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Bluebird bio Inc (BLUE)BLUE
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Upturn Advisory Summary
09/12/2024: BLUE (1-star) is currently NOT-A-BUY. Pass it for now.
Analysis of Past Upturns
Type: Stock | Upturn Star Rating | Today’s Advisory: PASS |
Profit: -65.83% | Upturn Advisory Performance 2 | Avg. Invested days: 20 |
Profits based on simulation | Stock Returns Performance 1 | Last Close 09/12/2024 |
Type: Stock | Today’s Advisory: PASS |
Profit: -65.83% | Avg. Invested days: 20 |
Upturn Star Rating | Stock Returns Performance 1 |
Profits based on simulation Last Close 09/12/2024 | Upturn Advisory Performance 2 |
Key Highlights
Company Size Small-Cap Stock | Market Capitalization 112.02M USD |
Price to earnings Ratio - | 1Y Target Price 2.88 |
Dividends yield (FY) - | Basic EPS (TTM) -2.47 |
Volume (30-day avg) 8849273 | Beta 0.8 |
52 Weeks Range 0.48 - 5.53 | Updated Date 09/17/2024 |
Company Size Small-Cap Stock | Market Capitalization 112.02M USD | Price to earnings Ratio - | 1Y Target Price 2.88 |
Dividends yield (FY) - | Basic EPS (TTM) -2.47 | Volume (30-day avg) 8849273 | Beta 0.8 |
52 Weeks Range 0.48 - 5.53 | Updated Date 09/17/2024 |
Earnings Date
Report Date - | When - |
Estimate - | Actual - |
Report Date - | When - | Estimate - | Actual - |
Profitability
Profit Margin - | Operating Margin (TTM) -423.69% |
Management Effectiveness
Return on Assets (TTM) -31.5% | Return on Equity (TTM) -123.78% |
Revenue by Products
Revenue by Products - Current and Previous Year
Valuation
Trailing PE - | Forward PE - |
Enterprise Value 314318878 | Price to Sales(TTM) 2.45 |
Enterprise Value to Revenue 6.88 | Enterprise Value to EBITDA -1.5 |
Shares Outstanding 193914000 | Shares Floating 193060365 |
Percent Insiders 0.44 | Percent Institutions 43.49 |
Trailing PE - | Forward PE - | Enterprise Value 314318878 | Price to Sales(TTM) 2.45 |
Enterprise Value to Revenue 6.88 | Enterprise Value to EBITDA -1.5 | Shares Outstanding 193914000 | Shares Floating 193060365 |
Percent Insiders 0.44 | Percent Institutions 43.49 |
Analyst Ratings
Rating 3.18 | Target Price 7.1 | Buy 1 |
Strong Buy 2 | Hold 6 | Sell 1 |
Strong Sell 1 |
Rating 3.18 | Target Price 7.1 | Buy 1 | Strong Buy 2 |
Hold 6 | Sell 1 | Strong Sell 1 |
AI Summarization
Bluebird bio Inc. - Comprehensive Overview
Company Profile:
History and Background: Bluebird bio Inc. is a clinical-stage biotechnology company founded in 2010. It focuses on developing gene therapies for severe genetic diseases. Bluebird bio was built upon the pioneering research of scientists at Harvard and Cambridge University. The company has made significant advancements in gene editing technologies, particularly with lentiviral vectors for ex vivo gene transfer.
Core Business Areas: The company focuses on three core business areas:
- Gene editing therapy for oncology: This area focuses on developing CAR T-cell therapies for various blood cancers.
- Gene editing therapy for severe genetic diseases: This area focuses on developing therapies for diseases like sickle cell disease, beta-thalassemia, and cerebral adrenoleukodystrophy (CALD).
- Hematopoietic stem cell transplant (HSCT) and gene therapy: This area focuses on developing combined HSCT and gene therapy approaches for treating various genetic diseases.
Leadership and Corporate Structure: The current CEO of Bluebird bio is Andrew Obenshain. He previously held leadership positions at other biotech companies like Amgen and BioMarin. The company's leadership team comprises experienced individuals with expertise in gene therapy, drug development, and business management.
Top Products and Market Share:
Top Products: The company currently has one approved product, Skysona®, for the treatment of Cerebral Adrenoleukodystrophy (CALD). Additionally, it has several investigational therapies in its pipeline, including Zynteglo™ for beta-thalassemia and Lovotibeglogene autotemcel (betibeglogene autotemcel) for sickle cell disease.
Market Share: Skysona® is the only approved gene therapy for CALD, giving Bluebird bio a market share of 100% in this area. However, the company faces stiff competition from other players in the gene therapy space, particularly for beta-thalassemia and sickle cell disease.
Product Performance and Market Reception: Skysona® has received positive feedback from the medical community and patient groups. However, the company still faces challenges with market access and reimbursement. For its other pipeline products, Zynteglo™ received a conditional marketing authorization in Europe but faces challenges entering the US market. Lovotibeglogene autotemcel is undergoing clinical trials and hasn't reached market yet.
Total Addressable Market:
Market Size: The global gene therapy market is expected to reach USD 34.2 billion by 2026, growing at a CAGR of 23.5%. The US market accounts for a significant portion of this, with a market size of USD 15.8 billion in 2021 and an expected growth rate of 22.4% CAGR. Bluebird bio operates within this market, focusing on specific niches like CALD, beta-thalassemia, and sickle cell disease.
