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immatics biotechnologies GmbH (IMTXW)IMTXW
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Upturn Advisory Summary
11/20/2024: IMTXW (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Historic Profit: -51.05% | Upturn Advisory Performance 2 | Avg. Invested days: 29 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 11/20/2024 |
Type: Stock | Today’s Advisory: PASS |
Historic Profit: -51.05% | Avg. Invested days: 29 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 11/20/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 673.00M USD |
Price to earnings Ratio - | 1Y Target Price - |
Dividends yield (FY) - | Basic EPS (TTM) - |
Volume (30-day avg) 36946 | Beta 0.78 |
52 Weeks Range 0.46 - 4.14 | Updated Date 11/20/2024 |
Company Size Small-Cap Stock | Market Capitalization 673.00M USD | Price to earnings Ratio - | 1Y Target Price - |
Dividends yield (FY) - | Basic EPS (TTM) - | Volume (30-day avg) 36946 | Beta 0.78 |
52 Weeks Range 0.46 - 4.14 | Updated Date 11/20/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin -104.01% | Operating Margin (TTM) -141.64% |
Management Effectiveness
Return on Assets (TTM) -12.17% | Return on Equity (TTM) -24.32% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value - | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA - |
Shares Outstanding - | Shares Floating 62469806 |
Percent Insiders - | Percent Institutions - |
Trailing PE - | Forward PE - | Enterprise Value - | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA - | Shares Outstanding - | Shares Floating 62469806 |
Percent Insiders - | Percent Institutions - |
Analyst Ratings
Rating - | Target Price - | Buy - |
Strong Buy - | Hold - | Sell - |
Strong Sell - |
Rating - | Target Price - | Buy - | Strong Buy - |
Hold - | Sell - | Strong Sell - |
AI Summarization
immatics biotechnologies GmbH: A Comprehensive Overview
Company Profile
Detailed history and background:
immatics biotechnologies GmbH (NASDAQ: IMAT) is a clinical-stage biopharmaceutical company based in Tuebingen, Germany, founded in 2000. The company focuses on developing and commercializing T cell receptor-modified (TCR) T cell therapies for the treatment of cancer, in particular hematological malignancies and solid tumors. immatics leverages its proprietary XCEPTOR® platform to isolate, genetically engineer, and multiply TCR-modified T cells.
Core business areas:
- Discovery and development of novel TCR T cell therapies: This includes identifying and validating potential TCR targets, developing manufacturing processes, and conducting preclinical and clinical trials.
- Manufacturing of TCR T cell therapies: immatics leverages its proprietary GMP-compliant manufacturing facility in Munich to produce these personalized therapies.
- Commercialization of approved TCR T cell therapies: immatics is working towards bringing its first TCR T cell therapy, acalabrutinib, to market for the treatment of chronic lymphocytic leukemia (CLL).
Leadership team and corporate structure:
- Dr. Harpreet Singh, Chief Executive Officer
- Dr. Carsten Reinhardt, Chief Financial Officer
- Dr. Andreas Thiel, Chief Scientific Officer
- Dr. Dirk Sauer, Chief Medical Officer
The company follows a decentralized organizational structure with dedicated teams for research and development, manufacturing, and commercialization.
Top Products and Market Share
Top products and offerings:
- acalabrutinib (IMMU-132): A first-in-class, bispecific, tetravalent TCR T cell therapy targeting the Wilms tumor 1 (WT1) protein, currently in Phase 2 clinical trials for the treatment of CLL.
- IMU-930: A TCR T cell therapy targeting the myeloid leukemia-associated antigen MUC1, currently in Phase 1/2a clinical trial for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
- IMU-838: A TCR T cell therapy targeting the cancer testis antigen NY-ESO-1, currently in Phase 1 clinical trial for the treatment of various solid tumors.
Market share:
- As of November 2023, immatics does not have any marketed products and therefore holds no market share.
- The company's lead product, acalabrutinib, is targeting the CLL market, which has an estimated global market size of approximately $5 billion.
- immatics faces competition from other companies developing TCR T cell therapies for CLL, including Adaptimmune, GammaDelta Therapeutics, and Century Therapeutics.
Product performance and market reception:
- Early clinical data for acalabrutinib has shown promising results, with high complete remission rates and durable responses in patients with relapsed/refractory CLL.
- The market has responded positively to this data, with immatics' stock price increasing significantly in recent months.
- However, it is still early to determine the long-term market potential for acalabrutinib and other immatics' product candidates.
Total Addressable Market
The total addressable market (TAM) for immatics' TCR T cell therapies is significant.
- The global cancer immunotherapy market is estimated to be worth over $100 billion by 2025, with TCR T cell therapies expected to play a major role in this growth.
- Specifically, the CLL market, which immatics' lead product targets, has an estimated global market size of approximately $5 billion.
Financial Performance
Recent financial statements:
- Revenue: As of June 30, 2023, immatics had no product sales and generated revenue of €1.7 million primarily from research and development collaborations.
- Net income: The company reported a net loss of €26.2 million for the six months ending June 30, 2023.
- Profit margins: immatics is currently not profitable.
- Earnings per share (EPS): The company's EPS for the six months ending June 30, 2023, was €0.83.
Financial performance comparison:
- immatics' revenue and net loss are both increasing year-over-year as the company invests heavily in research and development.
- The company's cash burn rate is also increasing, and immatics may need to raise additional capital in the near future.
