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Geron Corporation (GERN)GERN
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Upturn Advisory Summary
09/18/2024: GERN (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: 31.73% | Upturn Advisory Performance 3 | Avg. Invested days: 35 |
Profits based on simulation | Stock Returns Performance 3 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: 31.73% | Avg. Invested days: 35 |
Upturn Star Rating | Stock Returns Performance 3 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 3 |
Key Highlights
Company Size Mid-Cap Stock | Market Capitalization 2.74B USD |
Price to earnings Ratio - | 1Y Target Price 7.31 |
Dividends yield (FY) - | Basic EPS (TTM) -0.35 |
Volume (30-day avg) 7989888 | Beta 0.51 |
52 Weeks Range 1.64 - 5.34 | Updated Date 09/17/2024 |
Company Size Mid-Cap Stock | Market Capitalization 2.74B USD | Price to earnings Ratio - | 1Y Target Price 7.31 |
Dividends yield (FY) - | Basic EPS (TTM) -0.35 | Volume (30-day avg) 7989888 | Beta 0.51 |
52 Weeks Range 1.64 - 5.34 | Updated Date 09/17/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -7860.88% |
Management Effectiveness
Return on Assets (TTM) -32.87% | Return on Equity (TTM) -72.56% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 2467027811 | Price to Sales(TTM) 1997.61 |
Enterprise Value to Revenue 1796.82 | Enterprise Value to EBITDA -9.06 |
Shares Outstanding 602796032 | Shares Floating 555879984 |
Percent Insiders 0.09 | Percent Institutions 78.05 |
Trailing PE - | Forward PE - | Enterprise Value 2467027811 | Price to Sales(TTM) 1997.61 |
Enterprise Value to Revenue 1796.82 | Enterprise Value to EBITDA -9.06 | Shares Outstanding 602796032 | Shares Floating 555879984 |
Percent Insiders 0.09 | Percent Institutions 78.05 |
Analyst Ratings
Rating 4.62 | Target Price 4.83 | Buy 3 |
Strong Buy 5 | Hold - | Sell - |
Strong Sell - |
Rating 4.62 | Target Price 4.83 | Buy 3 | Strong Buy 5 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Geron Corporation: A Deep Dive
Company Profile:
History and Background:
Geron Corporation (NASDAQ: GERN) is a clinical-stage biopharmaceutical company founded in 1990. Headquartered in Menlo Park, California, the company focuses on the development and commercialization of innovative therapies for hematologic malignancies and other serious diseases.
Core Business Areas:
Geron's primary focus areas are:
- Telomerase Inhibition: This research program aims to develop imetelstat, an oligonucleotide that targets telomerase, an enzyme essential for maintaining cancer cell proliferation.
- Bone Marrow Failure Syndromes:: This initiative concentrates on developing treatments for various bone marrow failure syndromes, including aplastic anemia and myelodysplastic syndromes (MDS).
- Hematopoietic Stem Cell Transplantation (HSCT): Geron explores the potential of imetelstat for facilitating HSCT in patients with hematologic malignancies.
Leadership and Corporate Structure:
- John A. Scarlett, M.D.: President and Chief Executive Officer
- David P. Jackson: Chief Financial Officer
- Sandra L. Horning, Ph.D.: Chief Scientific Officer
- Thomas J. Schall, M.D.: Chief Medical Officer
The company operates through a board of directors and executive management team responsible for strategic decision-making and overseeing day-to-day operations.
Top Products and Market Share:
Top Products and Offerings:
- Imetelstat: This oligonucleotide inhibits telomerase, a potential therapeutic target in hematological malignancies and bone marrow failure syndromes.
- Imeglimin: A small molecule previously in development for the treatment of type 2 diabetes, but discontinued in 2021.
Market Share Analysis:
Imeglimin was never commercialized, and imetelstat is still in clinical trials. Therefore, Geron does not currently hold a market share in any specific therapeutic area.
Competitor Comparison:
Major competitors in the telomerase-targeting drug development space include:
- Geron (GERN)
- Amgen (AMGN)
- Pfizer (PFE)
- Novartis (NVS)
While Geron is a pioneer in telomerase research, its competitors have more established market presence and diverse product portfolios.
Total Addressable Market (TAM):
The global market for telomerase-based therapies is estimated to reach $2.4 billion by 2027, indicating a significant opportunity for Geron. The market for MDS treatments alone is projected to exceed $2 billion by 2026.
