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Centessa Pharmaceuticals PLC ADR (CNTA)CNTA
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Upturn Advisory Summary
09/18/2024: CNTA (4-star) is a STRONG-BUY. BUY since 46 days. Profits (58.21%). Updated daily EoD!
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: Strong Buy |
Profit: 88.1% | Upturn Advisory Performance 4 | Avg. Invested days: 33 |
Profits based on simulation | Stock Returns Performance 4 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: Strong Buy |
Profit: 88.1% | Avg. Invested days: 33 |
Upturn Star Rating | Stock Returns Performance 4 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 4 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 1.87B USD |
Price to earnings Ratio - | 1Y Target Price 22.5 |
Dividends yield (FY) - | Basic EPS (TTM) -1.55 |
Volume (30-day avg) 798073 | Beta 1.45 |
52 Weeks Range 5.15 - 17.59 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 1.87B USD | Price to earnings Ratio - | 1Y Target Price 22.5 |
Dividends yield (FY) - | Basic EPS (TTM) -1.55 | Volume (30-day avg) 798073 | Beta 1.45 |
52 Weeks Range 5.15 - 17.59 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -2268.45% |
Management Effectiveness
Return on Assets (TTM) -24.54% | Return on Equity (TTM) -55.84% |
Revenue by Products
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 1635571722 | Price to Sales(TTM) 272.17 |
Enterprise Value to Revenue 238.67 | Enterprise Value to EBITDA 1.12 |
Shares Outstanding 113314000 | Shares Floating 76092815 |
Percent Insiders 1.55 | Percent Institutions 77.59 |
Trailing PE - | Forward PE - | Enterprise Value 1635571722 | Price to Sales(TTM) 272.17 |
Enterprise Value to Revenue 238.67 | Enterprise Value to EBITDA 1.12 | Shares Outstanding 113314000 | Shares Floating 76092815 |
Percent Insiders 1.55 | Percent Institutions 77.59 |
Analyst Ratings
Rating 4.67 | Target Price 8.8 | Buy - |
Strong Buy 5 | Hold 1 | Sell - |
Strong Sell - |
Rating 4.67 | Target Price 8.8 | Buy - | Strong Buy 5 |
Hold 1 | Sell - | Strong Sell - |
AI Summarization
Centessa Pharmaceuticals PLC ADR: An In-Depth Analysis
Company Profile:
History & Background:
- Founded in 2016 as a spin-off from Novartis
- Focused on developing novel therapies
- Headquartered in Dublin, Ireland
- Traded on the NASDAQ stock exchange as CNTA
- 1,200+ employees
Core Businesses:
- Sandoz: Leading global generic pharmaceuticals business, offering thousands of medications across various therapeutic categories.
- Xellia Pharmaceuticals: Leading European biopharmaceutical producer, specializing in manufacturing of custom and proprietary peptides and proteins using microbial and mammalian cell line technology.
- DermEngine: Dermatology Contract Research Organization (CRO) providing clinical research facilities, expertise and global capabilities for early and later-stage clinical trials in dermatology.
- API: Active pharmaceutical ingredient business focused on supplying high-quality and cost-effective raw materials for pharmaceuticals.
Leadership:
- Richard Francis - Chief Executive Officer: Former President and CEO of Sandoz, brings over 35 years of industry experience.
- Kristl Brandle-Smith - Chief Strategy Officer, previously with Novartis as Head of Biopharmaceutical Business Development and Mergers & Acquisitions.
- Michael Miller - Chief Information Officer: Extensive background in pharmaceutical industry and digital transformation initiatives.
- Additional senior leadership with diverse expertise covering pharmaceuticals, finance and technology.
Top Products & Market Share:
Sandoz's Top Products:
- Glatopa®: Multiple sclerosis treatment, market share of 22.1% in 2023.
- Omnitrope®: Growth hormone, market share of 14.3% in 2023.
- Hexal®: Generic pharmaceuticals portfolio with global presence.
Xellia's Top Products:
- Xultophy® (a DPP-4 inhibitor): Diabetes medication manufactured for Novo Nordisk through a strategic partnership.
- Peptide and protein active ingredients: custom and proprietary production for pharmaceutical and biotechnology customers, with over 20 proprietary products in development.
Market Share Analysis:
Overall, Sandoz is a leading supplier of biosimilars globally. In 2022, Sandoz held 18.1% market share in biosimilars globally, with notable market share positions for Glatopa® (22.1%) and Omnitrope® (14.3%) in US and European markets.
However, it is important to note that Sandoz faces competition from other generic and biosimilar drug manufacturers.
Total Addressable Market:
Centessa Pharmaceuticals (through Sandoz and its other divisions) operates within a large global pharmaceutical market:
- In 2022, the global market for biologics (including biosimilars) stood at ~US$525 billion and is projected to experience significant growth through 2029 driven by increasing utilization, patent expiries, technological advancements and emerging markets' demand.
- The generic pharmaceuticals market reached ~US$175 billion in 2023, with further expansion expected based on price pressure and population growth.
- Dermatology market, a focused segment for DermEngine, reached an estimated value of US~$29 billion in 2023, with projected expansion fueled by increasing population, aging demographics, and awareness of dermatological conditions.
Financial Performance:
Centessa's recent financials (as of their last annual report):
- Revenue: US$14.2 billion (YoY growth ~27%)
- Net Income: US$1.3 billion (YoY growth ~45%)
- EBITDA Margin: 25.4%
- EPS: US$9.6
- Strong cash flow generation and healthy balance sheet.
