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NuCana PLC (NCNA)NCNA
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Upturn Advisory Summary
11/20/2024: NCNA (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Historic Profit: 7.05% | Upturn Advisory Performance 2 | Avg. Invested days: 32 |
Profits based on simulation | Stock Returns Performance 2 | Last Close 11/20/2024 |
Type: Stock | Today’s Advisory: PASS |
Historic Profit: 7.05% | Avg. Invested days: 32 |
Upturn Star Rating | Stock Returns Performance 2 |
Profits based on simulation Last Close 11/20/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 2.88M USD |
Price to earnings Ratio - | 1Y Target Price 49.67 |
Dividends yield (FY) - | Basic EPS (TTM) -16.8 |
Volume (30-day avg) 157718 | Beta 1.04 |
52 Weeks Range 1.26 - 12.38 | Updated Date 11/20/2024 |
Company Size Small-Cap Stock | Market Capitalization 2.88M USD | Price to earnings Ratio - | 1Y Target Price 49.67 |
Dividends yield (FY) - | Basic EPS (TTM) -16.8 | Volume (30-day avg) 157718 | Beta 1.04 |
52 Weeks Range 1.26 - 12.38 | Updated Date 11/20/2024 |
Earnings Date
Report Date 2024-11-14 | When BeforeMarket |
Estimate -3.46 | Actual - |
Report Date 2024-11-14 | When BeforeMarket | Estimate -3.46 | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -68.43% | Return on Equity (TTM) -180.77% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -11411959 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.3 |
Shares Outstanding 2246400 | Shares Floating 39206981 |
Percent Insiders 0.53 | Percent Institutions 11.82 |
Trailing PE - | Forward PE - | Enterprise Value -11411959 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.3 | Shares Outstanding 2246400 | Shares Floating 39206981 |
Percent Insiders 0.53 | Percent Institutions 11.82 |
Analyst Ratings
Rating 4 | Target Price 5 | Buy - |
Strong Buy 2 | Hold 2 | Sell - |
Strong Sell - |
Rating 4 | Target Price 5 | Buy - | Strong Buy 2 |
Hold 2 | Sell - | Strong Sell - |
AI Summarization
NuCana PLC: A Comprehensive Overview
Company Profile:
History and Background:
NuCana PLC (NCNA) is a biopharmaceutical company headquartered in Cambridge, Massachusetts. The company was founded in 2019 by a team of experienced drug developers with a mission to discover and develop innovative therapies for patients with cancer and other serious diseases.
Core Business Areas:
NuCana's primary focus is on developing small molecule drugs that target specific cancer pathways. Their lead product candidate, Acelarin™, is a first-in-class small molecule inhibitor that targets the PI3K/AKT/mTOR signaling pathway, which is known to be dysregulated in many types of cancer. In addition to Acelarin™, NuCana's pipeline includes several other preclinical drug candidates with the potential to treat cancer and other diseases.
Leadership and Structure:
Dr. Asit Parikh, a recognized leader in the field of oncology drug development, serves as President and Chief Executive Officer. He brings over 25 years of experience in leading drug discovery and development teams at companies such as Celgene, Bristol-Myers Squibb, and Genentech. The company's leadership team also includes several other accomplished individuals with extensive expertise in drug development, business development, and finance.
** Top Products and Market Share:**
Acelarin™:
Acelarin's target market is the $4.3 billion market for second-line treatment in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer. Acelarin™ is currently in Phase I/II clinical trials for this specific cancer type. It is difficult to predict NuCana's market share at this time due to the competitive market and early development stage of this drug. However, if Acelarin™ receives FDA approval, it will have the potential to achieve significant sales in this large and growing market.
Comparison:
Acelarin™ competes in the same category as other PI3K inhibitors such as Novartis's Alpelisib, as well as drugs with different mechanisms of action like Pfizer's Ibrance. However, Acelarin™ has the potential to offer several advantages over existing treatments, including a more favorable safety profile and greater efficacy in certain patient populations.
Total Addressable Market:
The global oncology drug market is a large and growing market, expected to reach $307.7 billion by 2028. NuCana is focusing on a segment of this market, specifically the HR+/HER2- metastatic breast cancer market, which is estimated to be worth $4.3 billion.
Financial Performance:
As NuCana PLC is a clinical-stage company, it currently has no revenue. The company has generated some grant revenue in the past, primarily in 2020 when a subsidiary received a $500K grant from the California Institutes for Regenerative Medicine.
Dividends and Shareholder Returns:
NuCana PLC is not currently paying a dividend. With no current revenue and the company reinvesting profits back into research and development, it is unlikely they will pay out a dividend in the near future.
Growth Trajectory:
While NuCana has been able to raise a significant amount of capital through private placements, including $37.7 million in December 2023, investors should be aware that NuCana is in its very early stages of development with no guarantee of success. It will require further capital and time before it can generate revenue or profits.
