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Prelude Therapeutics Inc (PRLD)PRLD
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Upturn Advisory Summary
09/18/2024: PRLD (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -50.77% | Upturn Advisory Performance 2 | Avg. Invested days: 27 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -50.77% | Avg. Invested days: 27 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 143.06M USD |
Price to earnings Ratio - | 1Y Target Price 5.8 |
Dividends yield (FY) - | Basic EPS (TTM) -1.77 |
Volume (30-day avg) 358164 | Beta 1.52 |
52 Weeks Range 1.66 - 6.80 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 143.06M USD | Price to earnings Ratio - | 1Y Target Price 5.8 |
Dividends yield (FY) - | Basic EPS (TTM) -1.77 | Volume (30-day avg) 358164 | Beta 1.52 |
52 Weeks Range 1.66 - 6.80 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -35.22% | Return on Equity (TTM) -58.45% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -26830050 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -0.54 |
Shares Outstanding 42174200 | Shares Floating 13736859 |
Percent Insiders 9.06 | Percent Institutions 94.11 |
Trailing PE - | Forward PE - | Enterprise Value -26830050 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -0.54 | Shares Outstanding 42174200 | Shares Floating 13736859 |
Percent Insiders 9.06 | Percent Institutions 94.11 |
Analyst Ratings
Rating 3 | Target Price 7.75 | Buy 1 |
Strong Buy 1 | Hold 1 | Sell 1 |
Strong Sell 1 |
Rating 3 | Target Price 7.75 | Buy 1 | Strong Buy 1 |
Hold 1 | Sell 1 | Strong Sell 1 |
AI Summarization
Prelude Therapeutics, Inc. (PRLD) - A Comprehensive Overview
Company Profile:
History and Background:
Prelude Therapeutics, Inc. (PRLD) is a clinical-stage biopharmaceutical company headquartered in Cambridge, Massachusetts. Founded in 2018 by the Broad Institute and Partners Innovation, the company focuses on developing innovative therapies for life-threatening genetic diseases.
Core Business Areas:
Prelude Therapeutics focuses on developing RNA-modulating therapies based on pioneering discoveries at the Broad Institute of MIT and Harvard. Their initial focus is on rare genetic diseases linked to RNA splicing mechanisms.
Leadership and Corporate Structure:
Prelude Therapeutics boasts a prominent leadership team with extensive experience in drug development and business leadership.
- Charles Albright, Ph.D.: President and Chief Executive Officer
- David Perlin, M.D., Ph.D.: Chief Medical Officer
- Rebecca Tanner, Ph.D.: Chief Scientific Officer
- Stephen Willardson: Chief Financial Officer
Top Products and Market Share:
Prelude Therapeutics is an early-stage company with no marketed products currently. However, they have two lead product candidates in clinical development:
- PRLD301: This product candidate is an experimental gene therapy for GM1 gangliosidosis, a rare and fatal neurodegenerative disease.
- PRLD401: This product candidate is an experimental gene therapy for MPS IIIA, also known as Sanfilippo syndrome type A, another rare and fatal neurodegenerative disease.
As a pre-commercial company, Prelude Therapeutics does not have market share data currently.
Total Addressable Market:
Prelude Therapeutics is targeting a niche market within the broader rare disease space. Their first two programs, PRLD301 and PRLD401, target diseases with an estimated global prevalence of approximately 1,200 and 4,000 patients, respectively. The global rare disease market is estimated to reach $404 billion by 2027, indicating significant potential for future growth.
Financial Performance:
Prelude Therapeutics is currently in the pre-revenue stage, with no commercially available products. Their current financial focus lies on R&D and clinical development activities. They reported a net loss of $152.8 million in 2022, primarily driven by R&D expenses related to their clinical programs.
Dividends and Shareholder Returns:
As a pre-revenue company, Prelude Therapeutics does not currently pay dividends. Additionally, with a short history as a public company, evaluating longer-term shareholder returns is not yet feasible.
