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IO Biotech Inc (IOBT)IOBT
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Upturn Advisory Summary
09/18/2024: IOBT (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -47.51% | Upturn Advisory Performance 2 | Avg. Invested days: 20 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -47.51% | Avg. Invested days: 20 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 78.40M USD |
Price to earnings Ratio - | 1Y Target Price 8.2 |
Dividends yield (FY) - | Basic EPS (TTM) -1.26 |
Volume (30-day avg) 718640 | Beta 0.51 |
52 Weeks Range 0.73 - 2.10 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 78.40M USD | Price to earnings Ratio - | 1Y Target Price 8.2 |
Dividends yield (FY) - | Basic EPS (TTM) -1.26 | Volume (30-day avg) 718640 | Beta 0.51 |
52 Weeks Range 0.73 - 2.10 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -50.98% | Return on Equity (TTM) -87.66% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -20198713 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 1.36 |
Shares Outstanding 65880900 | Shares Floating 26841861 |
Percent Insiders 0.24 | Percent Institutions 77.3 |
Trailing PE - | Forward PE - | Enterprise Value -20198713 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 1.36 | Shares Outstanding 65880900 | Shares Floating 26841861 |
Percent Insiders 0.24 | Percent Institutions 77.3 |
Analyst Ratings
Rating 4.4 | Target Price 10 | Buy 3 |
Strong Buy 2 | Hold - | Sell - |
Strong Sell - |
Rating 4.4 | Target Price 10 | Buy 3 | Strong Buy 2 |
Hold - | Sell - | Strong Sell - |
AI Summarization
IO Biotech Inc. (IOBT): A Comprehensive Overview
Company Profile
Detailed History and Background:
IO Biotech Inc. (IOBT) is a clinical-stage biotechnology company founded in 2015 and headquartered in Philadelphia, Pennsylvania. IOBT focuses on developing novel therapies for cancer and infectious diseases. The company utilizes a proprietary immunotherapy platform known as IOSTORM to engineer T cells and design tumor-targeted therapies.
Core Business Areas:
- Oncology: IOBT's primary focus lies in developing cancer immunotherapies. Its lead program, IO102-M, is a T cell receptor engineered T cell therapy targeting the MAGE-A4 antigen for various cancers.
- Infectious Diseases: IOBT is also exploring the application of its platform for infectious diseases. The company's IO103 program involves developing T cell therapies targeting the cytomegalovirus (CMV) for immunocompromised patients.
Leadership and Corporate Structure:
Dr. Maihle Ho is the CEO and President of IOBT. The leadership team comprises experienced professionals with expertise in biotechnology, immunology, and drug development.
Top Products and Market Share
Top Products and Offerings:
- IO102-M: This is a lead T cell receptor engineered T cell therapy targeting the MAGE-A4 antigen for various cancers, including non-small cell lung cancer, head and neck cancer, and bladder cancer.
- IO103: This program focuses on developing T cell therapies targeting the CMV for immunocompromised patients.
Market Share Analysis:
IOBT is currently in the clinical development stage and has not yet launched any commercial products. Therefore, it does not hold a market share in the global or US markets.
Product Performance and Market Reception:
IO102-M has shown promising results in early-stage clinical trials, demonstrating anti-tumor activity in patients with advanced MAGE-A4-positive cancers. However, it is still in the early stages of development, and further clinical trials are necessary to assess its long-term efficacy and safety.
Total Addressable Market
The global immunotherapy market is expected to reach USD 200.9 billion by 2027, growing at a CAGR of 13.7%. The US market represents a significant portion of this market, with an estimated value of USD 70 billion in 2023.
Financial Performance
Recent Financial Statements:
IOBT is a pre-revenue company, and its financial statements mainly reflect expenses related to research and development, clinical trials, and administrative costs. In 2022, the company reported a net loss of USD 74.4 million with no revenue.
Year-over-Year Comparison:
IOBT's net loss has increased significantly year-over-year, primarily due to increased investments in clinical trials for its lead programs.
Cash Flow and Balance Sheet:
As of December 31, 2022, IOBT had a cash and cash equivalents balance of USD 142.2 million. The company has a strong cash position, but it will require additional funding to support its ongoing clinical development programs.
Dividends and Shareholder Returns
Dividend History:
IOBT does not currently pay dividends as it is a pre-revenue company focused on reinvesting its resources into research and development.
