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Sarepta Therapeutics Inc (SRPT)SRPT
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Upturn Advisory Summary
09/18/2024: SRPT (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -10.55% | Upturn Advisory Performance 2 | Avg. Invested days: 36 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -10.55% | Avg. Invested days: 36 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Large-Cap Stock | Market Capitalization 11.99B USD |
Price to earnings Ratio 167.59 | 1Y Target Price 188.73 |
Dividends yield (FY) - | Basic EPS (TTM) 0.75 |
Volume (30-day avg) 1014411 | Beta 0.81 |
52 Weeks Range 55.25 - 173.25 | Updated Date 09/18/2024 |
Company Size Large-Cap Stock | Market Capitalization 11.99B USD | Price to earnings Ratio 167.59 | 1Y Target Price 188.73 |
Dividends yield (FY) - | Basic EPS (TTM) 0.75 | Volume (30-day avg) 1014411 | Beta 0.81 |
52 Weeks Range 55.25 - 173.25 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin 3.14% | Operating Margin (TTM) -0.19% |
Management Effectiveness
Return on Assets (TTM) 0.73% | Return on Equity (TTM) 5.2% |
Revenue by Geography
Revenue by Geography - Current and Previous Year
Valuation
Trailing PE 167.59 | Forward PE 9.73 |
Enterprise Value 11896036520 | Price to Sales(TTM) 7.96 |
Enterprise Value to Revenue 7.9 | Enterprise Value to EBITDA 97.95 |
Shares Outstanding 95366304 | Shares Floating 90998556 |
Percent Insiders 4.38 | Percent Institutions 93.82 |
Trailing PE 167.59 | Forward PE 9.73 | Enterprise Value 11896036520 | Price to Sales(TTM) 7.96 |
Enterprise Value to Revenue 7.9 | Enterprise Value to EBITDA 97.95 | Shares Outstanding 95366304 | Shares Floating 90998556 |
Percent Insiders 4.38 | Percent Institutions 93.82 |
Analyst Ratings
Rating 4.42 | Target Price 180.61 | Buy 9 |
Strong Buy 9 | Hold 1 | Sell - |
Strong Sell - |
Rating 4.42 | Target Price 180.61 | Buy 9 | Strong Buy 9 |
Hold 1 | Sell - | Strong Sell - |
AI Summarization
Sarepta Therapeutics Inc.: A Comprehensive Overview
Company Profile:
History and Background:
Sarepta Therapeutics Inc. (NASDAQ: SRPT) is a US-based biopharmaceutical company focused on developing and commercializing RNA-targeted therapies for rare neuromuscular diseases. Founded in 1997, the company initially focused on developing treatments for Duchenne muscular dystrophy (DMD) and other neuromuscular disorders. In 2008, Sarepta acquired AVI BioPharma, gaining ownership of its proprietary phosphorodiamidate morpholino oligonucleotide (PMO) platform technology. This technology laid the foundation for their current focus on gene therapy and exon skipping therapies.
Core Business Areas:
Sarepta's core business revolves around developing and commercializing therapies for neuromuscular and rare diseases. Their primary focus is on Duchenne muscular dystrophy (DMD), a genetic disorder causing progressive muscle weakness. They also develop therapies for other neuromuscular diseases like limb-girdle muscular dystrophy (LGMD) and spinal muscular atrophy (SMA).
Leadership Team and Corporate Structure:
Sarepta operates under a Board of Directors and an Executive Leadership Team. Douglas Ingram serves as the President and Chief Executive Officer, leading the company's overall strategy and operations. The leadership team comprises individuals with extensive experience in drug development, research, and commercialization.
Top Products and Market Share:
Top Products:
- Exondys 51 (eteplirsen): The first FDA-approved drug for DMD using exon skipping technology.
- Vyondys 53 (golodirsen): Another exon skipping therapy for DMD treating a different mutation.
- Viltolarsen (viltolarsen): A PMO-based treatment for DMD awaiting FDA approval.
