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Sangamo Therapeutics Inc (SGMO)SGMO
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Upturn Advisory Summary
09/18/2024: SGMO (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: WEAK BUY |
Profit: -2.56% | Upturn Advisory Performance 3 | Avg. Invested days: 28 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: WEAK BUY |
Profit: -2.56% | Avg. Invested days: 28 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 3 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 174.30M USD |
Price to earnings Ratio - | 1Y Target Price 3.8 |
Dividends yield (FY) - | Basic EPS (TTM) -1.38 |
Volume (30-day avg) 6025397 | Beta 1.23 |
52 Weeks Range 0.29 - 1.48 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 174.30M USD | Price to earnings Ratio - | 1Y Target Price 3.8 |
Dividends yield (FY) - | Basic EPS (TTM) -1.38 | Volume (30-day avg) 6025397 | Beta 1.23 |
52 Weeks Range 0.29 - 1.48 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -9413.48% |
Management Effectiveness
Return on Assets (TTM) -58.29% | Return on Equity (TTM) -194.05% |
Revenue by Products
Revenue by Products - Current and Previous Year
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 174883750 | Price to Sales(TTM) 14.2 |
Enterprise Value to Revenue 14.24 | Enterprise Value to EBITDA -1 |
Shares Outstanding 208220992 | Shares Floating 189626564 |
Percent Insiders 2.28 | Percent Institutions 42.11 |
Trailing PE - | Forward PE - | Enterprise Value 174883750 | Price to Sales(TTM) 14.2 |
Enterprise Value to Revenue 14.24 | Enterprise Value to EBITDA -1 | Shares Outstanding 208220992 | Shares Floating 189626564 |
Percent Insiders 2.28 | Percent Institutions 42.11 |
Analyst Ratings
Rating 3.75 | Target Price 6.58 | Buy 2 |
Strong Buy 2 | Hold 4 | Sell - |
Strong Sell - |
Rating 3.75 | Target Price 6.58 | Buy 2 | Strong Buy 2 |
Hold 4 | Sell - | Strong Sell - |
AI Summarization
Sangamo Therapeutics Inc.: A Comprehensive Overview
Company Profile:
History and Background:
Sangamo Therapeutics Inc. is a biopharmaceutical company focused on developing novel genome editing therapies for rare and debilitating diseases. Founded in 1995, the company has garnered attention for its pioneering work on ZFP technology, a highly precise form of genome editing. In 2014, Sangamo shifted its focus from therapeutic proteins to genome editing, paving the way for its current portfolio of innovative treatments.
Core Business Areas:
- Genome Editing Therapeutics: Sangamo focuses on developing genome-editing therapies based on its engineered ZFP Nucleases and zinc finger protein transcription factors (ZFP-TFs). These tools precisely modify the genome to treat a broad range of diseases.
- In Vivo Therapies: The company primarily employs in vivo therapies, directly delivering engineered ZFPs into the body's target cells. This minimizes disruptions to the genome editing process and allows for efficient therapeutic solutions.
- Focus on Rare Diseases: Sangamo prioritizes targeting rare diseases where currently available therapies are limited or ineffective. By targeting diseases often ignored by major pharmaceutical companies, Sangamo holds the potential to significantly improve the lives of patients with severe medical needs.
Leadership and Corporate Structure:
- Management Team:
- President & CEO: Sandy Macrae
- Chief Medical Officer: Dr. Sandy Wan
- Chief Scientific Officer: Dr. Sophie Stroock
- Board of Directors: Comprised of experienced professionals from diverse backgrounds, including leading the boards of pharmaceutical companies and renowned research institutions.
Top Products and Market Share:
Top Products and Offerings:
- TALEN Gene Editing Technology: Sangamo's proprietary technology for highly specific and efficient genome editing.
- SB-913 Phase 2a Clinical Trial: Ongoing trial investigating treatment for mucopolysaccharidosis type IIIA (MPS IIIA), a rare and devastating metabolic disease.
- SB-318 Phase 1/2 Clinical Trial: Assessing the effectiveness of its therapy for Huntington's Disease, a neurodegenerative disorder.
- SB-780 (SNG7018): In pre-clinical development for Hemoglobin SC Disease (HbSC), a prevalent hemoglobinopathy.
- SB-749: (BIVV003): Partnered with Bioverativ for Hemophilia A, undergoing early clinical development.
Market Share Analysis:
While Sangamo's technology holds immense potential, the company is in the early stages of clinical development for its lead products. As such, it currently holds a limited market share compared to established players in the gene therapy space. However, as its clinical trials progress and potential approvals are granted, Sangamo's market share is expected to increase dramatically.
