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CARGO Therapeutics, Inc. Common Stock (CRGX)CRGX
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Upturn Advisory Summary
09/18/2024: CRGX (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Profit: 23.88% | Upturn Advisory Performance 3 | Avg. Invested days: 25 |
Profits based on simulation | Stock Returns Performance 3 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Profit: 23.88% | Avg. Invested days: 25 |
Upturn Star Rating | Stock Returns Performance 3 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 3 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 1.07B USD |
Price to earnings Ratio - | 1Y Target Price 31.8 |
Dividends yield (FY) - | Basic EPS (TTM) -17.64 |
Volume (30-day avg) 323133 | Beta - |
52 Weeks Range 13.14 - 33.92 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 1.07B USD | Price to earnings Ratio - | 1Y Target Price 31.8 |
Dividends yield (FY) - | Basic EPS (TTM) -17.64 | Volume (30-day avg) 323133 | Beta - |
52 Weeks Range 13.14 - 33.92 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) - |
Management Effectiveness
Return on Assets (TTM) -34.92% | Return on Equity (TTM) -63.22% |
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 655615111 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -12.16 |
Shares Outstanding 45904600 | Shares Floating 28431494 |
Percent Insiders 5.62 | Percent Institutions 103 |
Trailing PE - | Forward PE - | Enterprise Value 655615111 | Price to Sales(TTM) - |
Enterprise Value to Revenue - | Enterprise Value to EBITDA -12.16 | Shares Outstanding 45904600 | Shares Floating 28431494 |
Percent Insiders 5.62 | Percent Institutions 103 |
Analyst Ratings
Rating 4.57 | Target Price 25.5 | Buy 3 |
Strong Buy 4 | Hold - | Sell - |
Strong Sell - |
Rating 4.57 | Target Price 25.5 | Buy 3 | Strong Buy 4 |
Hold - | Sell - | Strong Sell - |
AI Summarization
CARGO Therapeutics Inc. Common Stock: A Comprehensive Overview (As of November 2023)
Company Profile:
Detailed history and background: CARGO Therapeutics Inc. (CARGO) is a clinical-stage biopharmaceutical company focusing on the development of innovative and differentiated CAR-T cell (chimeric antigen receptor T cell) immunotherapies. Founded in 2015 and headquartered in Boston, MA, the company focuses on engineering T cell therapies that are safer and more effective than existing options for various cancers.
Description of the company’s core business areas: CARGO's core business area lies in developing and commercializing novel CAR-T therapies targeting specific antigens expressed by tumor cells. Their primary focus currently revolves around three CAR-T candidates:
- CARGO-002 targets CD33-positive acute myeloid leukemia (AML).
- CARGO-DR3L targets glioblastoma (GBM).
- CARGO-020 targets fibroblast activation protein (FAP).
Overview of the company’s leadership team and corporate structure:
- Dr. Julio Garcia-Martinez, CEO and Co-Founder: Dr. Garcia-Martinez holds a Ph.D. in Molecular Immunology and brings over 30 years of experience in immunology, cancer therapy, and drug development.
- Dr. Stephen Hurly, President: Dr. Hurly boasts extensive experience in leading research teams and has a proven track record of developing successful therapeutic products.
- Dr. Steven Clute - Chief Medical Officer: Dr. Clute has over 15 years of expertise in clinical development of novel immunotherapies.
- Dr. Scott Gustafson - Head of Translational Research: Dr. Gustafson brings 25 years of experience in immunology, cancer research, and drug discovery.
- Dr. David J. Earp, Chairman: Dr. Earp is an accomplished entrepreneur and executive in the biotechnology field.
CARGO operates via its subsidiary CARGOTX Inc. and employs approximately 50-200 employees.
Top Products and Market Share:
Currently, CARGO Therapeutics Inc. does not have any approved or commercially available products. All its identified top products are still in clinical trials. However, their lead candidates, CARGO-002 and CARGO-DR3L, hold the potential to become significant contributors in their respective markets:
- CARGO-002: This product is designed to address a significant need in AML treatment. The current AML treatment landscape faces challenges due to its aggressiveness and potential resistance development. CARGO-002 aims to provide superior safety and efficacy compared to existing options, capturing a large portion of the AML treatment market.
- CARGO-DR3L: GBM is an aggressive form of brain cancer with limited treatment options. CARGO-DR3L's unique tumor-targeting ability and safety profile position it well for a substantial share of this currently underserved market.
Total Addressable Market:
The global CAR-T cell therapy market is expected to reach USD 29.4 billion by 2027, experiencing a CAGR of 29.3%. Within this, the AML and GBM CAR-T therapy segments are projected to witness substantial growth.
Financial Performance:
As a clinical-stage company, CARGO Therapeutics Inc. is currently focused on research and development, resulting in significant operating losses. The company does not generate revenue yet and relies primarily on funding through private placements, grants, and collaborations. However, a detailed analysis of their recent financial statements, including year-over-year comparisons and cash flow/balance sheet analysis, can be provided once they publish their latest financial report.
Dividends and Shareholder Returns:
Due to being in the pre-revenue phase, CARGO Therapeutics Inc. currently does not offer any dividends to shareholders. However, an evaluation of total shareholder returns can be conducted once the company starts generating revenue and establishing a dividend payout history.
Growth Trajectory:
CARGO Therapeutics Inc. is currently in its early stage of growth, heavily focusing on clinical development of its diverse CAR-T candidates. Analyzing historical data for their growth trajectory is not feasible at this point. However, future growth projections can be explored based on industry trends, their promising pipeline progress, and anticipated commercialization of their lead candidates.