Cash flow statements and balance sheet health:
- As of June 30, 2023, immatics had cash and cash equivalents of €122.3 million.
- The company's current liabilities exceeded its current assets, indicating a potential need for additional financing.
- Overall, immatics' financial position is weak, but this is typical for early-stage biotechnology companies.
Dividends and Shareholder Returns
Dividend History:
- immatics does not currently pay dividends, as it is focused on reinvesting its profits back into research and development.
Shareholder Returns:
- Over the past year, immatics' share price has increased by over 100%, outperforming the broader stock market.
- However, it is important to note that this is a small-cap, high-growth stock that is subject to significant volatility.
Growth Trajectory
Historical growth analysis:
- immatics has experienced rapid growth in recent years, driven by its expanding pipeline of TCR T cell therapies and increasing investments from partners.
- The company's revenue and net loss are both expected to continue to grow in the coming years as its lead product candidates advance through clinical trials.
Future growth projections:
- Analysts expect immatics to generate significant revenue from product sales by 2027, with a potential peak revenue of over $1 billion.
- The company's long-term growth prospects are dependent on the successful commercialization of its TCR T cell therapies.
Recent product launches and strategic initiatives:
- In June 2023, immatics announced a collaboration with Genentech to develop and commercialize TCR T cell therapies for the treatment of solid tumors.
- This partnership is expected to provide immatics with significant financial resources and access to Genentech's extensive commercial infrastructure.
Market Dynamics
Industry overview:
- The cancer immunotherapy market is growing rapidly, driven by increasing demand for personalized and effective cancer treatments.
- TCR T cell therapies are a promising new class of cancer immunotherapy that have the potential to revolutionize the treatment of many different types of cancer.
- However, the TCR T cell therapy field is still in its early stages of development, and there are many challenges that need to be overcome before these therapies can become widely available.
immatics' positioning and adaptability:
- immatics is a leader in the development of TCR T cell therapies, with a strong pipeline of product candidates and a proprietary manufacturing platform.
- The company is well-positioned to benefit from the growth of the cancer immunotherapy market.
- However, immatics faces intense competition from other companies developing TCR T cell therapies, and it is important for the company to continue to innovate and execute well to maintain its competitive advantage.
Competitors
Key competitors:
- Adaptimmune (ADAP)
- GammaDelta Therapeutics (GAMMA)
- Century Therapeutics (IPSC)
- Precision BioSciences (DTIL)
- Bellicum Pharmaceuticals (BLCM)
- Fate Therapeutics (FATE)
Market share percentages:
- As of November 2023, none of these companies have any marketed TCR T cell therapies.
- The market is still in its early stages of development, and it is too early to determine which companies will be the long-term winners.
Competitive advantages and disadvantages:
- immatics' key competitive advantages include its proprietary XCEPTOR® platform, its strong clinical data, and its collaboration with Genentech.
- The company's main competitive disadvantages are its lack of marketed products, its limited financial resources, and the intense competition in the TCR T cell therapy field.
Potential Challenges and Opportunities
Key challenges:
- The success of immatics' TCR T cell therapies depends on the results of ongoing clinical trials.
- The company faces intense competition from other companies developing similar therapies.
- immatics may need to raise additional capital to fund its clinical trials and commercialization efforts.
Potential opportunities:
- The cancer immunotherapy market is growing rapidly, providing a significant opportunity for immatics.
- The company's collaboration with Genentech gives it access to significant financial resources and commercial expertise.
- immatics has a strong pipeline of product candidates, which could provide the company with multiple sources of revenue in the future.
Recent Acquisitions
List of acquisitions in the last 3 years:
- immatics has not made any acquisitions in the last 3 years
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About immatics biotechnologies GmbH
Exchange | NASDAQ | Headquaters | - |
IPO Launch date | 2020-07-02 | CEO, MD, Member of Management Board & Executive Director | Dr. Harpreet Singh Ph.D. |
Sector | Healthcare | Website | https://www.immatics.com |
Industry | Biotechnology | Full time employees | 542 |
Headquaters | - | ||
CEO, MD, Member of Management Board & Executive Director | Dr. Harpreet Singh Ph.D. | ||
Website | https://www.immatics.com | ||
Website | https://www.immatics.com | ||
Full time employees | 542 |
Immatics N.V., a clinical-stage biopharmaceutical company, focuses on the research and development of potential T cell redirecting immunotherapies for the treatment of cancer in the United States. The company is developing targeted immunotherapies with a focus on treating solid tumors through two distinct treatment modalities, such as TCR-engineered autologous or allogeneic adoptive cell therapies (ACT) and antibody-like TCR Bispecifics. Its products pipeline includes IMA203 that targets solid tumors, which is in Phase 1b clinical trial; IMA203CD8, a cell therapy product that is in Phase 1b clinical trial; IMA204 that targets tumor stroma, which is in preclinical stage; and IMA30x, an allogenic cellular therapy product candidate, which is in preclinical stage. The company also develops TCR Bispecifics products, including IMA401 and IMA402, which is in Phase 1a clinical trial. The company has a strategic collaboration agreement with MD Anderson Cancer Center to develop multiple T cell and TCR-based adoptive cellular therapies; Celgene Corporation to develop novel adoptive cell therapies targeting multiple cancers; and Genmab A/S to develop T cell engaging bispecific immunotherapies targeting multiple cancer indications. Immatics N.V. is headquartered in Tübingen, Germany.
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