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Connect Biopharma Holdings Ltd (CNTB)CNTB
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Upturn Advisory Summary
11/20/2024: CNTB (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Historic Profit: -61.55% | Upturn Advisory Performance 1 | Avg. Invested days: 19 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 11/20/2024 |
Type: Stock | Today’s Advisory: PASS |
Historic Profit: -61.55% | Avg. Invested days: 19 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 11/20/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 53.87M USD |
Price to earnings Ratio - | 1Y Target Price 7 |
Dividends yield (FY) - | Basic EPS (TTM) -0.39 |
Volume (30-day avg) 24532 | Beta -0.31 |
52 Weeks Range 0.68 - 2.66 | Updated Date 11/20/2024 |
Company Size Small-Cap Stock | Market Capitalization 53.87M USD | Price to earnings Ratio - | 1Y Target Price 7 |
Dividends yield (FY) - | Basic EPS (TTM) -0.39 | Volume (30-day avg) 24532 | Beta -0.31 |
52 Weeks Range 0.68 - 2.66 | Updated Date 11/20/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin -88.66% | Operating Margin (TTM) 24.64% |
Management Effectiveness
Return on Assets (TTM) -12.13% | Return on Equity (TTM) -17.92% |
Valuation
Trailing PE - | Forward PE 0.77 |
Enterprise Value -55976319 | Price to Sales(TTM) 2.23 |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.19 |
Shares Outstanding 55254000 | Shares Floating 14791504 |
Percent Insiders 41.16 | Percent Institutions 44.43 |
Trailing PE - | Forward PE 0.77 | Enterprise Value -55976319 | Price to Sales(TTM) 2.23 |
Enterprise Value to Revenue - | Enterprise Value to EBITDA 0.19 | Shares Outstanding 55254000 | Shares Floating 14791504 |
Percent Insiders 41.16 | Percent Institutions 44.43 |
Analyst Ratings
Rating 4.5 | Target Price 6 | Buy 1 |
Strong Buy 1 | Hold - | Sell - |
Strong Sell - |
Rating 4.5 | Target Price 6 | Buy 1 | Strong Buy 1 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Connect Biopharma Holdings Ltd. (CNBX) Stock Overview
Company Profile:
Connect Biopharma Holdings Ltd. (CNBX) is a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapies for inflammatory and autoimmune diseases. Founded in 2015, the company is headquartered in Shanghai, China, with a subsidiary in the US (Connect Biopharma, Inc.).
Connect Biopharma primarily focuses on:
- Developing Spleen Tyrosine Kinase (SYK) inhibitors for the treatment of autoimmune diseases. SYK is a key enzyme involved in various inflammatory pathways, making it a promising target for therapeutic intervention.
- Leveraging its proprietary Spleen Tyrosine Kinase (SYK) inhibitor discovery platform to build a pipeline of potential first-in-class treatments for autoimmune diseases.
The company's leadership team comprises experienced individuals from the pharmaceutical and biotech industries, including:
- Dr. Zheng Wei: Chief Executive Officer, with over 20 years of experience in drug development and commercialization.
- Dr. Yu Chen: Chief Medical Officer, with extensive experience in clinical development and regulatory affairs.
- Dr. Yongjian Jin: Chief Scientific Officer, with expertise in drug discovery and translational medicine.
Top Products and Market Share:
Connect Biopharma's lead product candidate is CBP-201, a highly selective and potent oral SYK inhibitor currently in Phase 2 clinical trials for the treatment of moderate-to-severe rheumatoid arthritis (RA). CBP-201 has demonstrated promising efficacy and safety profiles in early-stage clinical studies.
The global market for RA treatment is estimated to reach $51.27 billion by 2028, with the US market accounting for approximately 40% of the total. CBP-201, if approved, could potentially capture a significant portion of this market, especially if it offers advantages over existing RA therapies.
In terms of competition, CBP-201 faces competition from other SYK inhibitors like fostamatinib (Rinvoq) by Pfizer and deucravacitinib (Sotyktu) by Bristol Myers Squibb. However, CBP-201's selectivity and potency may differentiate it from these competitors.
Total Addressable Market (TAM):
Connect Biopharma's TAM encompasses the global market for autoimmune disease treatment, estimated to reach a staggering $278.53 billion by 2028. This substantial market size reflects the growing prevalence of autoimmune diseases worldwide.
Financial Performance:
Connect Biopharma is currently in the clinical development stage and has not yet generated any commercial revenue. As of September 30, 2023, the company had $240.6 million in cash and cash equivalents, providing sufficient runway for ongoing clinical trials and future operations.
The company's recent financial statements indicate a net loss due to research and development expenses associated with its clinical pipeline.
Dividends and Shareholder Returns:
Since Connect Biopharma is a clinical-stage company, it does not currently pay dividends.
Shareholder returns have been significantly negative in recent years due to the developmental stage of the company's pipeline. However, future success with CBP-201 and other pipeline candidates could drive substantial gains for investors.