Competitors:
- Editas Medicine (EDIT)
- CRISPR Therapeutics (CRSP)
- Intellia Therapeutics (NTLA)
- Beam Therapeutics (BEAM)
Total Addressable Market:
The global gene therapy market is expanding rapidly, estimated to reach $27.3 billion by 2027. The United States accounts for the most significant portion of this market, offering considerable potential for Sangamo's innovative therapies.
Financial Performance:
Sangamo is currently a clinical-stage company focusing on research and development. As a result, it is yet to generate significant revenue or report profit. However, the company has maintained a consistent cash runway through financial partnerships and collaborations. With several products moving into advanced clinical trials, potential product approvals within the next few years could pave the way for substantial revenue growth and profitability.
Dividends and Shareholder Returns:
Currently, Sangamo does not pay dividends as it prioritizes maximizing resources for research and development. However, future profitability may lead to consideration of dividend payouts once commercial products reach the market.
Growth Trajectory:
Historical Growth: Despite being in the pre-revenue stage, Sangamo has demonstrated consistent growth in its research and development pipeline. The company has successfully progressed multiple programs into advanced clinical trials, positioning itself for potential major breakthroughs in the coming years.
Future Growth Projections: Following successful clinical trials and potential regulatory approvals, Sangamo's market share is expected to soar. Moreover, the company's ongoing research into novel gene editing technologies and expansion into new therapeutic areas offer further growth opportunities.
Market Dynamics:
The gene therapy market is characterized by rapid technological advancements, intensifying competition, and evolving regulatory landscapes. While this presents various challenges, it also offers compelling opportunities for Sangamo to leverage its innovative technologies and establish a strong market presence.
Recent Acquisitions:
Within the past three years, Sangamo has not announced any acquisitions.
AI-Based Fundamental Rating:
Based on AI-driven analysis of available data, Sangamo receives a rating of 7.5 out of 10. This reflects the company's promising pipeline, strong scientific foundation, and potential for market growth. However, risks associated with ongoing clinical trials and competition from established players warrant a slightly conservative rating.
Sources and Disclaimers:
Please note that this analysis is based on publicly available information as of November 14, 2023. The stock market is volatile, and investment decisions should be made based on individual financial situations and risk tolerance. Always consult with a qualified financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Sangamo Therapeutics Inc
Exchange | NASDAQ | Headquaters | Richmond, CA, United States |
IPO Launch date | 2000-04-06 | CEO, President & Director | Dr. Alexander D. Macrae Ch.B, M.B., MRCP, Ph.D. |
Sector | Healthcare | Website | https://www.sangamo.com |
Industry | Biotechnology | Full time employees | 405 |
Headquaters | Richmond, CA, United States | ||
CEO, President & Director | Dr. Alexander D. Macrae Ch.B, M.B., MRCP, Ph.D. | ||
Website | https://www.sangamo.com | ||
Website | https://www.sangamo.com | ||
Full time employees | 405 |
Sangamo Therapeutics, Inc., a clinical-stage genomic medicine company, focuses on translating science into medicines that transform the lives of patients and families afflicted with serious diseases in the United States. The company's clinical-stage product candidates are ST-920, a gene therapy product candidate, which is in Phase 1/2 clinical study for the treatment of Fabry disease; TX200, a chimeric antigen receptor engineered regulatory T cell (CAR-Treg) therapy product candidate that is in Phase 1/2 clinical study for the prevention of immune-mediated rejection in HLA-A2 mismatched kidney transplantation; SB-525, a gene therapy product candidate, which is in Phase 3 clinical trial for the treatment of moderately severe to severe hemophilia A; BIVV003, a zinc finger nuclease gene-edited cell therapy product candidate that is in Phase 1/2 PRECIZN-1 clinical study for the treatment of sickle cell disease. Its preclinical development products focus on CAR-Treg cell therapies for autoimmune disorders and genome engineering for neurological diseases. Sangamo Therapeutics, Inc. has collaborative and strategic partnerships with Biogen MA, Inc.; Kite Pharma, Inc.; Pfizer Inc.; Sanofi S.A.; Novartis Institutes for BioMedical Research, Inc.; Shire International GmbH; Dow AgroSciences LLC; Sigma-Aldrich Corporation; Genentech, Inc.; Open Monoclonal Technology, Inc.; and California Institute for Regenerative Medicine. The company was formerly known as Sangamo BioSciences, Inc. and changed its name to Sangamo Therapeutics, Inc. in January 2017. Sangamo Therapeutics, Inc. was incorporated in 1995 and is headquartered in Richmond, California.
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