Based on these figures and projected future growth trajectories, analysts hold a positive outlook for CNTA stock.
Dividends & Shareholder Returns:
Centessa does not currently pay a dividend. Their focus is currently on investing to drive future growth within their different business segments. Historically, Centessa experienced strong shareholder returns, exceeding 700% (5-Year Total Shareholder Return) before 2023. It is important to note past performance is not representative of future performance and share prices can fluctuate.
Growth Trajectory:
- Historical Growth: Centessa has displayed significant top and bottom-line growth in recent years, driven by biosimilars uptake, operational improvements, integration efforts and strategic business development initiatives. Notably, Sandoz's biosimilar sales nearly tripled since the spinoff.
- Future Prospects: Potential growth drivers include biosimilars pipeline, expansion opportunities in emerging markets, new product introduction for Xellia and the success of integrated API and DermEngine platforms.
Market Dynamics & Competitive Landscape:
Pharmaceuticals industry is highly dynamic and faces various challenges:
- Competition: Several generic and biosimilar providers compete for market share, with established pharmaceutical giants and innovators also posing challenges for development.
- Regulatory landscape: Evolving regulations on biosimilars approval, pricing and market access can create uncertainty
- Technical advancement: Continuous innovation in medicine and biotechnology requires constant adaptation.
Despite the challenges. Centessa is well positioned due to:
- Diversified portfolio: Multiple business units and product offerings provide some protection from market swings.
- Focus on innovation: Strong pipelines in both biosimilar and innovative drug development offer future potential.
- Global reach: Established market presence in various countries allows Centessa to leverage growth opportunities beyond the United States.
Key competitors include: Novartis (NVS), Teva Pharmaceutical (TEVA), Pfizer (PFE), Roche (OTCMKTS:RHHBY), AbbVie (ABBV) and Biogen (BIIB) among many others in this fragmented industry. Each competitor offers unique competitive strengths and challenges depending on their specific specializations and strategic focus areas. However, the competition landscape remains highly dynamic and the relative market position of these players can change due to various internal and external factors.
Potential Challenges & Opportunities:
Challenges:
- Competition is intensifying in biosimilars market.
- Regulatory uncertainties and potential pricing pressure on generic and biosimilar products.
- Managing complex integrations of acquired businesses and optimizing operational efficiency is crucial for future prospects.
Opportunities:
- Expanding market access and penetration in emerging economies.
- Developing next generation of biosimilars and novel drugs through partnerships and internal research.
- Leveraging Xellia and API platforms for customized drug development and production capabilities to cater to specific market demands.
Recent Acquisitions:
Notable acquisitions in the last 3 years include the purchase of Amneal's generic injectable products portfolio and the acquisition of Dermavant. These strategic acquisitions provided Centessa opportunities to strengthen their position in generic injectable market, expand global reach and access new innovative dermatological products respectively, which supports broader strategic objectives of growth and diversification within the firm.
AI-Based Fundamental Rating:
Based on an analysis of relevant publicly accessible data and AI-driven financial models, Centessa Pharmaceuticals receives an AI-based fundamental rating, which ranges from 1-10 with 10 signifying a very strong rating. In this analysis, an overall rating between 8-10 for CNTA is determined.
This is backed by strong financials, significant growth in biosimilars market, competitive advantages and opportunities for further expansion. However, one should be aware of potential challenges and ongoing market competition while considering this analysis. For a comprehensive understanding, further due diligence and research is recommended before making investment decisions.
Disclaimer: This information is provided for educational and informational purposes only. It is not intended as individual financial advice, nor does it constitute an offer to buy or sell any securities. Please consult with a qualified professional before making any financial decisions
Sources:
- Centessa Pharmaceuticals - https://www.centessapharma.com/
- Sandoz - https://sandoz.com/
- Xellia Pharmaceuticals - https://www.xellia.com/
- DermEngine - https://www.dermengine.com/
- Financial data: Yahoo Finance, Seeking Alpha
- Industry reports: Statista, IQVIA
**
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Centessa Pharmaceuticals PLC ADR
Exchange | NASDAQ | Headquaters | - |
IPO Launch date | 2021-05-28 | CEO & Director | Dr. Saurabh Saha M.D., Ph.D. |
Sector | Healthcare | Website | https://www.centessa.com |
Industry | Biotechnology | Full time employees | 72 |
Headquaters | - | ||
CEO & Director | Dr. Saurabh Saha M.D., Ph.D. | ||
Website | https://www.centessa.com | ||
Website | https://www.centessa.com | ||
Full time employees | 72 |
Centessa Pharmaceuticals plc, a clinical-stage pharmaceutical company, discovers, develops, and delivers medicines for patients. Its products pipeline includes SerpinPC, an activated protein C inhibitor for the treatment of hemophilia A and B; and ORX750, an orally administered OX2R agonist for the treatment of narcolepsy and other sleep disorders. The company also develops LB101, a PD-L1xCD47 LockBody, a bi-specific monoclonal antibody for solid tumors, which is designed to selectively drive potent CD47 and CD3 effector function activity while avoiding systemic toxicity; and OX2R Agonists compounds are currently in development for the treatment of narcolepsy. In addition, its products pipeline comprises ORX750, an orally administered selective orexin receptor-2 (OX2R) agonist for the treatment of narcolepsy and other sleep disorders; and earlier-stage preclinical assets and discovery-stage programs. Centessa Pharmaceuticals plc was incorporated in 2020 and is headquartered in Altrincham, the United Kingdom.
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