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Opthea Ltd (OPT)OPT
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Upturn Advisory Summary
09/18/2024: OPT (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Profit: 15.08% | Upturn Advisory Performance 3 | Avg. Invested days: 33 |
Profits based on simulation | Stock Returns Performance 2 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Profit: 15.08% | Avg. Invested days: 33 |
Upturn Star Rating | Stock Returns Performance 2 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 3 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 525.29M USD |
Price to earnings Ratio - | 1Y Target Price 14.27 |
Dividends yield (FY) - | Basic EPS (TTM) -2.76 |
Volume (30-day avg) 12483 | Beta 1.61 |
52 Weeks Range 1.60 - 4.40 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 525.29M USD | Price to earnings Ratio - | 1Y Target Price 14.27 |
Dividends yield (FY) - | Basic EPS (TTM) -2.76 | Volume (30-day avg) 12483 | Beta 1.61 |
52 Weeks Range 1.60 - 4.40 | Updated Date 09/18/2024 |
Earnings Date
Report Date 2024-08-30 | When BeforeMarket |
Estimate -0.54 | Actual -1.22 |
Report Date 2024-08-30 | When BeforeMarket | Estimate -0.54 | Actual -1.22 |
Profitability
Profit Margin - | Operating Margin (TTM) -164535.56% |
Management Effectiveness
Return on Assets (TTM) -83.43% | Return on Equity (TTM) -3383.08% |
Valuation
Trailing PE - | Forward PE 6.73 |
Enterprise Value 492800227 | Price to Sales(TTM) 2006.02 |
Enterprise Value to Revenue 3952.96 | Enterprise Value to EBITDA -0.73 |
Shares Outstanding 153887008 | Shares Floating 822383515 |
Percent Insiders - | Percent Institutions 4.52 |
Trailing PE - | Forward PE 6.73 | Enterprise Value 492800227 | Price to Sales(TTM) 2006.02 |
Enterprise Value to Revenue 3952.96 | Enterprise Value to EBITDA -0.73 | Shares Outstanding 153887008 | Shares Floating 822383515 |
Percent Insiders - | Percent Institutions 4.52 |
Analyst Ratings
Rating 4.83 | Target Price 12.78 | Buy 1 |
Strong Buy 5 | Hold - | Sell - |
Strong Sell - |
Rating 4.83 | Target Price 12.78 | Buy 1 | Strong Buy 5 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Opthea Ltd. Stock Overview:
Company Profile:
History and Background:
Opthea Limited (ASX: OPT) is a clinical-stage biopharmaceutical company founded in 2010 and headquartered in Melbourne, Australia. The company focuses on developing novel biologics for the treatment of eye diseases, specifically wet age-related macular degeneration (AMD) and diabetic macular edema (DME).
Core Business Areas:
Opthea's primary business activities involve research, development, and commercialization of its lead product candidate, OPT-302. OPT-302 is a VEGF-C and VEGF-D dual antagonist designed to treat wet AMD and DME.
Leadership and Corporate Structure:
Leadership:
- Dr. Megan Baldwin (CEO and Managing Director)
- Dr. Ben Ho (Chief Medical Officer)
- Dr. Daniel Chan (Chief Scientific Officer)
Corporate Structure:
Opthea operates under a Board of Directors and an Executive Leadership team. The company maintains a lean structure with internal expertise mainly in clinical development, regulatory affairs, and commercial activities. Research and development activities are primarily outsourced to contract research organizations (CROs).
Top Products and Market Share:
Top Products:
- OPT-302 is the company's lead product candidate and is currently in Phase 3 clinical trials for the treatment of wet AMD and DME.
- OPT-302 has demonstrated potential for efficacy and safety in early-stage trials.
Market Share:
OPT-302 is not yet commercially available; therefore, a market share analysis is not applicable at this stage. However, the global market for wet AMD and DME is estimated to reach USD 14.5 billion by 2027, representing a significant growth opportunity for Opthea.
Product Performance and Market Reception:
Positive results from early-stage clinical trials for OPT-302 have been well received by the market, demonstrating potential for a competitive advantage compared to existing treatments. Investors remain optimistic about the company's progress and potential future market share within the wet AMD and DME treatment landscape.
Total Addressable Market:
The global market for the treatment of wet AMD and DME is currently estimated at USD 12 billion and is projected to reach USD 14.5 billion by 2027.
Financial Performance:
Recent Financial Statements:
- Revenue: Opthea is currently pre-revenue as its lead product, OPT-302, is still in clinical trials.