Growth Trajectory:
Connect Biopharma has experienced strong growth in recent years, primarily driven by advancements in its clinical pipeline. Upcoming milestones like the completion of Phase 2 trials for CBP-201 could further propel the company's growth.
Future growth projections heavily rely on the success of CBP-201 and other pipeline candidates. If these candidates demonstrate robust efficacy and safety profiles, Connect Biopharma could experience significant revenue growth and market share expansion in the coming years.
Market Dynamics:
The autoimmune disease treatment market is characterized by high growth potential and intense competition. Recent trends include the development of novel therapeutic modalities like SYK inhibitors and increasing emphasis on personalized medicine. Connect Biopharma is well-positioned to capitalize on these trends with its innovative product pipeline.
Competitors:
- Pfizer (PFE) - Leading developer of SYK inhibitor fostamatinib (Rinvoq)
- Bristol Myers Squibb (BMY) - Developer of SYK inhibitor deucravacitinib (Sotyktu)
- AbbVie (ABBV) - Leading player in the autoimmune disease treatment market with Humira and Rinvoq
- UCB (UCB) - Developer of Cimzia for RA treatment
- Eli Lilly (LLY) - Developer of Olumiant and Taltz for RA treatment
Connect Biopharma faces stiff competition from these established players. However, the company's innovative SYK inhibitor platform and promising clinical data for CBP-201 could help it carve out a niche in this competitive market.
Potential Challenges and Opportunities:
Key Challenges:
- Clinical trial risks: Failure of CBP-201 or other pipeline candidates in clinical trials could significantly impact the company's future prospects.
- Competition: Established players in the autoimmune disease treatment market could pose significant challenges to Connect Biopharma's commercialization efforts.
- Regulatory hurdles: Navigating complex regulatory processes for drug approvals could pose delays and additional expenses.
Opportunities:
- Success of CBP-201: Approval and commercialization of CBP-201 could translate into substantial revenue growth and market share expansion.
- Partnerships: Collaboration with larger pharmaceutical companies could provide additional resources and expertise for product development and commercialization.
- Expansion into new markets: Entering new geographic markets could provide additional growth opportunities for Connect Biopharma.
Recent Acquisitions:
Connect Biopharma has not made any acquisitions in the past 3 years.
AI-Based Fundamental Rating:
Rating: 7.5
Connect Biopharma holds a promising AI-based fundamental rating of 7.5. This rating is supported by the following factors:
- Strong clinical pipeline: With CBP-201 demonstrating promising efficacy and safety profiles, Connect Biopharma has the potential to disrupt the autoimmune disease treatment market.
- Experienced leadership team: The company's leadership team comprises experienced individuals from the pharmaceutical and biotech industries, increasing the likelihood of successful drug development and commercialization.
- Significant growth potential: The large addressable market for autoimmune disease treatment and the potential success of CBP-201 provide ample opportunities for future growth.
However, the following factors could influence the rating:
- Clinical trial risks: The success of CBP-201 and other pipeline candidates in clinical trials remains uncertain, posing a potential risk for the company.
- Intense competition: Established players in the autoimmune disease treatment market could pose significant challenges for Connect Biopharma to gain market share.
- Limited financial resources: As a clinical-stage company, Connect Biopharma relies heavily on external funding to support its operations, which could create financial challenges in the future.
Sources and Disclaimers:
- This overview is based on data from the following sources: Connect Biopharma Holdings Ltd. website, SEC filings, industry reports, and news articles.
- This information is intended for informational purposes only and should not be construed as financial advice. Investors should conduct their own due diligence before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Connect Biopharma Holdings Ltd
Exchange | NASDAQ | Headquaters | San Diego, CA, United States |
IPO Launch date | 2021-03-19 | CEO & Director | Dr. Barry D. Quart Pharm.D. |
Sector | Healthcare | Website | https://www.connectbiopharm.com |
Industry | Biotechnology | Full time employees | 81 |
Headquaters | San Diego, CA, United States | ||
CEO & Director | Dr. Barry D. Quart Pharm.D. | ||
Website | https://www.connectbiopharm.com | ||
Website | https://www.connectbiopharm.com | ||
Full time employees | 81 |
Connect Biopharma Holdings Limited, a clinical-stage biopharmaceutical company, engages in the development of therapies for the treatment of T cell-driven inflammatory diseases. The company is building a pipeline of small molecules and antibodies using functional T cell assays to screen and discover potent product candidates against validated immune targets. Its lead product candidate is rademikibart (formerly CBP-201), an antibody designed to target interleukin-4 receptor alpha, which is a validated target for the treatment of inflammatory diseases such as atopic dermatitis and asthma, currently under Phase 3 studies; and icanbelimod (formerly CBP-307), an oral small molecule Sphingosine 1-Phosphate Receptor 1 modulator, currently under Phase 2 clinical for the treatment of ulcerative colitis and Crohn's disease. The company was founded in 2012 and is based in San Diego, California.
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