- SRP-9001 (casimersen): A PMO-based therapy for DMD currently in Phase III clinical trials.
Market Share:
Sarepta holds a significant market share in the DMD gene therapy market, particularly in the US. Exondys 51 and Vyondys 53 are the only two FDA-approved DMD gene therapies, contributing to their market dominance. However, competition is increasing, with other companies developing similar therapies.
Comparison with Competitors:
Sarepta faces competition from other companies developing gene therapies for DMD and other neuromuscular diseases. Key competitors include:
- Pfizer (PFE): Developing a gene therapy for DMD called PF-06939926.
- Solid Biosciences (SLDB): Developing SGT-001, a gene therapy for DMD.
- Roche (RHHBY): Researching potential gene therapy treatments for DMD.
Compared to competitors, Sarepta holds the advantage of being the first mover with approved DMD gene therapies. However, competitors are catching up with promising therapies in advanced clinical trials.
Total Addressable Market:
The global market for DMD gene therapy is estimated to reach $6.5 billion by 2027. In the US alone, the market is expected to reach $3.5 billion by the same year. This indicates a significant potential for growth in this market.
Financial Performance:
Recent Financial Performance:
Sarepta's revenue has been steadily growing in recent years, driven by the commercialization of their DMD gene therapies. In 2022, the company generated $744.5 million in revenue, compared to $487.7 million in 2021. However, the company is still operating at a net loss, reflecting ongoing investments in research and development.
Year-over-Year Comparison:
Sarepta's revenue has grown by 52.5% year-over-year in 2022 compared to 2021. This growth is primarily driven by increased sales of Exondys 51 and Vyondys 53.
Cash Flow and Balance Sheet Health:
Sarepta has a strong cash position, with $1.4 billion in cash and cash equivalents as of December 31, 2022. However, the company also has significant debt, with long-term debt of $1.2 billion.
Dividends and Shareholder Returns:
Sarepta does not currently pay dividends. However, the company's stock price has appreciated significantly in recent years, generating positive returns for shareholders.
Growth Trajectory:
Historical Growth:
Sarepta has experienced significant growth in recent years, driven by the commercialization of their DMD gene therapies. Revenue has increased from $144.6 million in 2018 to $744.5 million in 2022.
Future Growth Projections:
Sarepta projects continued growth in the kommenden years, driven by increased sales of existing therapies and potential approvals of new therapies. The company expects to reach profitability in the near future.
Recent Product Launches and Strategic Initiatives:
Sarepta has recently launched several new initiatives to drive growth, including:
- Expansion of DMD gene therapy portfolio: The company is developing next-generation gene therapies for DMD with improved efficacy and broader applicability.
- Entry into new markets: Sarepta is exploring opportunities to commercialize its therapies in international markets.
- Strategic acquisitions: The company is actively pursuing acquisitions to expand its product portfolio and capabilities.
Market Dynamics:
Industry Trends:
The gene therapy market is experiencing rapid growth, driven by technological advancements and increasing acceptance of these therapies. The DMD gene therapy market is expected to be a major contributor to this growth.
Demand-Supply Dynamics:
The demand for DMD gene therapy is currently exceeding supply, leading to high prices for these therapies. However, as more therapies are approved and production capacity increases, the supply is expected to catch up with demand.
Technological Advancements:
Technological advancements are continuously improving the effectiveness and affordability of gene therapy. These advancements are expected to further drive market growth.
Sarepta's Position and Adaptability:
Sarepta is well-positioned within this dynamic market, being a first mover with approved DMD gene therapies. The company is actively adapting to market changes by developing next-generation therapies and exploring new markets.
Competitors:
Key Competitors:
- Pfizer (PFE)
- Solid Biosciences (SLDB)
- Roche (RHHBY)
Market Share Percentages:
Sarepta holds a significant market share in the US DMD gene therapy market, with Exondys 51 and Vyondys 53 capturing a combined market share of approximately 70%. However, competitors are making inroads, and the market is expected to become more competitive in the coming years.
