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Cellectis SA (CLLS)CLLS
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Upturn Advisory Summary
09/18/2024: CLLS (1-star) has a low Upturn Star Rating. Not recommended to BUY.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: Consider higher Upturn Star rating |
Profit: -66.8% | Upturn Advisory Performance 1 | Avg. Invested days: 25 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: Consider higher Upturn Star rating |
Profit: -66.8% | Avg. Invested days: 25 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 1 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 234.22M USD |
Price to earnings Ratio - | 1Y Target Price 7 |
Dividends yield (FY) - | Basic EPS (TTM) -1.23 |
Volume (30-day avg) 26141 | Beta 3.23 |
52 Weeks Range 0.96 - 3.77 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 234.22M USD | Price to earnings Ratio - | 1Y Target Price 7 |
Dividends yield (FY) - | Basic EPS (TTM) -1.23 | Volume (30-day avg) 26141 | Beta 3.23 |
52 Weeks Range 0.96 - 3.77 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -181.11% |
Management Effectiveness
Return on Assets (TTM) -17.3% | Return on Equity (TTM) -64.37% |
Revenue by Products
Revenue by Products - Current and Previous Year
Revenue by Geography
Revenue by Geography - Current and Previous Year
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 51297049 | Price to Sales(TTM) 11.93 |
Enterprise Value to Revenue 3.94 | Enterprise Value to EBITDA -3.9 |
Shares Outstanding 100094000 | Shares Floating 71462852 |
Percent Insiders 3.88 | Percent Institutions 14.77 |
Trailing PE - | Forward PE - | Enterprise Value 51297049 | Price to Sales(TTM) 11.93 |
Enterprise Value to Revenue 3.94 | Enterprise Value to EBITDA -3.9 | Shares Outstanding 100094000 | Shares Floating 71462852 |
Percent Insiders 3.88 | Percent Institutions 14.77 |
Analyst Ratings
Rating 4.33 | Target Price 7.5 | Buy 2 |
Strong Buy 3 | Hold 1 | Sell - |
Strong Sell - |
Rating 4.33 | Target Price 7.5 | Buy 2 | Strong Buy 3 |
Hold 1 | Sell - | Strong Sell - |
AI Summarization
Cellectis SA: A Comprehensive Overview
Company Profile
Detailed History and Background
Cellectis is a clinical-stage biopharmaceutical company founded in 1993 and headquartered in Paris, France, with a global presence in the US and other countries. Its primary focus is developing allogeneic CAR-T cell immunotherapies for cancer and gene editing technologies. The company pioneers the use of TALEN® and meganucleases for genome editing.
Core Business Areas
- Allogeneic CAR-T cell immunotherapies: Developing UCART cell therapies for various blood cancers.
- Gene editing technologies: Developing proprietary TALEN® and meganucleases for cell engineering and therapeutic applications.
Leadership and Structure
Leadership:
- André Choulika, PhD: Chairman and CEO, co-founded Cellectis.
- Carrie Brownstein, MD: Chief Medical Officer.
- David Gilham: Chief Financial Officer.
- Thomas Seznec: Chief Development Officer.
Corporate Structure:
- Board of Directors: 8 members with diverse expertise in biotechnology, finance, and business.
- Scientific Advisory Board: Team of distinguished scientists and researchers.
- Executive Leadership Team: Comprises senior executives leading various functions, including Research & Development, Finance, Commercial, and Operations.
Top Products and Market Share
Top Products
- UCART19: Investigational CAR-T cell therapy for B-cell acute lymphoblastic leukemia (B-ALL) and non-Hodgkin lymphoma (NHL).
- UCART22: Investigational CAR-T cell therapy for multiple myeloma.
- TALEN® technology: Technology platform used for genome editing and cell engineering.
Market Share
Cellectis does not have any approved products yet. The company's market share will be determined upon the commercialization of its CAR-T cell therapies, currently in clinical trials. The global CAR-T cell therapy market was valued at approximately $4.4 billion in 2023 and is expected to reach $18.5 billion by 2030, indicating substantial growth potential.
Product Performance and Comparison
The performance of Cellectis' products cannot be assessed yet as they are not yet commercially available. However, preclinical and clinical trial data for UCART19 and UCART22 show promising results. These therapies demonstrate high efficacy and favorable safety profiles in initial studies.
Competitors in the CAR-T cell therapy space include Novartis, Gilead Sciences, Bristol Myers Squibb, and others. Cellectis differentiates itself with its TALEN® technology, enabling efficient and targeted gene editing for CAR-T cells.
Total Addressable Market
The total addressable market for Cellectis encompasses patients with B-cell malignancies like B-ALL and NHL, multiple myeloma, and other potential indications for its CAR-T cell therapies. This market is estimated to be substantial, with millions of patients worldwide potentially benefiting from these therapies.
Financial Performance
Revenue: As of September 30, 2023, Cellectis generated no product revenue. The company primarily relies on collaboration agreements and grants for funding.
Net Income: Cellectis reported a net loss of €53.4 million as of September 30, 2023.
Profit Margins: Due to the lack of product revenue, Cellectis currently operates with negative profit margins.
Earnings per Share (EPS): The company's EPS was -€0.90 for the third quarter of 2023.
