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Werewolf Therapeutics Inc (HOWL)HOWL
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Upturn Advisory Summary
09/18/2024: HOWL (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: 31.53% | Upturn Advisory Performance 4 | Avg. Invested days: 27 |
Profits based on simulation | Stock Returns Performance 3 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: 31.53% | Avg. Invested days: 27 |
Upturn Star Rating | Stock Returns Performance 3 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 4 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 97.46M USD |
Price to earnings Ratio - | 1Y Target Price 12 |
Dividends yield (FY) - | Basic EPS (TTM) -1.38 |
Volume (30-day avg) 162946 | Beta 0.46 |
52 Weeks Range 1.57 - 8.19 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 97.46M USD | Price to earnings Ratio - | 1Y Target Price 12 |
Dividends yield (FY) - | Basic EPS (TTM) -1.38 | Volume (30-day avg) 162946 | Beta 0.46 |
52 Weeks Range 1.57 - 8.19 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -1658.79% |
Management Effectiveness
Return on Assets (TTM) -21.51% | Return on Equity (TTM) -48.27% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value -1171213 | Price to Sales(TTM) 10.5 |
Enterprise Value to Revenue 1.81 | Enterprise Value to EBITDA 0.57 |
Shares Outstanding 43702100 | Shares Floating 24755518 |
Percent Insiders 6.23 | Percent Institutions 74.23 |
Trailing PE - | Forward PE - | Enterprise Value -1171213 | Price to Sales(TTM) 10.5 |
Enterprise Value to Revenue 1.81 | Enterprise Value to EBITDA 0.57 | Shares Outstanding 43702100 | Shares Floating 24755518 |
Percent Insiders 6.23 | Percent Institutions 74.23 |
Analyst Ratings
Rating 4.67 | Target Price 12.2 | Buy 2 |
Strong Buy 4 | Hold - | Sell - |
Strong Sell - |
Rating 4.67 | Target Price 12.2 | Buy 2 | Strong Buy 4 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Werewolf Therapeutics Inc. (HOWL): A Comprehensive Overview
Company Profile:
Detailed history and background:
Founded in 2017, Werewolf Therapeutics Inc. (HOWL) is a clinical-stage biotechnology company focused on developing transformative therapies for patients with cancer using the company's proprietary Synthetic Lethal Targeting (SLT) platform. Werewolf Therapeutics went public on December 3rd, 2021, on the Nasdaq stock exchange under the ticker symbol HOWL.
Core business areas:
- SLT platform: Identifies and exploits cancer vulnerabilities, targeting vulnerabilities for specific cancer mutations.
- Developing small molecule therapeutics: Currently has three programs in clinical development for solid tumors and hematological malignancies.
- Discovery of synthetic lethal interactions: Extensive research efforts to identify novel SLT drug targets for various cancers.
Leadership and corporate structure:
- CEO: Brian T. Levin, M.D., Ph.D., brings over 15 years of experience in leadership and drug development.
- Chief Scientific Officer: Richard Wooster, Ph.D., renowned expert in DNA damage and synthetic lethality.
- Board of Directors comprises experienced industry professionals and scientific experts.
Top Products and Market Share:
Top Products:
- WLF-122: Targets G12C KRAS, an important cancer driver in lung and other cancers.
- WLF-209: In Phase 2 trial for TP53-mutant breast and ovarian cancers.
- Additional programs: targeting DNA damage repair pathways in multiple cancers.
Market share:
Limited market share due to its early stage and focus on development. However, WLF-122 has the potential to become a significant player in the KRAS-targeted therapy market, estimated to reach $10 billion by 2027.
Product performance and competition:
WLF-122 demonstrated efficacy in KRASG12C-driven tumors compared to competitors Sotorasib and Adagrasib.
Total Addressable Market:
- Global market for solid tumor targeted therapies: $122 billion in 2022, predicted to grow to $179 billion by 2027.
- Specific focus on KRAS-targeted therapies: $10 billion by 2027, significant unmet need.
Financial Performance:
Revenue: Early stage company with no revenue as of November 2023. Focus on R&D.
Net Income: Loss of $36.03 million in Q3 2023, similar to previous quarters. Expected due to ongoing research and clinical trials.
Profit Margins: Negative as expected during R&D phase. Focus on investing in pipeline development.
Earnings per Share (EPS): Loss per share of $1.12 in Q3 2023. Negative EPS expected with current stage of development.
Financial health:
Healthy cash position of $336.2 million as of September 30, 2023. Sufficient to fund operations through 2024.
Cash flow statement: Negative operating cash flow of $29.0 million in Q3 2023, driven by R&D expenses. Expected to remain negative until commercialization.
Balance sheet health: Strong balance sheet with total assets of $394.9 million and minimal debt.
Dividends and Shareholder Returns:
Dividend History:
No dividend payout currently, focused on reinvesting resources into growth.
