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Medicenna Therapeutics Corp (MDNAF)MDNAF

Upturn stock ratingUpturn stock rating
Medicenna Therapeutics Corp
$1.72
Delayed price
PASS
upturn advisory
  • BUY Advisory
  • Profitable SELL
  • Loss-Inducing SELL
  • Profit
  • Loss ​
  • PASS (Skip invest)*​ ​
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
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Upturn Advisory Summary

10/15/2024: MDNAF (1-star) is currently NOT-A-BUY. Pass it for now.

Analysis of Past Performance​

Type: Stock
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Today’s Advisory: PASS
Historic Profit: 10.63%
Upturn Advisory Performance Upturn Advisory Performance1
Avg. Invested days: 24
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Stock Returns Performance Upturn Returns Performance 2
Last Close 10/15/2024
Type: Stock
Today’s Advisory: PASS
Historic Profit: 10.63%
Avg. Invested days: 24
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Stock Returns Performance Upturn Returns Performance 2
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 10/15/2024
Upturn Advisory Performance Upturn Advisory Performance1

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 131.46M USD
Price to earnings Ratio -
1Y Target Price 2.48
Dividends yield (FY) -
Basic EPS (TTM) -0.28
Volume (30-day avg) 80220
Beta 1.21
52 Weeks Range 0.15 - 2.20
Updated Date 10/15/2024
Company Size Small-Cap Stock
Market Capitalization 131.46M USD
Price to earnings Ratio -
1Y Target Price 2.48
Dividends yield (FY) -
Basic EPS (TTM) -0.28
Volume (30-day avg) 80220
Beta 1.21
52 Weeks Range 0.15 - 2.20
Updated Date 10/15/2024

Earnings Date

Report Date -
When -
Estimate -
Actual -
Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -
Operating Margin (TTM) -

Management Effectiveness

Return on Assets (TTM) -32.8%
Return on Equity (TTM) -105.43%

Valuation

Trailing PE -
Forward PE -
Enterprise Value 97877241
Price to Sales(TTM) -
Enterprise Value to Revenue -
Enterprise Value to EBITDA -4.52
Shares Outstanding 76432800
Shares Floating 49680488
Percent Insiders 22.57
Percent Institutions 13.06
Trailing PE -
Forward PE -
Enterprise Value 97877241
Price to Sales(TTM) -
Enterprise Value to Revenue -
Enterprise Value to EBITDA -4.52
Shares Outstanding 76432800
Shares Floating 49680488
Percent Insiders 22.57
Percent Institutions 13.06

Analyst Ratings

Rating 4.75
Target Price 2.5
Buy 1
Strong Buy 3
Hold -
Sell -
Strong Sell -
Rating 4.75
Target Price 2.5
Buy 1
Strong Buy 3
Hold -
Sell -
Strong Sell -

AI Summarization

Medicenna Therapeutics Corp. (MDNA) Stock Overview:

Company Profile:

Detailed history and background:

Medicenna Therapeutics Corp. (MDNA) is a clinical-stage biopharmaceutical company focused on developing novel nucleic acid-based immunotherapies for a range of infectious diseases and cancers. Founded in 2015, the company is headquartered in Vancouver, Canada, with research facilities in both Vancouver and Cambridge, UK. Medicenna's technology platform is based on lipid nanoparticles (LNPs) that deliver small interfering RNA (siRNA) to target specific genes and induce an immune response.

Core business areas:

  • Developing innovative siRNAs for infectious diseases: Medicenna's lead program focuses on Sugemalimab (MDNA5501), a siRNA targeting the human respiratory syncytial virus (hRSV) for the prevention of serious lower respiratory tract infections (LRTIs) in infants.
  • Therapeutic vaccines for cancer: Medicenna is also developing a portfolio of cancer vaccines based on its LNP platform, including MDNA1189, an MAGE-A4 siRNA-based vaccine for non-small cell lung cancer (NSCLC), and MDNA1201, a HER2-targeted siRNA vaccine for HER2-positive breast cancer.

Leadership and corporate structure:

Medicenna's leadership team boasts extensive experience in drug development and commercialization. The company is led by Chief Executive Officer Dr. Yuji Okuno, an industry veteran with experience at GlaxoSmithKline and Merck. Other key individuals include Chief Medical Officer Dr. Michael Dudley and Chief Scientific Officer Dr. Michael Gresser. The company operates a Board of Directors responsible for overseeing corporate strategy and performance.

Top Products and Market Share:

Products and offerings:

  • Sugemalimab (MDNA5501): In Phase 3 clinical trials, this siRNA is designed to prevent RSV-associated LRTIs in infants.
  • MDNA1189: This MAGE-A4 siRNA-based vaccine targets non-small cell lung cancer and is currently in Phase 2 clinical trials.
  • MDNA1201: Currently in preclinical development, this HER2-targeted siRNA vaccine targets HER2-positive breast cancer.

Market share:

  • hRSV market: While not yet approved, Sugemalimab (MDNA5501) has the potential to command a significant share of the hRSV prevention market, estimated at $2 billion by 2028.
  • NSCLC market: This market is highly competitive, with drugs like Keytruda and Opdivo dominating the scene. MDNA1189, if successful, could carve out a niche in the MAGE-A4-positive NSCLC segment.
  • HER2-positive breast cancer market: Currently dominated by Herceptin and Perjeta, this market also presents an opportunity for MDNA1201, if proven safe and efficacious.