Year-over-Year Comparison: Financials are expected to improve as the company progresses through clinical trials and potentially commercializes its CAR-T cell therapies.
Financial Statements Analysis: A more in-depth analysis of Cellectis' financial statements would require a comprehensive review of their annual report and quarterly filings.
Dividends and Shareholder Returns
Cellectis currently does not pay dividends, as they are still in the clinical development stage and require investments for ongoing research and development. Shareholder returns have been negative due to the company's current financial position and lack of commercial products.
Growth Trajectory
Cellectis has experienced historical growth driven by advancements in its product pipeline and collaborations. Future growth will depend on the successful completion of clinical trials, regulatory approvals, and commercialization of its CAR-T cell therapies. Recent initiatives like strategic partnerships and expanded research and development activities indicate positive prospects for growth.
Market Dynamics
The CAR-T cell therapy market is characterized by rapid technological advancements, increasing demand, and growing competition. Cellectis is well-positioned with its innovative TALEN® technology and promising clinical trial data. Adaptability to regulatory changes, maintaining a robust pipeline, and navigating the competitive landscape are crucial for future success.
Competitors
- Novartis: (NVS) Kymriah and Tisagenlecleucel (CAR-T cell therapies)
- Gilead Sciences: (GILD) Yescarta (CAR-T cell therapy)
- Bristol Myers Squibb: (BMY) Breyanzi (CAR-T cell therapy)
- bluebird bio: (BLUE) Abecma (CAR-T cell therapy)
- Others: Pfizer, Johnson & Johnson, Adaptive Biotechnologies
Market share percentages for competitors vary depending on the specific indication and geographic region. Cellectis has the potential to compete with these established players through its differentiated technology and focus on addressing unmet medical needs.
Key Challenges and Opportunities
Key Challenges
- Regulatory approval: Successfully navigating the approval process for new CAR-T cell therapies is a critical challenge.
- Technological advancements: Continuously innovating and adapting to evolving technologies within the CAR-T space is essential.
- Competition: Facing fierce competition from established players with significant market share is a significant obstacle.
Potential Opportunities
- Market expansion: Expanding the reach of CAR-T cell therapies to a larger patient population through broader indications and approvals unlocks growth potential.
- New product innovation: Developing a pipeline of innovative and differentiated CAR-T cell therapies could strengthen the company's competitive position.
- Strategic partnerships: Collaborations with pharmaceutical giants can offer significant financial and developmental support for accelerating product development and commercialization.
Recent Acquisitions (last 3 years)
Cellectis has not made any acquisitions in the last three years.
AI-Based Fundamental Rating
An AI-based fundamental rating for Cellectis SA would require a separate analysis and evaluation using specific AI models and algorithms. However, considering the factors discussed above, including financial health, market position, and future prospects, a preliminary rating could fall between 5-7, indicating moderate to strong potential, depending on the AI model and underlying assumptions.
Sources and Disclaimers
Disclaimer: This overview is for informational purposes only and should not be considered financial advice. Users should conduct their own due diligence and consult with a financial professional before making any investment decisions.
Sources:
- Cellectis SA Investor Relations website: https://investors.cellectis.com/
- SEC filings: https://www.sec.gov/edgar/search/
- Company press releases and news articles
- Industry reports and market research
- Financial data platforms (e.g., Bloomberg, Reuters)
Please note: This overview does not replace professional financial advice. The information provided here is based on pública available data as of November 2023, and market conditions and financial data may have changed since then.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Cellectis SA
Exchange | NASDAQ | Headquaters | - |
IPO Launch date | 2007-02-07 | Co-Founder, CEO & Director | Dr. Andre Choulika Ph.D. |
Sector | Healthcare | Website | https://www.cellectis.com |
Industry | Biotechnology | Full time employees | 216 |
Headquaters | - | ||
Co-Founder, CEO & Director | Dr. Andre Choulika Ph.D. | ||
Website | https://www.cellectis.com | ||
Website | https://www.cellectis.com | ||
Full time employees | 216 |
Cellectis S.A., a clinical stage biotechnological company, develops products based on gene-editing with a portfolio of allogeneic chimeric antigen receptor T-cells product candidates. The company is developing ALLO-715 and ALLO-605 for the treatment of multiple myeloma; ALLO-501 to treat large B-cell lymphoma; ALLO-316, an allogeneic engineered CAR T-cell product targeting CD70; ALLO-819 to treat acute myeloid leukemia; ALLO-213 for the treatment of small cell lung cancer; and ALLO-182 to treat gastric and pancreatic cancer. It also develops UCART22 for the treatment of relapsed or refractory B-cell acute lymphoblastic leukemia; UCART123 to treat acute myeloid leukemia; UCART 20x22 for relapsed or refractory B-Cell non-hodgkin's lymphoma; and cema-cel to treat relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma. The company has strategic alliances with Allogene Therapeutics, Inc. and Les Laboratoires Servier; research collaboration and exclusive license agreement with Iovance Biotherapeutics, Inc.; and joint research and collaboration, and investment agreement with AstraZeneca Holdings B.V., as well as with AstraZeneca Ireland Limited. Cellectis S.A. was founded in 1999 and is headquartered in Paris, France.
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