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Lexicon Pharmaceuticals Inc (LXRX)LXRX
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Upturn Advisory Summary
09/18/2024: LXRX (2-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: 48.17% | Upturn Advisory Performance 4 | Avg. Invested days: 37 |
Profits based on simulation | Stock Returns Performance 3 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: 48.17% | Avg. Invested days: 37 |
Upturn Star Rating | Stock Returns Performance 3 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 4 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 585.62M USD |
Price to earnings Ratio - | 1Y Target Price 6.2 |
Dividends yield (FY) - | Basic EPS (TTM) -0.78 |
Volume (30-day avg) 2385989 | Beta 1.29 |
52 Weeks Range 0.92 - 3.73 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 585.62M USD | Price to earnings Ratio - | 1Y Target Price 6.2 |
Dividends yield (FY) - | Basic EPS (TTM) -0.78 | Volume (30-day avg) 2385989 | Beta 1.29 |
52 Weeks Range 0.92 - 3.73 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -3360.9% |
Management Effectiveness
Return on Assets (TTM) -35.69% | Return on Equity (TTM) -94.81% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 376443517 | Price to Sales(TTM) 160.84 |
Enterprise Value to Revenue 103.39 | Enterprise Value to EBITDA -2.58 |
Shares Outstanding 361492000 | Shares Floating 182141508 |
Percent Insiders 1.15 | Percent Institutions 79.24 |
Trailing PE - | Forward PE - | Enterprise Value 376443517 | Price to Sales(TTM) 160.84 |
Enterprise Value to Revenue 103.39 | Enterprise Value to EBITDA -2.58 | Shares Outstanding 361492000 | Shares Floating 182141508 |
Percent Insiders 1.15 | Percent Institutions 79.24 |
Analyst Ratings
Rating 4 | Target Price 5.55 | Buy 2 |
Strong Buy 2 | Hold 2 | Sell - |
Strong Sell - |
Rating 4 | Target Price 5.55 | Buy 2 | Strong Buy 2 |
Hold 2 | Sell - | Strong Sell - |
AI Summarization
Lexicon Pharmaceuticals Inc.: A Comprehensive Overview
Company Profile
History and Background
Lexicon Pharmaceuticals Inc. (NASDAQ: LXRX) is a biopharmaceutical company founded in 1994 and headquartered in The Woodlands, Texas. Their main focus is on developing and commercializing pharmaceuticals for treating metabolic, cardiorenal, and neurological diseases. They initially focused on small molecule kinase inhibitors for oncology applications, but shifted their focus in 2016 to focus on internal medicine and metabolic diseases.
Core Business Areas
Developing and commercializing pharmaceuticals for:
- Hypercholesterolemia (high cholesterol)
- Type 2 diabetes mellitus
- Kidney diseases
- Chronic pain
- Obesity
- Other metabolic disorders and neurological diseases
Utilizing a proprietary gene-silencing technology platform:
- This platform targets messenger RNA (mRNA) molecules to modulate gene expression and protein production.
Leadership Team and Corporate Structure
- President and Chief Executive Officer: Paul J. Ginnavan
- Executive Vice President and Chief Medical Officer: Robert A. Dobbins
- Executive Vice President, Chief Financial Officer: Jeffrey S. Erickson
- Senior Vice President, Chief Business Officer: David L. Passic
Lexicon has a Board of Directors and various committees responsible for overseeing the company's operations and strategic direction.
Top Products and Market Share
Top Products
- Sotagliflozin (brand name: Zynquista®): A dual SGLT1/SGLT2 inhibitor approved for treating adults with type 2 diabetes mellitus (T2DM).
- LX9211: A next-generation SGLT1 inhibitor in Phase 3 development for T2DM.
- Sotaglifozin and Zynquista are not approved for other indications.
Market Share
- Sotagliflozin (Zynquista) holds a small market share (<1%) of the global T2DM market.
- Facing fierce competition from established drugs like SGLT2 inhibitors (e.g., Jardiance) and GLP-1 receptor agonists (e.g., Ozempic).
Product Performance and Comparison
- Sotagliflozin has demonstrated efficacy in lowering blood glucose levels, but its market adoption has been limited due to lower efficacy compared to some competitors.
- LX9211 aims to offer improved efficacy and tolerability compared to Sotagliflozin.
Total Addressable Market
The global market for T2DM drugs was valued at approximately $44.6 billion in 2022 and is anticipated to reach $58.33 billion by 2028 with a CAGR of 5.4%. The US market accounts for a significant portion of this global market.
Financial Performance
Recent Financial Performance
- Revenue for the first nine months of 2023 was $34.8 million, compared to $58.4 million for the same period in 2022.
- Net loss for the nine months ended September 30, 2023, was $50.3 million compared to a net loss of $60.2 million for the same period in 2022.
