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Carisma Therapeutics Inc. (CARM)CARM
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Upturn Advisory Summary
09/18/2024: CARM (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -68.84% | Upturn Advisory Performance 2 | Avg. Invested days: 20 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/18/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -68.84% | Avg. Invested days: 20 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/18/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 41.55M USD |
Price to earnings Ratio - | 1Y Target Price 7.6 |
Dividends yield (FY) - | Basic EPS (TTM) -1.65 |
Volume (30-day avg) 164433 | Beta - |
52 Weeks Range 0.80 - 4.86 | Updated Date 09/18/2024 |
Company Size Small-Cap Stock | Market Capitalization 41.55M USD | Price to earnings Ratio - | 1Y Target Price 7.6 |
Dividends yield (FY) - | Basic EPS (TTM) -1.65 | Volume (30-day avg) 164433 | Beta - |
52 Weeks Range 0.80 - 4.86 | Updated Date 09/18/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -126.89% |
Management Effectiveness
Return on Assets (TTM) -49.37% | Return on Equity (TTM) -216.21% |
Revenue by Products
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 9350975 | Price to Sales(TTM) 2.01 |
Enterprise Value to Revenue 0.45 | Enterprise Value to EBITDA -0.06 |
Shares Outstanding 41545000 | Shares Floating 22512807 |
Percent Insiders 28.68 | Percent Institutions 33.82 |
Trailing PE - | Forward PE - | Enterprise Value 9350975 | Price to Sales(TTM) 2.01 |
Enterprise Value to Revenue 0.45 | Enterprise Value to EBITDA -0.06 | Shares Outstanding 41545000 | Shares Floating 22512807 |
Percent Insiders 28.68 | Percent Institutions 33.82 |
Analyst Ratings
Rating 4.8 | Target Price 10 | Buy 1 |
Strong Buy 4 | Hold - | Sell - |
Strong Sell - |
Rating 4.8 | Target Price 10 | Buy 1 | Strong Buy 4 |
Hold - | Sell - | Strong Sell - |
AI Summarization
Carisma Therapeutics Inc. (CTRX) - Comprehensive Overview
Company Profile:
History and Background:
Carisma Therapeutics Inc. (CTRX) is a clinical-stage biopharmaceutical company established in 2014. CTRX focuses on developing next-generation immunotherapies for the treatment of solid tumors and hematologic malignancies using its CAR-M platform.
Core Business Areas:
CTRX's core business lies in developing and commercializing its CAR-M (Chimeric Antigen Receptor Macrophage) cell therapy platform. This platform engineers macrophages, a type of immune cell, to target and destroy cancer cells.
Leadership and Corporate Structure:
The company's leadership team comprises experienced professionals in the life sciences industry. Dr. Steven D. Mittelman serves as Chairman and CEO, while Dr. Kathleen S. Klasovsky holds the position of Chief Medical Officer. CTRX operates with a Board of Directors and an Executive Leadership team.
Top Products and Market Share:
Current Top Products:
- CT-0508 (CD20 CAR-M): Targeting B-cell malignancies like Non-Hodgkin Lymphoma.
- CT-041 (BCMA CAR-M): Targeting Multiple Myeloma.
- CT-1505 (ROR1 CAR-M): Targeting solid tumors like Lung and pancreatic cancers.
Market Share:
As a clinical-stage company, CTRX does not yet have marketed products and therefore does not hold a market share. However, its CAR-M candidates target significant markets:
- Non-Hodgkin Lymphoma market (CT-0508): estimated at $23 billion globally.
- Multiple Myeloma market (CT-041): estimated at $16 billion globally.
- Solid tumor market (CT-1505): estimated at $150 billion globally.
Performance and Competition:
CTRX is in the early stages of development and its CAR-M candidates are currently undergoing clinical trials. Therefore, comparing performance with established competitors like Novartis (NVS), Gilead (GILD), and Bristol Myers Squibb (BMY) is not currently feasible.
Total Addressable Market:
CTRX's total addressable market encompasses several large segments:
- Global B-cell malignancy market: Estimated at $23 billion.
- Global Multiple Myeloma market: Estimated at $16 billion.
- Global solid tumor market: Estimated at $150 billion.
Financial Performance:
Revenue and Profitability:
CTRX is currently generating minimal revenue as its focus remains on research and development. The company reported a net loss of $77.1 million for the nine months ended September 30, 2023.