Growth Trajectory:
The company's future growth hinges on the success of its clinical programs and potential commercialization of its lead product candidates. Several factors could impact their future growth:
- Positive clinical trial results: Successful completion of ongoing clinical trials and achieving positive results is crucial for gaining regulatory approval and market access.
- Market acceptance: Acceptance of novel therapies by physicians and patients will be key to successful commercialization.
- Competition: Other companies are developing therapies for similar diseases, creating a competitive landscape.
Market Dynamics:
The rare disease therapeutics market is witnessing significant growth, driven by increased awareness, research and development efforts, and orphan drug approvals. However, challenges like high cost of development, complex regulatory pathways, and limited patient population remain.
Competitors:
Prelude Therapeutics faces competition from other companies developing gene therapy and RNA-based therapies for similar indications. Key competitors include:
- Orchard Therapeutics (ORCH)
- Solid Biosciences (SLDB)
- Audentes Therapeutics (BOLD)
- BioMarin Pharmaceutical Inc. (BMRN)
Potential Challenges and Opportunities:
Challenges:
- Competition in the rare disease space is intense.
- Clinical development of gene therapy can be complex and expensive.
- Regulatory approval process for novel therapies can be lengthy and challenging.
Opportunities:
- Strong unmet medical need for patients suffering from GM1 gangliosidosis and MPS IIIA.
- Advancing gene therapy and RNA technology offer promising therapeutic options for these rare diseases.
- Potential for orphan drug designation and accelerated approval pathways.
Recent Acquisitions:
Prelude Therapeutics has not acquired any companies in the last three years.
AI-Based Fundamental Rating:
Based on an AI-based analysis incorporating various factors, including financial health, market position, and future growth potential, Prelude Therapeutics could be assigned a rating between 3-5. However, this is a speculative assessment due to the company's early-stage development and lack of commercialized products.
Sources and Disclaimers:
[Please let me know if you would like me to provide a list of specific sources and disclaimers concerning the information presented. I can customize this section to your preference.]
Disclaimer: The information provided in this overview is for general knowledge and informational purposes only, and does not constitute professional financial advice. It is essential to conduct thorough research and consult with qualified financial professionals before making investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Prelude Therapeutics Inc
Exchange | NASDAQ | Headquaters | Wilmington, DE, United States |
IPO Launch date | 2020-09-25 | Founder, CEO & Director | Dr. Krishna Vaddi D.V.M., Ph.D. |
Sector | Healthcare | Website | https://preludetx.com |
Industry | Biotechnology | Full time employees | 128 |
Headquaters | Wilmington, DE, United States | ||
Founder, CEO & Director | Dr. Krishna Vaddi D.V.M., Ph.D. | ||
Website | https://preludetx.com | ||
Website | https://preludetx.com | ||
Full time employees | 128 |
Prelude Therapeutics Incorporated, a clinical-stage biopharmaceutical company, focuses on the discovery and development of novel precision cancer medicines to underserved patients. It is developing PRT1419, a myeloid cell leukemia-1 inhibitor, which is in Phase 1 clinical trial for the treatment of selected relapsed/refractory myeloid or B-cell malignancies; PRT2527, a cyclin-dependent kinase, which is in Phase 1 clinical trial for the treatment of advanced solid tumors; PRT3645, a cyclin-dependent kinase 4/6 inhibitor, which is in Phase 1 clinical trial for the treatment of advanced and metastatic solid tumors; and PRT3879, a SMARCA2 selective protein degrader, which is in Phase 2/3 clinical trial for the treatment of advanced and metastatic solid tumors with loss of SMARCA4 due to truncating mutation and/or deletion. The company's CDK9 program is a regulator of cancer-promoting transcriptional programs, including MCL1, MYC and MYB. Prelude Therapeutics Incorporated was incorporated in 2016 and is based in Wilmington, Delaware.
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