Shareholder Returns:
IOBT's stock has been volatile since its IPO in 2021. The share price has experienced significant fluctuations due to various factors, including clinical trial results and market sentiment towards the biotechnology sector.
Growth Trajectory
Historical Growth:
IOBT has experienced rapid growth in recent years, primarily driven by advancing its clinical development programs. The company has successfully completed several clinical trials and is currently enrolling patients in Phase 2 trials for its lead programs.
Future Growth Projections:
IOBT's future growth will depend on the success of its clinical trials and the commercialization of its lead programs. The company is targeting approval for IO102-M in 2025 and expects to launch additional programs in the coming years.
Recent Initiatives:
IOBT is actively pursuing strategic partnerships and collaborations to accelerate its growth. The company recently entered into a clinical trial collaboration with the University of Pennsylvania to evaluate IO102-M in combination with other cancer therapies.
Market Dynamics
Industry Overview:
The immunotherapy market is a rapidly growing sector driven by advancements in T cell engineering and the development of personalized therapies. The industry is characterized by intense competition, with several major pharmaceutical companies and smaller biotechnology firms developing similar approaches.
IOBT's Positioning:
IOBT is well-positioned in the immunotherapy market with its proprietary IOSTORM platform and promising lead programs. The company's focus on developing novel T cell therapies for difficult-to-treat cancers and infectious diseases positions it for future growth.
Competitors
Key Competitors:
- Adaptimmune Therapeutics (ADAP)
- Atara Biotherapeutics (ATRA)
- Carisma Therapeutics (CTRX)
- Century Therapeutics (IPSC)
- Legend Biotech (LEGN)
- Poseida Therapeutics (PSTX)
Competitive Advantages and Disadvantages:
IOBT's competitive advantages include its proprietary IOSTORM platform, experienced leadership team, and promising clinical development programs. However, the company faces competition from established pharmaceutical companies and other smaller biotechnology firms with similar approaches.
Potential Challenges and Opportunities
Key Challenges:
- Clinical Trial Success: The success of IOBT's clinical trials is crucial for its future growth. The company needs to demonstrate the efficacy and safety of its lead programs to gain regulatory approval and commercialize its therapies.
- Competition: The immunotherapy market is highly competitive, and IOBT faces competition from established players with significant resources and experience.
- Funding Requirements: As a pre-revenue company, IOBT will require additional funding to support its ongoing clinical development programs and commercialization efforts.
Potential Opportunities:
- Commercialization of IO102-M: The successful commercialization of IO102-M could generate significant revenue for IOBT and establish the company as a leader in the immunotherapy market.
- Expansion into New Markets and Indications: IOBT could explore opportunities to expand its pipeline into new therapeutic areas and indications beyond cancer and infectious diseases.
- Strategic Partnerships: Entering into strategic partnerships with larger pharmaceutical companies could provide IOBT with access to additional funding, expertise, and market reach.
Recent Acquisitions (Last 3 Years)
IOBT has not made any acquisitions in the last 3 years.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About IO Biotech Inc
Exchange | NASDAQ | Headquaters | - |
IPO Launch date | 2021-11-05 | Founder, President, CEO, Principal Financial Officer & Director | Dr. Mai-Britt Zocca Ph.D. |
Sector | Healthcare | Website | https://www.iobiotech.com |
Industry | Biotechnology | Full time employees | 74 |
Headquaters | - | ||
Founder, President, CEO, Principal Financial Officer & Director | Dr. Mai-Britt Zocca Ph.D. | ||
Website | https://www.iobiotech.com | ||
Website | https://www.iobiotech.com | ||
Full time employees | 74 |
IO Biotech, Inc., a clinical-stage biopharmaceutical company, develops immune-modulating therapeutic cancer vaccines based on the T-win technology platform. The company's lead product candidate, IO102-IO103, which is designed to target immunosuppressive mechanisms mediated by Indoleamine 2,3-dehydrogenase (IDO), and programmed death-ligand (PD-L1) that is in phase 3 clinical trial to treat melanoma, as well as in phase 2 clinical trial to treat lung, head and neck, bladder, and melanoma cancer. It also develops IO112, a product candidate that contains a single Arginase 1-derived peptide designed to target T cells that recognize epitopes derived from Arginase 1 for the treatment of cancers. The company was incorporated in 2014 and is based in Copenhagen, Denmark.
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