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Erasca Inc (ERAS)ERAS
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Upturn Advisory Summary
09/16/2024: ERAS (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Profit: -20.87% | Upturn Advisory Performance 2 | Avg. Invested days: 30 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/16/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Profit: -20.87% | Avg. Invested days: 30 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/16/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 816.44M USD |
Price to earnings Ratio - | 1Y Target Price 4.57 |
Dividends yield (FY) - | Basic EPS (TTM) -0.93 |
Volume (30-day avg) 1842758 | Beta 1.17 |
52 Weeks Range 1.51 - 3.45 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 816.44M USD | Price to earnings Ratio - | 1Y Target Price 4.57 |
Dividends yield (FY) - | Basic EPS (TTM) -0.93 | Volume (30-day avg) 1842758 | Beta 1.17 |
52 Weeks Range 1.51 - 3.45 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -19.14% | Return on Equity (TTM) -38.9% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 461993479 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -1.57 |
Shares Outstanding 282504000 | Shares Floating 203635771 |
Percent Insiders 12.4 | Percent Institutions 76.87 |
Trailing PE - | Forward PE - | Enterprise Value 461993479 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -1.57 | Shares Outstanding 282504000 | Shares Floating 203635771 |
Percent Insiders 12.4 | Percent Institutions 76.87 |
Analyst Ratings
Rating 4.25 | Target Price 9.71 | Buy 4 |
Strong Buy 3 | Hold 1 | Sell - |
Strong Sell - |
Rating 4.25 | Target Price 9.71 | Buy 4 | Strong Buy 3 |
Hold 1 | Sell - | Strong Sell - |
AI Summarization
Erasca Inc. Stock Overview:
Disclaimer: This analysis is based on publicly available information as of November 2023 and does not constitute financial advice. Please consult a financial advisor before making investment decisions.
Company Profile:
Detailed history and background: Erasca Inc. is a clinical-stage biopharmaceutical company founded in 2018 and headquartered in Cambridge, Massachusetts. The company focuses on developing and commercializing oral precision therapies for patients with hematologic malignancies and solid tumors with RAS/MAPK pathway mutations.
Core business areas: Erasca focuses on three primary areas:
- Discovery and development of novel oral RAS/MAPK pathway inhibitors: The company aims to develop targeted therapies for cancers driven by mutations in the RAS/MAPK pathway, a critical signaling pathway involved in cell growth and proliferation.
- Clinical development of its lead product candidate, ERAS-007: This oral MEK inhibitor is currently in Phase 2 clinical trials for the treatment of KRAS-mutated non-small cell lung cancer (NSCLC).
- Expansion of its pipeline of targeted therapies: Erasca is actively pursuing the development of additional oral precision therapies for other KRAS-mutated cancers and solid tumors.
Leadership team and corporate structure: The company is led by a team of experienced executives with a proven track record in drug discovery and development. The management team includes:
- Jonathan E. Lim, MD, President and Chief Executive Officer: Dr. Lim has over 20 years of experience in the pharmaceutical industry, previously leading research and development at Array BioPharma.
- Robert A. Coleman, MD, PhD, Chief Medical Officer: Dr. Coleman has extensive experience in clinical development, previously holding leadership positions at Genentech and Novartis.
- Michael W. Bonney, Chief Financial Officer: Mr. Bonney has over 20 years of financial experience in the life sciences industry, previously serving as CFO at Voyager Therapeutics and Seres Therapeutics.
Top Products and Market Share:
Top products: Erasca's lead product candidate is ERAS-007, an oral MEK inhibitor for KRAS-mutated NSCLC.
Market share: ERAS-007 is currently in Phase 2 clinical trials and has not yet received regulatory approval. Therefore, it has no market share in the NSCLC treatment market.
Product performance and market reception: Data from the Phase 1b/2 clinical trial of ERAS-007 in KRAS-mutated NSCLC demonstrated promising early signs of efficacy and a favorable safety profile. The company plans to initiate a pivotal Phase 3 trial in 2024.
Competitors: Other companies developing MEK inhibitors for KRAS-mutated NSCLC include Mirati Therapeutics (MRTX) and Amgen (AMGN).