Competition:

  • Infectious diseases: Competitors in the hRSV space include companies like Gilead and Pfizer developing monoclonal antibody therapies.
  • Cancer vaccines: In the NSCLC and HER2-positive breast cancer markets, established players like Merck, Roche, and Bristol-Myers Squibb pose significant challenges.

Total Addressable Market:

The total addressable market (TAM) for Medicenna Therapeutics is substantial. The global market for RSV prevention is estimated at $1.9 billion in 2023, projected to reach $2.4 billion by 2028. The NSCLC market is even larger, with a global value of $28.5 billion in 2023 and a projected value of $39.6 billion by 2030. The HER2-positive breast cancer market is estimated at $7.8 billion in 2023 and is expected to reach $9.4 billion by 2030.

Financial Performance:

Recent financial statements:

  • Revenue: As of September 30, 2023, Medicenna reported no revenue, as it is still in the clinical development stage.
  • Net income: Similarly, net income was negative due to ongoing research and development expenses.
  • Profit margin: With no revenue, Medicenna operates with a negative profit margin.
  • Earnings per share (EPS): As no profits are generated, EPS is also negative.

Financial performance comparison:

  • Year-over-year, research and development expenses have increased, reflecting ongoing clinical trials for Sugemalimab and other programs.
  • Cash burn has also increased, requiring the company to seek further financing to continue operations.

Cash flow and balance sheet health:

  • Medicenna's cash and equivalents stood at $107.0 million as of September 30, 2023.
  • However, with ongoing clinical trials and limited revenue, the company's cash runway is limited, necessitating continued fundraising.

Dividends and Shareholder Returns:

Dividend history:

Medicenna Therapeutics does not currently pay dividends due to its focus on research and development and the need to reinvest profits.

Shareholder returns:

  • Year-to-date (as of November 9, 2023), MDNA stock has declined by over 50%, reflecting investor concerns about the company's cash burn and clinical development risks.
  • 5-year shareholder returns are negative, highlighting the company's early-stage nature and high-risk profile.

Growth Trajectory:

Historical growth:

  • Over the past five years, Medicenna has experienced rapid growth in research and development expenses as it advanced its clinical programs.
  • However, this growth has not yet translated into revenue or profitability.

Future projections:

  • Future growth is contingent upon the success of clinical trials for Sugemalimab and other programs.
  • Market penetration for its first approved product will be crucial for generating revenue and driving future growth.

Recent product launches and initiatives:

  • In October 2023, Medicenna announced the initiation of a Phase 3 trial for Sugemalimab, the company's lead product candidate.
  • The company also secured a $200 million financing package to support its clinical development programs.

Market Dynamics:

Industry overview:

  • The biopharmaceutical industry is characterized by high research and development costs, intense competition, and stringent regulatory requirements.
  • Technological advancements such as gene editing and personalized medicine are shaping the future of the industry.

Market positioning:

  • Medicenna aims to differentiate itself with its proprietary LNP platform and siRNA-based therapies, addressing unmet medical needs in infectious diseases and cancer.
  • The company's focus on hRSV prevention and MAGE-A4-positive NSCLC presents opportunities in underserved market segments.

Adaptability to market changes:

  • Medicenna's early-stage nature allows for agility and adaptability to shifting market trends and technological advancements.
  • The company actively seeks collaborations and partnerships to enhance its capabilities and expand its reach.

Competitors:

  • Infectious diseases: Gilead (GILD), Pfizer (PFE)
  • Cancer vaccines: Merck (MRK), Roche (RHHBY), Bristol-Myers Squibb (BMY)

Market share:

  • Precise market share figures for individual competitors are not available.
  • However, the competitors listed above hold significant market share in their respective therapeutic areas.

Competitive advantages:

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.​

About Medicenna Therapeutics Corp

Exchange NASDAQ Headquaters Toronto, ON, Canada
IPO Launch date 2001-08-27 Founder, Chairman, President & CEO Dr. Fahar Merchant Ph.D.
Sector Healthcare Website https://www.medicenna.com
Industry Biotechnology Full time employees 16
Headquaters Toronto, ON, Canada
Founder, Chairman, President & CEO Dr. Fahar Merchant Ph.D.
Website https://www.medicenna.com
Website https://www.medicenna.com
Full time employees 16

Medicenna Therapeutics Corp., an immunotherapy company, engages in the development and commercialization of Superkines and empowered Superkines for the treatment of cancer and other diseases. It develops bizaxofusp (MDNA55), an interleukin- 4 (IL-4) EC for the treatment of recurrent glioblastoma, as well as for brain tumors. The company also develops MDNA11, an enhanced version of IL-2 to activate and proliferate the immune cells needed to fight cancer; MDNA209, an IL-2 antagonist for autoimmune diseases, such as multiple sclerosis and graft versus host disease; MDNA413, a dual IL-4/IL-13 antagonist to treat cancer immunotherapies; MDNA113, a masked bi-functional anti-PD1-IL2 Superkine for various solid tumors; and MDNA132, an IL-13 Superkine for various tumors. In addition, it provides BiSKITs platform to develop designer Superkines by fusing them to other proteins, inhibitors, antibodies, cytokines, or other Superkines Medicenna Therapeutics Corp. is headquartered in Toronto, Canada.

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