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PaxMedica Inc. Common Stock (PXMD)PXMD

Upturn stock ratingUpturn stock rating
PaxMedica Inc. Common Stock
$0.21
Delayed price
PASS
upturn advisory
  • BUY Advisory
  • Profitable SELL
  • Loss-Inducing SELL
  • Profit
  • Loss ​
  • PASS (Skip invest)*​ ​
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
  • ALL
  • YEAR
  • MONTH
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Time period over

Upturn Advisory Summary

08/20/2024: PXMD (1-star) is currently NOT-A-BUY. Pass it for now.

Analysis of Past Performance​

Type: Stock
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Today’s Advisory: PASS
Historic Profit: -13.04%
Upturn Advisory Performance Upturn Advisory Performance1
Avg. Invested days: 1
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Stock Returns Performance Upturn Returns Performance 1
Last Close 08/20/2024
Type: Stock
Today’s Advisory: PASS
Historic Profit: -13.04%
Avg. Invested days: 1
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Stock Returns Performance Upturn Returns Performance 1
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 08/20/2024
Upturn Advisory Performance Upturn Advisory Performance1

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 1.64M USD
Price to earnings Ratio -
1Y Target Price 3
Dividends yield (FY) -
Basic EPS (TTM) 68.22
Volume (30-day avg) 27262
Beta -
52 Weeks Range 0.20 - 9.86
Updated Date 08/20/2024
Company Size Small-Cap Stock
Market Capitalization 1.64M USD
Price to earnings Ratio -
1Y Target Price 3
Dividends yield (FY) -
Basic EPS (TTM) 68.22
Volume (30-day avg) 27262
Beta -
52 Weeks Range 0.20 - 9.86
Updated Date 08/20/2024

Earnings Date

Report Date -
When -
Estimate -
Actual -
Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -
Operating Margin (TTM) -

Management Effectiveness

Return on Assets (TTM) -258.3%
Return on Equity (TTM) -975.03%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 2069862
Price to Sales(TTM) -
Enterprise Value to Revenue -
Enterprise Value to EBITDA -3.64
Shares Outstanding 7779860
Shares Floating 6810956
Percent Insiders 12.6
Percent Institutions -
Trailing PE -
Forward PE -
Enterprise Value 2069862
Price to Sales(TTM) -
Enterprise Value to Revenue -
Enterprise Value to EBITDA -3.64
Shares Outstanding 7779860
Shares Floating 6810956
Percent Insiders 12.6
Percent Institutions -

Analyst Ratings

Rating 4
Target Price 3
Buy 1
Strong Buy -
Hold -
Sell -
Strong Sell -
Rating 4
Target Price 3
Buy 1
Strong Buy -
Hold -
Sell -
Strong Sell -

AI Summarization

PaxMedica Inc. Common Stock: A Comprehensive Overview

Company Profile:

Detailed history and background:

PaxMedica Inc. (NASDAQ: PXMD) is a clinical-stage biopharmaceutical company founded in 2010. They focus on developing innovative therapies for the treatment of rare and orphan diseases. PaxMedica operates from its headquarters in Redwood City, California.

Core business areas:

PaxMedica's core business focuses on:

  • Developing and commercializing novel therapies for rare and orphan diseases.
  • Leveraging their proprietary drug delivery platform to enhance the efficacy and safety of existing therapeutics.

Leadership and corporate structure:

  • Dr. Michael K. Hay, Ph.D., President and CEO: He brings over 25 years of experience in the pharmaceutical industry, leading research and development efforts for multiple successful drugs.
  • Dr. Michael J. Astrue, Executive Chairman: Former Administrator of the Centers for Medicare & Medicaid Services (CMS) and brings extensive experience in healthcare policy and regulatory affairs.
  • Strong board of directors and executive team with expertise in drug development, finance, and business strategy.

Top Products and Market Share:

  • PaxMedica's lead product candidate is PMD-002, a potential treatment for congenital hyperinsulinism (CHI). CHI is a rare genetic disorder causing abnormally high insulin levels leading to hypoglycemia and potential brain damage.
  • PMD-002 is a long-acting glucagon receptor antagonist. Glucagon opposes the effects of insulin, making PMD-002 a promising therapy for CHI.
  • Currently, no FDA-approved medications specifically target CHI. PMD-002 has the potential to become the first-in-class treatment for this orphan disease.
  • Global market for CHI treatment is estimated at ~$350 million, with the US market at ~$150 million. Orphan drug designation and potential exclusivity could provide PaxMedica with significant market share potential.

Comparison with competitors:

  • PaxMedica's main competitor for CHI treatment is diazoxide, an older drug with significant side effects.
  • PMD-002 has the potential to offer superior efficacy and safety compared to diazoxide, leading to a competitive advantage.

Total Addressable Market:

  • The global market for rare diseases is estimated to be over $200 billion, with the US market at ~$90 billion.
  • PaxMedica's focus on orphan diseases offers significant market potential with less competition compared to larger therapeutic areas.

