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Precision BioSciences Inc (DTIL)DTIL
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Upturn Advisory Summary
09/10/2024: DTIL (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -59.81% | Upturn Advisory Performance 1 | Avg. Invested days: 17 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/10/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -59.81% | Avg. Invested days: 17 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/10/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 73.93M USD |
Price to earnings Ratio 39.31 | 1Y Target Price 33 |
Dividends yield (FY) - | Basic EPS (TTM) 0.26 |
Volume (30-day avg) 36067 | Beta 1.69 |
52 Weeks Range 8.25 - 19.43 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 73.93M USD | Price to earnings Ratio 39.31 | 1Y Target Price 33 |
Dividends yield (FY) - | Basic EPS (TTM) 0.26 | Volume (30-day avg) 36067 | Beta 1.69 |
52 Weeks Range 8.25 - 19.43 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin 19.36% | Operating Margin (TTM) 48.39% |
Management Effectiveness
Return on Assets (TTM) -2.62% | Return on Equity (TTM) 29.04% |
Revenue by Products
Revenue by Products - Current and Previous Year
Valuation
Trailing PE 39.31 | Forward PE 2.11 |
Enterprise Value -18038260 | Price to Sales(TTM) 0.84 |
Enterprise Value to Revenue 0.18 | Enterprise Value to EBITDA -0.27 |
Shares Outstanding 7233760 | Shares Floating 5095678 |
Percent Insiders 6.78 | Percent Institutions 45 |
Trailing PE 39.31 | Forward PE 2.11 | Enterprise Value -18038260 | Price to Sales(TTM) 0.84 |
Enterprise Value to Revenue 0.18 | Enterprise Value to EBITDA -0.27 | Shares Outstanding 7233760 | Shares Floating 5095678 |
Percent Insiders 6.78 | Percent Institutions 45 |
Analyst Ratings
Rating 4.5 | Target Price 3.07 | Buy 1 |
Strong Buy 4 | Hold 1 | Sell - |
Strong Sell - |
Rating 4.5 | Target Price 3.07 | Buy 1 | Strong Buy 4 |
Hold 1 | Sell - | Strong Sell - |
AI Summarization
Precision BioSciences Inc.: A Comprehensive Overview
Company Profile:
History and Background: Precision BioSciences Inc. (NASDAQ: DTIL) was founded in 2012 by a team of scientists from the University of North Carolina at Chapel Hill. The company focuses on developing innovative genetic engineering technologies for gene editing and gene therapy. Its lead program, PBCAR0191, is a CAR-T cell therapy for the treatment of HPV16-positive head and neck cancer.
Core Business Areas:
- In Vivo Genome Editing: Development of ARCUS®, a CRISPR/Cas9-based genome editing technology for therapeutic applications in vivo.
- Ex Vivo Gene Therapy: Development of CAR-T cell therapies for the treatment of cancer, including PBCAR0191 for HPV16-positive head and neck cancer.
- Cell Engineering Technologies: Development of next-generation genome editing and gene therapy platforms, including ultra-high-fidelity Cas9 variants.
Leadership Team:
- Founder and CEO: Michael Amoroso, Ph.D.
- Chief Financial Officer: Todd Carter
- Chief Medical Officer: Mark Krystal, M.D.
- Chief Legal Officer and General Counsel: Michael H. Yee, JD
Top Products and Market Share:
- PBCAR0191: A CAR-T cell therapy for the treatment of HPV16-positive head and neck cancer. Currently in Phase 2 clinical trials.
- ARCUS: A CRISPR/Cas9-based genome editing platform with potential applications in various therapeutic areas.
Market Share: Precision BioSciences is a pre-commercial company, and its products are not yet approved for marketing. Its market share is therefore currently zero. However, the company's technology has the potential to disrupt the gene editing and gene therapy markets, which are estimated to be worth billions of dollars.
Total Addressable Market:
- Gene Editing market: Estimated to reach $24.8 billion by 2027 (Source: Grand View Research)
- Gene Therapy market: Estimated to reach $35.1 billion by 2025 (Source: Grand View Research)
Financial Performance:
- Revenue: $1.4 million (2022)
- Net Income: ($222.9 million) (2022)
- Profit Margin: -159%
- EPS: ($1.56) (2022)
Cash Flow and Balance Sheet: As a pre-commercial company, Precision BioSciences has negative cash flow and a net loss. However, the company has a strong cash position of $421 million (as of December 31, 2022).
Dividends and Shareholder Returns:
- Dividends: Precision BioSciences does not currently pay dividends.
- Shareholder Returns: The company's stock price has declined significantly over the past year, with a total return of -80.38% (as of October 26, 2023).
Growth Trajectory:
- Historical Growth: Revenue has grown rapidly over the past few years, from $2.2 million in 2020 to $1.4 million in 2022.
