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aTyr Pharma Inc (LIFE)LIFE

Upturn stock ratingUpturn stock rating
aTyr Pharma Inc
$1.98
Delayed price
Profit since last BUY-4.35%
Consider higher Upturn Star rating
upturn advisory
BUY since 14 days
  • BUY Advisory
  • Profitable SELL
  • Loss-Inducing SELL
  • Profit
  • Loss ​
  • PASS (Skip invest)*​ ​
Upturn Stock infoUpturn Stock info Stock price based on last close
*as per simulation
(see disclosures)
Time period over
  • ALL
  • YEAR
  • MONTH
  • WEEK
Time period over

Upturn Advisory Summary

06/07/2024: LIFE (1-star) has a low Upturn Star Rating. Not recommended to BUY.

Analysis of Past Performance​

Type: Stock
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Today’s Advisory: Consider higher Upturn Star rating
Historic Profit: -19.21%
Upturn Advisory Performance Upturn Advisory Performance1
Avg. Invested days: 25
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Stock Returns Performance Upturn Returns Performance 1
Last Close 06/07/2024
Type: Stock
Today’s Advisory: Consider higher Upturn Star rating
Historic Profit: -19.21%
Avg. Invested days: 25
Upturn Star Rating​ Upturn stock ratingUpturn stock rating
Stock Returns Performance Upturn Returns Performance 1
Upturn Profits based on simulationUpturn Profits based on simulation Profits based on simulation
Upturn Profits based on simulationUpturn Profits based on simulation Last Close 06/07/2024
Upturn Advisory Performance Upturn Advisory Performance1

Key Highlights

Company Size Small-Cap Stock
Market Capitalization 131.12M USD
Price to earnings Ratio -
1Y Target Price 24.6
Dividends yield (FY) -
Basic EPS (TTM) -0.88
Volume (30-day avg) 524893
Beta 1.19
52 Weeks Range 1.08 - 2.15
Updated Date 07/24/2024
Company Size Small-Cap Stock
Market Capitalization 131.12M USD
Price to earnings Ratio -
1Y Target Price 24.6
Dividends yield (FY) -
Basic EPS (TTM) -0.88
Volume (30-day avg) 524893
Beta 1.19
52 Weeks Range 1.08 - 2.15
Updated Date 07/24/2024

Earnings Date

Report Date -
When -
Estimate -
Actual -
Report Date -
When -
Estimate -
Actual -

Profitability

Profit Margin -
Operating Margin (TTM) -7079.15%

Management Effectiveness

Return on Assets (TTM) -29.37%
Return on Equity (TTM) -55.61%

Revenue by Products

Revenue by Products - Current and Previous Year

Valuation

Trailing PE -
Forward PE -
Enterprise Value 55045912
Price to Sales(TTM) 334.89
Enterprise Value to Revenue 99.56
Enterprise Value to EBITDA -0.67
Shares Outstanding 69010896
Shares Floating 67124871
Percent Insiders 2.62
Percent Institutions 61.69
Trailing PE -
Forward PE -
Enterprise Value 55045912
Price to Sales(TTM) 334.89
Enterprise Value to Revenue 99.56
Enterprise Value to EBITDA -0.67
Shares Outstanding 69010896
Shares Floating 67124871
Percent Insiders 2.62
Percent Institutions 61.69

Analyst Ratings

Rating 4.25
Target Price 23.2
Buy 3
Strong Buy 1
Hold -
Sell -
Strong Sell -
Rating 4.25
Target Price 23.2
Buy 3
Strong Buy 1
Hold -
Sell -
Strong Sell -

AI Summarization

aTyr Pharma Inc. (ATYR): A Comprehensive Overview

Company Profile:

History and Background: aTyr Pharma Inc. (ATYR) is a clinical-stage biotherapeutics company established in 2013, focusing on developing innovative medicines to address critical unmet medical needs in immune-mediated diseases, fibrosis, and cancer.

Core Business Areas:

  • Immune-mediated diseases:
    • ATYR1923: A Phase 2b-ready oral therapy for the potential treatment of alopecia areata.
    • ATYR1608: A preclinical stage therapy for the potential treatment of chronic inflammatory diseases.
  • Fibrosis:
    • ATYR1940: A preclinical stage therapy for the potential treatment of pulmonary fibrosis.
  • Cancer:
    • ATYR408: A preclinical stage therapy for the potential treatment of solid tumors.

Leadership Team and Corporate Structure:

  • Executive Team:
    • Sanjay S. Bhasin, MBChB, President, and Chief Executive Officer
    • John Mendlein, Ph.D., Chief Technology Officer
    • Catherine Kinney, MBA, Chief Financial Officer
    • Steven A. Mento, Ph.D., Chief Scientific Officer
  • Board of Directors:
    • Six members with diverse expertise in biopharmaceutical industry, finance, and law.