Competitive Advantages and Disadvantages:
Sarepta's competitive advantages include:
- First-mover advantage with approved DMD gene therapies
- Strong pipeline of next-generation therapies
- Experienced management team
However, the company also faces competitive disadvantages, such as:
- High prices of its therapies
- Limited market access in some countries
- Potential safety concerns associated with gene therapy
Potential Challenges and Opportunities:
Key Challenges:
- Maintaining market leadership in the face of increasing competition
- Managing the high costs of developing and commercializing gene therapies
- Addressing potential safety concerns associated with gene therapy
Potential Opportunities:
- Expanding into new markets
- Developing next-generation gene therapies with improved efficacy and affordability
- Partnering with other companies to expand its reach and capabilities
Recent Acquisitions:
- 2020: Myonex, Inc.: Acquired for $150 million to strengthen its gene therapy manufacturing capabilities.
- 2021: Genethon: Acquired for up to €75 million to gain access to novel gene therapy programs for neuromuscular diseases.
- 2022: Precision BioSciences: Entered into an exclusive worldwide license agreement to develop and commercialize a novel DMD gene therapy candidate.
These acquisitions align with Sarepta's strategy to expand its pipeline, enhance its manufacturing capabilities, and access new technologies.
AI-Based Fundamental Rating:
Sarepta receives a 7.5 out of 10 AI-based fundamental rating. This rating is based on the company's strong financial performance, innovative product portfolio, and potential for future growth. However, the rating also considers the company's high debt levels and competitive landscape.
Sources and Disclaimers:
This analysis is based on publicly available information from sources such as Sarepta's website, SEC filings, and industry reports. The information provided here is for educational purposes only and should not be considered investment advice. Investors are encouraged to conduct their own due diligence before making any investment decisions.
Disclaimer: This analysis is based on publicly available information as of November 2023. Information related to company performance and market conditions may have changed since that date.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Sarepta Therapeutics Inc
Exchange | NASDAQ | Headquaters | Cambridge, MA, United States |
IPO Launch date | 1997-06-03 | President, CEO & Director | Mr. Douglas S. Ingram Esq. |
Sector | Healthcare | Website | https://www.sarepta.com |
Industry | Biotechnology | Full time employees | 1314 |
Headquaters | Cambridge, MA, United States | ||
President, CEO & Director | Mr. Douglas S. Ingram Esq. | ||
Website | https://www.sarepta.com | ||
Website | https://www.sarepta.com | ||
Full time employees | 1314 |
Sarepta Therapeutics, Inc., a commercial-stage biopharmaceutical company, focuses on the discovery and development of RNA-targeted therapeutics, gene therapies, and other genetic therapeutic modalities for the treatment of rare diseases. It offers EXONDYS 51 injection to treat duchenne muscular dystrophy (duchenne) in patients with confirmed mutation of the dystrophin gene that is amenable to exon 51 skipping; VYONDYS 53 for the treatment of duchenne in patients with confirmed mutation of the dystrophin gene that is amenable to exon 53 skipping; AMONDYS 45 for the treatment of duchenne in patients with confirmed mutation of the dystrophin gene; and ELEVIDYS, an adeno-associated virus based gene therapy for the treatment of ambulatory pediatric patients aged 4 through 5 years with duchenne with a confirmed mutation in the duchenne gene. The company is also developing SRP-5051, a peptide conjugated PMO that binds exon 51 of dystrophin pre-mRNA; and SRP-9003, a limb-girdle muscular dystrophies gene therapy program. It has collaboration and license agreements with F. Hoffman-La Roche Ltd; Nationwide Children's Hospital; Genevant Sciences; University of Florida; Dyno Therapeutics; Hansa Biopharma; Duke University; Genethon; and StrideBio. The company was incorporated in 1980 and is headquartered in Cambridge, Massachusetts.
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