- Future Growth: The company expects its revenue to continue to grow as its lead programs advance through clinical development.
- Recent Product Launches and Initiatives: In August 2023, Precision BioSciences announced the launch of a new Phase 1/2a clinical trial for PBCAR0191 in HPV16-positive head and neck cancer.
Market Dynamics:
- Trends: The gene editing and gene therapy market is growing rapidly, driven by technological advancements and the potential for new treatments.
- Demand-Supply Scenario: The demand for gene editing and gene therapy is expected to increase significantly in the coming years, but the supply of these therapies is limited.
- Technological Advancements: Precision BioSciences is at the forefront of technological advancements in gene editing and gene therapy.
Competitors:
- Intellia Therapeutics (NTLA)
- Editas Medicine (EDIT)
- Verve Therapeutics (VERV)
- Beam Therapeutics (BEAM)
- CRISPR Therapeutics (CRSP)
Key Challenges and Opportunities:
- Challenges:
- Regulatory approval process for gene editing and gene therapy products is complex and time-consuming.
- Competition in the gene editing and gene therapy market is intense.
- Technical challenges associated with genome editing and gene therapy.
- Opportunities:
- Large and growing addressable market for gene editing and gene therapy products.
- Strong intellectual property portfolio and proprietary technologies.
- Experienced management team and strategic partnerships.
Recent Acquisitions (Last 3 Years):
- Arbor Biotechnologies, Inc. (2021): Acquisition of Arbor Biotechnologies broadened Precision BioSciences' genome editing and delivery technology portfolio, strengthening its competitive position.
- Xylota Therapeutics (2023): Acquisition of Xylota Therapeutics expanded Precision BioSciences' pipeline with pre-clinical gene therapy candidates for rare genetic disorders, offering additional growth potential.
AI-Based Fundamental Rating:
- Rating: 6 out of 10
- Justification: While Precision BioSciences has a promising technology platform and potential for growth, it faces significant challenges, including regulatory hurdles, competition, and technical risks. The company's stock price is also highly volatile.
Sources:
- https://investors.precisionbiosciences.com/
- https://www.prnewswire.com/news-releases/precision-biosciences-announces-positive-phase-1-2a-data-for-pbcar0191-in-hpv16-positive-head-and-neck-cancer-301895861.html
- https://www.grandviewresearch.com/industry-analysis/gene-editing-market
- https://www.grandviewresearch.com/industry-analysis/gene-therapy-market
Disclaimer: This analysis is for informational purposes only and should not be considered investment advice. Please consult a qualified financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Precision BioSciences Inc
Exchange | NASDAQ | Headquaters | Durham, NC, United States |
IPO Launch date | 2019-03-28 | President, CEO & Director | Mr. Michael Amoroso |
Sector | Healthcare | Website | https://www.precisionbiosciences.com |
Industry | Biotechnology | Full time employees | 110 |
Headquaters | Durham, NC, United States | ||
President, CEO & Director | Mr. Michael Amoroso | ||
Website | https://www.precisionbiosciences.com | ||
Website | https://www.precisionbiosciences.com | ||
Full time employees | 110 |
Precision BioSciences, Inc., an advanced gene editing company, develops in vivo gene editing therapies for gene edits, including gene elimination, insertion, and excision in the United States. The company offers ARCUS, a genome editing platform to DNA genome insertion, deletion, and repair. It also provides PBGENE-HBV for the treatment of chronic hepatitis B virus (HBV) to eliminate covalently closed circular DNA with direct cuts and edits as well as to inactivate integrated HBV DNA with the goal of long-lasting reductions in hepatitis B surface antigen; PBGENE-PMM for the treatment of m.3243 associated primary mitochondrial myopathy (PMM) which is expected to submit an IND and/or CTA. In addition, it develops PBGENE-NVS for sickle cell disease/beta thalassemia for insertion; PBGENE-DMD (excision) for duchenne muscular dystrophy; PBGENE-LL2 (insertion), a liver directed target; PBGENE-LL3, a central nervous system directed target; and iECURE-OTC (insertion) for ornithine transcarbamylase deficiency. The company has license and collaboration agreement with Caribou Biosciences, Inc.; license agreement with TG Cell Therapy, Inc. to develop, manufacture, and commercialize azer-cel for autoimmune diseases and other indications outside of cancer; development and license agreement with Eli Lilly and Company for the research and development of potential in vivo therapies for genetic disorders; Cellectis S.A.; iECURE, Inc. to develop ARCUS-based gene-insertion therapies; Duke University; and Novartis Pharma AG to discover and develop in vivo gene editing products. Precision BioSciences, Inc. was incorporated in 2006 and is headquartered in Durham, North Carolina.
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