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Krystal Biotech Inc (KRYS)KRYS
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Upturn Advisory Summary
09/05/2024: KRYS (2-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: 8.63% | Upturn Advisory Performance 3 | Avg. Invested days: 38 |
Profits based on simulation | Stock Returns Performance 2 | Last Close 09/05/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: 8.63% | Avg. Invested days: 38 |
Upturn Star Rating | Stock Returns Performance 2 |
Profits based on simulation Last Close 09/05/2024 | Upturn Advisory Performance 3 |
Key Highlights
Company Size Mid-Cap Stock | Market Capitalization 5.44B USD |
Price to earnings Ratio 47.79 | 1Y Target Price 207.22 |
Dividends yield (FY) - | Basic EPS (TTM) 3.96 |
Volume (30-day avg) 243819 | Beta 0.82 |
52 Weeks Range 93.95 - 219.34 | Updated Date 09/18/2024 |
Company Size Mid-Cap Stock | Market Capitalization 5.44B USD | Price to earnings Ratio 47.79 | 1Y Target Price 207.22 |
Dividends yield (FY) - | Basic EPS (TTM) 3.96 | Volume (30-day avg) 243819 | Beta 0.82 |
52 Weeks Range 93.95 - 219.34 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin 63.73% | Operating Margin (TTM) 29.97% |
Management Effectiveness
Return on Assets (TTM) 0.31% | Return on Equity (TTM) 14.2% |
Valuation
Trailing PE 47.79 | Forward PE 27.25 |
Enterprise Value 4885505337 | Price to Sales(TTM) 32.71 |
Enterprise Value to Revenue 29.39 | Enterprise Value to EBITDA 40.71 |
Shares Outstanding 28730000 | Shares Floating 22894897 |
Percent Insiders 12.32 | Percent Institutions 108.6 |
Trailing PE 47.79 | Forward PE 27.25 | Enterprise Value 4885505337 | Price to Sales(TTM) 32.71 |
Enterprise Value to Revenue 29.39 | Enterprise Value to EBITDA 40.71 | Shares Outstanding 28730000 | Shares Floating 22894897 |
Percent Insiders 12.32 | Percent Institutions 108.6 |
Analyst Ratings
Rating 4.6 | Target Price 150.44 | Buy 2 |
Strong Buy 7 | Hold 1 | Sell - |
Strong Sell - |
Rating 4.6 | Target Price 150.44 | Buy 2 | Strong Buy 7 |
Hold 1 | Sell - | Strong Sell - |
AI Summarization
Krystal Biotech Inc. Overview
Company Profile:
History and Background: Founded in 2015, Krystal Biotech Inc. (KRYS) is a clinical-stage gene therapy company focused on developing treatments for severe and rare diseases. Their initial focus was on the treatment of Biliary Atresia (BA), but they have expanded to other indications.
Core Business Areas: Krystal's primary focus lies in utilizing adeno-associated virus (AAV) vectors to deliver gene therapies to targeted tissues. Their pipeline includes therapies for BA, Crigler-Najjar Syndrome (CNS), and Hematologic Malignancies.
Leadership Team: The leadership team comprises industry veterans with expertise in gene therapy development and commercialization, including:
- Dr. Krishnendu Chakrabarty, Chief Executive Officer and Chairman
- Dr. Paul Colter, Chief Medical Officer
- Dr. Ivan Germenji, Chief Scientific Officer
- Ms. Cynthia Behrens, Chief Financial Officer
- Dr. David Kirn, Chief Operating Officer
Top Products and Market Share:
Products: Krystal's lead candidate, B-VEC, is currently in Phase 1/2 clinical trials for the treatment of BA. Other pipeline assets include AAV-ANGPTL3 for the treatment of CNS and a BCMA-directed CAR-T cell therapy for Hematologic Malignancies.
Market Share: As a clinical-stage company, Krystal currently holds no market share in the commercial space. However, their targeted diseases have the following estimated prevalence:
- BA: 1 in 15,000 births globally
- CNS: 1 in 1,000,000 births worldwide
- Hematologic Malignancies: Varies significantly by specific cancer type
Competition: Krystal faces competition from other companies developing gene therapies for BA and CNS, such as Orphazyme and Intellia Therapeutics. In the Hematologic Malignancies space, the competition is broader and includes established players like Gilead Sciences and Novartis.
