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INmune Bio Inc (INMB)INMB
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Upturn Advisory Summary
11/07/2024: INMB (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Historic Profit: -25.57% | Upturn Advisory Performance 2 | Avg. Invested days: 21 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 11/07/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Historic Profit: -25.57% | Avg. Invested days: 21 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 11/07/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 137.91M USD |
Price to earnings Ratio - | 1Y Target Price 19.83 |
Dividends yield (FY) - | Basic EPS (TTM) -2.18 |
Volume (30-day avg) 256174 | Beta 1.85 |
52 Weeks Range 4.78 - 14.74 | Updated Date 11/8/2024 |
Company Size Small-Cap Stock | Market Capitalization 137.91M USD | Price to earnings Ratio - | 1Y Target Price 19.83 |
Dividends yield (FY) - | Basic EPS (TTM) -2.18 | Volume (30-day avg) 256174 | Beta 1.85 |
52 Weeks Range 4.78 - 14.74 | Updated Date 11/8/2024 |
Earnings Date
Report Date 2024-10-31 | When AfterMarket |
Estimate -0.5 | Actual -0.6 |
Report Date 2024-10-31 | When AfterMarket | Estimate -0.5 | Actual -0.6 |
Profitability
Profit Margin - | Operating Margin (TTM) -98921.43% |
Management Effectiveness
Return on Assets (TTM) -44.97% | Return on Equity (TTM) -98.96% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 107273645 | Price to Sales(TTM) 3283.64 |
Enterprise Value to Revenue 2670.28 | Enterprise Value to EBITDA -5.31 |
Shares Outstanding 22172500 | Shares Floating 14310100 |
Percent Insiders 28.73 | Percent Institutions 21.43 |
Trailing PE - | Forward PE - | Enterprise Value 107273645 | Price to Sales(TTM) 3283.64 |
Enterprise Value to Revenue 2670.28 | Enterprise Value to EBITDA -5.31 | Shares Outstanding 22172500 | Shares Floating 14310100 |
Percent Insiders 28.73 | Percent Institutions 21.43 |
Analyst Ratings
Rating 4.5 | Target Price 17.33 | Buy 3 |
Strong Buy 3 | Hold - | Sell - |
Strong Sell - |
Rating 4.5 | Target Price 17.33 | Buy 3 | Strong Buy 3 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Inmune Bio Inc.: A Detailed Overview
Company Profile:
Detailed history and background of INmune Bio Inc.:
Founded in 2010 and headquartered in Philadelphia, Pennsylvania, Inmune Bio Inc. (NASDAQ: INMB) is a clinical-stage biopharmaceutical company dedicated to developing and commercializing transformative therapies for patients with severe autoimmune diseases. Initially called Ribon Therapeutics, the company rebranded as Inmune Bio in 2022 to better reflect its focus on immunology and biologics.
Description of the company’s core business areas:
Inmune Bio primarily focuses on two main areas:
- XPro™ technology platform: This proprietary platform allows the identification and production of fully human polyclonal antibodies from the blood of patients with rare autoimmune diseases. These antibodies, known as XPro™ antibodies, are highly specific and potent, with the potential to revolutionize the treatment of autoimmune diseases.
- Therapeutic development: Utilizing the XPro™ platform, Inmune Bio is developing a pipeline of potential therapies for various autoimmune diseases, including its lead candidate, XPro1595, which is currently in Phase 2 clinical trials for the treatment of neuromyelitis optica spectrum disorder (NMOSD).
Overview of the company’s leadership team and corporate structure:
The leadership team of Inmune Bio comprises experienced individuals with expertise in biopharmaceutical development, finance, and business operations. Notably, the team includes:
- Dr. Raymond J. Tesi, Ph.D., MBA: President and Chief Executive Officer, with extensive experience in leadership roles across various pharmaceutical companies.
- Dr. Arthur A. Krieg, Ph.D.: Chief Scientific Officer, a veteran in the field of immunology and gene therapy.
- Mr. Robert J. Landry: Chief Financial Officer, bringing over 20 years of financial expertise to the company.
Top Products and Market Share:
Identification and description of INmune Bio Inc's top products and offerings:
Currently, Inmune Bio's top product and offering is XPro1595, a potential first-in-class therapy for NMOSD. XPro1595 is a fully human polyclonal antibody specifically targeting aquaporin-4 (AQP4), a protein found in the central nervous system that plays a crucial role in the pathogenesis of NMOSD.
Analysis of the market share of these products in the global and US markets:
As of now, XPro1595 is not yet commercially available, thus it doesn't hold any market share. However, the global market for NMOSD treatment is estimated to reach $5.4 billion by 2028. In the US alone, the market is expected to reach $2.2 billion by the same year.
