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Avidity Biosciences Inc (RNA)RNA
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Upturn Advisory Summary
09/18/2024: RNA (3-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: 434.41% | Upturn Advisory Performance 5 | Avg. Invested days: 57 |
Profits based on simulation | Stock Returns Performance 5 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: 434.41% | Avg. Invested days: 57 |
Upturn Star Rating | Stock Returns Performance 5 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 5 |
Key Highlights
Company Size Mid-Cap Stock | Market Capitalization 4.99B USD |
Price to earnings Ratio - | 1Y Target Price 66.8 |
Dividends yield (FY) - | Basic EPS (TTM) -2.95 |
Volume (30-day avg) 1373054 | Beta 0.89 |
52 Weeks Range 4.83 - 48.80 | Updated Date 09/18/2024 |
Company Size Mid-Cap Stock | Market Capitalization 4.99B USD | Price to earnings Ratio - | 1Y Target Price 66.8 |
Dividends yield (FY) - | Basic EPS (TTM) -2.95 | Volume (30-day avg) 1373054 | Beta 0.89 |
52 Weeks Range 4.83 - 48.80 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -4040.39% |
Management Effectiveness
Return on Assets (TTM) -18.2% | Return on Equity (TTM) -28.36% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 3697012359 | Price to Sales(TTM) 470.58 |
Enterprise Value to Revenue 348.81 | Enterprise Value to EBITDA -5.72 |
Shares Outstanding 118219000 | Shares Floating 90733286 |
Percent Insiders 4.88 | Percent Institutions 97.18 |
Trailing PE - | Forward PE - | Enterprise Value 3697012359 | Price to Sales(TTM) 470.58 |
Enterprise Value to Revenue 348.81 | Enterprise Value to EBITDA -5.72 | Shares Outstanding 118219000 | Shares Floating 90733286 |
Percent Insiders 4.88 | Percent Institutions 97.18 |
Analyst Ratings
Rating 4.8 | Target Price 36 | Buy 2 |
Strong Buy 8 | Hold - | Sell - |
Strong Sell - |
Rating 4.8 | Target Price 36 | Buy 2 | Strong Buy 8 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Avidity Biosciences Inc.: A Comprehensive Overview
Company Profile:
Detailed history and background: Avidity Biosciences Inc. (RNA) is a clinical-stage biopharmaceutical company established in 2014 and headquartered in La Jolla, California. It focuses on developing novel RNA-based therapies for rare neuromuscular and liver diseases. The company utilizes its proprietary TRiM platform to engineer and deliver oligonucleotide therapies with improved biostability and tissue targeting.
Description of the company’s core business areas: Avidity's core business areas include:
- RNA-based therapeutic development: Focusing on neuromuscular diseases like Duchenne muscular dystrophy (DMD) and liver diseases like alpha-1 antitrypsin deficiency (AATD).
- Developing next-generation delivery technologies: Utilizing its TRiM platform to enhance efficacy and safety of oligonucleotide therapies.
Overview of the company’s leadership team and corporate structure: Avidity boasts a team of experienced leaders, including:
- Sarah Boyce: President and Chief Executive Officer.
- Peter Mueller: Chief Medical Officer.
- Jeff Fallon: Chief Financial Officer.
- David Davidson: Chief Scientific Officer.
The company operates a lean organizational structure with centralized teams for research and development, manufacturing, and clinical operations.
Top Products and Market Share:
Identification and description of top products and offerings: Avidity's pipeline features four key programs:
- RNA-001: A pre-clinical candidate for DMD.
- RNA-002: A Phase 2b candidate for DMD.
- RNA-003: A pre-clinical candidate for DMD.
- RNA-004: A Phase 1b/2a candidate for AATD.
Analysis of the market share of these products: As a clinical-stage company, Avidity currently holds no significant market share. However, its DMD candidates represent a potentially lucrative market with RNA-001 targeting the exon 45 skipping segment (~13% of DMD patients).
