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Poseida Therapeutics Inc (PSTX)PSTX
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Upturn Advisory Summary
10/22/2024: PSTX (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Historic Profit: -75.64% | Upturn Advisory Performance 1 | Avg. Invested days: 33 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 10/22/2024 |
Type: Stock | Today’s Advisory: PASS |
Historic Profit: -75.64% | Avg. Invested days: 33 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 10/22/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 299.17M USD |
Price to earnings Ratio - | 1Y Target Price 14 |
Dividends yield (FY) - | Basic EPS (TTM) -1.18 |
Volume (30-day avg) 527832 | Beta 0.54 |
52 Weeks Range 1.87 - 4.27 | Updated Date 11/9/2024 |
Company Size Small-Cap Stock | Market Capitalization 299.17M USD | Price to earnings Ratio - | 1Y Target Price 14 |
Dividends yield (FY) - | Basic EPS (TTM) -1.18 | Volume (30-day avg) 527832 | Beta 0.54 |
52 Weeks Range 1.87 - 4.27 | Updated Date 11/9/2024 |
Earnings Date
Report Date 2024-11-07 | When BeforeMarket |
Estimate -0.41 | Actual - |
Report Date 2024-11-07 | When BeforeMarket | Estimate -0.41 | Actual - |
Profitability
Profit Margin -40.28% | Operating Margin (TTM) 27.52% |
Management Effectiveness
Return on Assets (TTM) -13.11% | Return on Equity (TTM) -57.63% |
Revenue by Products
Revenue by Products - Current and Previous Year
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 152067280 | Price to Sales(TTM) 3.22 |
Enterprise Value to Revenue 1.31 | Enterprise Value to EBITDA -1.24 |
Shares Outstanding 97133904 | Shares Floating 64579350 |
Percent Insiders 27.74 | Percent Institutions 55.38 |
Trailing PE - | Forward PE - | Enterprise Value 152067280 | Price to Sales(TTM) 3.22 |
Enterprise Value to Revenue 1.31 | Enterprise Value to EBITDA -1.24 | Shares Outstanding 97133904 | Shares Floating 64579350 |
Percent Insiders 27.74 | Percent Institutions 55.38 |
Analyst Ratings
Rating 4.6 | Target Price 12.25 | Buy 2 |
Strong Buy 3 | Hold - | Sell - |
Strong Sell - |
Rating 4.6 | Target Price 12.25 | Buy 2 | Strong Buy 3 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Poseida Therapeutics Inc.: A Comprehensive Overview
Company Profile:
Detailed history and background: Poseida Therapeutics Inc. (NASDAQ: PSTX) is a clinical-stage biotechnology company founded in 2014 and headquartered in San Diego, California. Their mission is to develop next-generation, non-viral gene therapies for patients with severe medical needs.
Core business areas: Poseida focuses on two core business areas:
- Gene Therapy Platform: This proprietary platform utilizes piggyBac® DNA Modification Technology to develop non-viral gene therapies.
- Cell Therapy Platform: This platform focuses on developing chimeric antigen receptor (CAR)-T cell therapies targeting various hematologic and solid tumor indications.
Leadership team and corporate structure: Poseida's leadership team comprises experienced professionals with expertise in gene therapy, cell therapy, and drug development. Key members include:
- Eric Ostertag, MD, President and CEO: Extensive experience in leading biotechnology companies.
- Michael Hoy, M.D., Ph.D., Chief Medical Officer: Over 20 years of experience in clinical development of gene therapy products.
- Michael Davidson, Ph.D., Chief Scientific Officer: Renowned scientist with over 30 years of experience in gene therapy research.
Top Products and Market Share:
Top products and offerings: Poseida's current pipeline includes various gene therapy and cell therapy programs in various stages of development:
- Gene therapy programs: P-MUC1C-CAR-T, P-PSMA-CAR-T, P-BCMA-101
- Cell therapy programs: P-PSMA-101, P-BCMA-101, P-KMS-101
Market share and competitor comparison: Poseida is a relatively young company with no products currently on the market. Their market share is therefore currently non-existent. However, they compete with established companies in the gene therapy and cell therapy space, including:
- Gene therapy: Novartis, BioMarin, UniQure, Spark Therapeutics
- Cell therapy: Gilead, Novartis, Celgene, bluebird bio
Total Addressable Market:
The global gene therapy market is expected to reach $29.47 billion by 2027, with a CAGR of 20.8%. The cell therapy market is expected to reach $38.6 billion by 2028, with a CAGR of 22.6%.
Financial Performance:
Poseida is currently a pre-revenue company, meaning they haven't generated any revenue from product sales. Their primary source of income comes from research and development collaborations and grants. As a result, they are not yet profitable and have accumulated significant losses.
Dividends and Shareholder Returns:
Due to their pre-revenue status, Poseida does not currently pay dividends. Shareholder returns have been negative in recent years, reflecting the company's early-stage development and investment phase.
Growth Trajectory:
Poseida's future growth depends heavily on the success of their clinical development programs. Several key milestones are expected in the coming years, including:
- P-MUC1C-CAR-T: Initiation of Phase 2 trial in 2024 for advanced ovarian cancer.