- Net Income: Opthea has yet to achieve profitability due to its focus on research and development activities.
- Profit Margins: N/A due to pre-revenue status.
- EPS: N/A due to pre-revenue status.
Financial Performance Comparison:
Financial data comparison is limited due to Opthea's pre-revenue status. The company's primary focus continues to be on advancing OPT-302 through clinical development stages.
Cash Flow and Balance Sheet:
- Cash flow analysis and balance sheet health evaluation are relevant once the company enters the commercialization stage with a marketed product.
Dividends and Shareholder Returns:
- Dividend History: Opthea is a pre-revenue company and currently does not distribute dividends.
- Shareholder Returns: Shareholder returns are primarily influenced by Opthea's stock performance. The stock has experienced volatility due to various factors, including clinical trial results and market sentiment.
Growth Trajectory:
Historical Growth:
Opthea has demonstrated significant growth in recent years, primarily driven by advancements in its clinical trial pipeline.
Future Growth Projections:
Future growth prospects are highly dependent on the success of OPT-302 in ongoing clinical trials and subsequent regulatory approval. Successful commercialization of OPT-302 could result in substantial revenue growth and improved profitability.
Product Launches and Strategic Initiatives:
- OPT-302 Phase 3 clinical trial data are expected in 2023 and 2024, representing significant catalysts for potential growth.
- Opthea continues to explore strategic partnerships to expand its global reach and commercialization capabilities.
Market Dynamics:
Industry Overview:
The global ophthalmology market is expected to reach USD 45 billion by 2027, driven by an aging population and increasing prevalence of eye diseases. The wet AMD and DME treatment market is a major segment within the broader ophthalmology landscape.
Competitive Landscape:
Key Competitors:
- Regeneron (REGN)
- Bayer (BAYRY)
- Novartis (NVS)
- Roche (RHHBY)
Competitive Advantages and Disadvantages:
Opthea's key competitive advantage lies in its dual VEGF-C and VEGF-D targeting mechanism in OPT-302, potentially offering greater efficacy and improved outcomes for patients with wet AMD and DME compared to existing treatments. However, the company faces stiff competition from established pharmaceutical giants with strong market presence and extensive product portfolios.
Key Challenges and Opportunities:
Key Challenges:
- Continued clinical development and regulatory approval for OPT-302 remain a key challenge.
- Competition from existing players with marketed therapies poses a significant challenge in gaining market share.
- Securing sufficient funding to support research and development activities and potential commercialization efforts is crucial.
Potential Opportunities:
- Successful development and commercialization of OPT-302 could disrupt the existing market landscape and generate substantial revenue growth for Opthea.
- Expanding into new geographic markets through strategic partnerships offers significant growth potential.
- Continued innovation in ophthalmology treatment development presents exciting opportunities for Opthea to pursue novel therapeutic solutions.
Recent Acquisitions:
Opthea has not completed any acquisitions in the past 3 years.
AI-Based Fundamental Rating:
Rating:
Based on the analysis of various factors such as financial health, market position, future prospects, and industry dynamics, Opthea Ltd.'s
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Opthea Ltd
Exchange | NASDAQ | Headquaters | South Yarra, VIC, Australia |
IPO Launch date | 2012-04-12 | CEO | - |
Sector | Healthcare | Website | https://opthea.com |
Industry | Biotechnology | Full time employees | 33 |
Headquaters | South Yarra, VIC, Australia | ||
CEO | - | ||
Website | https://opthea.com | ||
Website | https://opthea.com | ||
Full time employees | 33 |
Opthea Limited, a clinical-stage biopharmaceutical company, develops and commercializes drugs for eye diseases in Australia and the United States. Its development activities are based on the intellectual property portfolio covering vascular endothelial growth factors (VEGF) VEGF-C, VEGF-D, and VEGF Receptor-3 for the treatment of diseases associated with blood and lymphatic vessel growth, as well as vascular leakage. The company's lead product candidate is sozinibercept (OPT-302), a biologic drug in Phase 3 clinical trials designed to inhibit VEGF-C and VEGF-D and complement VEGF-A inhibitors for the treatment of wet age-related macular degeneration and diabetic macular edema. It serves the biotechnology and healthcare industries. The company was formerly known as Circadian Technologies Limited and changed its name to Opthea Limited in December 2015. Opthea Limited was incorporated in 1984 and is headquartered in South Yarra, Australia.
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