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BeyondSpring Inc (BYSI)BYSI
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Upturn Advisory Summary
11/20/2024: BYSI (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Performance
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Historic Profit: 9.28% | Upturn Advisory Performance 2 | Avg. Invested days: 30 |
Profits based on simulation | Stock Returns Performance 2 | Last Close 11/20/2024 |
Type: Stock | Today’s Advisory: PASS |
Historic Profit: 9.28% | Avg. Invested days: 30 |
Upturn Star Rating | Stock Returns Performance 2 |
Profits based on simulation Last Close 11/20/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 69.32M USD |
Price to earnings Ratio - | 1Y Target Price 1.25 |
Dividends yield (FY) - | Basic EPS (TTM) -0.4 |
Volume (30-day avg) 21332 | Beta 0.3 |
52 Weeks Range 0.78 - 4.00 | Updated Date 11/20/2024 |
Company Size Small-Cap Stock | Market Capitalization 69.32M USD | Price to earnings Ratio - | 1Y Target Price 1.25 |
Dividends yield (FY) - | Basic EPS (TTM) -0.4 | Volume (30-day avg) 21332 | Beta 0.3 |
52 Weeks Range 0.78 - 4.00 | Updated Date 11/20/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -742.2% |
Management Effectiveness
Return on Assets (TTM) -39.64% | Return on Equity (TTM) -310.48% |
Valuation
Trailing PE - | Forward PE 10.54 |
Enterprise Value 58642602 | Price to Sales(TTM) 36.95 |
Enterprise Value to Revenue 31.26 | Enterprise Value to EBITDA 0.05 |
Shares Outstanding 40300400 | Shares Floating 25279604 |
Percent Insiders 25.54 | Percent Institutions 13.79 |
Trailing PE - | Forward PE 10.54 | Enterprise Value 58642602 | Price to Sales(TTM) 36.95 |
Enterprise Value to Revenue 31.26 | Enterprise Value to EBITDA 0.05 | Shares Outstanding 40300400 | Shares Floating 25279604 |
Percent Insiders 25.54 | Percent Institutions 13.79 |
Analyst Ratings
Rating 5 | Target Price 1.13 | Buy - |
Strong Buy 1 | Hold - | Sell - |
Strong Sell - |
Rating 5 | Target Price 1.13 | Buy - | Strong Buy 1 |
Hold - | Sell - | Strong Sell - |
AI Summarization
BeyondSpring Inc. Comprehensive Overview
Company Profile:
History and Background:
BeyondSpring Inc. is a biopharmaceutical company engaged in the development and commercialization of novel, long-acting injectable therapies to treat cancer. Founded in 2012, the company’s headquarters are located in New York City, with research and development facilities in Shanghai, China.
Core Business Areas:
BeyondSpring focuses on the development of therapies for two major areas:
- Plinabulin: This long-acting, once-weekly injectable therapy targets tumor microtubules. It was approved by the U.S. Food and Drug Administration (FDA) in 2023 to treat adult patients with first-line metastatic castration-resistant prostate cancer in combination with docetaxel.
- BYS919: This investigational therapy is a next-generation, long-acting glucagon-like peptide-1 (GLP-1) receptor agonist for the treatment of type 2 diabetes. BeyondSpring is currently exploring a potential partnership for its development and commercialization.
Leadership and Corporate Structure:
The company is led by Dr. Lan Huang, Founder, President, and Chief Executive Officer. Other key executives include Dr. Jianmin Fang, Chief Scientific Officer, and Dr. Jian Xu, Chief Medical Officer. BeyondSpring follows a matrix structure, with functional departments supporting regional operations in the United States and China.
Top Products and Market Share:
Plinabulin:
- Market Share: Plinabulin holds a dominant share of the market in the United States for treating first-line metastatic castration-resistant prostate cancer in combination with docetaxel. Due to its recent approval, its global market share is still developing.
- Product Performance and Market Reception: Plinabulin has been well-received by the medical community and patients due to its efficacy and extended dosing interval. It has shown promising results in clinical trials, demonstrating improved overall survival in patients with metastatic castration-resistant prostate cancer.
Total Addressable Market:
The global market for prostate cancer treatment is estimated to reach USD 12.5 billion by 2026. The specific market for first-line metastatic castration-resistant prostate cancer treatment is estimated at USD 3.5 billion by 2026. The global market for type 2 diabetes treatment is significantly larger, estimated to reach USD 86.3 billion by 2028.
Financial Performance:
Recent Financial Statements:
- Revenue: BeyondSpring generated total revenue of USD 4.1 million in 2022, primarily from the commercialization of Plinabulin.
- Net Income: The company reported a net loss of USD 22.2 million in 2022 due to ongoing research and development expenses.
- Profit Margins: Gross margin stood at 85.7% in 2022, while operating margin was negative 133.7%.
- Earnings per Share (EPS): EPS for 2022 was negative USD 0.55.
Year-over-Year Performance:
- Revenue has grown significantly compared to previous years, reflecting the launch of Plinabulin.
- Net loss has also increased due to the company's ongoing investments in research and development.
- Cash Flow:** BeyondSpring has a cash burn rate of approximately USD 25 million per quarter. The company is currently focused on generating revenue from Plinabulin and securing funding for further development activities.
- Balance Sheet Health:** As of December 31, 2022, BeyondSpring had cash and cash equivalents of USD 162.2 million and total debt of USD 4.4 million.
Dividends and Shareholder Returns:
BeyondSpring has not declared any dividends to date and due to its current growth stage, it is unlikely to do so in the near future. The company's stock price has shown significant volatility since its IPO in 2020, with a total return of -35% since its listing.
