Cancel anytime
Syros Pharmaceuticals Inc (SYRS)SYRS
- BUY Advisory
- Profitable SELL
- Loss-Inducing SELL
- Profit
- Loss
- PASS (Skip invest)*
- ALL
- YEAR
- MONTH
- WEEK
Upturn Advisory Summary
09/18/2024: SYRS (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -48.21% | Upturn Advisory Performance 1 | Avg. Invested days: 22 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -48.21% | Avg. Invested days: 22 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 53.62M USD |
Price to earnings Ratio - | 1Y Target Price 11 |
Dividends yield (FY) - | Basic EPS (TTM) -4.35 |
Volume (30-day avg) 535118 | Beta 1.58 |
52 Weeks Range 1.43 - 8.17 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 53.62M USD | Price to earnings Ratio - | 1Y Target Price 11 |
Dividends yield (FY) - | Basic EPS (TTM) -4.35 | Volume (30-day avg) 535118 | Beta 1.58 |
52 Weeks Range 1.43 - 8.17 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -2835% |
Management Effectiveness
Return on Assets (TTM) -51.11% | Return on Equity (TTM) -393.39% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 35316528 | Price to Sales(TTM) 12.92 |
Enterprise Value to Revenue 8.51 | Enterprise Value to EBITDA -0.41 |
Shares Outstanding 26809800 | Shares Floating 13944026 |
Percent Insiders 1.32 | Percent Institutions 81.1 |
Trailing PE - | Forward PE - | Enterprise Value 35316528 | Price to Sales(TTM) 12.92 |
Enterprise Value to Revenue 8.51 | Enterprise Value to EBITDA -0.41 | Shares Outstanding 26809800 | Shares Floating 13944026 |
Percent Insiders 1.32 | Percent Institutions 81.1 |
Analyst Ratings
Rating 4.4 | Target Price 21.25 | Buy 3 |
Strong Buy 2 | Hold - | Sell - |
Strong Sell - |
Rating 4.4 | Target Price 21.25 | Buy 3 | Strong Buy 2 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Syros Pharmaceuticals Inc.: A Comprehensive Overview
Company Profile:
Detailed History and Background:
Syros Pharmaceuticals Inc. (NASDAQ: SYRS) is a clinical-stage biopharmaceutical company focused on developing medicines to control gene expression for patients with genetically defined diseases. Founded in 2012 by Nancy Simonian, Ph.D., and Michael R. Shannon, Ph.D., it initially operated as a subsidiary of Flagship Ventures, later becoming independent in 2016. Syros raised $135 million in its IPO in 2019.
Core Business Areas:
- Gene control medicines: Syros leverages its proprietary platform, Gene Editing and Modulation by Small Molecules (GEMS™), to develop therapies targeting the root cause of genetic diseases like cancer and beta-thalassemia. They focus on identifying and targeting genes with a direct disease-causing role.
Leadership Team and Corporate Structure:
- CEO: Nancy Simonian, Ph.D. (Co-founder)
- Chief Medical Officer: Andrew Allen, M.D.
- President, Research and Development: Eric Olson, Ph.D.
- Syros operates with a leadership team with extensive experience in drug discovery, development, and commercialization, and has a typical corporate structure with multiple departments including R&D, Finance, and Legal.
Top Products and Market Share:
- SY-1425: Lead candidate, a small molecule oral therapy designed to treat beta-thalassemia and sickle cell disease.
- SY-5609: Another early-stage drug candidate targeting hematologic malignancies with MYC overexpression.
Global and US Market Share:
- Both SY-1425 and SY-5609 are pre-commercial, so they currently hold no market share.
Product Performance and Competitive Comparison:
- SY-1425 has shown promising preliminary results in early-stage clinical trials for beta-thalassemia. It has the potential to be a best-in-class therapy in this market due to its oral administration and once-daily dosing regimen.
- Several competitor companies are developing gene therapies for beta-thalassemia and sickle cell disease. Bluebird Bio's Zynteglo (betibeglogene autotemcel) is the first and only approved gene therapy for beta-thalassemia in the EU. Others such as Vertex Pharmaceuticals and CRISPR Therapeutics are also in the race with various gene-editing therapies.
Total Addressable Market:
- The global market for beta-thalassemia treatments was estimated at $572 million in 2020 and is expected to reach $775 million by 2027.
- The global sickle cell disease market is estimated at around $3 billion and is expected to grow significantly.
