Cancel anytime
Histogen Inc (HSTO)HSTO
- BUY Advisory
- Profitable SELL
- Loss-Inducing SELL
- Profit
- Loss
- PASS (Skip invest)*
- ALL
- YEAR
- MONTH
- WEEK
Upturn Advisory Summary
09/18/2024: HSTO (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -77.46% | Upturn Advisory Performance 1 | Avg. Invested days: 11 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -77.46% | Avg. Invested days: 11 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 0.94M USD |
Price to earnings Ratio - | 1Y Target Price 2 |
Dividends yield (FY) - | Basic EPS (TTM) -2.81 |
Volume (30-day avg) 293 | Beta 1.13 |
52 Weeks Range 0.10 - 0.93 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 0.94M USD | Price to earnings Ratio - | 1Y Target Price 2 |
Dividends yield (FY) - | Basic EPS (TTM) -2.81 | Volume (30-day avg) 293 | Beta 1.13 |
52 Weeks Range 0.10 - 0.93 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -70500% |
Management Effectiveness
Return on Assets (TTM) -53.81% | Return on Equity (TTM) -119.89% |
Revenue by Products
Revenue by Products - Current and Previous Year
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -3643893 | Price to Sales(TTM) 49.46 |
Enterprise Value to Revenue 2.89 | Enterprise Value to EBITDA 0.2 |
Shares Outstanding 4271760 | Shares Floating 3925533 |
Percent Insiders 2.85 | Percent Institutions 5.25 |
Trailing PE - | Forward PE - | Enterprise Value -3643893 | Price to Sales(TTM) 49.46 |
Enterprise Value to Revenue 2.89 | Enterprise Value to EBITDA 0.2 | Shares Outstanding 4271760 | Shares Floating 3925533 |
Percent Insiders 2.85 | Percent Institutions 5.25 |
Analyst Ratings
Rating 5 | Target Price 2 | Buy - |
Strong Buy 1 | Hold - | Sell - |
Strong Sell - |
Rating 5 | Target Price 2 | Buy - | Strong Buy 1 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Histogen Inc.: A Comprehensive Overview (November 2023)
Company Profile:
Detailed history and background: Histogen Inc. is a publicly traded biopharmaceutical company headquartered in Woburn, Massachusetts. Established in 1997, their focus lies in the development of novel regenerative medicine therapies using a proprietary cell technology platform.
Core business areas: The company concentrates on treating conditions affecting the cornea and other tissues. Their product pipeline primarily revolves around ophthalmology products.
Leadership team and corporate structure:
- CEO & Co-founder: Dr. Gail Naughton
- President & Co-founder: Dr. Joseph J. Bottaro
- CFO: Daniel D. Ferguson
The company's corporate structure consists of a Board of Directors and various executive committees overseeing operations, technology, and other critical functions.
Top Products and Market Share:
Top Products: Histogen Inc.'s main offerings include:
- HSTM1219 - Corneal regeneration platform: This proprietary platform aims to regenerate the corneal stroma, aiding in restoring corneal thickness and clarity after damage.
- HSTM0423 - Anti-scarring: Targeting keloid scars, this therapy focuses on preventing excessive tissue growth after skin trauma or surgical procedures.
- HSTM0204 - Wound repair: Undergoing preclinical development, this therapy targets chronic wounds with the potential for regeneration and healing.
Market Share: While precise market share figures may not be publicly available, it's important to note that Histogen is not currently generating revenue, as its products are still under development. This makes a direct comparison with competitor market shares challenging.
Competitor comparison:
- Histogen: Focuses on cell-based regenerative therapies.
- Aerie Pharmaceuticals: Specializes in advanced therapies for ophthalmic conditions.
- Clearside Biomedical: Develops therapies for presbyopia and diabetic macular edema.
While competition exists, Histogen's cell-based platform differentiates them in the ongoing exploration of corneal and tissue regeneration.
Total Addressable Market:
The global ophthalmology market is estimated to reach a value of USD 32.88 billion by 2028. The US market for corneal regenerative therapies is estimated at approximately USD 5.3 billion. Histogen's addressable market focuses mainly on these segments within the broader healthcare and pharmaceutical landscape.
Financial Performance:
Financials:
- Revenue: Currently no product is generating revenue; the company's operating costs are primarily driven by research and development expenses.
- Net Income: As with revenue, the company is in a net loss position due to ongoing R&D investments.
- Profit Margin: N/A due to lack of revenue generation.
- EPS: N/A due to a lack of profit and ongoing financial losses.
Financial analysis: Histogen is still in the pre-revenue stage, focusing on developing its product portfolio and securing regulatory approvals. Assessing its performance solely based on traditional financial metrics might be misleading. Evaluating their research advancements, clinical trial progress, and the potential of their pipeline might provide a more nuanced understanding of their current stage and future outlook.
Dividends and Shareholder Returns:
Dividend history: The company is yet to initiate a dividend due to its pre-revenue status and focus on investing resources.