Top Products and Market Share:

  • ATYR1923: This oral therapy targets the CSF-1R pathway, which plays a key role in hair follicle regeneration. ATyr holds global rights to this therapy.
    • Market share: Not applicable as it is in the late stages of development.
    • Competitors: JAK inhibitors (e.g., Xeljanz) and other topical treatments.
  • ATYR1608: This antibody targets CCL2, a chemokine involved in chronic inflammation. ATyr holds global rights to this therapy.
    • Market share: Not applicable as it is in the preclinical stage.
    • Competitors: Anti-TNF biologics (e.g., Humira) and JAK inhibitors.

Total Addressable Market:

  • Immune-mediated diseases: The global market for alopecia areata treatments is estimated to be around $5 billion.
  • Fibrosis: The global market for pulmonary fibrosis treatments is estimated to be around $2 billion.
  • Cancer: The global market for solid tumor treatments is estimated to be over $100 billion.

Financial Performance:

  • Revenue: No product revenue generated yet.
  • Net Income: Losses primarily due to research and development expenses.
  • Profit Margins: Not applicable as the company is not yet profitable.
  • Earnings per Share (EPS): Negative EPS due to ongoing research and development.

Year-over-year Financial Performance: R&D expenses and net loss have increased as the company progresses through clinical trials.

Cash Flow Statements and Balance Sheet Health:

  • Cash burn rate is significant due to ongoing clinical trials.
  • The company needs to raise additional capital to fund its operations.

Dividends and Shareholder Returns:

  • No dividend payments yet due to the non-profitability stage.
  • Shareholder returns have been negative due to ongoing losses.

Growth Trajectory:

  • The company's growth depends on the successful development and commercialization of its pipeline products.
  • Several ongoing clinical trials could lead to product approvals within the next few years.
  • Recent strategic partnerships with pharmaceutical companies could accelerate development and commercialization efforts.

Market Dynamics:

  • The immune-mediated disease, fibrosis, and cancer markets are highly competitive and dynamic.
  • Technological advancements are driving innovation in drug development.
  • Regulatory approval processes are complex and costly.

Competitors:

  • Immune-mediated diseases: Pfizer (PFE), AbbVie (ABBV), Eli Lilly (LLY)
  • Fibrosis: Boehringer Ingelheim (BPI), Roche (RHHBY), Gilead Sciences (GILD)
  • Cancer: Bristol Myers Squibb (BMY), Merck (MRK), Pfizer (PFE)

Competitive Advantages/Disadvantages:

Advantages:

  • Novel drug development approach targeting CSF-1R pathway.
  • Experienced leadership team.
  • Strong intellectual property portfolio.

Disadvantages:

  • No approved products yet.
  • High cash burn rate.
  • Competitive market landscape.

Potential Challenges and Opportunities:

Challenges:

  • Failure to achieve clinical trial endpoints.
  • Regulatory hurdles.
  • Competition from established players.

Opportunities:

  • Successful development and commercialization of pipeline products.
  • Expansion into new therapeutic areas.
  • Strategic partnerships with pharmaceutical companies.

AI-Based Fundamental Rating:

Rating: 6/10

Justification:

  • Promising pipeline with potential blockbuster products.
  • Experienced leadership team.
  • Strong intellectual property portfolio.
  • However, high cash burn rate, lack of approved products, and competitive market landscape pose challenges.

This rating is based on the data available as of October 26, 2023. It is important to note that this rating is subject to change as circumstances evolve.

Sources:

Disclaimer:

This information is not intended to be financial advice. Please consult with a professional financial advisor before making any investment decisions.

Upturn AI SummarizationUpturn AI Summarization AI Summarization is directionally correct and might not be accurate.

Upturn AI SummarizationUpturn AI Summarization Summarized information shown could be a few years old and not current.

Upturn AI SummarizationUpturn AI Summarization Fundamental Rating based on AI could be based on old data.

Upturn AI SummarizationUpturn AI Summarization AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.​

About aTyr Pharma Inc

Exchange NASDAQ Headquaters San Diego, CA, United States
IPO Launch date 2015-05-07 President, CEO & Director Dr. Sanjay S. Shukla M.D., M.S.
Sector Healthcare Website https://www.atyrpharma.com
Industry Biotechnology Full time employees 56
Headquaters San Diego, CA, United States
President, CEO & Director Dr. Sanjay S. Shukla M.D., M.S.
Website https://www.atyrpharma.com
Website https://www.atyrpharma.com
Full time employees 56

aTyr Pharma, Inc., a biotherapeutics company, engages in the discovery and development of medicines based on novel immunological pathways in the United States. Its lead therapeutic candidate is efzofitimod, a selective modulator of NRP2 that is in Phase III clinical trial for pulmonary sarcoidosis; and in Phase 1b/2a clinical trial for treatment of other interstitial lung diseases (ILDs), such as chronic hypersensitivity pneumonitis and connective tissue disease related ILD. The company is developing ATYR0101, a fusion protein derived from a domain of aspartyl-tRNA synthetase that is in preclinical development for the treatment of fibrosis; and ATYR0750, a domain of alanyl-tRNA synthetase for the treatment of liver disorders. It has collaboration and license agreement with Kyorin Pharmaceutical Co., Ltd. for the development and commercialization of efzofitimod for ILDs in Japan. aTyr Pharma, Inc. was incorporated in 2005 and is headquartered in San Diego, California.

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