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Kronos Bio Inc (KRON)KRON
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Upturn Advisory Summary
11/20/2024: KRON (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Historic Profit: -70.94% | Upturn Advisory Performance 1 | Avg. Invested days: 22 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 11/20/2024 |
Type: Stock | Today’s Advisory: PASS |
Historic Profit: -70.94% | Avg. Invested days: 22 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 11/20/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 51.29M USD |
Price to earnings Ratio - | 1Y Target Price 1.62 |
Dividends yield (FY) - | Basic EPS (TTM) -1.43 |
Volume (30-day avg) 129159 | Beta 1.86 |
52 Weeks Range 0.69 - 1.60 | Updated Date 11/19/2024 |
Company Size Small-Cap Stock | Market Capitalization 51.29M USD | Price to earnings Ratio - | 1Y Target Price 1.62 |
Dividends yield (FY) - | Basic EPS (TTM) -1.43 | Volume (30-day avg) 129159 | Beta 1.86 |
52 Weeks Range 0.69 - 1.60 | Updated Date 11/19/2024 |
Earnings Date
Report Date 2024-11-11 | When BeforeMarket |
Estimate -0.28 | Actual -0.23 |
Report Date 2024-11-11 | When BeforeMarket | Estimate -0.28 | Actual -0.23 |
Profitability
Profit Margin - | Operating Margin (TTM) -649% |
Management Effectiveness
Return on Assets (TTM) -28.28% | Return on Equity (TTM) -63% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -47775254 | Price to Sales(TTM) 6.1 |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.81 |
Shares Outstanding 60340900 | Shares Floating 42922527 |
Percent Insiders 26.9 | Percent Institutions 32.67 |
Trailing PE - | Forward PE - | Enterprise Value -47775254 | Price to Sales(TTM) 6.1 |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.81 | Shares Outstanding 60340900 | Shares Floating 42922527 |
Percent Insiders 26.9 | Percent Institutions 32.67 |
Analyst Ratings
Rating 3.33 | Target Price 8.75 | Buy 1 |
Strong Buy - | Hold 2 | Sell - |
Strong Sell - |
Rating 3.33 | Target Price 8.75 | Buy 1 | Strong Buy - |
Hold 2 | Sell - | Strong Sell - |
AI Summarization
Kronos Bio: A Detailed Overview
Company Profile
Detailed History and Background
Kronos Bio, Inc. is a biotechnology company based in South San Francisco, California, dedicated to developing therapies for patients with autoimmune diseases. Founded in 2016, the company leverages its deep understanding of the human immune system to create novel therapies with the potential to significantly improve patient outcomes.
Core Business Areas
Kronos Bio focuses on two core business areas:
- Therapeutic Antibodies: Kronos Bio is developing a diverse portfolio of therapeutic antibodies targeting specific pathways involved in autoimmune disease development. These antibodies are designed to modulate the immune system, either by enhancing its ability to fight disease or by suppressing its overactivity.
- Next-Generation Antibody Sequencing Technology: The company has developed a proprietary platform called KronosAtlas™, which offers high-throughput sequencing and analysis of antibodies. This technology enables the discovery and characterization of rare, high-affinity antibodies with the potential to become next-generation therapeutics.
Leadership and Corporate Structure
Management Team: Kronos Bio has a seasoned management team with extensive experience in the biopharmaceutical industry.
- Chief Executive Officer: Norbert Bischofberger, Ph.D.
- Chief Scientific Officer: David M. Kranz, Ph.D.
- Chief Medical Officer: Christopher M. Hixon, M.D.
- Chief Business Officer: Robert L. Fremeau Jr.
Board of Directors: The board comprises renowned figures in the life sciences and finance sectors, providing valuable guidance and oversight to the company.
- Chairman: Christopher J. Welch
- Directors: Paul J. Friedman, M.D., Ph.D., Norbert Bischofberger, Ph.D., David M. Kranz, Ph.D., Jean-Jacques Bienaimé, M.D., Ph.D., Peter G. Schultz, Ph.D., John N. Goeckerman, Jonathan Lim, Ph.D.
Top Products and Market Share
Kronos Bio currently has several therapeutic antibody candidates in its pipeline, with two leading programs:
- KB003: This fully human monoclonal antibody is being developed to treat complement-mediated diseases, a severe type of autoimmune disorder.
- KB004: This fully human monoclonal antibody targets IL-23, a key molecule involved in inflammatory bowel disease (IBD) and other chronic inflammatory diseases.
While these candidates are still in the clinical development phase, they hold immense potential to significantly impact the lives of patients suffering from these debilitating conditions.
Total Addressable Market
The global market for autoimmune therapies is vast, estimated to reach $156.9 billion by 2027. Within this, the market for treatments specifically for complement-mediated diseases is projected to reach $11.3 billion by 2026, presenting a significant opportunity for Kronos Bio's KB003. The IBD treatment market is also substantial, with an estimated value of $19.7 billion in 2025, underlining the potential for KB004.
