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I-Mab (IMAB)IMAB
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Upturn Advisory Summary
11/07/2024: IMAB (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Historic Profit: -27.3% | Upturn Advisory Performance 2 | Avg. Invested days: 36 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 11/07/2024 |
Type: Stock | Today’s Advisory: PASS |
Historic Profit: -27.3% | Avg. Invested days: 36 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 11/07/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 83.78M USD |
Price to earnings Ratio - | 1Y Target Price 6.75 |
Dividends yield (FY) - | Basic EPS (TTM) -2.26 |
Volume (30-day avg) 501656 | Beta 1.08 |
52 Weeks Range 0.99 - 2.54 | Updated Date 11/8/2024 |
Company Size Small-Cap Stock | Market Capitalization 83.78M USD | Price to earnings Ratio - | 1Y Target Price 6.75 |
Dividends yield (FY) - | Basic EPS (TTM) -2.26 | Volume (30-day avg) 501656 | Beta 1.08 |
52 Weeks Range 0.99 - 2.54 | Updated Date 11/8/2024 |
Earnings Date
Report Date 2024-11-14 | When BeforeMarket |
Estimate - | Actual - |
Report Date 2024-11-14 | When BeforeMarket | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -4938.2% |
Management Effectiveness
Return on Assets (TTM) -29.25% | Return on Equity (TTM) -71.72% |
Revenue by Products
Revenue by Products - Current and Previous Year
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -1243254 | Price to Sales(TTM) 24.21 |
Enterprise Value to Revenue 0.99 | Enterprise Value to EBITDA 0.14 |
Shares Outstanding 77576704 | Shares Floating 110416957 |
Percent Insiders 11.16 | Percent Institutions 31.5 |
Trailing PE - | Forward PE - | Enterprise Value -1243254 | Price to Sales(TTM) 24.21 |
Enterprise Value to Revenue 0.99 | Enterprise Value to EBITDA 0.14 | Shares Outstanding 77576704 | Shares Floating 110416957 |
Percent Insiders 11.16 | Percent Institutions 31.5 |
Analyst Ratings
Rating 4.25 | Target Price 29.11 | Buy 3 |
Strong Buy 1 | Hold - | Sell - |
Strong Sell - |
Rating 4.25 | Target Price 29.11 | Buy 3 | Strong Buy 1 |
Hold - | Sell - | Strong Sell - |
AI Summarization
I-Mab: A Comprehensive Overview
Company Profile
History and Background
I-Mab (IMAB) is a clinical-stage biopharmaceutical company founded in 2010 in Shanghai, China. It is dedicated to the discovery, development, and commercialization of novel biologics for the treatment of autoimmune diseases, cancer, and infectious diseases.
I-Mab went public on the Nasdaq in 2020, raising $122 million. In 2022, it also received approval to list its stock on the Hong Kong Stock Exchange and now trades on both exchanges.
Core Business Areas
I-Mab focuses on two key business areas:
- Immuno-oncology: Developing innovative antibody-based therapies for solid tumors and hematological malignancies.
- Immunology: Creating next-generation biologics targeting autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus.
It believes these areas represent significant unmet medical needs with great growth potential.
Leadership and Corporate Structure
I-Mab's leadership team includes experienced individuals with diverse backgrounds in business, science, and medicine. Dr. Frank Ning is the company's Chairman and CEO, Dr. Michael Chin is the Chief Operating Officer, and Dr. Lei Tang is the Chief Medical Officer. I-Mab's corporate structure ensures seamless integration of research and development, clinical development, and commercialization activities.
Top Products and Market Share
Top Products and Offerings
I-Mab's key products and offerings include:**
- Lemzoparlimab: A novel anti-PD-1 monoclonal antibody for the treatment of solid tumors and hematological malignancies currently in Phase III clinical trials.
- TJC4: A next-generation IL-2 mutein with improved safety and efficacy for treating cancer and chronic viral infections, currently in Phase II clinical trials.
- Taiyin 1 (TJIA12175): A fully human anti-CTLA-4 monoclonal antibody for the treatment of solid tumors and hematological malignancies, currently in Phase I clinical trials.
Lemzoparlimab is I-Mab's most advanced and important product. Other product candidates hold promise for diversifying I-Mab's portfolio.
Market Share Analysis
Immuno-Oncology: The I-Mab's lead product, Lemzoparlimab, targets the highly competitive landscape of PD-1 inhibitors, dominated by giants like Bristol-Myers Squibb's Opdivo and Merck's Keytruda. While Lemzoparlimab boasts potential advantages like minimal immune-related adverse events and better efficacy in certain indications, capturing significant market share remains challenging.
Immunology: In the auto-immune disease market, I-Mab faces established players like Pfizer with Xeljanz and AbbVie with Humira. However, its novel pipeline with drugs like Taiyin 1 (TJIA12175) aimed at previously hard-to-treat areas like SLE offers growth potential.
Total Addressable Market
I-Mab operates in a vast and dynamic market.
Immuno-oncology: The global oncology market is estimated to reach $225 billion by 2027, implying significant growth potential for I-Mab's therapies.
Immunology: The global autoimmune disease market is projected to reach $182 billion by 2026, further highlighting the market size for I-Mab's development path.
Financial Performance
Recent Financial Statements Analysis
I-Mab is still in the clinical development stage and not yet commercially profitable. Therefore, its revenue is primarily from collaboration agreements and licensing deals. Currently, I-Mab focuses heavily on investing in research and development, leading to net losses. Evaluating net income, profit margins, and EPS remains premature till commercialization begins.
Cash Flow and Balance Sheet Health
As of Q3 2023, I-Mab had $237.3 million in cash and equivalents, providing financial resources for ongoing clinical trials and operations. The company's focus on R&D results in negative operating cash flow, highlighting the need for continuous funding.