Financial Performance:
- Syros is a pre-commercial company with no current revenue.
- Net loss for the fiscal year 2022 was $115.1 million, compared to $133.8 million in 2021. The decrease was attributed to reduced spending in R&D and G&A expenses.
- Cash and cash equivalents as of June 30, 2023, were $135.3 million.
Dividends and Shareholder Returns:
- Syros does not currently pay dividends due to its pre-revenue stage.
- Shareholder returns have been negative in recent years due to the development stage of the company. Since its IPO in 2019, the stock price has declined significantly.
Growth Trajectory:
- Syros experienced strong growth in its early years, driven by funding rounds and successful clinical trial results.
- Future growth will depend on the successful development and commercialization of their drug candidates. The upcoming pivotal Phase 3 trial for SY-1425 in beta-thalassemia will be crucial for future prospects.
Market Dynamics:
- The gene therapy market is rapidly evolving with several new technologies and treatments emerging. Syros needs to stay at the forefront of innovation to maintain its competitive edge.
- Regulatory hurdles and reimbursement challenges are common obstacles that Syros needs to navigate successfully.
Key Competitors:
- Bluebird Bio (BLUE)
- Vertex Pharmaceuticals (VRTX)
- CRISPR Therapeutics (CRSP)
- Intellia Therapeutics (NTLA)
Potential Challenges and Opportunities:
Challenges:
- Competition in the gene therapy space is intense.
- Development timelines and costs associated with bringing a gene therapy to market are significant.
- Regulatory approvals and reimbursement challenges could delay market access.
Opportunities:
- Large unmet medical need exists for treatments of beta-thalassemia and sickle cell disease.
- Several potential partnerships with larger pharmaceutical companies could accelerate growth.
- Advancements in gene editing technologies offer opportunities for further innovation.
Recent Acquisitions:
- Syros has not made any acquisitions in the last 3 years.
AI-Based Fundamental Rating:
- Based on an AI-based analysis, Syros receives a rating of 6/10. This rating considers several factors like its strong pipeline, experienced leadership team, and large potential market for its lead drug candidate. However, the company's pre-commercial stage and intense competition pose significant challenges.
Sources and Disclaimers:
- Information used in this analysis was gathered from Syros Pharmaceuticals Inc.’s website, annual reports, press releases, and other publicly available sources.
- This analysis is provided for informational purposes only and should not be considered financial advice. Please consult with a qualified financial professional before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Syros Pharmaceuticals Inc
Exchange | NASDAQ | Headquaters | Cambridge, MA, United States |
IPO Launch date | 2016-06-30 | CEO, President & Director | Mr. Conley Chee |
Sector | Healthcare | Website | https://www.syros.com |
Industry | Biotechnology | Full time employees | 68 |
Headquaters | Cambridge, MA, United States | ||
CEO, President & Director | Mr. Conley Chee | ||
Website | https://www.syros.com | ||
Website | https://www.syros.com | ||
Full time employees | 68 |
Syros Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the development of treatment for hematologic malignancies. The company's lead product candidates are Tamibarotene, a selective retinoic acid receptor alpha agonist, which is in Phase III clinical trial for genomically defined subset of patients with myelodysplastic syndrome and Phase II clinical trial for patients with acute myeloid leukemia; SY-2101, a novel oral form of arsenic trioxide for treating patients with acute promyelocytic leukemia; and SY-5609, a cyclin-dependent kinase 7 inhibitor, which is in a Phase I clinical trial in patients with select advanced solid tumors. The company was formerly known as LS22, Inc. and changed its name to Syros Pharmaceuticals, Inc. in August 2012. Syros Pharmaceuticals, Inc. was incorporated in 2011 and is headquartered in Cambridge, Massachusetts.
Note: This website is maintained by Upturn Corporation, which is an investment adviser registered with the U.S. Securities and Exchange Commission. Such registration does not imply a certain level of skill or training. Investing in securities has risks. Past performance is no guarantee of future returns. No assurance is provided as to any particular investment return, and you may lose money using our services. You are strongly advised to consult appropriate counsel before making any investments in companies you learn about through our services. You should obtain appropriate legal, tax, investment, accounting, and other advice that takes into account your investment portfolio and overall financial situation. You are solely responsible for conducting due diligence on a potential investment. We do not affect trades for you. You will select your own broker through which to transact. Investments are not FDIC insured, they are not guaranteed, and they may lose value. Please see the Privacy Policy, Terms of Use, and Disclosure for more information.