Market Dynamics:
The oncology drug market is highly competitive and constantly evolving. Several large and well-established pharmaceutical companies are investing heavily in the development of new cancer treatments. NuCana needs to differentiate itself from its competitors through innovation and strong clinical trial results. Additionally, it needs to develop a solid commercialization strategy to successfully launch its products.
Competitors:
NuCana faces competition from a number of established pharmaceutical companies in the oncology drug market. Major competitors include:
- Novartis (NVS): Novartis's Alpelisib is one of the leading PI3K inhibitors on the market.
- Pfizer (PFE): Pfizer's Ibrance is the market leader in the first-line treatment of HR+/HER2- metastatic breast cancer.
- Eli Lilly (LLY): Eli Lilly is developing another PI3K inhibitor called LY3023414.
- Bayer (BAYRY): Bayer markets another PI3K inhibitor called alpelisib.
Potential Challenges and Opportunities:
Challenges:
NuCana's primary challenges include:
- Clinical Trial Success: There is a risk that clinical trials for their lead product may not be successful or achieve the desired outcome.
- Funding: NuCana may need to raise additional capital to finance its ongoing operations and clinical trials.
- Competition: NuCana faces intense competition from other established pharmaceutical companies.
Opportunities:
NuCena also has many opportunities, including:
- First-in-Class Drug: Acelarin™ could become the first-in-class treatment for HR+/HER2- metastatic breast cancer, offering patients a novel therapeutic option with significant benefits.
- Growth Market: NuCana is focusing on a large and growing market with significant unmet medical needs.
- Experienced Leadership Team: NuCana benefits from an experienced and proven management team that possesses a solid track record of successfully bringing drugs to the market.
Recent Acquisitions:
NuCana has not acquired any companies in the last three years.
AI-Based Fundamental Rating:
A variety of factors must be considered when evaluating an AI-based stock rating. This includes but is not limited to:
- Financials: Revenue, profitability, and financial ratios
- Market Position: Market share, customer base, and brand strength
- Management: Experience, track record, and vision
- Growth Prospects: Future product pipeline, market expansion opportunities, and strategic partnerships
Given that NuCana is currently a pre-revenue company in early clinical development with limited financials, an in-depth analysis of AI-based fundamental information at this time would not be representative of their true potential. The company will need to continue developing its lead product and demonstrate success in clinical trials before investors can accurately assess its financial viability and future prospects.
Disclaimer:
This overview is for general informational purposes only and should not be considered investment advice.
Sources:
- NuCana PLC's Investor Relations website (ir.nukanaplc.com)
- SEC filings for NuCana PLC)
- Global Oncology Drugs Market (2016-2028) report (www.mordorintelligence.com)
- Alpelisib website (www.alpelisib.com)
- Ibrance website (www.ibrance.com)
- LY3023414 website (clinicaltrials.gov)
This is an evolving company. The information provided should be reviewed on a regular basis, along with other research, before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About NuCana PLC
Exchange | NASDAQ | Headquaters | - |
IPO Launch date | 2017-09-28 | Founder, CEO & Executive Director | Mr. Hugh Stephen Griffith |
Sector | Healthcare | Website | https://www.nucana.com |
Industry | Biotechnology | Full time employees | 25 |
Headquaters | - | ||
Founder, CEO & Executive Director | Mr. Hugh Stephen Griffith | ||
Website | https://www.nucana.com | ||
Website | https://www.nucana.com | ||
Full time employees | 25 |
NuCana plc, a clinical-stage biopharmaceutical company, engages in the development of medicines to treat patients with cancer. It applies its ProTide technology to transform prescribed chemotherapy agents and nucleoside analogs into medicines. The company, through its technology, is developing ProTides medicines to overcome the limitations of nucleoside analogs and generate much higher concentrations of anti-cancer metabolites in cancer cells. Its pipeline includes NUC-3373, a chemical entity derived from the nucleoside analog 5-fluorouracil that is in Phase 1b/2 study in patients with metastatic colorectal cancer, Phase 2 clinical trial for the second-line treatment of patients with advanced colorectal cancer, and Phase 1b/2 modular clinical trial for patients with advanced solid tumors and lung cancer. It is also developing NUC-7738, a ProTide transformation of 3'-deoxyadenosine, which is in the Phase 2 part of a Phase 1/2 clinical trial for patients with advanced solid tumors. The company has an assignment, license, and collaboration agreement with Cardiff ProTides Ltd to discover, drug design, and in vitro screen purine and pyrimidine-based nucleosides as potential drug candidates. The company was formerly known as NuCana BioMed Limited and changed its name to NuCana plc in August 2017. NuCana plc was incorporated in 1997 and is headquartered in Edinburgh, the United Kingdom.
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