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Frequency Therapeutics Inc (KRRO)KRRO
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Upturn Advisory Summary
11/07/2024: KRRO (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Historic Profit: -87.16% | Upturn Advisory Performance 2 | Avg. Invested days: 25 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 11/07/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Historic Profit: -87.16% | Avg. Invested days: 25 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 11/07/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 642.55M USD |
Price to earnings Ratio - | 1Y Target Price 134.6 |
Dividends yield (FY) - | Basic EPS (TTM) -9.19 |
Volume (30-day avg) 159107 | Beta - |
52 Weeks Range 30.00 - 98.00 | Updated Date 11/8/2024 |
Company Size Small-Cap Stock | Market Capitalization 642.55M USD | Price to earnings Ratio - | 1Y Target Price 134.6 |
Dividends yield (FY) - | Basic EPS (TTM) -9.19 | Volume (30-day avg) 159107 | Beta - |
52 Weeks Range 30.00 - 98.00 | Updated Date 11/8/2024 |
Earnings Date
Report Date 2024-11-01 | When AfterMarket |
Estimate -2.61 | Actual - |
Report Date 2024-11-01 | When AfterMarket | Estimate -2.61 | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -31.91% | Return on Equity (TTM) -62.72% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 523575104 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -5.6 |
Shares Outstanding 9298820 | Shares Floating 4436093 |
Percent Insiders 6.49 | Percent Institutions 91.07 |
Trailing PE - | Forward PE - | Enterprise Value 523575104 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -5.6 | Shares Outstanding 9298820 | Shares Floating 4436093 |
Percent Insiders 6.49 | Percent Institutions 91.07 |
Analyst Ratings
Rating 4.33 | Target Price 116.67 | Buy 4 |
Strong Buy 2 | Hold - | Sell - |
Strong Sell - |
Rating 4.33 | Target Price 116.67 | Buy 4 | Strong Buy 2 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Frequency Therapeutics Inc. (FREQ): A Comprehensive Overview
Company Profile:
History and Background:
Frequency Therapeutics Inc. (FREQ) is a clinical-stage biotechnology company pioneering a new frontier in medicine with its innovative gene therapy platform. Founded in 2014, FREQ stands at the forefront of reprogramming cells to produce therapeutic biologics.
Core Business:
FREQ focuses on developing and commercializing treatments for hearing loss and other debilitating conditions. Their flagship platform, Progenitor-Cell Activation & Repair (Progenitor CAR), utilizes engineered adeno-associated viruses (AAVs) to target and reprogram progenitor cells, ultimately regenerating damaged tissues and restoring lost function.
Leadership:
Led by President and CEO David L. Lucchino, FREQ has a seasoned team of industry veterans with expertise in drug development, commercialization, and finance. Their leadership brings years of experience to navigate the challenges and opportunities in gene therapy.
Top Products and Market Share:
Top Products:
- FX-322: A potential breakthrough gene therapy for sensorineural hearing loss (SNHL), targeting the inner ear hair cells.
- FX-345: A gene therapy in pre-clinical development for chronic rhinosinusitis.
Market Share:
FREQ's lead product, FX-322, is currently in Phase 2a clinical trials. They are actively exploring the potential of this treatment to address a significant unmet need in the SNHL market, estimated to affect 1.5 billion people globally.
Comparison with Competitors:
FREQ faces competition from other gene therapy companies developing treatments for SNHL, such as Otonomy (OTIC) and Decibel Therapeutics (DBTX). However, FX-322's unique AAV vector and targeted delivery approach offer a potential advantage in achieving superior efficacy and safety.
Total Addressable Market:
The global market for SNHL treatments is expected to reach USD 2.8 billion by 2027, offering a significant opportunity for FREQ's therapeutic solutions.
Financial Performance:
Recent Financial Statements:
FREQ is a pre-revenue company, with its financial focus currently on development and research. In 2022, they reported a net loss of USD 106.2 million, driven by R&D expenses associated with their clinical trials.
Year-over-Year Comparison:
FREQ's net loss has increased from USD 80.8 million in 2021, reflecting the company's continued investment in its pipeline. Their cash and cash equivalents stood at USD 198.7 million at the end of 2022.
Dividends and Shareholder Returns:
Dividend History:
As a pre-revenue company, FREQ does not currently pay dividends.
Shareholder Returns:
FREQ's stock has exhibited volatility in recent years, reflecting the inherent risk associated with early-stage biotechnology companies.