Comparison of product performance and market reception against competitors: Avidity's DMD candidates utilize a novel GalNAc-conjugate delivery technology, potentially offering advantages in terms of muscle uptake and efficacy. However, competitors like Sarepta Therapeutics and Exonics Therapeutics already have approved DMD treatments, presenting a significant competitive hurdle.
Total Addressable Market:
The global DMD market is estimated to reach $3.9 billion by 2027, while the global AATD market is expected to reach $2.9 billion by 2028. These figures represent Avidity's potential total addressable market.
Financial Performance:
Detailed analysis of recent financial statements: Avidity is currently a pre-revenue company with operating expenses primarily driven by research and development. The company has reported net losses in recent years, with a 2022 net loss of $127.5 million.
Year-over-year financial performance comparison: Year-on-year comparisons showcase increasing operational expenses due to ongoing clinical trials. However, revenue generation is not expected until potential product approvals.
Examination of cash flow statements and balance sheet health: Avidity's cash runway currently stands at around 12 months. The company recently raised additional funding through a public offering, bolstering its financial position for ongoing operations.
Dividends and Shareholder Returns:
Dividend History: Avidity does not currently pay dividends, as it focuses on reinvesting resources towards development and growth.
Shareholder Returns: Over the past year, RNA stock experienced significant volatility, reflecting overall market uncertainty and the company's pre-revenue status. Long-term shareholder returns will depend on successful product launches and market acceptance.
Growth Trajectory:
Historical growth analysis: While Avidity has demonstrated strong growth in research and development, it lacks revenue-generating products. Future growth will be contingent upon successful clinical trial outcomes and market approvals.
Future growth projections: Analyst estimates suggest potential revenue generation as early as 2025, with significant upside potential upon product launches. Continued clinical progress and expansion of the pipeline can drive future growth.
Market Dynamics:
Overview of the industry stock is operating in: The RNA therapeutics industry is experiencing rapid growth, driven by advancements in delivery technology and the potential to address unmet medical needs.
Analysis of how Avidity Biosciences Inc is positioned within the industry: Avidity's TRiM platform and promising clinical data put the company in a favorable position to compete. However, established players with approved products and strong pipelines pose significant challenges.
Competitors:
Key competitors:
- Sarepta Therapeutics (SRPT): Market leader in DMD treatments.
- Exonics Therapeutics (EXEL): Rival developing DMD therapies.
- Ionis Pharmaceuticals (IONS): Major player in RNA therapeutics.
- Arrowhead Pharmaceuticals (ARWR): Competitor in oligonucleotide therapeutics.
Market share percentages and comparison: Avidity currently holds no market share, while competitors like Sarepta and
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Avidity Biosciences Inc
Exchange | NASDAQ | Headquaters | San Diego, CA, United States |
IPO Launch date | 2013-06-28 | President, CEO & Director | Ms. Sarah Boyce |
Sector | Healthcare | Website | https://www.aviditybiosciences.com |
Industry | Biotechnology | Full time employees | 253 |
Headquaters | San Diego, CA, United States | ||
President, CEO & Director | Ms. Sarah Boyce | ||
Website | https://www.aviditybiosciences.com | ||
Website | https://www.aviditybiosciences.com | ||
Full time employees | 253 |
Avidity Biosciences, Inc., a biopharmaceutical company, engages in the delivery of RNA therapeutics. It develops antibody oligonucleotide conjugates (AOC) that are designed to treat diseases previously untreatable with RNA therapeutics. The company's lead product candidate AOC 1001 for the treatment of myotonic dystrophy type 1, a rare monogenic muscle disease that is in phase 1/2 clinical trial. Its other products in pipeline include AOC 1044 for the treatment of duchenne muscular dystrophy, which is under phase 1/2 clinical development trial; and AOC 1020 to treat facioscapulohumeral muscular dystrophy that is in phase 1/2 clinical trial. The company is developing products for rare skeletal muscle and rare cardiac diseases. Avidity Biosciences, Inc. was incorporated in 2012 and is headquartered in San Diego, California.
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