Total Addressable Market (TAM):
- BA: Estimated at $2 billion globally
- CNS: Estimated at $500 million globally
- Hematologic Malignancies: Estimated at $100 billion globally
Financial Performance:
Revenue and Earnings: Krystal has not yet generated any product revenue as they are still in the clinical development stage. Their primary revenue comes from research collaborations and government grants.
Profitability: As expected for a clinical-stage company, Krystal is currently unprofitable and operates with net losses primarily driven by R&D expenses.
Cash Flow and Balance Sheet: Krystal has a relatively strong cash position, which provides them runway for continued development of their pipeline. Their balance sheet is also healthy with limited liabilities.
Dividends and Shareholder Returns: Krystal is not currently paying dividends, and its focus on R&D limits its ability to deliver significant shareholder returns in the short term.
Growth Trajectory:
Historical Growth: Krystal has experienced significant growth in its pipeline and partnerships over the past few years. They have successfully progressed their lead candidate through clinical trials and secured several key collaborations.
Future Growth: The success of their ongoing clinical trials and the development of their other pipeline candidates will be crucial drivers of future growth.
Market Dynamics:
Industry Trends: The gene therapy market is experiencing rapid growth driven by advancements in technology, increasing demand for personalized therapies, and supportive government policies.
Krystal's Position: Krystal is well-positioned within this growing market, focusing on rare and severe diseases with significant unmet medical needs.
Potential Challenges and Opportunities:
Key Challenges:
- Clinical trial success: The success of their ongoing trials will determine the future trajectory of the company.
- Competition: The company faces stiff competition from established and emerging players in the gene therapy space.
- Regulatory hurdles: Navigating complex regulatory pathways for gene therapies poses a challenge.
Key Opportunities:
- Expanding Pipeline: Continued development of their pipeline for additional indications could lead to significant growth.
- Strategic Partnerships: Collaboration with larger pharmaceutical companies could accelerate development and commercialization efforts.
- Market Growth: The growing gene therapy market presents a significant opportunity for expansion.
Recent Acquisitions: Krystal has not made any acquisitions within the past three years.
AI-Based Fundamental Rating:
Rating: 7 out of 10.
Justification: Krystal has a promising pipeline and a strong leadership team, but they are still in the clinical stage of development and face stiff competition. The success of their clinical trials will be critical to their future success.
Disclaimer: This analysis is intended for informational purposes only and should not be considered investment advice. It is essential to conduct your own due diligence before making any investment decisions.
Sources:
- Krystal Biotech website: https://krystalaat.com/
- Securities and Exchange Commission filings: https://www.sec.gov/cgi-bin/srch-edgar
- Market research reports from reputable sources such as Grand View Research and EvaluatePharma
I hope this comprehensive overview provides valuable insights into Krystal Biotech Inc.
Please let me know if you have any other questions or require additional information.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Krystal Biotech Inc
Exchange | NASDAQ | Headquaters | Pittsburgh, PA, United States |
IPO Launch date | 2017-09-20 | Founder, Chairman, President & CEO | Mr. Krish S. Krishnan M.B.A., M.S. |
Sector | Healthcare | Website | https://www.krystalbio.com |
Industry | Biotechnology | Full time employees | 229 |
Headquaters | Pittsburgh, PA, United States | ||
Founder, Chairman, President & CEO | Mr. Krish S. Krishnan M.B.A., M.S. | ||
Website | https://www.krystalbio.com | ||
Website | https://www.krystalbio.com | ||
Full time employees | 229 |
Krystal Biotech, Inc., a commercial-stage biotechnology company, discovers, develops, and commercializes genetic medicines for patients with rare diseases in the United States. It commercializes VYJUVEK (beremagene geperpavec-svdt, or B-VEC) for the treatment of dystrophic epidermolysis bullosa (DEB). The company also develops KB105, which is in Phase 1/2 clinical trials for treating patients with deficient autosomal recessive congenital ichthyosis; KB104 for treating netherton syndrome; KB407 that is in Phase 1 clinical trials for treating cystic fibrosis; KB707 that is in Phase 1 clinical trials for the treatment of anti-PD-1 relapsed/refractory; KB408, which is in Phase 1 clinical trials for treating Alpha-1 antitrypsin deficiency; and KB301 that is in Phase 2 clinical trials for treating aesthetic skin conditions, as well as in open label study with ophthalmic B-VEC for treating for ocular complications of deb. Krystal Biotech, Inc. was founded in 2016 and is headquartered in Pittsburgh, Pennsylvania.
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