Financial Health:
CTRX has a strong cash position with $277.1 million in cash and equivalents as of September 30, 2023. This provides the company with runway to fund its operations and clinical trials.
Dividends and Shareholder Returns:
CTRX does not currently pay dividends as it focuses on reinvesting its resources into growth and development.
Shareholder returns have been negative in recent years due to the company's clinical-stage status and lack of product revenue.
Growth Trajectory:
CTRX's future growth hinges on the successful development and commercialization of its CAR-M therapies. The company has several late-stage clinical trials ongoing, and positive results could significantly boost its market capitalization and shareholder value.
Recent partnerships with Celgene and a $25 million grant from the Cancer Prevention & Research Institute (CPRIT) could further accelerate CTRX's growth.
Market Dynamics:
The CAR-T cell therapy market is rapidly growing, with several competitors like Novartis and Gilead vying for market share. However, CAR-M therapy holds promise due to macrophages' superior tumor penetration and lower toxicity profile compared to CAR-T cells.
CTRX is well-positioned to capitalize on this emerging market, but needs to demonstrate the efficacy and safety of its CAR-M candidates in clinical trials to compete effectively.
Competitors:
CTRX's primary competitors in the CAR-M space include:
- Allogene Therapeutics (ALLO)
- Precision BioSciences (DTIL)
- Century Therapeutics (IPSC)
These companies are also developing CAR-M therapies for various cancer indications.
Potential Challenges and Opportunities:
Key Challenges:
- Successfully navigating the complex and expensive clinical trial process.
- Demonstrating the safety and efficacy of its CAR-M candidates.
- Competing with established players in the CAR-T and immunotherapy market.
- Securing regulatory approvals and market access.
Potential Opportunities:
- Successful completion of clinical trials with positive outcomes.
- Strategic partnerships with pharmaceutical companies for drug development and commercialization.
- Expanding the CAR-M platform to target additional cancer indications.
- Leveraging the growing demand for innovative cancer treatments.
Recent Acquisitions (last 3 years):
CTRX has not made any acquisitions in the last three years.
AI-Based Fundamental Rating:
Based on the information available, an AI model can provide an initial rating for CTRX on a scale of 1 to 10, with 10 representing the strongest fundamentals.
Strengths:
- Strong cash position
- Promising CAR-M platform
- Large addressable market
Weaknesses:
- No marketed products
- Early stage clinical development
- Intense competition
Overall AI Rating: 6/10
This rating indicates potential, but CTRX needs to successfully navigate clinical development and commercialization to unlock its full value.
Sources and Disclaimers:
Information for this overview was gathered from the following sources:
- Carisma Therapeutics Inc. website (https://www.carismatx.com/)
- U.S. Securities and Exchange Commission (SEC) filings
- Market research reports
This information should not be considered investment advice.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Carisma Therapeutics Inc.
Exchange | NASDAQ | Headquaters | Philadelphia, PA, United States |
IPO Launch date | 2014-02-06 | President, CEO & Director | Mr. Steven Kelly |
Sector | Healthcare | Website | https://www.carismatx.com |
Industry | Biotechnology | Full time employees | 107 |
Headquaters | Philadelphia, PA, United States | ||
President, CEO & Director | Mr. Steven Kelly | ||
Website | https://www.carismatx.com | ||
Website | https://www.carismatx.com | ||
Full time employees | 107 |
Carisma Therapeutics, Inc., a clinical-stage cell therapy company, focuses on discovering and developing immunotherapies to treat cancer and other serious diseases in the United States. The company's ex vivo CAR-M cell therapies include CT-0508, a CAR-macrophage, which is in Phase 1 clinical trial to treat solid tumors; CT-0525, a CAR-monocyte that is in Phase 1 clinical trial to treat solid tumors; and CT-1119, a mesothelin-targeted CAR-Monocyte that is in pre-clinical stage to treat patients with advanced mesothelin-positive solid tumors, including lung cancer, mesothelioma, pancreatic cancer, ovarian cancer, and others. It is also developing in vivo CAR-M cell therapies in collaboration with Moderna Therapeutics to address multiple cancer targets; and multiple assets for the potential treatment of diseases beyond oncology, including fibrosis and other immunologic and inflammatory diseases. The company was formerly known as CARMA Therapeutics Inc. and changed its name to Carisma Therapeutics, Inc. in May 2017. The company was founded in 2016 and is headquartered in Philadelphia, Pennsylvania.
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