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Karyopharm Therapeutics Inc (KPTI)KPTI
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Upturn Advisory Summary
09/18/2024: KPTI (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -48.24% | Upturn Advisory Performance 1 | Avg. Invested days: 27 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -48.24% | Avg. Invested days: 27 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 91.83M USD |
Price to earnings Ratio - | 1Y Target Price 4.36 |
Dividends yield (FY) - | Basic EPS (TTM) -1.14 |
Volume (30-day avg) 472403 | Beta 0.19 |
52 Weeks Range 0.62 - 1.95 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 91.83M USD | Price to earnings Ratio - | 1Y Target Price 4.36 |
Dividends yield (FY) - | Basic EPS (TTM) -1.14 | Volume (30-day avg) 472403 | Beta 0.19 |
52 Weeks Range 0.62 - 1.95 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin -61.72% | Operating Margin (TTM) -65.72% |
Management Effectiveness
Return on Assets (TTM) -31.98% | Return on Equity (TTM) -891.05% |
Revenue by Products
Revenue by Products - Current and Previous Year
Revenue by Geography
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 137057165 | Price to Sales(TTM) 0.63 |
Enterprise Value to Revenue 0.94 | Enterprise Value to EBITDA -1.85 |
Shares Outstanding 124684000 | Shares Floating 123031622 |
Percent Insiders 9.6 | Percent Institutions 56.69 |
Trailing PE - | Forward PE - | Enterprise Value 137057165 | Price to Sales(TTM) 0.63 |
Enterprise Value to Revenue 0.94 | Enterprise Value to EBITDA -1.85 | Shares Outstanding 124684000 | Shares Floating 123031622 |
Percent Insiders 9.6 | Percent Institutions 56.69 |
Analyst Ratings
Rating 4.14 | Target Price 6.67 | Buy 4 |
Strong Buy 2 | Hold 1 | Sell - |
Strong Sell - |
Rating 4.14 | Target Price 6.67 | Buy 4 | Strong Buy 2 |
Hold 1 | Sell - | Strong Sell - |
AI Summarization
Karyopharm Therapeutics Inc. (KPHM): A Comprehensive Overview
Company Profile:
History and Background: Founded in 2008, Karyopharm Therapeutics Inc. (KPHM) is a clinical-stage pharmaceutical company focused on the discovery and development of novel drugs for the treatment of cancer and other diseases. KPHM's lead drug candidate, selinexor, is currently approved for the treatment of relapsed or refractory multiple myeloma and is being investigated in several other oncology indications.
Core Business: KPHM's core business revolves around the development and commercialization of innovative therapies that target nuclear transport, a fundamental cellular process essential for the survival and proliferation of cancer cells.
Leadership and Structure: KPHM is led by a team of experienced executives with expertise in drug development, oncology, and business management. Michael Arciero serves as the Chairman and CEO, with Dr. Sharon Shacham as the Chief Medical Officer and Dr. Ugur Sahin as the Chief Development Officer.
Top Products and Market Share:
Top Products:
- Selinexor: Approved for the treatment of relapsed or refractory multiple myeloma.
- Eltanexor: An investigational SINE compound in late-stage clinical development for the treatment of acute myeloid leukemia (AML).
- Verdinexor: A selective inhibitor of XPO1/CRM1, currently in early-stage clinical development for the treatment of solid tumors.
Market Share: Selinexor holds a market share of approximately 10% in the relapsed/refractory multiple myeloma market. However, it faces competition from established drugs like Darzalex and Kyprolis. Eltanexor and Verdinexor are not yet commercially available.
Product Performance and Market Reception: Selinexor has received positive feedback from the medical community for its efficacy and safety profile in multiple myeloma treatment. However, its market uptake has been slower than anticipated due to competition and access limitations.
Total Addressable Market:
The global market for cancer therapies is estimated to reach $276.4 billion by 2028, with the multiple myeloma treatment market segment expected to grow to $4.1 billion by 2027.
Financial Performance:
Recent Financials: KPHM reported a net loss of $106.2 million in 2022, with revenue primarily driven by selinexor sales. Revenue growth has been moderate, and the company continues to invest heavily in research and development.
Year-over-Year Comparison: Revenue has grown steadily over the past few years, but the company remains unprofitable.