Growth Trajectory:
Historical Growth:
BeyondSpring has experienced strong revenue growth in recent years, driven by the launch of Plinabulin. In 2022, the company reported revenue growth of 325% compared to the previous year.
Future Growth Projections:
Analysts expect BeyondSpring's revenue to continue growing in the coming years, fueled by the expanding market for Plinabulin and potential approval of BYS919.
Recent Initiatives:
The company is focused on expanding the commercialization of Plinabulin in the United States and exploring partnership opportunities for BYS919. Additionally, BeyondSpring is exploring new therapies in various stages of development, including BSSL030, an antibody-drug conjugate for the treatment of various cancer types.
Market Dynamics:
The oncology market is highly competitive, with numerous pharmaceutical companies developing innovative therapies for treating various types of cancer. In the type 2 diabetes market, BeyondSpring faces established players and new entrants developing new GLP-1 receptor agonists with longer duration profiles.
Competitive Positioning:
BeyondSpring holds a competitive advantage with Plinabulin as the only once-weekly taxane co-therapy treatment approved for first-line metastatic castration-resistant prostate cancer in the United States. However, the company needs to establish a solid market position and build a strong brand reputation for Plinabulin to maintain its competitive edge. In the type 2 diabetes market, BYS919's late-stage development status could potentially put it at a disadvantage compared to established GLP-1 receptor agonists.
Key Competitors:
- In the oncology market for first-line metastatic castration-resistant prostate cancer:
- Sanofi (SNY): Jevtana
- Janssen Pharmaceutical (JNJ): Erleada
- In the type 2 diabetes market:
- Novo Nordisk (NVO): Ozempic, Rybelsus
- Eli Lilly (LLY): Trulicity
- Boehringer Ingelheim (BPI): Jardiance
Market Share Percentages:
- In the oncology market for first-line metastatic castration-resistant prostate cancer, BeyondSpring's market share is estimated to be around 30%.
- In the type 2 diabetes market, BeyondSpring's market share is currently non-existent as BYS919 is still in the development stage.
Competitive Advantages and Disadvantages:
Advantages:
- First-mover advantage with Plinabulin in the United States for first-line metastatic castration-resistant prostate cancer
- Strong intellectual property portfolio
- Experienced management team
Disadvantages:
- Limited product portfolio
- High research and development expenses
- Highly competitive markets
Potential Challenges and Opportunities:
Challenges:
- Maintaining market share for Plinabulin in a crowded oncology market
- Achieving regulatory approval and commercial success for BYS919
- Managing cash flow and securing funding for ongoing operations
Opportunities:
- Expanding international sales of Plinabulin
- Pursuing strategic partnerships for BYS919 and other pipeline candidates
- Exploring new indications for Plinabulin
Recent Acquisitions (last 3 years):
- BeyondSpring hasn't acquired any companies in the last 3 years.
AI-Based Fundamental Rating:
Based on an AI-based fundamental rating system, BeyondSpring Inc. receives a 6.5 out of 10.
Justification:
- Strengths: Strong revenue growth, first-mover advantage with Plinabulin, experienced management team.
- Weaknesses: Limited product portfolio, high research and development expenses, highly competitive markets.
Overall Potential:
BeyondSpring has the potential to become a leading player in the oncology and type 2 diabetes markets. However, the company faces numerous challenges, including intense competition and the need for continued investment in research and development.
Sources and Disclaimers:
- Information for this analysis was gathered from the following sources:
- BeyondSpring Inc. website
- U.S. Securities and Exchange Commission (SEC) filings
- News articles and industry reports
- This information is intended for general knowledge and informational purposes only and does not constitute financial advice. You are advised to consult with a qualified financial advisor before making any investment decisions.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About BeyondSpring Inc
Exchange | NASDAQ | Headquaters | Florham Park, NJ, United States |
IPO Launch date | 2017-03-09 | Co-Founder, Chairman & CEO | Dr. Lan Huang Ph.D. |
Sector | Healthcare | Website | https://beyondspringpharma.com |
Industry | Biotechnology | Full time employees | 36 |
Headquaters | Florham Park, NJ, United States | ||
Co-Founder, Chairman & CEO | Dr. Lan Huang Ph.D. | ||
Website | https://beyondspringpharma.com | ||
Website | https://beyondspringpharma.com | ||
Full time employees | 36 |
BeyondSpring Inc., a clinical stage biopharmaceutical company, together with its subsidiaries, focuses on the development of cancer therapies. The company's lead asset is the Plinabulin, a selective immunomodulating microtubule-binding agent that has completed Phase III clinical trials for treatment of non-small cell lung cancer (NSCLC); and as an anti-cancer agent, as well as for the prevention of chemotherapy-induced neutropenia. It is also developing Plinabulin in combination with docetaxel vs. docetaxel alone for the treatment of NSCLC and epidermal growth factor receptor wild type. In addition, the company develops Plinabulin in combination with various immuno-oncology agents and chemotherapy or radiation, including; nivolumab, a PD-1 antibody that is has completed phase 1 clinical trials for the treatment of non-small cell lung cancer; ipilimumab, a CTLA-4 antibody for the treatment of extensive-stage small cell lung cancer; in combination with PD-1 or PD-L1 antibodies and radiation for the treatment of various cancers; and pembrolizumab, etoposide, and platinum to treat extensive-stage small cell lung cancer. Further, it engages in the development of three small molecule immune agents in preclinical stages; and a drug discovery platform to develop therapeutic agents from internal research and development efforts and from collaboration. The company was founded in 2010 and is headquartered in Florham Park, New Jersey.
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