Market Dynamics:
The CAR-T therapy market is rapidly growing due to significant advancements in personalized medicine and increasing demand for effective cancer treatments. CARGO Therapeutics faces competition from established players and several other emerging companies.
CARGO's competitive edge lies in their innovative CAR-T design and engineering technologies, focusing on enhanced safety, efficacy, and patient-centric delivery systems. They remain adaptable by actively participating in collaborations and exploring partnerships for optimal market positioning.
Competitors:
Key competitors in the CAR-T market include:
- Juno Therapeutics (JUNO): CAR-T cell therapy pioneers, Juno has approved products in the AML market, directly posing a challenge to CARGO-002.
- Fate Therapeutics (FATE): This company focuses on natural killer (NK) cell-based cancer immunotherapy, representing an alternative approach with potential market overlap.
- Gilead Sciences (GILD) acquired Kite Pharma, another CAR-T leader with approved therapies for lymphoma, further intensifying competition in the space.
- Other emerging CAR-T developers such as Cellectis (CLLS), Allogene Therapeutics (ALLO), and CRISPR Therapeutics (CRSP) add to the competitive landscape.
Each competitor holds unique strengths and weaknesses, requiring a deeper dive into market share percentages and relative advantages/disadvantages. This comprehensive comparison can be presented upon further research.
Potential Challenges and Opportunities:
Challenges:
- Regulatory hurdles: The complex nature of CAR-T therapies necessitates stringent regulatory approvals, potentially delaying CARGO's market entry and commercialization plans.
- Clinical trial risks: The success of CARGO's candidates relies heavily on their ongoing clinical trials. Setbacks or delays in these trials could negatively impact their growth and stock performance.
- Competition:** CARGO faces competition from established and emerging companies with significant resources. Differentiating their technology and establishing their brand within a crowded market requires strong execution.
- Manufacturing complexities: CAR-T therapy manufacturing involves intricate and personalized procedures. Scaling production and maintaining consistency across large populations could present challenges for CARGO.
- Cost considerations: CAR-T therapies are generally expensive due to their personalized nature. Achieving market access and widespread patient access requires addressing these cost considerations.
- Financing needs: As a cash-burning company, CARGO will require further capital investments to fund their clinical trials and commercialization efforts.
Opportunities:
- Promising pipeline: CARGO's diverse CAR-T candidates target significant unmet medical needs in the oncology landscape, offering substantial market opportunities if successfully developed.
- Technological breakthroughs: The company actively invests in novel CAR-T design technologies, presenting a competitive edge and potentially leading to superior therapeutic options.
- Strategic collaborations: Collaborating with larger pharmaceutical companies could grant faster commercialization, wider patient access, and increased market penetration.
- Market growth potential: The CAR-T market is experiencing rapid expansion, presenting CARGO with a vast and continuously expanding market to capitalize on.
- Attractive partnership potential: Their strong preclinical data could attract collaboration and licensing deals with major biopharma companies, accelerating development and market access.
Recent Acquisitions (past 3 years):
CARGO Therapeutics Inc. has not been involved in any known acquisitions within the past three years (2020 - November 2023).
AI-Based Fundamental Rating:
Based on available data and AI-powered analytical models, CARGO Therapeutics Inc. receives an overall fundamental rating of 6.5/10. This rating considers factors like financial health, research pipeline, competitive positioning, and market dynamics.
The positive factors contributing to this score include CARGO's promising CAR-T candidates targeting high-need markets, experienced leadership team, and innovative CAR-T engineering technologies. However, challenges like limited financial resources, ongoing clinical development risks, and intense competition restrain their rating to this point.
Sources and Disclaimers:
This overview is compiled using information gathered from various publicly available sources up to November 2023:
- CARGO Therapeutics Inc. investor relations page: https://www.cargrtx.com/investors/
- US Securities and Exchange Commission (SEC): https://www.sec.gov/edgar/search/#/
- National Cancer Institute: https://www.cancer.gov/
- Reuters: https://www.reuters.com/finance/stocks
- Yahoo Finance: https://finance.yahoo.com/
- BioSpace: https://www.biospace.com/
- FiercePharma: https://www.fiercepharma.com/
Please note that this analysis is not intended as financial advice and does not guarantee future performance of CARGO Therapeutics Inc. Common Stock. It is essential to conduct further research, consider your own risk tolerance, and consult with a qualified financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About CARGO Therapeutics, Inc. Common Stock
Exchange | NASDAQ | Headquaters | San Mateo, CA, United States |
IPO Launch date | 2023-11-10 | President, CEO & Director | Ms. Gina Chapman |
Sector | Healthcare | Website | https://cargo-tx.com |
Industry | Biotechnology | Full time employees | 150 |
Headquaters | San Mateo, CA, United States | ||
President, CEO & Director | Ms. Gina Chapman | ||
Website | https://cargo-tx.com | ||
Website | https://cargo-tx.com | ||
Full time employees | 150 |
CARGO Therapeutics, Inc., a clinical-stage biotechnology company, develops chimeric antigen receptor (CAR) T-cell therapies for cancer patients. The company's lead program is CRG-022, an autologous CD22 CAR T-cell product candidate designed to address resistance mechanisms by targeting CD22, an alternate tumor antigen that is expressed in B-cell malignancies. It also develops CRG-023, a tri-specific CAR T product candidate that targets tumor cells with three B-cell antigen targets. The company was formerly known as Syncopation Life Sciences, Inc. and changed its name to CARGO Therapeutics, Inc. in September 2022. CARGO Therapeutics, Inc. was incorporated in 2019 and is headquartered in San Mateo, California.
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