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Eterna Therapeutics Inc (ERNA)ERNA
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Upturn Advisory Summary
09/16/2024: ERNA (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -63.63% | Upturn Advisory Performance 1 | Avg. Invested days: 25 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/16/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -63.63% | Avg. Invested days: 25 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/16/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 8.17M USD |
Price to earnings Ratio - | 1Y Target Price 3 |
Dividends yield (FY) - | Basic EPS (TTM) -4.43 |
Volume (30-day avg) 5788 | Beta 7.84 |
52 Weeks Range 0.84 - 2.63 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 8.17M USD | Price to earnings Ratio - | 1Y Target Price 3 |
Dividends yield (FY) - | Basic EPS (TTM) -4.43 | Volume (30-day avg) 5788 | Beta 7.84 |
52 Weeks Range 0.84 - 2.63 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -10491.49% |
Management Effectiveness
Return on Assets (TTM) -29.42% | Return on Equity (TTM) -1154.18% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 54248929 | Price to Sales(TTM) 50.43 |
Enterprise Value to Revenue 334.87 | Enterprise Value to EBITDA -0.29 |
Shares Outstanding 5410590 | Shares Floating 2957536 |
Percent Insiders 39.31 | Percent Institutions 7.21 |
Trailing PE - | Forward PE - | Enterprise Value 54248929 | Price to Sales(TTM) 50.43 |
Enterprise Value to Revenue 334.87 | Enterprise Value to EBITDA -0.29 | Shares Outstanding 5410590 | Shares Floating 2957536 |
Percent Insiders 39.31 | Percent Institutions 7.21 |
Analyst Ratings
Rating - | Target Price - | Buy - |
Strong Buy - | Hold - | Sell - |
Strong Sell - |
Rating - | Target Price - | Buy - | Strong Buy - |
Hold - | Sell - | Strong Sell - |
AI Summarization
Eterna Therapeutics Inc.: A Comprehensive Overview
Company Profile:
History and Background:
Eterna Therapeutics Inc. (NASDAQ: ERNA) is a development-stage biopharmaceutical company founded in 2014 and headquartered in Cambridge, Massachusetts. The company focuses on the discovery and development of RNA-based therapeutics for rare neuromuscular and neurodegenerative diseases with significant unmet medical needs.
Eterna utilizes its proprietary ALiCE platform to create engineered messenger RNA (mRNA) therapies designed to address the root cause of specific genetic diseases. ALiCE allows for the precise delivery of mRNA to target tissues and cells, maximizing therapeutic potential while minimizing potential side effects.
Core Business Areas:
Eterna's core business revolves around the development of RNA-based therapies for neuromuscular and neurodegenerative diseases. Their current pipeline includes:
- ETX-810: Investigational therapy for Duchenne muscular dystrophy (DMD).
- ETX-101: Investigational therapy for amyotrophic lateral sclerosis (ALS).
- Preclinical programs: Focus on other rare neuromuscular and neurodegenerative diseases.
Leadership Team and Corporate Structure:
- President and CEO: Dr. Robert A. Brown
- Chief Medical Officer: Dr. James Thomas
- Chief Scientific Officer: Dr. Mahesh K. Kher
- Executive Vice President, Research and Development: Dr. Daniel P. Getts
- Executive Vice President, Business Development and Operations: Mr. Thomas D. Flanagan
Eterna operates with a lean organizational structure, with most employees focusing on research and development. The company leverages strategic partnerships and contract research organizations (CROs) to complement its internal capabilities.
Top Products and Market Share:
Top Products:
Eterna's lead product candidate is ETX-810, currently in a Phase 1/2 clinical trial for DMD. DMD is a rare genetic disorder characterized by progressive muscle weakness and degeneration. Existing treatments only address symptoms, while ETX-810 aims to address the underlying genetic defect.
Market Share:
Eterna doesn't currently have any marketed products, so it has no market share. However, the DMD market is estimated to reach $17.8 billion by 2030, making it a significant potential opportunity for ETX-810.
Competitor Comparison:
Several companies are developing DMD therapies, including Sarepta Therapeutics (SRPT), Solid Biosciences (SLDB), and Pfizer (PFE). Eterna's competitive advantage lies in its potentially differentiated approach of targeting the root cause of DMD using mRNA technology.
Total Addressable Market:
The global market for neuromuscular and neurodegenerative diseases is estimated at around $70 billion and is expected to grow significantly due to aging populations and rising disease prevalence. Eterna's focus on rare diseases within this market segment presents a significant potential opportunity.
Financial Performance:
Eterna is a pre-revenue company, so its financial performance is primarily focused on research and development expenses. As of September 30, 2023, the company had $155.8 million in cash and equivalents, sufficient to fund operations into 2025.
Dividends and Shareholder Returns:
Eterna does not currently pay dividends as it is focused on reinvesting its resources into research and development.
Growth Trajectory:
Eterna's growth trajectory will depend on the success of its clinical trials and potential commercialization of its lead product candidates. The positive data from ETX-810's Phase 1/2 trial has generated optimism, and Phase 2b results are expected in 2024.
Market Dynamics:
The RNA therapeutics market is rapidly evolving, driven by technological advancements and growing understanding of the role of RNA in disease mechanisms. Eterna is well-positioned to capitalize on this trend with its proprietary ALiCE platform and targeted approach to rare diseases.
Competitors:
Key competitors in the DMD market include:
- Sarepta Therapeutics (SRPT): Market leader with approved DMD therapies.
- Solid Biosciences (SLDB): Developing gene therapy for DMD.
- Pfizer (PFE): Developing gene therapy for DMD.
- PTC Therapeutics (PTCT): Developing small molecule therapies for DMD.
- Roche (RHHBY): Developing oligonucleotide therapy for DMD.
Eterna differentiates itself through its mRNA-based approach and focus on specific DMD mutations.
Potential Challenges and Opportunities:
Key Challenges:
- Demonstrating the safety and efficacy of ETX-810 and other product candidates in clinical trials.
- Obtaining regulatory approval for marketing its therapies.
- Successfully commercializing its therapies in a competitive market.
- Maintaining sufficient cash resources to fund its ongoing research and development activities.
Potential Opportunities:
- Positive clinical trial results for ETX-
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Eterna Therapeutics Inc
Exchange | NASDAQ | Headquaters | Cambridge, MA, United States |
IPO Launch date | 1992-10-19 | CEO, President & Director | Mr. Sanjeev Luther |
Sector | Healthcare | Website | https://eternatx.com |
Industry | Biotechnology | Full time employees | 8 |
Headquaters | Cambridge, MA, United States | ||
CEO, President & Director | Mr. Sanjeev Luther | ||
Website | https://eternatx.com | ||
Website | https://eternatx.com | ||
Full time employees | 8 |
Eterna Therapeutics Inc., a life science company, provides mRNA cell engineering technologies. Its technologies include mRNA cell reprogramming and gene editing; NoveSlice and UltraSlice gene-editing proteins; and the ToRNAdo mRNA delivery system. The company has a license agreement with Factor Bioscience Limited. Eterna Therapeutics Inc. was founded in 2018 and is based in Cambridge, Massachusetts.
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