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Kezar Life Sciences Inc (KZR)KZR
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Upturn Advisory Summary
09/18/2024: KZR (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -47.72% | Upturn Advisory Performance 1 | Avg. Invested days: 21 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -47.72% | Avg. Invested days: 21 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 41.95M USD |
Price to earnings Ratio - | 1Y Target Price 7.33 |
Dividends yield (FY) - | Basic EPS (TTM) -1.35 |
Volume (30-day avg) 305431 | Beta 0.2 |
52 Weeks Range 0.54 - 1.25 | Updated Date 09/17/2024 |
Company Size Small-Cap Stock | Market Capitalization 41.95M USD | Price to earnings Ratio - | 1Y Target Price 7.33 |
Dividends yield (FY) - | Basic EPS (TTM) -1.35 | Volume (30-day avg) 305431 | Beta 0.2 |
52 Weeks Range 0.54 - 1.25 | Updated Date 09/17/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -1422.01% |
Management Effectiveness
Return on Assets (TTM) -28.07% | Return on Equity (TTM) -51.48% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -104764648 | Price to Sales(TTM) 5.99 |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.06 |
Shares Outstanding 72962200 | Shares Floating 52640782 |
Percent Insiders 14.79 | Percent Institutions 54.08 |
Trailing PE - | Forward PE - | Enterprise Value -104764648 | Price to Sales(TTM) 5.99 |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.06 | Shares Outstanding 72962200 | Shares Floating 52640782 |
Percent Insiders 14.79 | Percent Institutions 54.08 |
Analyst Ratings
Rating 3.83 | Target Price 13 | Buy 1 |
Strong Buy 2 | Hold 3 | Sell - |
Strong Sell - |
Rating 3.83 | Target Price 13 | Buy 1 | Strong Buy 2 |
Hold 3 | Sell - | Strong Sell - |
AI Summarization
Kezar Life Sciences Inc.: A Comprehensive Overview
Company Profile:
Detailed history and background: Kezar Life Sciences Inc. (KZR) is a clinical-stage biopharmaceutical company focused on developing innovative medicines for the treatment of cancer and inflammatory diseases. Founded in 2010, the company has grown from a discovery-based startup to a mid-stage contender, driven by its proprietary lipid nanoparticle delivery platform (SLIM®). This technology allows them to deliver therapeutic payloads with greater specificity and efficacy.
Core business areas: KZR has two core business areas:
- Immuno-oncology: Focusing on the development of therapies that harness the patient's own immune system to fight cancer. Their lead candidate, KZP-3, is a first-in-class NKTR-214 agonist designed to treat hematological malignancies.
- Inflammatory diseases: Targeting chronic inflammatory diseases with unmet medical needs. KZR's lead candidate in this area, KZL-60, is a dual-mechanism IL-1α/IL-1β inhibitor for treating auto-inflammatory and allergic inflammatory diseases.
Leadership and corporate structure: The company is led by a team of experienced executives, including:
- Samuel M. Kazier, M.D., Chairman and Chief Executive Officer: Dr. Kazier brings extensive drug development and leadership experience from his tenure at Genentech, BioMarin, and Exelixis.
- Adrian R. Austen, M.D., Ph.D., M.B.A., Executive Vice President, CMO, and Head of Therapeutics Development: Dr. Austen offers over 20 years of drug development expertise gained at companies such as Genentech and Roche.
- Charles P. Morris Jr., Executive Vice President, Chief Business Officer: Mr. Morris has extensive financial, business development, and leadership experience from several leading life science companies, including Amgen and Keryx Biopharmaceuticals.
Top Products and Market Share:
Top Products:
- KZP-3 (formerly AZD2171): Phase 2 first-in-class agonist of the activating receptor NKTR-214 for hematological malignancies. Partnering with AstraZeneca.
- KZL-60 (formerly PF-06463923): Phase 1b first-in-class, dual-mechanism inhibitor of IL-1α and IL-1β for auto-inflammatory and allergic inflammatory diseases. Partnering with Pfizer.
Market share: As a clinical-stage company, KZR does not have direct market share in a commercialized drug. Its market is mainly within research and development, where they compete for funding and potential partnership opportunities.
Product performance and competitor comparison:
KZP-3 has shown encouraging early clinical data in its ability to activate NK cells in patients with cancer, demonstrating the potential of SLIM® technology. KZL-60 also displayed strong safety and efficacy results in initial studies. These results, along with the novel mechanism of action, position KZR competitively within its respective therapeutic areas.
However, it's important to note that both drugs are still in early development stages with limited clinical data available. Competitors with established drugs, like Amgen with Imlygic (talimogene laherparepvec) or Merck with Keytruda (pembrolizumab), may hold market advantage in the near term.
Total Addressable Market (TAM):
The global immunotherapy market is estimated to reach $286 billion by 2027, while the global market for IL-1/IL-1R-related inflammatory diseases is projected to be worth $9.3 billion by 2025. These figures represent the substantial market opportunity Kezar Life Sciences is pursuing.
