment of hepatocellular carcinoma. The company was incorporated in 2018 and is headquartered in Carlsbad, California.
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