- P-PSMA-CAR-T: Completion of Phase 1 trial in 2024 for advanced metastatic castration-resistant prostate cancer.
- P-BCMA-101: Initiation of Phase 1 trial in 2024 for multiple myeloma.
Market Dynamics:
The gene therapy and cell therapy markets are experiencing rapid growth driven by technological advancements and increasing awareness of these innovative treatment modalities. However, several challenges exist, including high development costs, regulatory hurdles, and manufacturing complexities.
Competitors:
Key competitors in the gene therapy and cell therapy space include:
- Gene therapy: Novartis (NVS), BioMarin (BMRN), UniQure (QURE), Spark Therapeutics (ONCE)
- Cell therapy: Gilead (GILD), Novartis (NVS), Celgene (CELG), bluebird bio (BLUE)
Competitive advantages and disadvantages:
Poseida's competitive advantages include:
- Proprietary piggyBac® DNA Modification Technology: Offers advantages like efficient gene editing, non-viral delivery, and reduced potential for insertional mutagenesis.
- Strong intellectual property portfolio: Provides protection for their platform and pipeline.
- Experienced leadership team: Possesses deep expertise in gene therapy and cell therapy development.
However, they also face disadvantages:
- Pre-revenue stage: Lack of product sales and profitability.
- Relatively small size compared to competitors: Limits resources and market reach.
- Unproven technology: Their piggyBac® platform is still in the early stages of development.
Potential Challenges and Opportunities:
Key challenges:
- Ensuring the safety and efficacy of their gene therapy and cell therapy candidates.
- Navigating the complex regulatory landscape for gene and cell therapy approvals.
- Managing the high costs of clinical development and commercialization.
Potential opportunities:
- Expanding their pipeline to address new therapeutic areas.
- Establishing strategic partnerships with larger companies for development and commercialization.
- Leveraging their piggyBac® platform for gene editing applications beyond therapeutic development.
Recent Acquisitions:
Poseida has not completed any acquisitions in the past three years.
AI-Based Fundamental Rating:
Based on an AI-based analysis of various factors like financial health, market position, and future prospects, Poseida Therapeutics receives a rating of 6 out of 10. This reflects the company's strong potential but also acknowledges the inherent risks associated with its early-stage development and pre-revenue status.
Sources and Disclaimers:
- https://www.poseida.com/
- https://finance.yahoo.com/quote/PSTX?p=PSTX
- https://www.globenewswire.com/news-release/2023/10/26/2725965/0/en/Poseida-Therapeutics-Reports-Third-Quarter-2023-Financial-Results-and-Recent-Corporate-Highlights.html
- https://www.grandviewresearch.com/industry-analysis/gene-therapy-market
- https://www.grandviewresearch.com/industry-analysis/cellular-therapy-market
Disclaimer: This analysis is intended for informational purposes only and should not be considered investment advice. Investors should conduct their own due diligence before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Poseida Therapeutics Inc
Exchange | NASDAQ | Headquaters | San Diego, CA, United States |
IPO Launch date | 2020-07-10 | President, CEO & Director | Dr. Kristin Yarema Ph.D. |
Sector | Healthcare | Website | https://poseida.com |
Industry | Biotechnology | Full time employees | 337 |
Headquaters | San Diego, CA, United States | ||
President, CEO & Director | Dr. Kristin Yarema Ph.D. | ||
Website | https://poseida.com | ||
Website | https://poseida.com | ||
Full time employees | 337 |
Poseida Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing therapeutics for patients with high unmet medical needs. The company's development candidates for Heme Malignancies includes P-BCMA-ALLO1, which is in Phase I trial to treat patients with relapsed/refractory multiple myeloma; P-CD19CD20-ALLO1, which is in Phase I trial for treating B cell malignancies and other autoimmune diseases; P-BCMACD19-ALLO1, an allogeneic, off-the-shelf CAR-T product candidate in preclinical development for treating multiple myeloma; and P-CD70-ALLO1 under preclinical development to treat hematological indications. It is also involved in the development of P-MUC1C-ALLO1 that is in Phase I trial for treating a range of solid tumors, including breast, colorectal, lung, ovarian, pancreatic, and renal cancers; P-PSMA-ALLO1, an autologous chimeric antigen receptor T cell (CAR-T) product candidate that is in preclinical development for the treatment of patients with metastatic castrate resistant prostate cancer (mCRPC); and P-PSMA-101, an allogeneic CAR-T product candidate under Phase 1 clinical trial for treating mCRPC. In addition, the company engages in the development of P-FVIII-101, a clinical stage liver-directed gene therapy for the in vivo treatment of hemophilia A; P-OTC-101, a clinical stage liver-directed gene therapy for the in vivo treatment of ornithine transcarbamylase deficiency; and P-PAH-101, a clinical stage liver-directed gene therapy for the in vivo treatment of phenylketonuria. It has a research collaboration and license agreement with F. Hoffmann-La Roche Ltd, and Hoffmann-La Roche Inc. The company was incorporated in 2014 and is headquartered in San Diego, California.
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