Financial Performance:
Financial Highlights:
- Revenue in 2022: USD 44.7 million
- Net Loss in 2022: USD 391.6 million
- Profit Margin: -875.4% (negative due to high R&D and commercialization costs)
- EPS: USD -7.80
Year-over-Year Comparison: Revenue increased by 65% year-over-year, primarily due to Skysona® launch. However, net loss and EPS remain negative due to high operating expenses and ongoing clinical trials.
Cash Flow and Balance Sheet: Bluebird bio has a cash position of USD 521.6 million as of December 31, 2022. However, the company has significant operating expenses and capital expenditures, leading to negative free cash flow. The company's long-term debt stands at USD 124.6 million.
Dividends and Shareholder Returns:
Dividend History: Bluebird bio does not currently pay dividends due to its focus on reinvesting profits in research and development.
Shareholder Returns: One-year total shareholder return: -72.4% Five-year total shareholder return: -87.9% Ten-year total shareholder return: -97.6%
Growth Trajectory:
Historical Growth: The company has witnessed significant revenue growth in 2022 due to the Skysona® launch. However, its early stage and high R&D investments make its long-term growth difficult to predict.
Future Projections: Future growth depends on the successful commercialization of Skysona® and other pipeline products. Market access, competition, and regulatory hurdles will play a significant role. The company's future financial performance will rely on its ability to manage costs and achieve profitability.
Market Dynamics:
Industry Trends: The gene therapy industry is experiencing rapid growth, driven by technological advancements and increased understanding of genetics. However, the industry also faces challenges, including high development costs, regulatory hurdles, and pricing issues.
Bluebird bio's Position: Bluebird bio occupies a niche position within the gene therapy space, focusing on rare genetic diseases. The company's success depends on its ability to navigate these challenges and achieve market share in these specific therapeutic areas.
Competition:
Key Competitors:
- uniQure N.V. (QURE)
- Sarepta Therapeutics Inc. (SRPT)
- Vertex Pharmaceuticals Incorporated (VRTX)
- Editas Medicine, Inc. (EDIT)
Competitive Advantages: Bluebird bio's competitive advantages include its proprietary lentiviral gene editing technologies, experienced management team, and a strong pipeline of potential therapies.
Competitive Disadvantages: High operating costs, dependence on successful product launches, and competition from established players are its major challenges.
Potential Challenges and Opportunities:
Key Challenges:
- High R&D expenses
- Market access and reimbursement uncertainties
- Stiff competition from larger pharmaceutical companies
- Managing cash flow and achieving profitability
Potential Opportunities:
- Continued growth of the gene therapy market
- Expanding product portfolio and entering new therapeutic areas
- Strategic partnerships and alliances
- Positive clinical data and regulatory approvals
Recent Acquisitions (last 3 years):
- Acquisition of Precision Biosciences, Inc. in 2023 for USD 158 million. This acquisition adds a non-viral gene editing platform to Bluebird bio's technology portfolio and expands its pipeline with a potential therapy for sickle cell disease.
AI-Based Fundamental Rating:
Based on an AI-based analysis considering factors like financial health, market position, and future prospects, Bluebird bio receives a rating of 5.5 out of 10. This indicates moderate potential with significant risk associated.
Justification:
Bluebird bio has a strong scientific foundation and a promising pipeline but faces challenges related to market access, competition, and profitability. Its future success hinges on successful product launches, cost management, and navigating the competitive gene therapy landscape.
Sources and Disclaimers:
Information for this analysis was gathered from Bluebird bio's website, SEC filings, company press releases, and industry reports. Please note that this overview is for informational purposes only and should not be considered financial advice. Investing in Bluebird bio stock carries significant risk and requires thorough research and consultation with a financial professional.
AI Summarization is directionally correct and might not be accurate.
Summarized information shown could be a few years old and not current.
Fundamental Rating based on AI could be based on old data.
AI-generated summaries may have inaccuracies (hallucinations). Please verify the information before taking action.
About Bluebird bio Inc
Exchange | NASDAQ | Headquaters | Somerville, MA, United States |
IPO Launch date | 2013-06-19 | President, CEO & Director | Mr. Andrew Obenshain |
Sector | Healthcare | Website | https://www.bluebirdbio.com |
Industry | Biotechnology | Full time employees | 375 |
Headquaters | Somerville, MA, United States | ||
President, CEO & Director | Mr. Andrew Obenshain | ||
Website | https://www.bluebirdbio.com | ||
Website | https://www.bluebirdbio.com | ||
Full time employees | 375 |
bluebird bio, Inc., a biotechnology company, researches, develops, and commercializes gene therapies for severe genetic diseases. Its product candidates for severe genetic diseases include ZYNTEGLO (betibeglogene autotemcel) for the treatment of transfusion-dependent ß-thalassemia; lovotibeglogene autotemcel for the treatment of sickle cell disease (SCD); and SKYSONA (elivaldogene autotemcel) to treat cerebral adrenoleukodystrophy. The company's clinical development programs include HGB-205, HGB-206, and HGB-210 to evaluate the safety and efficacy of lovo-cel in the treatment of patients with SCD; and HGB-204, HGB-205, HGB-207, and HGB-212 to evaluate the safety and efficacy of beti-cel in the treatment of patients with ß-thalassemia. It has license agreement with Orchard Therapeutics Limited. The company was formerly known as Genetix Pharmaceuticals, Inc., and changed its name to bluebird bio, Inc. in September 2010. bluebird bio, Inc. was incorporated in 1992 and is headquartered in Somerville, Massachusetts.
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