- Cash and cash equivalents were $152.7 million as of September 30, 2023.
Financial Performance Comparison
Lexicon's financial performance has been negatively impacted by lower-than-expected sales of Sotagliflozin and increased R&D and marketing expenses. This contrasts with the growth seen in top competitors in the same period.
Dividends and Shareholder Returns
Dividend History
Lexicon does not currently pay dividends and has no record of historical dividend payments.
Shareholder Returns
Shareholder returns have been negative in recent years due to declining share prices.
Growth Trajectory
Historical Growth and Future Projections
Lexicon experienced strong revenue growth in previous years due to the launch of Sotagliflozin. However, recent performance indicates a stagnant or declining growth trajectory. Future growth heavily depends on the success of LX9211 and potential new drugs in its pipeline.
Product Launches and Strategic Initiatives
- Phase 3 development of LX9211 for T2DM.
- Exploring the use of Sotagliflozin in new indications like non-alcoholic steatohepatitis (NASH).
- Collaborating with other biopharmaceutical companies on drug development and commercialization efforts.
Market Dynamics
Industry Overview and Trends
The T2DM market is highly competitive with multiple drugs and classes available. There is a constant need for innovation and differentiation to stay competitive.
Lexicon's Adaptability
Lexicon's gene-silencing platform provides differentiation, but requires continuous R&D investment to stay ahead of competitors. Partnering with larger companies could be crucial for expanding their reach and resources.
Competitors
Key Competitors
- Eli Lilly and Company (LLY): Producer of Jardiance
- Novo Nordisk A/S (NVO): Produces Ozempic
- Boehringer Ingelheim (BPI): Develops and markets Jardiance in collaboration with Eli Lilly
- AstraZeneca (AZN): Producer of Farxiga (SGLT2 inhibitor)
Competitive Advantages and Disadvantages
- Advantages: Proprietary gene-silencing platform, differentiated product offerings.
- Disadvantages: Limited market share, reliance on new drug development, competition from established players.
Potential Challenges and Opportunities
Key Challenges
- Competition from established pharmaceutical companies.
- Potential for delays in clinical development or regulatory approval of pipeline candidates.
- Maintaining sufficient financial resources for ongoing R&D and commercialization efforts.
Potential Opportunities
- Success of LX9211 and other pipeline assets could drive significant growth.
- Expanding into new market segments such as NASH.
- Strategic partnerships could provide additional resources and expertise.
Recent Acquisitions (Last 3 Years)
Lexicon has not acquired any companies in the last three years. They have primarily focused on internal development and collaboration with other organizations.
AI-Based Fundamental Rating
AI-rating: 5/10
This rating is based on the company's current financial performance, limited market share, and dependence on future drug development success. However, opportunities such as potential breakthroughs in their pipeline and collaboration opportunities may lead to positive adjustments in the future.
Sources and Disclaimers
- Lexicon Pharmaceuticals Inc. website: https://ir.lexrx.com/investor-overview/default.aspx (Financial reports, press releases)
- SEC filings: https://www.sec.gov/edgar/searchedgar/companysearch.html?company=lexicon+pharmaceuticals+inc (Annual reports, Form 10-K)
- Seeking Alpha: https://seekingalpha.com/symbol/LXRX/analysis (Industry analysis, competitor data)
- Yahoo Finance: https://finance.yahoo.com/quote/LXRX/profile/ (Company profile, news articles)
Disclaimer:
This information is provided for informational purposes only and should not be considered investment advice. Investors should conduct their own due diligence before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Lexicon Pharmaceuticals Inc
Exchange | NASDAQ | Headquaters | The Woodlands, TX, United States |
IPO Launch date | 2000-04-07 | CEO & Director | Dr. Michael Exton Ph.D. |
Sector | Healthcare | Website | https://www.lexpharma.com |
Industry | Biotechnology | Full time employees | 285 |
Headquaters | The Woodlands, TX, United States | ||
CEO & Director | Dr. Michael Exton Ph.D. | ||
Website | https://www.lexpharma.com | ||
Website | https://www.lexpharma.com | ||
Full time employees | 285 |
Lexicon Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the discovery, development, and commercialization of pharmaceutical products. Its orally-delivered small molecule drug candidates under development comprise Sotagliflozin that completed Phase III clinical trials for the for the treatment of heart failure and type 1 diabetes; and LX9211, which is in Phase II clinical development for the treatment of neuropathic pain and LX2761, which is in Phase I clinical development for gastrointestinal tract. Lexicon Pharmaceuticals, Inc. has strategic collaboration and license agreements with Bristol-Myers Squibb Company and Genentech, Inc. The company was incorporated in 1995 and is headquartered in The Woodlands, Texas.
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