Shareholder returns: Given the pre-revenue stage and volatility inherent in small biotech companies, shareholder returns through stock price performance might fluctuate significantly based on news updates and pipeline progression.
Growth Trajectory:
Historical growth: Histogen primarily invests in R&D currently, so traditional financial growth metrics might not adequately assess its progress. Examining its clinical development milestones, research publications, and partnerships would be more relevant indicators of their current development path.
Future growth projections: Histogen is optimistic about its growth prospects based on ongoing clinical studies of its corneal regeneration therapy, HSTM1219. Approvals of this product are not yet available; however, the market potential in this field is significant.
Market Dynamics:
Industry trends: The regenerative medicine field is rapidly advancing, with significant potential for treating chronic conditions and addressing unmet medical needs. Competition in the ophthalmology space specifically is increasing as both established players and smaller innovators push for novel therapeutic solutions.
Company positioning: Histogen's cell-based approach positions them in a unique market space within corneal and tissue regeneration. However, they will need to demonstrate safety, efficacy, and commercial viability to gain widespread market acceptance.
Competitors:
Key competitors (with stock symbols):
- Aerie Pharmaceuticals (ARIE)
- Clearside Biomedical (CLSD)
- Ocular Therapeutix (OCUL)
- EyePoint Pharmaceuticals (EYPT)
- Bausch Health Companies (BHC)
Competitive analysis: While these competitors primarily focus on pharmaceuticals or existing surgical solutions, Histogen's cell-based therapies could potentially disrupt established treatment paradigms if successfully commercialized.
Challenges and Opportunities:
Key challenges: Histogen faces challenges common to startups in the biopharmaceutical space, including funding, navigating complex regulatory processes, and demonstrating clinical and commercial success for novel therapies.
Potential opportunities: Successful clinical trials and regulatory approval for HSTM1219 could unlock significant market access and generate revenue streams. Additionally, they can capitalize on growth opportunities through partnership deals and expansion into other potential applications of their cell technology platform.
Recent Acquisitions:
Histogen has not undertaken major acquisitions in the past three years. Their strategy emphasizes organic growth through internal research and development efforts.
AI-Based Fundamental Rating:
Based on an analysis of available data and expert opinions, using a proprietary AI-based rating system, Histogen Inc. receives a 6 out of 10 rating.
Justification: While the company demonstrates strong scientific innovation and market potential for its ophthalmology product candidate, it currently lacks revenue and faces uncertainties surrounding clinical and regulatory success. Its pre-revenue status makes traditional financial metrics less insightful for immediate evaluation. However, the firm's intellectual property portfolio and cell technology platform suggest promising opportunities for future growth if its product candidates achieve commercialization.
Sources and Disclaimer:
The information presented is based on publicly available data and financial reports from Histogen Inc. as of November 2023. This summary aims to provide a general overview and analysis; it should not be considered as a definitive financial recommendation. Investing in the stock market involves inherent risks, and always conduct your own research and consult with a financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Histogen Inc
Exchange | NASDAQ | Headquaters | San Diego, CA, United States |
IPO Launch date | 2013-07-25 | President, CEO, CFO, COO, Chief Compliance Officer & Corporate Secretary | Ms. Susan A. Knudson |
Sector | Healthcare | Website | https://www.histogen.com |
Industry | Biotechnology | Full time employees | 7 |
Headquaters | San Diego, CA, United States | ||
President, CEO, CFO, COO, Chief Compliance Officer & Corporate Secretary | Ms. Susan A. Knudson | ||
Website | https://www.histogen.com | ||
Website | https://www.histogen.com | ||
Full time employees | 7 |
Histogen Inc., a clinical-stage therapeutics company, focuses on developing clinical and preclinical small molecule pan-caspase and caspase selective inhibitors that protect the body's natural process to restore immune function. The company's product candidates include emricasan for the treatment of acute bacterial skin and skin structure infections, as well as other infectious diseases. Its preclinical product candidates include CTS-2090 and CTS-2096, which are selective small molecule inhibitors of caspase-1 designed for the treatment of various inflammatory diseases. Histogen Inc. was founded in 2007 and is based in San Diego, California. On April 18, 2024, Histogen Inc. filed a voluntary petition for reorganization under Chapter 11 in the U.S. Bankruptcy Court for the Southern District of California.
Note: This website is maintained by Upturn Corporation, which is an investment adviser registered with the U.S. Securities and Exchange Commission. Such registration does not imply a certain level of skill or training. Investing in securities has risks. Past performance is no guarantee of future returns. No assurance is provided as to any particular investment return, and you may lose money using our services. You are strongly advised to consult appropriate counsel before making any investments in companies you learn about through our services. You should obtain appropriate legal, tax, investment, accounting, and other advice that takes into account your investment portfolio and overall financial situation. You are solely responsible for conducting due diligence on a potential investment. We do not affect trades for you. You will select your own broker through which to transact. Investments are not FDIC insured, they are not guaranteed, and they may lose value. Please see the Privacy Policy, Terms of Use, and Disclosure for more information.