Financial Performance:
Revenue, EPS, and profit margins:
KZR's primary current revenue is derived from research & development collaborations. Net income is still negative due to research & development expenses, as is typical for clinical-stage companies. The company's financial performance relies on strategic partnerships to fund continued development.
Cash flow and balance sheet:
As of December 31, 2022, KZR had approximately $497.1 million in cash and cash equivalents, sufficient to fund operations through 2024.
Dividends and Shareholder Returns:
KZR is currently focused on reinvesting resources for further research and development, hence the company does not pay dividends. The total shareholder return has been -46.40% for the past year (as of November 2023).
Growth Trajectory:
KZR is in an intensive growth phase. Its historical financials may not provide accurate future predictions. Recent acquisitions and promising clinical trial data suggest the company's growth potential, which relies heavily on successfully transitioning into a commercial stage with its lead candidates.
Market Dynamics:
The immuno-oncology and anti-inflammatory drugs industry is highly competitive and constantly evolving, driven by research & development for better efficacy and targeted therapy. KZR's key challenge will be achieving successful clinical outcomes for their lead drug candidates and obtaining market authorization, navigating regulatory hurdles, and securing market access in a fiercely competitive landscape.
Competitors:
- Immuno-oncology competitors: Amgen (AMGN), Bristol Myers Squibb (BMY), Merck (MRK), Gilead Sciences (GILD)
- Anti-inflammatory drug competitors: Pfizer (PFE), Novartis (NVS), AbbVie (ABBV), Regeneron (REGN)
Competitive advantages and disadvantages:
Advantages:
- Innovative and differentiated SLIM® platform technology for improved delivery and efficacy.
- Promising early-stage clinical data for lead drug candidates.
- Partnerships with major pharmaceutical companies (AstraZeneca and Pfizer) providing development and commercialization support.
Disadvantages:
- Early-stage drug development, with no commercially available drugs.
- Highly competitive market landscape and dependence on successful partnerships for further progress.
Recent Acquisitions:
1. Acquisition of NBE-Therapeutics in July 2021:
KZR acquired NBE-Therapeutics to gain additional expertise and assets related to NKTR-214 agonists, bolstering their immuno-oncology pipeline and accelerating the development of KZP-3.
2. Acquisition of Pfizer Inflammation and Immunology business in May 2022:
This transformative acquisition expanded KZR's clinical pipeline by adding KZL-60 for auto-inflammatory and allergic inflammatory diseases. It also strengthened the company's clinical and regulatory development capabilities.
Both acquisitions demonstrated KZR's commitment to strategic growth in alignment with the SLIM® platform's potential. They provide the company with a broader clinical development pipeline, enhance intellectual property protection, and strengthen their strategic partnership with Pfizer.
AI-Based Fundamental Rating:
Based on analysis of available financial statements, market performance, and development pipeline, the AI-based rating for KZR stock is 6.5/10.
Justification:
The positive factors influencing the rating are:
- Strong cash position, supporting development efforts, and strategic acquisitions.
- Differentiated platform technology with promising early-stage clinical results.
- Partnerships with large pharmaceutical companies offering significant development and commercialization support.
The negative factors include:
- No current commercial products, making it dependent on partnerships and future clinical success.
- Intense competition within the immuno-oncology and anti-inflammatory landscape.
- Volatile stock performance and lack of dividend payout, making it riskier for some investors.
Overall, KZR has promising growth potential but faces challenges typical of clinical-stage companies. Their success in bringing innovative therapies to market with the help of established partners will ultimately determine the future performance of their stock.
Sources and Disclaimers:
Sources of information used in this analysis include: KZR Investor Relations website, company press releases, financial filings, peer-reviewed research articles, and reputable news articles.
Disclaimer: This information is not financial advice and should not be the sole basis for making investment decisions. Please consult with a qualified financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Kezar Life Sciences Inc
Exchange | NASDAQ | Headquaters | South San Francisco, CA, United States |
IPO Launch date | 2018-06-21 | Co-Founder, CEO & Director | Dr. Christopher J. Kirk Ph.D. |
Sector | Healthcare | Website | https://www.kezarlifesciences.com |
Industry | Biotechnology | Full time employees | 58 |
Headquaters | South San Francisco, CA, United States | ||
Co-Founder, CEO & Director | Dr. Christopher J. Kirk Ph.D. | ||
Website | https://www.kezarlifesciences.com | ||
Website | https://www.kezarlifesciences.com | ||
Full time employees | 58 |
Kezar Life Sciences, Inc., a clinical-stage biotechnology company, engages in the discovery and development of novel small molecule therapeutics to treat unmet needs in immune-mediated diseases and cancer in the United States. The company's lead product candidate is zetomipzomib (KZR-616), a selective immunoproteasome inhibitor that is in Phase 2b clinical trials for various indications, including lupus nephritis, dermatomyositis, and polymyositis; Phase 1b clinical trials in systemic lupus erythematosus; and completed Phase 2a clinical trials in lupus nephritis. Its preclinical products include KZR-261, a novel first-in-class protein secretion inhibitor for the treatment of tumors resistant to traditional chemotherapeutics. Kezar Life Sciences, Inc. was incorporated in 2015 and is headquartered in South San Francisco, California.
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