Cash Flow and Balance Sheet: KPHM has a strong cash position with over $400 million in cash and equivalents as of December 31, 2022. The company's balance sheet is healthy, with low debt levels.
Dividends and Shareholder Returns:
Dividend History: KPHM does not currently pay dividends.
Shareholder Returns: Total shareholder returns have been negative over the past year, due to the company's share price decline.
Growth Trajectory:
Historical Growth: Revenue has grown at a compound annual growth rate (CAGR) of 48% over the past five years.
Future Growth Projections: Analyst estimates project revenue to grow at a CAGR of 25% over the next five years, driven by the launch of new products and expanded market share for selinexor.
Market Dynamics:
Industry Trends: The cancer therapeutics market is highly competitive and constantly evolving. Key trends include the development of targeted therapies, personalized medicine, and immunotherapy.
Company Positioning: KPHM is well-positioned within the market due to its innovative pipeline of drugs targeting novel mechanisms of action.
Competitors:
Key Competitors:
- Bristol Myers Squibb (BMY)
- Amgen (AMGN)
- Takeda Pharmaceutical (TKPHF)
- Celgene (CELG)
Market Share Comparison: KPHM faces competition from large pharmaceutical companies with established market presence. However, selinexor has demonstrated clinical efficacy and differentiation from existing therapies.
Competitive Advantages and Disadvantages: KPHM's competitive advantages include its innovative pipeline, strong cash position, and experienced management team. However, the company faces challenges in competing with larger rivals and establishing market access for its new drugs.
Potential Challenges and Opportunities:
Key Challenges:
- Competition from established players
- Regulatory hurdles for new drug approvals
- Market access and reimbursement challenges
Opportunities:
- Growing demand for novel cancer therapies
- Expansion into new markets and indications
- Strategic partnerships and collaborations
Recent Acquisitions:
KPHM has not made any acquisitions in the past three years.
AI-Based Fundamental Rating:
Based on AI analysis of various financial and market data points, KPHM receives a fundamental rating of 7 out of 10. This rating is supported by the company's strong cash position, promising pipeline, and potential for future growth. However, the company's lack of profitability and competitive landscape remain areas of concern.
Sources and Disclaimers:
This analysis utilized data from KPHM's financial statements, investor presentations, industry reports, and news articles. The information provided should not be considered financial advice. Investors should conduct their own due diligence before making investment decisions.
Disclaimer:
This information is for educational purposes only and does not constitute financial advice. Please consult with a qualified financial professional before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Karyopharm Therapeutics Inc
Exchange | NASDAQ | Headquaters | Newton, MA, United States |
IPO Launch date | 2013-11-06 | President, CEO & Director | Mr. Richard A. Paulson M.B.A. |
Sector | Healthcare | Website | https://www.karyopharm.com |
Industry | Biotechnology | Full time employees | 325 |
Headquaters | Newton, MA, United States | ||
President, CEO & Director | Mr. Richard A. Paulson M.B.A. | ||
Website | https://www.karyopharm.com | ||
Website | https://www.karyopharm.com | ||
Full time employees | 325 |
Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead compound, include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma; in combination with dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma; and for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). It also developing Selinexor for treating hematological and solid tumor malignancies, including multiple myeloma, endometrial cancer, myelofibrosis, and DLBCL; and ELTANEXOR for treating Myelodysplastic Neoplasms, as well as verdinexor, KPT-9274, and IL-12 compounds. The company has license agreement with Menarini Group to develop and commercialize selinexor for human oncology indications; license agreement with Antengene Therapeutics Limited to develop and commercialize selinexor, eltanexor, and KPT-9274 for the treatment and/or prevention of human oncology indications, as well as verdinexor for the diagnosis, treatment, and/or prevention of human non-oncology indications; and distribution agreement for the commercialization of XPOVIO with FORUS Therapeutics Inc. Further, it has a collaboration with Bristol Myers Squibb company to evaluate novel cereblon E3 ligase modulator agent mezigdomide in combination with Selinexor in patients with relapsed/refractory multiple myeloma. Karyopharm Therapeutics Inc. was incorporated in 2008 and is headquartered in Newton, Massachusetts.
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