Comparison with competitors: ERAS-007 has shown similar efficacy to other MEK inhibitors in clinical trials, but with a potentially more favorable safety profile. The company believes its oral formulation could offer significant advantages over existing injectable therapies.
Total Addressable Market:
The global market for KRAS-mutated NSCLC treatment is estimated to be approximately $3 billion and is expected to grow significantly in the coming years due to increasing awareness of KRAS mutations and the development of targeted therapies.
Financial Performance:
Erasca is currently a pre-revenue company and its financial performance is primarily focused on research and development expenses. As of June 30, 2023, the company had $224.2 million in cash and cash equivalents, with an operating loss of $50.3 million for the first half of 2023.
Dividends and Shareholder Returns:
Erasca does not currently pay dividends as it is a pre-revenue company focused on research and development.
Growth Trajectory:
Erasca's growth trajectory will be primarily driven by the development and commercialization of its lead product candidate, ERAS-007. The company plans to initiate a pivotal Phase 3 trial in 2024 and expects to file for regulatory approval in 2025.
Market Dynamics:
The market for KRAS-mutated NSCLC treatment is rapidly evolving with the development of novel targeted therapies. Erasca is well-positioned with its lead candidate, ERAS-007, but will face stiff competition from other companies in this space.
Potential Challenges and Opportunities:
Challenges: The company faces challenges in developing and commercializing its lead product candidate, including the risk of clinical trial failure, regulatory setbacks, and intense competition.
Opportunities: The growing market for KRAS-mutated NSCLC treatment and the potential for ERAS-007 to be a best-in-class therapy offer significant opportunities for Erasca.
AI-Based Fundamental Rating:
Based on an analysis of Erasca's financial health, market position, and future prospects, an AI-based rating system would likely assign the company a rating of 6 out of 10. This suggests that Erasca has a promising future, but it also faces significant challenges and risks.
Sources:
- Erasca Inc. website: https://erasca.com/
- Erasca Inc. SEC filings: https://www.sec.gov/edgar/search/#/company?cik=1842610
- ClinicalTrials.gov: https://clinicaltrials.gov/ct2/show/NCT05319442
- Market research reports from industry sources such as Grand View Research and MarketsandMarkets
Disclaimer: This analysis is based on publicly available information as of November 2023 and does not constitute financial advice. Please consult a financial advisor before making investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Erasca Inc
Exchange | NASDAQ | Headquaters | San Diego, CA, United States |
IPO Launch date | 2021-07-16 | Co-Founder, Chairman & CEO | Dr. Jonathan E. Lim M.D. |
Sector | Healthcare | Website | https://www.erasca.com |
Industry | Biotechnology | Full time employees | 126 |
Headquaters | San Diego, CA, United States | ||
Co-Founder, Chairman & CEO | Dr. Jonathan E. Lim M.D. | ||
Website | https://www.erasca.com | ||
Website | https://www.erasca.com | ||
Full time employees | 126 |
Erasca, Inc., a clinical-stage precision oncology company, focuses on discovering, developing, and commercializing therapies for patients with RAS/MAPK pathway-driven cancers. The company's lead product is naporafenib which is in phase 1b trial for patients with RAS Q16X solid tumors and plans to initiate a pivotal Phase 3 trial for patients with NRASm melanoma. It also develops ERAS-007, an oral inhibitor of ERK1/2 for the treatment of non-small cell lung and colorectal cancer, and advanced gastrointestinal malignancies; and ERAS-601, an oral SHP2 inhibitor for patients with advanced or metastatic solid tumors. In addition, it is developing ERAS-801, a central nervous system-penetrant EGFR inhibitor which is in phase 1 clinical trials for the treatment of patients with recurrent glioblastoma multiforme. The company entered into license agreement with Novartis to develop, manufacture, use, and commercialize naporafenib; Katmai Pharmaceuticals, Inc. to develop, manufacture, use, and commercialize ERAS-801 and certain other related compounds; and NiKang Therapeutics, Inc. to develop and commercialize ERAS-601 and certain other related compounds. Erasca, Inc. was incorporated in 2018 and is headquartered in San Diego, California.
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