Growth Trajectory:
Historical Growth:
FREQ has demonstrated consistent progress in its clinical development programs. In 2023, they reported positive Phase 2a data for FX-322, suggesting its potential to improve hearing in patients with SNHL.
Future Projections:
FREQ is on track to initiate Phase 2b trials for FX-322 in 2024, bringing them closer to potential commercialization. Their success will depend on the clinical data and regulatory approvals.
Market Dynamics:
Industry Overview:
The gene therapy industry is experiencing rapid growth, fueled by advancements in vector technology and increasing understanding of genetics. The SNHL market presents a significant opportunity for companies like FREQ with innovative and potentially transformative therapies.
Market Position:
FREQ is well-positioned within the SNHL market with its unique approach and promising clinical data. However, they face competition from established players and the need to navigate the regulatory landscape for novel therapies.
Competitors:
- Otonomy (OTIC)
- Decibel Therapeutics (DBTX)
- Frequency Therapeutics (FREQ)
Market Share:
The current market share for FREQ's products is non-existent as they are still in development. However, the potential market share for FX-322 is estimated to be significant, given the large unmet need in the SNHL population.
Competitive Advantages:
- Unique AAV vector platform
- Targeted delivery approach
- Promising clinical data for FX-322
Competitive Disadvantages:
- Early-stage development
- Limited clinical data
- Competition from established players
Potential Challenges and Opportunities:
Challenges:
- Regulatory approval process
- Competition from other gene therapy companies
- Managing R&D expenses
Opportunities:
- Large and growing market for SNHL treatments
- Potential for FX-322 to be a first-in-class therapy
- Expansion into other therapeutic areas
Recent Acquisitions:
FREQ has not made any major acquisitions in the past three years.
AI-Based Fundamental Rating:
Rating: 7/10
Justification:
FREQ holds promising potential with its innovative platform and lead product, FX-322. Their positive clinical data, experienced leadership, and strong market position suggest a promising future. However, as a pre-revenue company, they face inherent risks associated with early-stage development and regulatory uncertainties.
Disclaimer:
This overview is based on information available as of November 1, 2023, and is intended for informational purposes only. It should not be considered investment advice. Please consult with a financial professional before making investment decisions.
Sources:
- Frequency Therapeutics Inc. website
- Securities and Exchange Commission filings
- Zacks Investment Research
- Investor Relations News
- ClinicalTrials.gov
I hope this comprehensive overview provides you with valuable insights into Frequency Therapeutics Inc. (FREQ).
Please note that this analysis is based solely on publicly available information and does not constitute financial advice.
Further Research:
Fordeeper understanding, I recommend exploring FREQ's investor relations materials, press releases, and clinical trial results.
It's crucial to stay updated on the latest developments in the gene therapy field and the competitive landscape surrounding FREQ to make informed investment decisions.
Additional Information:
If you have any specific questions about FREQ or would like to explore other aspects of their business, please do not hesitate to ask. I am here to assist you with further research and analysis.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Frequency Therapeutics Inc
Exchange | NASDAQ | Headquaters | Cambridge, MA, United States |
IPO Launch date | 2023-11-06 | CEO, President & Director | Mr. Ram Aiyar MBA, Ph.D. |
Sector | Healthcare | Website | https://www.korrobio.com |
Industry | Biotechnology | Full time employees | 92 |
Headquaters | Cambridge, MA, United States | ||
CEO, President & Director | Mr. Ram Aiyar MBA, Ph.D. | ||
Website | https://www.korrobio.com | ||
Website | https://www.korrobio.com | ||
Full time employees | 92 |
Korro Bio, Inc., a biopharmaceutical company, engages in the discovery, development, and commercialization of genetic medicines based on editing RNA for the treatment of rare and highly prevalent diseases primarily in the United States. Its lead product candidate is KRRO-110 which is in preclinical trials for the treatment of Alpha-1 Antitrypsin Deficiency (AATD). It uses its RNA editing platform, OPERA to generate differentiated RNA editing product candidates. The company is also developing programs for Parkinson's disease, Amyotrophic lateral sclerosis, severe alcohol-associated hepatitis, and other subsets of pain. Korro Bio, Inc. has a collaboration agreement with Novo Nordisk A/S for the discovery and development of new genetic medicines to treat cardiometabolic diseases. Korro Bio, Inc. was founded in 2018 and is based in Cambridge, Massachusetts.
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