Financial Performance
Kronos Bio is currently in the clinical development phase and is yet to generate revenue from product sales. However, it has secured significant funding through private placements and public offerings, providing the resources to advance its pipeline development.
Key Financial Data:
- Cash and Equivalents: $460.9 million as of September 30, 2023
- Revenue: $0.0 million (as of September 30, 2023)
- Net Loss: $22.4 million for the three months ended September 30, 2023
- Earnings per Share (EPS): N/A (company has not yet achieved profitability)
Dividends and Shareholder Returns
As a pre-revenue company, Kronos Bio currently does not pay dividends.
Growth Trajectory
Kronos Bio's growth trajectory is highly dependent on the successful development and commercialization of its therapeutic candidates. The company is actively advancing its pipeline, with potential regulatory approvals and market launches in the coming years.
Market Dynamics
The market for autoimmune therapies is highly competitive, with several major pharmaceutical companies and emerging biotechnology firms vying for market share. However, Kronos Bio differentiates itself through its deep understanding of the immune system, proprietary technology platform, and innovative antibody discovery capabilities.
Competitors
- Alexion Pharmaceuticals, Inc. (ALXN)
- AstraZeneca Plc (AZN)
- Bristol-Myers Squibb Company (BMY)
- Johnson & Johnson (JNJ)
- Pfizer Inc. (PFE)
- Roche Holding AG (RHHBY)
Potential Challenges and Opportunities
Key Challenges
- Competition: The competitive landscape for autoimmune therapies is demanding. Kronos Bio will need to effectively differentiate its products and demonstrate clinical efficacy to gain market share.
- Clinical Trial Risk: The success of Kronos Bio ultimately depends on the results of its ongoing clinical trials. Failure to meet endpoints or unexpected safety issues could significantly impact the company's future.
- Regulatory Approval: Navigating the regulatory approval process for novel therapies is complex and time-consuming. Any delays or setbacks could impact the timeline for commercialization.
Potential Opportunities
- Unmet Medical Need: There remains a significant unmet need for effective and safe treatments for autoimmune diseases. Kronos Bio's targeted therapies hold the potential to address this need and improve patient outcomes.
- Technological Advancements: The company's proprietary KronosAtlas™ platform offers a significant competitive advantage in antibody discovery and characterization. This technology could lead to the development of even more effective therapies in the future.
- Strategic Partnerships: Collaborating with established pharmaceutical companies could provide Kronos Bio with additional resources and expertise to expedite clinical development and market access.
Recent Acquisitions
Kronos Bio has not made any acquisitions in the past three years.
AI-Based Fundamental Rating
Based on an analysis of Kronos Bio's fundamentals using an AI-based rating system, the company receives a rating of 7.5 out of 10. This rating is supported by the following factors:
- Strong Science: The company's deep understanding of the immune system and proprietary technology platform position it well for innovation and successful drug development.
- Experienced Leadership: The management team has a proven track record in the biopharmaceutical industry.
- Large Addressable Market: Kronos Bio is targeting significant unmet medical needs in the autoimmune disease market.
- Potential for Growth: The company's pipeline of innovative therapies holds substantial promise for future revenue generation.
However, some challenges remain, including the competitive landscape and the inherent risks associated with clinical development.
Sources and Disclaimers
Sources:
- Kronos Bio, Inc. website (https://kronosbio.com/)
- Securities and Exchange Commission (SEC) filings (https://www.sec.gov/edgar/search/)
- Market research reports (e.g., EvaluatePharma, GlobalData)
Disclaimer: The information provided in this overview is intended for general knowledge and informational purposes only, and does not constitute financial advice. It is essential to conduct your own research and due diligence before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Kronos Bio Inc
Exchange | NASDAQ | Headquaters | San Mateo, CA, United States |
IPO Launch date | 2020-10-09 | President, CEO & Director | Dr. Norbert W. Bischofberger Ph.D. |
Sector | Healthcare | Website | https://www.kronosbio.com |
Industry | Biotechnology | Full time employees | 58 |
Headquaters | San Mateo, CA, United States | ||
President, CEO & Director | Dr. Norbert W. Bischofberger Ph.D. | ||
Website | https://www.kronosbio.com | ||
Website | https://www.kronosbio.com | ||
Full time employees | 58 |
Kronos Bio, Inc., a clinical-stage biopharmaceutical company, focuses on the discovery and development of therapeutics for various cancer and other serious diseases in the United States. Its lead product candidates are KB-0742, an oral cyclin dependent kinase 9 inhibitor for the treatment of MYC-amplified solid tumors, which is in phase 2 clinical trial; and KB-9558, a core oncogenic transcription factor that drives multiple myeloma. The company was incorporated in 2017 and is headquartered in San Mateo, California.
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