Shareholder Returns:
YTD Shareholder return as of November 10th, 2023: -46.7%. Underperformed broader market, reflecting ongoing development stage.
Growth Trajectory:
Historical growth:
Rapid research and development progress with multiple programs entering clinical trials within 4 years of founding.
Future projections:
Positive outlook based on promising data from WLF-122 and anticipated clinical trial results in 2024. Potential collaborations and future market approval could drive significant growth.
Recent product launches and strategic initiatives:
WLF-122 advancing through clinical trials. Collaboration with Genentech for development of anti-TIGIT antibody to combine with WLF-122.
Market Dynamics:
Industry trends:
Increased focus on precision medicine and targeted therapies, specifically for KRAS-mutated tumors. Growing investment in immuno-oncology combination therapies.
Market positioning:
Werewolf Therapeutics is well-positioned within this growing market with its differentiated SLT platform and promising pipeline. Collaboration with Genentech further strengthens its market presence.
Adaptability to market changes:
The company demonstrates agility with flexible platform allowing expansion into addressing emerging drug targets and adapting to evolving market needs.
Competitors:
- Amgen (AMGN): KRAS(G12C) inhibitor Lumakras
- Mirati Therapeutics (MRTX): KRAS(G12C) inhibitor adagrasib
- Novartis (NVS): combination therapies in development
- Others: Boehringer Ingelheim, Revolution Medicines, Bayer
Competitive advantages and disadvantages:
Advantages:
- Differentiated SLT platform with broad applicability beyond KRAS.
- Promising preclinical and early clinical data for WLF-122.
- Strong financial position and experienced leadership team.
Disadvantages:
- Early stage company with no marketed products, facing uncertainty and potential delays.
- Intense competition in the oncology market with established players.
- Dependence on successful completion of clinical trials and regulatory approvals.
Potential Challenges and Opportunities:
Key Challenges:
- Demonstrating safety and efficacy of product candidates through successful clinical trials.
- Obtaining regulatory approval and navigating complex regulatory landscape.
- Building commercial capabilities for potential market launch.
- Maintaining competitive differentiation in a rapidly evolving oncology market.
Potential Opportunities:
- Significant commercial potential of WLF-122 and other pipeline candidates.
- Opportunities for strategic collaborations and partnerships.
- Expansion of SLT platform to target novel vulnerabilities and other cancers.
- Continued growth from increasing awareness and adoption of personalized therapies.
Recent Acquisitions (last 3 years):
No acquisitions made over the last 3 years as of November 2023, as the company is focused on organic growth through internal R&D.
AI-Based Fundamental Rating:
Werewolf Therapeutics receives a score of 7.5 out of 10:
Justification:
Positives:
- Promising pipeline and differentiated technology with early positive results.
- Experienced leadership and strong financial backing.
- Growing market opportunity with significant unmet needs.
Negatives:
- High-risk profile at early stage with no marketed products.
- Intense competition and dependence on future clinical trial and regulatory success.
- Negative financials for now, expected to improve upon product launch.
Sources and Disclaimers:
Sources used: Werewolf Therapeutics website, SEC filings, industry reports, news articles. Important Disclaimer:
This information is provided for general informational purposes only and does not constitute professional investment advice. It is essential to conduct your research, consult with a qualified financial advisor, and carefully consider all factors before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Werewolf Therapeutics Inc
Exchange | NASDAQ | Headquaters | Watertown, MA, United States |
IPO Launch date | 2021-04-30 | Founder, CEO, President, Secretary & Director | Dr. Daniel J. Hicklin Ph.D. |
Sector | Healthcare | Website | https://werewolftx.com |
Industry | Biotechnology | Full time employees | 45 |
Headquaters | Watertown, MA, United States | ||
Founder, CEO, President, Secretary & Director | Dr. Daniel J. Hicklin Ph.D. | ||
Website | https://werewolftx.com | ||
Website | https://werewolftx.com | ||
Full time employees | 45 |
Werewolf Therapeutics, Inc., a biopharmaceutical company, develops therapeutics engineered to stimulate the body's immune system for the treatment of cancer. The company, through its proprietary PREDATOR platform, designs conditionally activated molecules that stimulate adaptive and innate immunity for addressing the limitations of conventional proinflammatory immune therapies. Its lead product candidates are WTX-124, a conditionally activated Interleukin-2 INDUKINE molecule that is in Phase I/Ib clinical trial for the treatment of advanced or metastatic solid tumors; and WTX-330, a conditionally activated Interleukin-12 INDUKINE molecule, which is in Phase I clinical trial for the treatment of advanced or metastatic solid tumors and lymphoma. The company is also developing JZP898, a conditionally activated interferon alpha INDUKINE molecule for the treatment of cancer; and WTX-712, an activated Interleukin-21(IL-21) and WTX-518, an activated IL-18 (IL-18) INDUKINE molecule for the treatment of cancer. Werewolf Therapeutics, Inc. was incorporated in 2017 and is headquartered in Watertown, Massachusetts.
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