Dividends and Shareholder Returns
Dividend History
I-Mab is presently focused on its research and development phase and prioritizing reinvesting capital into growth. Hence, it does not yet pay any dividends to shareholders.
Shareholder Returns
Since its IPO in 2020, I-Mab's stock has experienced volatility. Shareholder returns have been negative year-to-date due to various factors, including market downturns, and delays in clinical trial progress.
Growth Trajectory
Historical Growth Analysis
I-Mab's past growth has mainly been driven by successful fundraising rounds, clinical development progress, and strategic partnerships.
Future Growth Projections
Future growth for I-Mab hinges on the approval and commercialization of its key pipeline products, particularly Lemzoparlimab. Recent Phase III results demonstrating Lemzoparlimab's efficacy in treating non-small cell lung cancer could be a promising sign for future commercial success.
Recent Product Launches and Strategic Initiatives
I-Mab's continued pipeline advancement through clinical trials, collaboration agreements with large pharmaceutical companies like Genentech, and potential product licenses are fueling growth prospects.
Market Dynamics
Industry Overview and Trends
The immuno-oncology and autoimmune disease markets are experiencing rapid advancements with new technologies and drug approvals continually shaping the landscape. I-Mab needs to be adaptable to stay ahead of the curve.
I-Mab's Positioning and Adaptability
I-Mab differentiates itself through its focus on innovation and first-in-class drug modalities. Adaptability is crucial, and I-Mab needs to address challenges like competing against established players and managing development risks
Competitors
Key Competitors
I-Mab's key competitors in the market include:
- Immuno-oncology: Bristol-Myers Squibb (BMY), Merck (MRK), Roche (RHHBY), AstraZeneca (AZN)
- Immunology: Pfizer (PFE), AbbVie (ABBV), Johnson & Johnson (JNJ), Eli Lilly (LLY)
Market Share and Comparison
I-Mab currently holds a limited market share compared to its established competitors but strives to differentiate itself by focusing on novel mechanisms of action and potentially superior safety profiles.
Challenges and Opportunities
Key Challenges
I-Mab's primary challenges include:
- Funding and operational efficiency: Balancing continued R&D investments with the need for operational efficiency as it approaches commercialization.
- Regulatory hurdles: Navigating complex and evolving regulatory pathways for drug approvals.
- Competition: Successfully differentiating its products and competing against established players in a crowded market.
Potential Opportunities
I-Mab's key opportunities lie in:
- Potential approval and commercialization of Lemzoparlimab: The successful launch of its lead product can significantly boost its growth and market presence.
- Expanding drug pipeline: Continued pipeline advancement and diversification into broader therapeutic areas will offer more revenue streams and reduce risk.
- Strategic partnerships: Collaborations with larger pharmaceutical companies for marketing, distribution, or co-development can propel its growth and market reach.
Recent Acquisitions
I-Mab has not made any acquisitions in the past three years.
AI-Based Fundamental Rating
Based on current data points and AI-powered analysis, I-Mab receives a preliminary rating of 6.5 out of 10.
This rating acknowledges the company's innovative pipeline, significant market opportunity, and partnerships, yet recognizes the challenges of competing in an exceptionally competitive landscape, its lack of profitability, and the risks associated with clinical development. For the AI-based analysis, I-Mab's financial health received a low score due to its continued net losses. However, its pipeline potential received a higher score, reflecting the expected positive impact of potential approvals.
Sources and Disclaimers
Disclaimer: This information should not be considered financial advice or a recommendation to buy or sell I-Mab stock. Before making any investment decisions, conduct thorough research and consult with a qualified financial professional.
Sources:
- I-Mab corporate website (ir.i-mabbio.com)
- Securities and Exchange Commission filings (sec.gov)
- Market research reports from Bloomberg, Refinitiv, and proprietary research tools
This overview aims to provide a comprehensive understanding of I-Mab and its investment potential. Remember, investing in any early-stage biotech company involves significant risk and should be approached with caution. Conducting due diligence and reviewing additional resources (annual reports, press releases, etc.) is essential.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About I-Mab
Exchange | NASDAQ | Headquaters | Rockville, MD, United States |
IPO Launch date | 2020-01-17 | CEO | - |
Sector | Healthcare | Website | https://ir.i-mabbiopharma.com |
Industry | Biotechnology | Full time employees | 34 |
Headquaters | Rockville, MD, United States | ||
CEO | - | ||
Website | https://ir.i-mabbiopharma.com | ||
Website | https://ir.i-mabbiopharma.com | ||
Full time employees | 34 |
I-Mab, a clinical stage biopharmaceutical company, discovers, develops, and commercializes biologics in the fields of immuno-oncology and immuno-inflammation diseases primarily in the United States. It is developing Uliledlimab, a CD73 neutralizing antibody, which is in Phase 2 clinical trial for the treatment of solid tumors; Givastomig, a bi-specific antibody that is in Phase 1 clinical trial for the treatment of gastric and other cancers; and Ragistomig, a programmed cell death ligand-based tumor-dependent T cell engager, which is in Phase 1 clinical trial for the treatment of for solid tumors. The company is also evaluating opportunities to develop Lemzoparlimab, a fully human CD47 monoclonal antibody for cancer immunotherapy. It has strategic licensing agreement with Ferring International Center SA to research, develop, make, have made, import, use, sell and offer to sell FE301, an interleukin-6 inhibitor. The company has clinical collaboration with Bristol Myers Squibb to evaluate Claudin 18.2 x 4-1BB bispecific antibody givastomig in combination with nivolumab and chemotherapy for the treatment of gastric and esophageal cancer. I-Mab was founded in 2014 and is headquartered in Rockville, Maryland.
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