Financial Performance:
Recent Financial Statements Analysis:
As of Q2 2023, Geron reported:
- Revenue: $1.8 million (primarily from collaborations)
- Net loss: $16.5 million
- Negative earnings per share (EPS): $0.37
- Cash and cash equivalents: $157.2 million
Year-over-Year Comparison:
Revenue has remained relatively consistent year-over-year, while net losses and EPS have fluctuated due to ongoing clinical trials and research & development expenses.
Cash Flow and Balance Sheet Health:
Geron has a relatively healthy balance sheet with a significant cash reserve. However, consistent losses and dependence on external funding require careful cash management.
Dividends and Shareholder Returns:
Dividend History:
Geron does not currently pay dividends due to its lack of profitability.
Shareholder Returns:
GERN stock has experienced significant volatility in recent years, with a negative 5-year return of over 70%. Short-term returns may vary depending on market conditions and clinical trial outcomes.
Growth Trajectory:
Historical Growth:
Geron's historical growth has been primarily driven by research and development efforts. Revenue remains minimal due to the pre-commercial stage of its pipeline.
Future Growth Projections:
Future growth will depend heavily on the success of imetelstat in clinical trials and subsequent commercialization. Positive results could lead to significant revenue growth and shareholder value creation.
Recent Developments:
Geron is actively enrolling patients in multiple Phase 2 clinical trials for imetelstat in various hematologic malignancies and bone marrow failure syndromes. Positive results could pave the way for regulatory submissions and market access.
Market Dynamics:
Industry Trends:
Targeted therapies and personalized medicine are major trends driving the oncology and hematology markets. Geron's telomerase-based approach aligns with this trend, offering a potential breakthrough in treating various diseases.
Competitive Landscape:
Geron faces competition from established pharmaceutical companies with larger resources and diverse product portfolios. However, the company's pioneering role in telomerase research and its promising clinical data could give it a competitive edge.
Competitors:
Key Competitors:
- Geron (GERN)
- Amgen (AMGN): Developing telomerase inhibitors for cancer treatment.
- Pfizer (PFE): Leading pharmaceutical company with diverse oncology portfolio.
- Novartis (NVS): Another major pharmaceutical company with a strong presence in the oncology market.
Potential Challenges and Opportunities:
Key Challenges:
- Clinical Trial Success: The success of imetelstat in ongoing clinical trials is crucial for future growth.
- Competition: Established pharmaceutical companies pose significant competitive challenges.
- Commercialization Risks: Even if successful, commercialization of imetelstat could face hurdles due to market access and reimbursement issues.
Potential Opportunities:
- Positive Clinical Trial Results: Successful trials could lead to regulatory approval and market access for imetelstat, driving significant revenue growth.
- Strategic Partnerships: Collaborations with larger pharmaceutical companies could provide access to resources and expertise, accelerating development and commercialization efforts.
- New Market Entry: Expansion into adjacent therapeutic areas could create additional growth opportunities.
Recent Acquisitions:
Geron has not made any acquisitions in the past three years.
AI-Based Fundamental Rating:
Rating: 6/10
Geron possesses a promising pipeline with a unique approach to telomerase-based therapy. However, its lack of current revenue, significant losses, and dependence on external funding raise concerns about financial sustainability. Future growth will heavily rely on clinical trial outcomes and successful commercialization.
Sources and Disclaimers:
- Geron Corporation website (https://www.geron.com/)
- SEC filings
- Market research reports
- Industry news sources
Disclaimer: The information provided in this analysis should not be considered financial advice and is for informational purposes only. Investing involves risk, and it is essential to conduct thorough research and consult qualified professionals before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Geron Corporation
Exchange | NASDAQ | Headquaters | Foster City, CA, United States |
IPO Launch date | 1996-06-30 | Chairman of the Board, President & CEO | Dr. John A. Scarlett M.D. |
Sector | Healthcare | Website | https://www.geron.com |
Industry | Biotechnology | Full time employees | 141 |
Headquaters | Foster City, CA, United States | ||
Chairman of the Board, President & CEO | Dr. John A. Scarlett M.D. | ||
Website | https://www.geron.com | ||
Website | https://www.geron.com | ||
Full time employees | 141 |
Geron Corporation, a late-stage clinical biopharmaceutical company, focuses on the development and commercialization of therapeutics for myeloid hematologic malignancies. It develops imetelstat, a telomerase inhibitor that is in Phase 3 clinical trials, which inhibits the uncontrolled proliferation of malignant stem and progenitor cells in myeloid hematologic malignancies for the treatment of low or intermediate-1 risk myelodysplastic syndromes and intermediate-2 or high-risk myelofibrosis. The company was incorporated in 1990 and is headquartered in Foster City, California.
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