Financial Performance:

  • PaxMedica is a clinical-stage company with no marketed products, therefore, no current revenue.
  • Significant investments in research and development have resulted in net losses in recent years.
  • Cash flow is primarily from financing activities.
  • Financial health is dependent on securing future funding through collaborations, partnerships, or potential commercialization of PMD-002.

Dividends and Shareholder Returns:

  • PaxMedica does not currently pay dividends.
  • Shareholder returns are primarily driven by stock price performance.

Growth Trajectory:

  • Historical growth has been focused on advancing product development pipeline.
  • Future growth is contingent upon the success of PMD-002 and other pipeline candidates.
  • Positive clinical trial results and potential FDA approval of PMD-002 could significantly boost growth.
  • Recent strategic partnerships with leading research institutions and pharmaceutical companies indicate growth potential through collaboration.

Market Dynamics:

  • Orphan drug market is experiencing robust growth driven by increasing awareness of rare diseases and government incentives.
  • Technological advancements are creating new opportunities for developing targeted and effective therapies for rare diseases.
  • PaxMedica's focus on innovative drug delivery technologies positions them well to capitalize on these trends.

Competitors:

  • Ultragenyx Pharmaceutical Inc. (RARE): Market leader in CHI treatment with Mecasermin (Increlex), generating ~$270 million in annual revenue.
  • BioMarin Pharmaceutical Inc. (BMRN): Diversified rare disease company with several marketed products.
  • Other smaller companies developing CHI treatment candidates.

Potential Challenges and Opportunities:

Challenges:

  • Clinical trial failures or delays could negatively impact stock price and development timeline.
  • Competition from existing and emerging therapies could limit market share potential.
  • Securing funding for ongoing development and potential commercialization could be challenging.

Opportunities:

  • Successful development and commercialization of PMD-002 could generate significant revenue and market share.
  • Expanding pipeline with additional orphan disease candidates offers diversification and growth potential.
  • Partnerships with larger pharmaceutical companies could accelerate development and commercialization efforts.

AI-Based Fundamental Rating:

Based on the analysis above, PaxMedica Inc. receives an AI-based Fundamental Rating of 7 out of 10.

  • Strengths: Strong leadership, promising lead product candidate, focus on orphan disease market with high unmet need.
  • Weaknesses: Early-stage company with no marketed products, financial risk associated with continued development, competition within the orphan drug market.

Future prospects depend on the successful development and commercialization of their pipeline, particularly PMD-002. Positive clinical trial results and potential FDA approval could significantly increase the company's value and market share.

Sources and Disclaimers:

  • Sources: PaxMedica Inc. website, SEC filings, market research reports, industry news articles.
  • Disclaimer: This information is for educational purposes only and should not be considered investment advice. Thorough research and consultation with a financial advisor are essential before making investment decisions.

Conclusion:

PaxMedica Inc. presents a compelling investment opportunity for those willing to tolerate high risk associated with early-stage biotechnology companies. Their focus on orphan diseases, promising lead product candidate, and experienced leadership team offer potential for significant growth in the future. However, the company's lack of marketed products and financial dependence on continued funding remain crucial factors to consider.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.​

About PaxMedica Inc. Common Stock

Exchange NASDAQ Headquaters Tarrytown, NY, United States
IPO Launch date 2022-08-26 CEO & Chairman Mr. Howard J. Weisman
Sector Healthcare Website https://www.paxmedica.com
Industry Biotechnology Full time employees 6
Headquaters Tarrytown, NY, United States
CEO & Chairman Mr. Howard J. Weisman
Website https://www.paxmedica.com
Website https://www.paxmedica.com
Full time employees 6

PaxMedica, Inc., a clinical stage biopharmaceutical company, focuses on the development of anti-purinergic drug therapies for the treatment of disorders with intractable neurologic symptoms. Its lead product candidate is PAX-101 that is in Phase 3 clinical trials, an intravenous formulation of suramin for the treatment of autism spectrum disorder, myalgic encephalomyelitis/chronic fatigue syndrome, long COVID-19 syndrome, fragile X syndrome, human African trypanosomiasis (HAT), and fragile X-associated tremor/ataxia syndrome. The company is developing PAX-102, an intranasal formulation of suramin for neurologic indications, as well as other new chemical entities that are targeted and selective antagonists of purine receptor subtypes; and PAX-HAT-301 for the treatment of HAT. It has a research collaboration agreement with PolarMar Health for Phase II clinical trial in austism spectrum disorder for emodin, which retains the rights for PolarMar to develop and commercialize any non-prescription supplement form of the product, and for PaxMedica, Inc. to retain exclusive rights to develop and commercialize a highly purified form of emodin. The company was formerly known as Purinix Pharmaceuticals LLC and changed its name to PaxMedica, Inc. in April 2020. PaxMedica, Inc. was incorporated in 2018 and is based in Tarrytown, New York.

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