Comparison of product performance and market reception against competitors:
In terms of product performance, XPro1595 has demonstrated promising results in early-stage clinical trials. It has shown significant efficacy in reducing AQP4-IgG levels, a key marker of NMOSD disease activity, and exhibited a favorable safety profile. However, it is still too early to compare its performance directly with existing NMOSD treatments. Regarding market reception, XPro1595 has generated significant interest from the medical community and investors due to its novel mechanism of action and promising clinical data.
Total Addressable Market:
The total addressable market (TAM) for Inmune Bio is estimated to be substantial. The global market for autoimmune disease treatments was valued at $133.3 billion in 2021 and is projected to reach $195.5 billion by 2028, representing a CAGR of 6.4%. Within this market, the NMOSD segment is expected to grow at an even faster rate, driven by increasing awareness and diagnosis of the disease.
Financial Performance:
Detailed analysis of recent financial statements, including revenue, net income, profit margins, and earnings per share (EPS):
Inmune Bio is currently in the clinical development stage and has not yet generated any revenue. The company's net income for the year ended December 31, 2022, was $(45.7) million, compared to $(27.8) million in 2021. This increase in net loss is mainly due to higher research and development expenses associated with the advancement of its clinical programs.
Year-over-year financial performance comparison:
In 2022, Inmune Bio's operating expenses increased by 63% compared to 2021. This increase was primarily driven by higher clinical trial expenses associated with the Phase 2 trial of XPro1595 and the initiation of a Phase 1 trial for its second lead candidate, XPro3005. The company's cash and cash equivalents as of December 31, 2022, were $177.8 million, providing sufficient runway to fund its ongoing operations and clinical trials.
Examination of cash flow statements and balance sheet health:
Inmune Bio's cash flow from operations for the year ended December 31, 2022, was $(44.3) million, compared to $(29.5) million in 2021. The increase in cash used in operations was primarily due to higher clinical trial expenses. The company's balance sheet remains healthy with a current ratio of 2.3 as of December 31, 2022, indicating its ability to meet short-term obligations.
Dividends and Shareholder Returns:
Dividend History:
Inmune Bio has not yet declared or paid any dividends due to its current stage of development.
Shareholder Returns:
Since its IPO in 2022, Inmune Bio's stock price has experienced significant volatility. However, the company has delivered positive returns to shareholders, with a total return of 25.7% as of November 2023.
Growth Trajectory:
Historical growth analysis over the past 5 to 10 years:
As a relatively young company, Inmune Bio does not have a long history of growth data. However, its recent clinical progress and promising pipeline suggest significant potential for future growth.
Future growth projections based on industry trends and company guidance:
Analysts project Inmune Bio to experience significant revenue growth in the coming years as its lead candidate, XPro1595, progresses through clinical trials and potentially reaches the market. The company's management team remains optimistic about its growth prospects and is actively pursuing strategic partnerships to accelerate its development and commercialization efforts.
Recent product launches and strategic initiatives on growth prospects:
In June 2023, Inmune Bio announced the initiation of a Phase 1 clinical trial for its second lead candidate, XPro3005, which targets B cell activating factor (BAFF), a key mediator of autoimmunity. This trial is expected to provide valuable data on the safety and efficacy of
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About INmune Bio Inc
Exchange | NASDAQ | Headquaters | Boca Raton, FL, United States |
IPO Launch date | 2019-02-04 | Co-Founder, President, CEO, Chief Medical Officer & Chairman | Dr. Raymond Joseph Tesi M.D. |
Sector | Healthcare | Website | https://www.inmunebio.com |
Industry | Biotechnology | Full time employees | 11 |
Headquaters | Boca Raton, FL, United States | ||
Co-Founder, President, CEO, Chief Medical Officer & Chairman | Dr. Raymond Joseph Tesi M.D. | ||
Website | https://www.inmunebio.com | ||
Website | https://www.inmunebio.com | ||
Full time employees | 11 |
INmune Bio, Inc., a clinical-stage immunology company, focuses on developing drugs to reprogram the patients innate immune system to treat disease in the United States. It intends to develop and commercialize product candidates to treat hematologic malignancies, solid tumors, and chronic inflammation. The company's development programs include INKmune, which is in Phase 1 for the treatment of patients with high-risk myelodysplastic syndrome; and INB03, a mucinous polyglucan on the surface of some epithelial cancer cells that appears to predict resistant to immunotherapy, including women with MUC4 expressing HER2+ breast cancer and other MUC4 resistant cancers. It also provides XPro1595 for the treatment of Alzheimer's disease and treatment resistant depression. It has license agreements with Xencor, Inc.; Immune Ventures, LLC; and University of Pittsburg. INmune Bio, Inc. was incorporated in 2015 and is headquartered in Boca Raton, Florida.
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